Article
Neurosciences
Yang Liu, Zhiyuan Huang, Honghe Liu, Zhicheng Ji, Amit Arora, Danfeng Cai, Hongjin Wang, Mingming Liu, Eric A. J. Simko, Yanjun Zhang, Goran Periz, Zhe Liu, Jiou Wang
Summary: The C9orf72 HRE DNA binds to DAXX and promotes its liquid-liquid phase separation, resulting in chromatin remodeling and epigenetic changes. DAXX regulates global gene expression and suppresses the expression of C9orf72 through chromatin remodeling and epigenetic modifications. Modulating DAXX or rebalancing epigenetic modifications can mitigate the stress-induced sensitivity of C9orf72-patient-derived motor neurons.
Review
Clinical Neurology
Leanne M. Holt, Eric J. Nestler
Summary: Addiction is a major global disease burden and a challenge in neuroscience research. This review focuses on the transcriptional and epigenetic mechanisms of drug action in astrocytes, highlighting their role in regulating drug-seeking behaviors and their robust transcriptional response to substances of abuse.
JOURNAL OF NEURAL TRANSMISSION
(2023)
Article
Plant Sciences
Serine Soudani, Cesar Poza-Carrion, Noelia De la Cruz Gomez, Azucena Gonzalez-Coloma, Maria Fe Andres, Marta Berrocal-Lobo
Summary: In this study, the direct and indirect plant protection effects of Artemisia absinthium essential oil (AEO) on tomato seedlings against Fusarium oxysporum sp. oxysporum radicis lycopersici (Fol) were investigated. AEO exhibited toxicity against Fol in vitro and protected tomato seedlings against Fol when applied as a seed coating. AEO treatment enhanced plant defenses through increased calloase deposition and reactive oxygen species production, without affecting seed germination or plant development. Furthermore, AEO induced epigenetic changes in tomato, modulating the speed and extent of its immune response to Fol. Overall, AEO seed coating could be a promising strategy to enhance durable tomato resistance to pathogens.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Mi Kyoung Seo, Ah Jeong Choi, Dae-Hyun Seog, Jung Goo Lee, Sung Woo Park
Summary: Research indicates that an enriched environment in early life may enhance the ability to cope with adult stress through epigenetic modification, preventing depression-like behavior induced by chronic stress and preserving expression and modification of the p11 gene. These findings demonstrate the positive effects of early-life environments on adult mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Fan Zhao, Jing Yu, Weiliang Gao, Xue Yang, Liying Liang, Xiaolian Sun, Dan Su, Yao Ying, Wangchang Li, Juan Li, Jingwu Zheng, Liang Qiao, Wei Cai, Shenglei Che, Xiaozhou Mou
Summary: This article introduces a H2O2-free chemodynamic therapy technique with tumor-specificity using pH-sensitive magnetic iron carbide nanoparticles to trigger the production of reactive oxygen species, resulting in effective tumor cell apoptosis. The study demonstrates enhanced and tumor-specific CDT efficacy for effective tumor inhibition based on ROS generation, offering a new direction to improve CDT efficacy without relying on H2O2.
Review
Neurosciences
C. Noschang, C. Lampert, R. Krolow, R. M. M. de Almeida
Summary: Adolescent social isolation can increase the risk of drug use, and the specific timing of the effect may depend on multiple factors.
PSYCHOPHARMACOLOGY
(2021)
Article
Chemistry, Analytical
Margaret Sotom, Paul Bowdler, Kevin C. Honeychurch
Summary: A liquid chromatography-tandem mass spectrometry screening method in sweat was developed for the simultaneous determination of licit drugs, illicit drugs, and metabolites. The method was linear and had limits of quantitation and detection suitable for drug analysis. The study showed that sweat patches can be used to indicate an individual's drug use.
ANALYTICAL METHODS
(2023)
Article
Chemistry, Inorganic & Nuclear
Pablo Labra-Vazquez, Vladyslav Mudrak, Marine Tasse, Sonia Mallet-Ladeira, Alix Sournia-Saquet, Jean-Pierre Malval, Pascal G. Lacroix, Isabelle Malfant
Summary: A fundamental challenge in phototriggered therapies is to develop stable molecular frameworks that can withstand biological media. In this study, we successfully prepared stable RuNO photoNORMs with enhanced pi-backbonding between the Ru and NO ligand, resulting in remarkable stability and significant NO release efficiency in water. Moreover, we demonstrated the possibility of using two-photon absorption to activate water-stable multipolar NO-delivery platforms in the near-IR region.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Maciej Zaranek, Mateusz Nowicki, Piotr Andruszak, Marcin Hoffmann, Piotr Pawluc
Summary: Sodium trialkylborohydrides were confirmed as selective catalysts for hydrogermylation of aromatic alkenes. Addition of phenylgermane and diphenylgermane in the presence of 10 mol% NaHB(sec-Bu)3 showed high selectivity, producing beta-germylated products, in contrast to the hydrosilylation process. DFT calculations supported the mechanism proceeding through a trisubstituted germanide anion attacking the terminal vinyl carbon.
