Article
Biochemistry & Molecular Biology
Jafar Sharifi, Mohammad Reza Khirehgesh, Bahman Akbari, Bijan Soleymani, Kamran Mansouri
Summary: Targeted therapy is an effective approach in cancer treatment, and a novel humanized anti-EGFR biparatopic nanobody, hu7CG2, showed potential in inhibiting the growth of EGFR-overexpressing tumor cells by grafting specific regions from camelid anti-EGFR nanobodies.
MOLECULAR BIOTECHNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Javier Vaquero, Allan Pavy, Ester Gonzalez-Sanchez, Mark Meredith, Ander Arbelaiz, Laura Fouassier
Summary: EGFR can be targeted through selective tyrosine kinase inhibitors and monoclonal antibodies, but the majority of patients do not benefit due to the presence of drug resistance mechanisms. Extensive research is being conducted to find novel approaches to overcome resistance.
DRUG RESISTANCE UPDATES
(2022)
Review
Gastroenterology & Hepatology
Feng Xiong, Yu-Wen Zhou, Ya-Ting Hao, Gui-Xia Wei, Xiao-Rong Chen, Meng Qiu
Summary: Monoclonal antibodies targeting EGFR, such as cetuximab and panitumumab, have limitations as a single therapy for mCRC and the use of immunotherapy alone has unsatisfactory outcomes. Combination therapy of anti-EGFR therapy with immunotherapy shows promise in improving the therapeutic effect for refractory mCRC patients.
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Pharmacology & Pharmacy
Anjong Florence Tikum, Anand Krishnan Nambisan, Jessica Pougoue Ketchemen, Hanan Babeker, Musharraf N. Khan, Emina E. Torlakovic, Humphrey Fonge
Summary: This study developed a PET probe for diagnosis and monitoring of a noncompeting anti-EGFR antibody drug treatment, and evaluated its efficacy in a mouse colorectal cancer model.
Review
Pharmacology & Pharmacy
Jafar Sharifi, Mohammad Reza Khirehgesh, Fatemeh Safari, Bahman Akbari
Summary: This review discusses the use of nanobodies in targeted therapy, focusing on recent advancements and future prospects in targeting EGFR.
JOURNAL OF DRUG TARGETING
(2021)
Article
Cell Biology
Wenxiang Hu, Chunjie Jiang, Mindy Kim, Wenjian Yang, Kun Zhu, Dongyin Guan, Wenjian Lv, Yang Xiao, Jessica R. Wilson, Daniel J. Rader, Ching-Hon Pui, Mary Relling, Mitchell A. Lazar
Summary: The study revealed cell type-specific and individual-specific responses to glucocorticoids, attributed to single-nucleotide polymorphisms that altered the binding motifs of the glucocorticoid receptor or its cooperating factors. Additionally, genetic variants affecting chromatin accessibility or structure were found to modulate the response to glucocorticoids. These genetic variations influenced glucocorticoid-induced metabolic perturbations and were associated with increased serum glucose, lipids, and body mass in subjects on glucocorticoid therapy.
Article
Pharmacology & Pharmacy
Dianlong Jia, Feifei Wang, Yue Lu, Ping Hu, Rui Wang, Guangyong Li, Renmin Liu, Jun Li, Huimin Liu, Qing Fan, Fengjiao Yuan
Summary: In this study, EGFR-targeting TRAIL (Z-TRAIL) was successfully designed by genetically fusing an EGFR-antagonistic affibody (ZEGFR:1907) to TRAIL. Z-TRAIL showed enhanced cytotoxicity and apoptosis-inducing ability in EGFR-overexpressing tumors both in vitro and in vivo, and also exhibited antitumor efficacy against low-expressing EGFR tumors. Furthermore, Z-TRAIL did not show obvious acute toxicity in mice, suggesting its potential as a promising agent for targeted therapy of EGFR-expressing tumors.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Cell Biology
Alessandro Leonetti, Mjriam Capula, Roberta Minari, Giulia Mazzaschi, Alessandro Gregori, Btissame El Hassouni, Filippo Papini, Paola Bordi, Michela Verze, Amir Avan, Marcello Tiseo, Elisa Giovannetti
Summary: Our study found that patients with an increase in miR-21 levels after two months of EGFR-TKI treatment were more likely to experience disease stability/progression. Patients who experienced clinical benefit lasting at least six months showed higher levels of circulating miR-21.
