期刊
SCIENCE TRANSLATIONAL MEDICINE
卷 5, 期 170, 页码 -出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/scitranslmed.3004912
关键词
-
资金
- Bill & Melinda Gates Foundation through the Grand Challenges Exploration Initiative
- Canadian Cancer Society
- KaviKrishna Foundation, Sualkuchi, Assam, India
- Laurel Foundation
- NIH [R01AI076425, R01 CA105102, CA89305-0351, CA112973]
- Department of Defense [PR080163]
Mycobacterium tuberculosis (Mtb) can persist in hostile intracellular microenvironments evading immune cells and drug treatment. However, the protective cellular niches where Mtb persists remain unclear. We report that Mtb may maintain long-term intracellular viability in a human bone marrow (BM)-derived CD271(+)/CD45(-) mesenchymal stem cell (BM-MSC) population in vitro. We also report that Mtb resides in an equivalent population of BM-MSCs in a mouse model of dormant tuberculosis infection. Viable Mtb was detected in CD271(+)/CD45(-) BM-MSCs isolated from individuals who had successfully completed months of anti-Mtb drug treatment. These results suggest that CD271(+) BM-MSCs may provide a long-term protective intracellular niche in the host in which dormant Mtb can reside.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据