Review
Medicine, Research & Experimental
Dominik Hartl, Valeria de Luca, Anna Kostikova, Jason Laramie, Scott Kennedy, Enrico Ferrero, Richard Siegel, Martin Fink, Sohail Ahmed, John Millholland, Alexander Schuhmacher, Markus Hinder, Luca Piali, Adrian Roth
Summary: In the era of precision medicine, drug discovery and development are undergoing unprecedented opportunities and challenges. By adopting new technologies and methods, the transition from serendipity-driven to data-driven approach is achieved, promoting the development of modern Translational Precision Medicine methods.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Education, Scientific Disciplines
Maria Maddalena Sirufo, Francesca De Pietro, Enrica Maria Bassino, Lia Ginaldi, Massimo De Martinis
Summary: Omalizumab, the first monoclonal antibody successfully used in allergology, has been the subject of over 5000 scientific articles published in the past 20 years, with nearly 500 published in 2018 alone. The significant impact of this molecule in the field of allergology highlights the potential and success of translational research in this area.
INDIAN JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Marco Casadio, Francesca Biancaniello, Diletta Overi, Rosanna Venere, Guido Carpino, Eugenio Gaudio, Domenico Alvaro, Vincenzo Cardinale
Summary: This review discusses the critical issues concerning the status of precision medicine in cholangiocarcinomas, including molecular signatures, classifications, and therapeutic strategies. The proposed integrated approach aims to improve patient allocations in clinical trials and personalized therapy responses by analyzing the CCA molecular mechanism, pathobiology, clinical and histological findings.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Editorial Material
Immunology
Donatella Lippi, Elena Varotto, Sara Boccalini, Angela Bechini, Francesco Maria Galassi
Summary: This article reviews the significant role played by Marcel Proust's father, Achille-Adrien Proust, in the fight against cholera in the 19th century. It highlights his contributions in promoting a global vision of public hygiene and health, serving as an inspiring example for modern physicians combating contemporary epidemics.
Review
Urology & Nephrology
Giovanni Tripepi, Davide Bolignano, Kitty J. Jager, Friedo W. Dekker, Vianda S. Stel, Carmine Zoccali
Summary: Translational research aims to bridge the gap between prognostic research results and clinical practice, by developing, validating, and evaluating the impact of prognostic models on patient decision-making and outcomes.
CLINICAL KIDNEY JOURNAL
(2022)
Article
Medicine, Research & Experimental
Meina Li, Bin Lian, Xiaoxiong Xu, Pan Zhao, Bihan Tang, Chaoqun Hu, Xiang Liu, Wenya Yu, Lulu Zhang
Summary: The study revealed that the majority of clinicians are willing to collaborate in translational medical research, with their willingness being influenced by factors such as current research type, role, burdens, preferred partners, and relationship independence. Clinicians should evaluate their time, role, burdens, personal preferences for research relationships, and appropriate partners before deciding to collaborate based on their current translational medical research and its goals.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Review
Health Care Sciences & Services
Ruggero De Maria Marchiano, Gabriele Di Sante, Geny Piro, Carmine Carbone, Giampaolo Tortora, Luca Boldrini, Antonella Pietragalla, Gennaro Daniele, Maria Tredicine, Alfredo Cesario, Vincenzo Valentini, Daniela Gallo, Gabriele Babini, Marika D'Oria, Giovanni Scambia
Summary: The emergence of Precision Medicine has revolutionized translational research globally, emphasizing patient-centric therapeutic choices and digitizing individual health status. Real world data-based translational applications offer a promising alternative to traditional evidence-based medicine approaches.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Medicine, Research & Experimental
Yusheng Lin, Li Jiang, Qiaojun He, Meng Yuan, Ji Cao
Summary: The simplified and miniature microcosms called organoids have garnered great interest for their potential applications in tissue development, disease models, clinical diagnosis, drug screening, and personalized medicine. The success of organoid culture has greatly advanced translational medicine research, particularly in cancer treatment, by overcoming the limitations of traditional 2D cell culture. The establishment success rate and diversity of organoids have also been significantly improved, and the application scope has been expanded with the use of cutting-edge technologies such as CRISPRCas9 gene editing.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Medicine, General & Internal
A. Riera-Mestre, P. Cerda, A. Iriarte, M. Graupera, F. Vinals
Summary: Translational Medicine plays a crucial role in bridging the gap between basic and clinical research, providing new tools and treatment methods that have important implications for disease management and future developments.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Geosciences, Multidisciplinary
Marta Caviglia, Joseph L. Cuthbertson, Evangelos Sdongos, Roberto Faccincani, Luca Ragazzoni, Eric S. Weinstein
Summary: The Sendai Framework for Disaster Risk Reduction 2015-2030 recognizes the importance of increasing resilience to disasters, which is the aim of the NIGHTINGALE project funded by Horizon 2020. The project aims to support the preparedness of first responders during sudden onset disasters and mass casualty incidents through an innovative toolkit. This manuscript describes the translational science methodology adopted for the development of the NIGHTINGALE toolkit, showing its potential to translate grant requirements into evidence-based tools and guidelines.