Review
Pharmacology & Pharmacy
Dongling Liu, Xiang Zeng, Zufeng Ding, Fenghua Lv, Jawahar L. Mehta, Xianwei Wang
Summary: COVID-19 infection has a high mortality rate in patients with preexisting cardiovascular diseases, and those with cardiovascular comorbidities have a higher risk of death. Drugs used to treat COVID-19 can have adverse effects on the heart.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Quan Ke Thai, Thanh-Cong Nguyen, Cong-Trieu Le, Anh-Dung Chung, Tran Minh-Ly Nguyen, Quoc-Dung Tran, Peter Savolainen, Quoc-Dang Quan, Dai-Long Tran, Hoang-Dung Tran
Summary: This study evaluated the genetic diversity and origin of Vietnamese domestic dogs based on genetic data. The results showed the existence of 56 haplotypes, including 14 indigenous ones. It was found that Australian dingo and Polynesian dogs originated from Southeast Asian dogs. Samples from 429 dogs across Vietnam were collected to study the genetic diversity and rare haplotype E in the Vietnamese dog population. The study confirmed the presence of two rare haplotypes E (E1 and E4) in Vietnamese dogs.
Article
Biology
Leying Chen, Qing You, Min Liu, Shuaihu Li, Zhaoyu Wu, Jiajun Hu, Yurui Ma, Liangyong Xia, Ying Zhou, Nan Xu, Shiyi Zhang
Summary: This study found that the atrophy of dermal white adipose tissue (dWAT) is associated with the occurrence and exacerbation of rash in a murine model of EGFR inhibitor-induced rash. Activation of PPAR gamma can improve the severity of rash without affecting the antitumor effects.
Article
Chemistry, Multidisciplinary
Shambojit Roy, Shane D. Curry, Conrad Corbella Bagot, Evan N. Mueller, Abdulrahman M. Mansouri, Wounjhang Park, Jennifer N. Cha, Andrew P. Goodwin
Summary: In this study, a photo-cross-linkable conjugate of upconverting nanoparticles and cytosine deaminase was successfully used for specific prodrug conversion at tumor sites in vivo. The technology demonstrated the ability to localize prodrug conversion to tumor sites, effectively inhibiting tumor growth and improving mouse survival time.
Article
Oncology
Li Li, Lan Deng, Xiaoqing Meng, Changling Gu, Kai Li, Xuesai Zhang, Yun Meng, Wei Xu, Le Zhao, Jianhe Chen, Zhenping Zhu, Haomin Huang
Summary: The study developed a new strategy by combining conventional targeted therapy with immune checkpoint blockade using a tumor-targeting bispecific antibody. This antibody not only directly inhibits tumor growth through EGFR inhibition but also activates T cell anti-tumor immunity by blocking the interaction between PD1 and PDL1.
TRANSLATIONAL ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Rose Parisi, Hemali Shah, Neil H. Shear, Michael Ziv, Alina Markova, Roni P. Dodiuk-Gad
Summary: The rapid development of anti-cancer therapy has improved treatment outcomes for cancer patients, but it has also been associated with the occurrence of bullous dermatologic adverse events (DAE), which can negatively impact patients' quality of life and treatment continuation. Effective management of these adverse events is crucial for minimizing treatment interruptions and maintaining the anti-tumor effect.
Review
Biochemistry & Molecular Biology
Meiqin Yuan, Zeng Wang, Wangxia Lv, Hongming Pan
Summary: Currently, the combination of anti-EGFR mAb and chemotherapy is the first-line treatment standard for RAS wild-type mCRC. However, there is ongoing debate regarding the use of anti-EGFR mAb for maintenance treatment after the initial treatment. Despite the lack of evidence from large-scale clinical trials, more studies support the use of anti-EGFR mAb for maintenance therapy, although cost and drug resistance remain concerns.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Clinical Neurology
Ashley M. Goodwin, Kayla M. D. Cornett, Marnee J. McKay, Joshua Burns, Carol Ewing Garber, Darryl C. De Vivo, Jacqueline Montes Pt
Article
Chemistry, Analytical
Aston K. McCullough, Melanie Rodriguez, Carol Ewing Garber
Article
Hospitality, Leisure, Sport & Tourism
Ciaran P. Friel, Carol Ewing Garber
JOURNAL OF SPORT & EXERCISE PSYCHOLOGY
(2020)
Article
Transplantation
Augustine W. Kang, Andrew G. Bostom, Hongseok Kim, Charles B. Eaton, Reginald Gohh, John W. Kusek, Marc A. Pfeffer, Patricia M. Risica, Carol E. Garber
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2020)
Article
Education & Educational Research
Mindy Feldman Hecht, Carol Ewing Garber
Summary: This study evaluated the impact of a multimodal classroom program on physical activity and executive function of fifth graders. Results showed that the intervention group had significantly higher classroom physical activity and improved executive function scores. Student math test scores also significantly increased, showing the potential of the program to improve children's socioemotional and physical health.
