Article
Immunology
Eun-Ha Kim, Young-ll Kim, Se Mi Kim, Kwang-Min Yu, Mark Anthony B. Casel, Seung-Gyu Jang, Philippe Noriel Q. Pascua, Richard J. Webby, Young Ki Choi
Summary: This study highlights the ability of wild migratory birds to carry various low-pathogenic avian influenza viruses that can infect land-based poultry and mammalian hosts while causing minimal signs of clinical disease. These viruses pose a significant threat to human health, emphasizing the need for continued surveillance.
EMERGING MICROBES & INFECTIONS
(2021)
Article
Multidisciplinary Sciences
V Caliendo, N. S. Lewis, A. Pohlmann, S. R. Baillie, A. C. Banyard, M. Beer, I. H. Brown, R. A. M. Fouchier, R. D. E. Hansen, T. K. Lameris, A. S. Lang, S. Laurendeau, O. Lung, G. Robertson, H. van der Jeugd, T. N. Alkie, K. Thorup, M. L. van Toor, J. Waldenstrom, C. Yason, T. Kuiken, Y. Berhane
Summary: Recent detection of highly pathogenic avian influenza viruses in North America, closely related to the viruses in Europe, raises concerns about further spread across the Americas through wild bird migration.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Mariana Leguia, Alejandra Garcia-Glaessner, Breno Munoz-Saavedra, Diana Juarez, Patricia Barrera, Carlos Calvo-Mac, Javier Jara, Walter Silva, Karl Ploog, Lady Amaro, Paulo Colchao-Claux, Christine K. Johnson, Marcela M. Uhart, Martha I. Nelson, Jesus Lescano
Summary: Highly pathogenic avian influenza A/H5N1 viruses have invaded the Americas and pose a threat to wildlife, poultry, and humans. The HPAI/H5N1 viruses in Peru have genetic reassortment between Eurasian and American lineages, emphasizing the need for surveillance and control measures.
NATURE COMMUNICATIONS
(2023)
Article
Immunology
Jingman Tian, Xiaoli Bai, Minghui Li, Xianying Zeng, Jia Xu, Peng Li, Miao Wang, Xingdong Song, Zhiguo Zhao, Guobin Tian, Liling Liu, Yuntao Guan, Yanbing Li, Hualan Chen
Summary: Since 2020, highly pathogenic avian influenza subtype H5N1 clade 2.3.4.4b virus has spread globally, causing large-scale avian influenza outbreaks. In China, 17 highly pathogenic H5N1 avian influenza viruses were isolated from wild birds, belonging to genotypes G07 and G10 from eastern Asia and Russia, respectively. These viruses were moderately pathogenic in mice but highly lethal in ducks. The H5/H7 trivalent vaccine provided complete protection against the H5N1 virus challenge in chickens.
EMERGING INFECTIOUS DISEASES
(2023)
Article
Microbiology
Zhongzi Yao, Huabin Zheng, Jiasong Xiong, Liping Ma, Rui Gui, Gongliang Zhu, Yong Li, Guoxiang Yang, Guang Chen, Jun Zhang, Quanjiao Chen
Summary: This study conducted a 5-year active surveillance of avian influenza virus (AIV) in wild birds in central China, revealing the long-term circulation and prevalence of AIVs in this region, as well as frequent and continuous intercontinental gene exchange. Spillover events from poultry to wild birds were observed, and some AIV strains showed the ability to bind human-type receptors and replicate in mice without preadaptation. These findings underscore the potential threat of wild bird AIVs to public health.
MICROBIOLOGY SPECTRUM
(2022)
Article
Infectious Diseases
Leo Loth, Long Thanh Pham, Mark Anthony Stevenson
Summary: The study revealed statistically significant spatio-temporal clustering of HPAI-H5N1 outbreaks in poultry in Vietnam, with frequent outbreaks in the southern region. Shortcomings in control measures led to difficulties in effectively controlling the outbreaks, highlighting the need for a better understanding of the relative impact of various control measures on spatio-temporal interactions in order to focus efforts on the most effective measures.