CHEMICAL COMMUNICATIONS
(2022)
Article
Neurosciences
Yi-Xiao Luo, Donald Huang, Changyong Guo, Yao-Ying Ma
Summary: The study suggests that limited, but not extended drug exposure, may lead to higher risk of relapse in young rats. However, the neuronal adaptations in the insular cortex observed in the study may not fully explain the increased drug-taking behaviors caused by limited cocaine IVSA.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Review
Environmental Sciences
Sujin Kim, Isha Thapar, Bryan W. Brooks
Summary: Studies have shown that per- and polyfluoroalkyl substances (PFAS) can cause epigenetic modifications, including DNA methylation, histone modification, and microRNA expression. Different types of research have revealed the potential harm of PFAS to human health, and further studies are needed to understand the specific effects of PFAS.
ENVIRONMENTAL POLLUTION
(2021)
Article
Environmental Sciences
Maissa A. Adi, Mohammednoor Altarawneh
Summary: This study aims to understand the impact of hydrofluoroethers on the atmosphere. By examining the decomposition products and atmospheric fate of perfluoro methyl vinyl ether and perfluoro ethyl vinyl ether, it is found that they act as greenhouse gases. The atmospheric lifetimes and photochemical ozone creation potentials are calculated.
ATMOSPHERIC ENVIRONMENT
(2023)
Article
Astronomy & Astrophysics
Joseph R. Dwyer
Summary: Terrestrial gamma-ray flashes (TGFs) are powerful submillisecond bursts of gamma rays produced by thunderstorms. While most TGFs have been observed by spacecraft in low-Earth orbit, recent measurements have also detected TGFs on the ground. It is found that TGFs can be produced by positive leaders and may pose a radiation threat to aviation safety with doses exceeding 1 Sievert.
Article
Chemistry, Multidisciplinary
C. Blake Wilson, Robert Tycko
Summary: Elucidating the detailed mechanisms of structural conversions in biological macromolecules is crucial for biophysical chemistry, and new experimental methods are needed for further understanding. The article presents a simple technique called rapid inverse temperature jump, which enables the initiation of a structural conversion process in solutions by rapidly decreasing the temperature. The technique is demonstrated using a 26-residue peptide called melittin, where the conversion from a disordered state to a helical state was studied. Time-resolved solid-state nuclear magnetic resonance (ssNMR) was used to analyze the kinetics and mechanism of the conversion.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Environmental Sciences
Beiran Yang, Aobo Liang, Liming Wang
Summary: The atmospheric oxidation mechanism of acetophenone (AP) initiated by its reaction with the OH radical in gas phase was investigated. The reaction starts by OH additions to the aromatic ring, and the predicted rate coefficient suggests a lifetime of around 8 days in the atmosphere. The main products of AP oxidation include phenol and three isomers of hydroxyacetophenones, indicating that oxidation by OH can reduce its unpleasant effects on human beings.
ATMOSPHERIC ENVIRONMENT
(2023)
Article
Behavioral Sciences
S. N. Reisinger, E. Kong, B. Molz, T. Humberg, S. Sideromenos, A. Cicvaric, T. Steinkellner, J. -W. Yang, M. Cabatic, F. J. Monje, H. H. Sitte, B. J. Nichols, D. D. Pollak
GENES BRAIN AND BEHAVIOR
(2019)
Article
Biochemistry & Molecular Biology
Fabian Dorninger, Theresa Koenig, Petra Scholze, Michael L. Berger, Gerhard Zeitler, Christoph Wiesinger, Anna Gundacker, Daniela D. Pollak, Sigismund Huck, Wilhelm W. Just, Sonja Forss-Petter, Christian Pifl, Johannes Berger
HUMAN MOLECULAR GENETICS
(2019)
Article
Multidisciplinary Sciences
Marianne Ronovsky, Alice Zambon, Ana Cicvaric, Vincent Boehm, Bastian Hoesel, Bernhard A. Moser, Jiaye Yang, Johannes A. Schmid, Wulf E. Haubensak, Francisco J. Monje, Daniela D. Pollak
SCIENTIFIC REPORTS
(2019)
Article
Immunology
Silke Kreitz, Alice Zambon, Marianne Ronovsky, Lubos Budinsky, Thomas H. Helbich, Spyros Sideromenos, Claudiu Ivan, Laura Konerth, Isabel Wank, Angelika Berger, Arnold Pollak, Hess Andreas, Daniela D. Pollak
BRAIN BEHAVIOR AND IMMUNITY
(2020)
Article
Cell Biology
Stefanie Berger, Sarah Gureczny, Sonali N. Reisinger, Orsolya Horvath, Daniela D. Pollak
Article
Biochemistry & Molecular Biology