JOURNAL OF SCHOOL HEALTH
(2021)
Review
Physiology
Darya Moosavi, David Wolovsky, Angela Depompeis, David Uher, David Lennington, Roddy Bodden, Carol Ewing Garber
Summary: The systematic review aims to investigate the effects of exposure to microgravity on the musculoskeletal system and the efficacy of exercise countermeasures in this environment. The interaction between the bone and muscle systems is complex, with resistive exercise targeting muscle mass and strength likely to be the most effective countermeasure.
PHYSIOLOGICAL RESEARCH
(2021)
Article
Clinical Neurology
Jacqueline Montes, Ashley M. Goodwin, Michael P. McDermott, David Uher, Feliz Marie Hernandez, Kayla Coutts, Julia Cocchi, Margarethe Hauschildt, Kayla M. Cornett, Ashwini K. Rao, Umrao R. Monani, Carol Ewing Garber, Darryl C. De Vivo
Summary: This study reveals reduced muscle oxygen uptake and increased fatigue during exercise in individuals with spinal muscular atrophy (SMA) compared to healthy controls, with significant correlations between muscle oxygen uptake and aerobic capacity, workload, and body composition in SMA patients. Understanding the mechanisms underlying these changes may lead to identifying new therapeutic targets for alleviating symptoms and reducing disease burden in SMA patients.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2021)
Article
Clinical Neurology
Zeinab Khodaverdi, David Moreau, Carol Ewing Garber
Summary: ADHD is the most prevalent neurodevelopmental disorder in children, associated with academic failure, interpersonal problems, mental illness, and criminality. This study found that acute aerobic exercise lasting 20-30 minutes at moderate intensity improved all aspects of executive functions in children with ADHD. Furthermore, chronic exercise lasting at least 45 minutes and in the range of moderate to high intensity showed additional benefits in inhibition and set-shifting.
CHILD NEUROPSYCHOLOGY
(2022)
Article
Sport Sciences
Shirit Kamil-Rosenberg, Mary L. Greaney, Carol Ewing Garber
Summary: A study found that individuals with disabilities were less likely to meet muscle strengthening exercise recommendations compared to those without disabilities. Those who were older and had poor health status in the disabled group had the lowest likelihood of participating in exercise.
SPORT SCIENCES FOR HEALTH
(2021)
Meeting Abstract
Sport Sciences
Mindy K. Feldman Hecht, Tamar Z. Kahane, Carol E. Garber
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2020)
Meeting Abstract
Sport Sciences
Vincenzo Lauriola, Grace Liu, Kathleen M. McIntyre, Carol Ewing Garber, Richard P. Sloan
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2020)
Meeting Abstract
Sport Sciences
Miguel Blacutt, Matthew Stults-Kolehmainen, Nia Fogelman, Carol E. Garber, John B. Bartholomew, Rajita Sinha
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2020)
Article
Oncology
A. Rossi, C. E. Garber, M. Ortiz, V Shankar, D. Y. Kuo, N. S. Nevadunsky
EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY
(2020)
Article
Public, Environmental & Occupational Health
Ciaran P. Friel, Carol Ewing Garber
AMERICAN JOURNAL OF HEALTH PROMOTION
(2020)
Review
Sport Sciences
Garrett I. Ash, Matthew Stults-Kolehmainen, Michael A. Busa, Robert Gregory, Carol Ewing Garber, Jason Liu, Mark Gerstein, Jose Antonio Casajus, Alex Gonzalez-Aguero, Demitri Constantinou, Michael Geistlinger, Fergus M. Guppy, Fabio Pigozzi, Yannis P. Pitsiladis
CURRENT SPORTS MEDICINE REPORTS
(2020)