TRANSBOUNDARY AND EMERGING DISEASES
(2021)
Letter
Immunology
Jiasong Xiong, Hao Zhou, Lifang Fan, Gongliang Zhu, Yong Li, Guang Chen, Jun Zhang, Jundong Li, Hesong Zheng, Wei Feng, Jing Chen, Guoxiang Yang, Quanjiao Chen
Summary: The study identified eleven highly pathogenic avian influenza H5N8 viruses that were detected in migratory birds in Central China between November and December 2020. These strains were found to be highly homologous to those isolated in Europe from October to December 2020, suggesting a possible spread from Siberia via migratory birds. The research also revealed that H5N8 virus infection in migratory birds could lead to severe pathological damage and high viral load in multiple organs.
EMERGING MICROBES & INFECTIONS
(2021)
Article
Immunology
Wendy Puryear, Kaitlin Sawatzki, Nichola Hill, Alexa Foss, Jonathon J. Stone, Lynda Doughty, Dominique Walk, Katie Gilbert, Maureen Murray, Elena Cox, Priya Patel, Zak Mertz, Stephanie Ellis, Jennifer Taylor, Deborah Fauquier, Ainsley Smith, Robert A. DiGiovanni Jr, Adriana van de Guchte, Ana Silvia Gonzalez-Reiche, Zain Khalil, Harm van Bakel, Mia K. Torchetti, Kristina Lantz, Julianna B. Lenoch, Jonathan Runstadler
Summary: We report the spread of highly pathogenic avian influenza A(H5N1) in marine mammals in the northeastern United States, which is concurrent with the presence of H5N1 in wild birds in the same area. Our findings highlight the importance of monitoring both wild coastal birds and marine mammals in assessing the potential for an influenza A virus pandemic.
EMERGING INFECTIOUS DISEASES
(2023)
Article
Biochemistry & Molecular Biology
Olivier Duriez, Yohan Sassi, Chloe Le Gall-Ladeveze, Lea Giraud, Robert Straughan, Lise Dauverne, Anna Terras, Thierry Boulinier, Remi Choquet, Anne van de Wiele, Julien Hirschinger, Jean-Luc Guerin, Guillaume Le Loc'h
Summary: A study found that terrestrial birds infected with highly pathogenic avian influenza (HPAI) virus exhibit immobility behavior during the breeding season, which may reduce the risk of virus transmission. However, these infections pose a threat to endangered vulture species, raising concerns about their resistance to the virus.
Article
Multidisciplinary Sciences
Claire S. Teitelbaum, Nicholas M. Masto, Jeffery D. Sullivan, Allison C. Keever, Rebecca L. Poulson, Deborah L. Carter, Abigail G. Blake-Bradshaw, Cory J. Highway, Jamie C. Feddersen, Heath M. Hagy, Richard W. Gerhold, Bradley S. Cohen, Diann J. Prosser
Summary: Avian influenza viruses pose a threat to wildlife and livestock health, and little is known about how they spread in wild bird populations. A study found that infected mallards showed no significant differences in body condition, movement behavior, or survival rates compared to uninfected birds, suggesting that they may contribute to the maintenance and dispersal of the virus. Further research on more species, larger geographic areas, and multiple seasons is needed to understand the potential impacts of avian influenza on waterfowl and how the disease spreads across different species and large scales.
SCIENTIFIC REPORTS
(2023)
Article
Immunology
Jing Yang, Chunge Zhang, Yue Yuan, Ju Sun, Lu Lu, Honglei Sun, Heting Sun, Dong Chu, Siyuan Qin, Jianjun Chen, Chengbo Zhang, Xiyan Hao, Weifeng Shi, Wenjun Liu, George F. Gao, Paul Digard, Samantha Lycett, Yuhai Bi
Summary: Two novel reassortant highly pathogenic avian influenza viruses (H5N1) clade 2.3.4.4b.2 were discovered in dead migratory birds in China in November 2021. These viruses likely evolved among wild birds through different flyways connecting Europe and Asia. The low antigenic reaction to vaccine antiserum indicates high risks to poultry and public health.