Solomiia Korchynska, Maria Krassnitzer, Katarzyna Malenczyk, Rashmi B. Prasad, Evgenii O. Tretiakov, Sabah Rehman, Valentina Cinquina, Victoria Gernedl, Matthias Farlik, Julian Petersen, Sophia Hannes, Julia Schachenhofer, Sonali N. Reisinger, Alice Zambon, Olof Asplund, Isabella Artner, Erik Keimpema, Gert Lubec, Jan Mulder, Christoph Bock, Daniela D. Pollak, Roman A. Romanov, Christian Pifl, Leif Groop, Tomas G. M. Hoekfelt, Tibor Harkany
Article
Behavioral Sciences
Michael O. Gabriel, Maria Nikou, Oluwole B. Akinola, Daniela D. Pollak, Spyridon Sideromenos
BEHAVIOURAL BRAIN RESEARCH
(2020)
Article
Endocrinology & Metabolism
Sonali N. Reisinger, Martin Bilban, Tamara Stojanovic, Sophia Derdak, Jiaye Yang, Ana Cicvaric, Orsolya Horvath, Spyros Sideromenos, Alice Zambon, Francisco J. Monje, Stefan Boehm, Daniela D. Pollak
PSYCHONEUROENDOCRINOLOGY
(2020)
Article
Neurosciences
Stefanie Berger, Miranda Stattmann, Ana Cicvaric, Francisco J. Monje, Pierluca Coiro, Matej Hotka, Gerda Ricken, Johannes Hainfellner, Susanne Greber-Platzer, Makiko Yasuda, Robert J. Desnick, Daniela D. Pollak
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2020)
Article
Cell Biology
Spyridon Sideromenos, Claudia Lindtner, Alice Zambon, Orsolya Horvath, Angelika Berger, Daniela D. Pollak
Article
Biochemistry & Molecular Biology
Sonali N. Reisinger, Spyros Sideromenos, Orsolya Horvath, Sophia Derdak, Ana Cicvaric, Francisco J. Monje, Martin Bilban, Martin Haering, Micaela Glat, Daniela D. Pollak
Summary: Studies have shown that changes in STAT3 signaling in the midbrain serotonergic system can affect emotional behavior in mice, including reducing negative behavioral reactivity and sensitivity to amphetamine, which may be related to the activity of serotonergic neurons and transcriptional control of gene networks relevant to neuropsychiatric disorders.
MOLECULAR PSYCHIATRY
(2021)
Article
Multidisciplinary Sciences
Zsofia Hevesi, Dora Zelena, Roman A. Romanov, Janos Hanics, Attila Ignacz, Alice Zambon, Daniela D. Pollak, David Lendvai, Katalin Schlett, Miklos Palkovits, Tibor Harkany, Tomas G. M. Hokfelt, Alan Alpar
Summary: In this study, a specific cell population was identified that gates danger avoidance behavior, with secretagogin serving as both a selective marker and regulatory protein in their excitatory postsynaptic machinery. Additionally, Scgn was found to regulate the cell-surface availability of NMDA receptor 2B subunits, leading to reduced cell membrane delivery of GluN2B at least in vitro.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Immunology
Zsofia Hevesi, Daniela Anna Gerges, Sebastian Kapps, Raimundo Freire, Sophie Schmidt, Daniela D. Pollak, Klaus Schmetterer, Tobias Frey, Rita Lang, Wolfgang Winnicki, Alice Schmidt, Tibor Harkany, Ludwig Wagner
Summary: Researchers engineered a divalent gene construct combining the receptor-binding domain (RBD) of the spike protein and the immunodominant region of the viral nucleocapsid. They demonstrated that this approach can effectively generate antibody response and stimulate T cell immune response.
Article
Neurosciences
Spyridon Sideromenos, Anna Gundacker, Maria Nikou, Raimund Oberle, Orsolya Horvath, Peter Stoehrmann, Timo Partonen, Daniela D. Pollak
Summary: This study investigates the role of brown adipose tissue (BAT) in the bidirectional link between metabolic and psychiatric disorders. It suggests that uncoupling protein 1 (UCP-1), a key metabolic regulator highly expressed in BAT, plays a inhibitory role in anxiety-related behavior, particularly under thermogenic conditions. This function of UCP-1 may be mediated through its central role in brain regions involved in energy and emotional control.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Micaela Glat, Anna Gundacker, Laura Cuenca Rico, Barbara Czuczu, Yoav Ben-Simon, Tibor Harkany, Daniela D. Pollak
Summary: Maternal care behavior in virgin females, without prior experience, is initiated by the activation of the anterior cingulate cortex (ACC), which is dependent on feedback excitation by Vglut2(+)/Galanin(+) neurons of the centrolateral nucleus of the thalamus (CL). The acute bidirectional chemogenetic manipulation of neuronal activity in the ACC can either facilitate or impair the attainment of maternal behavior in virgin females. These findings reveal the ACC-CL neurocircuit as an accessory loop for the initiation of maternal care in virgin females upon first-time exposure to pups.