EMERGING INFECTIOUS DISEASES
(2023)
Article
Immunology
Shailesh D. Pawar, Sadhana S. Kode, Sachin S. Keng, Deeksha S. Tare, Satish A. Pande
Summary: This report describes the distribution and seasonality of highly pathogenic avian influenza (HPAI) outbreaks in India from 2006 to 2021. The study found that most outbreaks occurred from post-monsoon to pre-summer season, with a peak in winter, particularly in January. In addition to poultry, other bird species such as owls, Indian peafowls, lesser adjutants, crows, and migratory birds like demoiselle cranes, northern pintails, and bar-headed geese tested positive for HPAI.
INDIAN JOURNAL OF MEDICAL RESEARCH
(2023)
Article
Immunology
Fatou T. Lo, Bianca Zecchin, Alpha A. Diallo, Racky O. Ba, Luca Tassoni, Aida Diop, Moussa Diouf, Mayekor Diouf, Yacine N. Samb, Ambra Pastori, Federica Gobbo, Francesca Ellero, Mariame Diop, Modou M. Lo, Mame N. Diouf, Mathioro Fall, Amadou A. Ndiaye, Adji M. Gaye, Medoune Badiane, Mbargou Lo, Babacor N. Youm, Ibrahima Ndao, Marius Niaga, Calogero Terregino, Boly Diop, Youssou Ndiaye, Angelique Angot, Ismaila Seck, Mamadou Niang, Baba Soumare, Alice Fusaro, Isabella Monne
Summary: In January 2021, the emergence of highly pathogenic avian influenza virus A(H5N1) was reported in Senegal, detected on a poultry farm and in great white pelicans in the Djoudj National Bird Sanctuary. This provides evidence of new transcontinental spread of H5N1 from Europe to Africa.
EMERGING INFECTIOUS DISEASES
(2022)
Article
Microbiology
Zienab Mosaad, Mohamed H. Elhusseiny, Ali Zanaty, Mustafa M. Fathy, Naglaa M. Hagag, Wesam H. Mady, Dalia Said, Moataz M. Elsayed, Ahmed M. Erfan, Neveen Rabie, Abdelhafez Samir, Mohamed Samy, Abdel-Satar Arafa, Abdullah Selim, Ali M. Abdelhakim, Johanna F. Lindahl, Samah Eid, Ake Lundkvist, Momtaz A. Shahein, Mahmoud M. Naguib
Summary: In response to recent outbreaks of highly pathogenic avian influenza (HPAI) H5N1 virus, 190 migratory birds were closely monitored in Egypt, and swab and tissue samples were collected. The samples were tested for various AIV subtypes and other pathogens, and it was found that HPAI H5N1 virus was present in six samples. These findings highlight the risk of introducing this strain into the local poultry population, emphasizing the need for continued epidemiological and molecular monitoring of AIV in close proximity to the domestic-wild bird interface.
Article
Immunology
Mabusetsa R. J. Makalo, William G. Dundon, Tirumala B. K. Settypalli, Sneha Datta, Charles E. Lamien, Giovanni Cattoli, Moeketsi S. Phalatsi, Relebohile J. Lepheana, Mpaliseng Matlali, Relebohile G. Mahloane, Marosi Molomo, Palesa C. Mphaka
Summary: In May 2021, Lesotho reported its first outbreak of highly pathogenic avian influenza (HPAI) caused by H5N1 subtype. The virus showed high genetic similarity with A/H5N1 viruses identified in Nigeria and Senegal. This discovery has significant implications for disease management and food security in the region.
EMERGING MICROBES & INFECTIONS
(2022)
Letter
Virology
Lijia Jia, Jianjun Chen, Haizhou Liu, Wenhui Fan, Depeng Wang, Jing Li, Di Liu
Article
Gastroenterology & Hepatology
Jumin Huang, Di Liu, Yuwei Wang, Liang Liu, Jian Li, Jing Yuan, Zhihong Jiang, Zebo Jiang, W. L. Wendy Hsiao, Haizhou Liu, Imran Khan, Ying Xie, Jianlin Wu, Yajia Xie, Yizhong Zhang, Yu Fu, Junyi Liao, Wenjun Wang, Huanling Lai, Axi Shi, Jun Cai, Lianxiang Luo, Runze Li, Xiaojun Yao, Xingxing Fan, Qibiao Wu, Zhongqiu Liu, Peiyu Yan, Jingguang Lu, Mingrong Yang, Lin Wang, Yabing Cao, Hong Wei, Elaine Lai-Han Leung
Summary: This study demonstrated that the combination of GPs and alpha PD-1 mAb enhanced the antitumor response by modulating gut microbiota. The GPs increased microbial metabolites and reshaped gut microbiota towards responders, sensitizing non-small cell lung cancer patients to anti-PD-1 immunotherapy. Additionally, gut microbiota could serve as a novel biomarker to predict the response to anti-PD-1 immunotherapy.
Article
Biotechnology & Applied Microbiology
Peng Li, Runjie Song, Fan Yin, Mei Liu, Huijiao Liu, Shuoqian Ma, Xiaomeng Jia, Xiaohui Lu, Yuting Zhong, Lei Yu, Xiru Li, Xiangdong Li
Summary: This study identifies circMRPS35 as a highly expressed circRNA in HCC and shows that its knockdown inhibits cell proliferation, migration, invasion, and colony formation, as well as tumor growth. circMRPS35 regulates PTEN expression and degradation through miR-148a and STX3. Additionally, the circMRPS35-encoded peptide circMRPS35-168aa promotes cisplatin resistance in HCC.
Article
Infectious Diseases
Wenhui Fan, Ying Cao, Pengtao Jiao, Ping Yu, He Zhang, Teng Chen, Xintao Zhou, Yu Qi, Lei Sun, Di Liu, Hongfei Zhu, Wenjun Liu, Rongliang Hu, Jing Li
Summary: Research shows that different tissues cooperate in responding to African swine fever virus infection, coordinating defense against ASFV through an inflammatory cytokine storm and interferon activation. The lung and spleen are mainly involved in the innate immune response pathway; the liver and kidney are involved in the metabolic regulatory pathway and inflammatory response; the lymph nodes cooperate with the liver to complete energy metabolism regulation.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Article
Cell Biology
Kamila Pulawska, Donata Ponikwicka-Tyszko, Weronika Lebiedzinska, Peilan Guo, Piotr Bernaczyk, Agata Pilaszewicz-Puza, Xiangdong Li, Marcin Chrusciel, Oana Lupu, Sini Leskinen, Juho-Antti Makela, Jorma Toppari, Slawomir Wolczynski, Herjan J. T. Coelingh Bennink, Ilpo Huhtaniemi, Nafis A. Rahman
Summary: The study reveals unexpected ZP3 expression in the testis of healthy human and mouse, besides ovary, suggesting implications for the development of cancer immunotherapies and male immunocontraceptives targeting ZP3.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2022)
Article
Genetics & Heredity
Yanxue Yu, Qi Wang, Ping Zhou, Na Lv, Wei Li, Fangqing Zhao, Shuifang Zhu, Di Liu
Summary: This study developed a tracing method based on insect gut microbiota to rapidly determine the geographical origin of insects. The diversity of the insect gut microbiota was found to be closely associated with geographical and environmental factors, and different insect species and populations could be distinguished based on the composition of gut microbiota.
GENOMICS PROTEOMICS & BIOINFORMATICS
(2022)
Article
Biochemistry & Molecular Biology
Runjie Song, Yaqi Du, Peng Li, Lijun Zhou, Han Zheng, Xiaohui Lu, Shenghong Wang, Wenqiang Ma, Hua Zhang, Xiangdong Li
Summary: This study found that LETMD1 plays a crucial role in the thermogenesis and energy homeostasis of brown adipose tissue. By regulating mitochondrial structures and functions, LETMD1 can affect mitochondrial fission and the concentration of Ca2+, thereby influencing the thermogenesis of brown adipose tissue.
Article
Biochemistry & Molecular Biology
Peng Li, Runjie Song, Yaqi Du, Huijiao Liu, Xiangdong Li
Summary: Brown and beige adipose tissues play a crucial role in maintaining body temperature and their impaired function can lead to metabolic diseases. This study identified a functional thermogenic regulator, Adtrp, which was significantly overexpressed in mature brown/beige adipocytes and played a key role in thermogenesis and metabolism.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Medical Laboratory Technology
Shanshan Zhang, Yajing Liu, Mingming Wang, Donata Ponikwicka-Tyszko, Wenqiang Ma, Anna Krentowska, Irina Kowalska, Ilpo Huhtaniemi, Slawomir Wolczynski, Nafis A. Rahman, Xiangdong Li
Summary: Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of reproductive age, but its etiology and targeted therapy options are still unknown. The reduced expression of miR-335-5p in PCOS patients suggests its potential as a diagnostic biomarker and therapeutic target for PCOS. Further studies revealed the mechanistic pathway of miR-335-5p in the etiopathogenesis of PCOS, making it a promising candidate for further research and development.
TRANSLATIONAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Xiaomeng Jia, Huijiao Liu, Xinmin Ren, Peng Li, Runjie Song, Xiru Li, Yangdong Guo, Xiangdong Li
Summary: This study identified a novel SIRT1 regulatory protein, NOC4L, that binds to and inhibits the deacetylation of p53 mediated by SIRT1. Overexpression of NOC4L increases p53 acetylation and promotes cell apoptosis, while inhibiting tumor cell proliferation and tumor growth in a p53-dependent manner.
Article
Biochemistry & Molecular Biology
Runjie Song, Shuoqian Ma, Jiajia Xu, Xin Ren, Peilan Guo, Huijiao Liu, Peng Li, Fan Yin, Mei Liu, Qiang Wang, Lei Yu, Jiali Liu, Binwei Duan, Nafis A. Rahman, Slawomir Wolczynski, Guangming Li, Xiangdong Li
Summary: This study aims to elucidate the potential role and molecular mechanism of circZKSaa in the regulation of hepatocellular carcinoma (HCC) progression. Through a series of experiments, it was found that circZKSaa inhibited HCC progression and sensitized HCC cells to sorafenib. Furthermore, the high expression of cicZKSCAN1 in sorafenib-treated HCC cells was regulated by QKI-5. These findings demonstrate that circZKSaa has the potential to serve as a therapeutic target and biomarker for HCC treatment.
Article
Medical Laboratory Technology
Yajing Liu, Shanshan Zhang, Li Chen, Xuan Huang, Mingming Wang, Donata Ponikwicka-Tyszko, Nafis A. Rahman, Slawomir Wolczynski, Bing Yao, Xiangdong Li
Summary: The study found that miR-96-5p plays a crucial role in the pathogenesis of PCOS and may serve as a novel diagnostic biomarker and therapeutic target for PCOS.
TRANSLATIONAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Runjie Song, Peilan Guo, Xin Ren, Lijun Zhou, Peng Li, Nafis A. Rahman, Slawomir Wolczynski, Xiru Li, Yanjun Zhang, Mei Liu, Jiali Liu, Xiangdong Li
Summary: This study reanalyzed the circRNA expression data of TNBC and identified circCAPG as a potential biomarker in TNBC. Further experiments showed that circCAPG could encode a novel polypeptide, CAPG-171aa, which promoted the proliferation and metastasis of TNBC cells. Additionally, SLU7 was found to be involved in the formation of circCAPG. These findings provide new insights into the role of circCAPG in TNBC and its potential as a therapeutic target and prognostic biomarker.
Article
Virology
Yi Yan, Decheng Wang, Ying Li, Zhiyong Wu, Haizhou Liu, Yue Shi, Xiaoxia Lu, Di Liu
Summary: This study conducted a systematic surveillance on hospitalized children in Hubei province from 2020 to 2021, and identified 106 RSV-positive samples. RSV-A and RSV-B groups co-circulated during the surveillance with RSV-B being predominant. The study also revealed the intra-host and inter-regional evolution of RSV, and provided evidence for understanding the evolution of RSV.
Article
Virology
Bangyao Sun, Ming Ni, Haizhou Liu, Di Liu
Summary: Analyses of viral inter- and intra-host mutations are important for the prevention and control of infectious diseases. Previous studies have mainly focused on inter-host variations, but with the advancement of next-generation sequencing, more attention is now being given to intra-host diversity. However, there is still much to be understood about the theoretical basis and dynamic characteristics of intra-host mutations.