INTERNATIONAL JOURNAL OF DISASTER RISK REDUCTION
(2023)
Article
Clinical Neurology
Babak Daneshfard, Makan Sadr, Ali Abdolahinia, Hassan Azari, Mohsen Naseri, Maryam Iranzadasl, Aliakbar Velayati
Summary: The history of anatomy is deeply intertwined with the history of medicine itself. Iranian scholars, despite religious limitations, have played a significant role in the development of anatomical sciences. Mansur ibn Ilyas Shirazi, an Iranian physician from the fourteenth century, was a pioneer in neuroanatomy, writing the first color illustrated anatomical book.
NEUROLOGICAL SCIENCES
(2022)
Article
Developmental Biology
Chenchao Yan, Yajing Meng, Jie Yang, Jian Chen, Wei Jiang
Summary: This study investigates the translational regulation during early human neural differentiation by performing ribosome sequencing and RNA sequencing on human embryonic stem cells (ESCs) and neural progenitor cells (NPCs). The findings reveal the importance of transcriptional and post-transcriptional regulation in neural fate determination, as well as the role of untranslated region (UTR) sequence characteristics in translation efficiency.
Article
Biochemistry & Molecular Biology
Rajan Iyyappan, Daria Aleshkina, Hao Ming, Michal Dvoran, Kianoush Kakavand, Denisa Jansova, Edgar del Llano, Lenka Gahurova, Alexander W. Bruce, Tomas Masek, Martin Pospisek, Filip Horvat, Michal Kubelka, Zongliang Jiang, Andrej Susor
Summary: The study reveals a highly dynamic and oscillatory pattern of translational reprogramming in oocytes and early embryos, which is crucial for their developmental competence.
NUCLEIC ACIDS RESEARCH
(2023)
Review
Engineering, Biomedical
Tyler J. DiStefano, Keti Vaso, George Danias, Henry N. Chionuma, Jennifer R. Weiser, James C. Iatridis
Summary: Research has shown that stem cell-derived EVs can slow down the progression of IVDD at the molecular, cellular, and organ levels. The pathophysiological and differentiation state of the EV parent cell affects downstream treatment responses and therapeutic outcomes. These findings support the use of EVs as a promising cell-free strategy for treating IVDD and enhancing endogenous repair.
ADVANCED HEALTHCARE MATERIALS
(2022)
Review
Oncology
Vanessa Ortiz-Barahona, Ricky S. Joshi, Manel Esteller
Summary: DNA methylation plays a critical role in human development and cell homeostasis, while aberrant DNA methylation in cancer-related pathways is becoming more prevalent. DNA methylation profiling is essential for understanding malignant transformation and is increasingly important in cancer diagnosis, prognosis, and therapy monitoring.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hossein Aleyasin, Saravanan S. Karuppagounder, Amit Kumar, Sama Sleiman, Manuela Basso, Thong Ma, Ambreena Siddiq, Shankar J. Chinta, Camille Brochier, Brett Langley, Renee Haskew-Layton, Susan L. Bane, Gregory J. Riggins, Irina Gazaryan, Anatoly A. Starkov, Julie K. Andersen, Rajiv R. Ratan
ANTIOXIDANTS & REDOX SIGNALING
(2015)
Article
Neurosciences
Carol A. Lazzara, Rebeccah R. Riley, Anand Rane, Julie K. Andersen, Yong-Hwan Kim
Article
Geriatrics & Gerontology
Shankar J. Chinta, Georgia Woods, Anand Rane, Marco Demaria, Judith Campisi, Julie K. Andersen
EXPERIMENTAL GERONTOLOGY
(2015)
Article
Neurosciences
Almas Siddiqui, Dipa Bhaumik, Shankar J. Chinta, Anand Rane, Subramanian Rajagopalan, Christopher A. Lieu, Gordon J. Lithgow, Julie K. Andersen
JOURNAL OF NEUROSCIENCE
(2015)
Article
Neurosciences
Subramanian Rajagopalan, Anand Rane, Shankar J. Chinta, Julie K. Andersen
JOURNAL OF NEUROSCIENCE
(2016)
Article
Neurosciences
Almas Siddiqui, Anand Rane, Subramanian Rajagopalan, Shankar J. Chinta, Julie K. Andersen
NEUROBIOLOGY OF DISEASE
(2016)
Article
Pharmacology & Pharmacy
Edilio Borroni, Bernd Bohrmann, Fiona Grueninger, Eric Prinssen, Stephane Nave, Hansruedi Loetscher, Shankar J. Chinta, Subramanian Rajagopalan, Anand Rane, Almas Siddiqui, Bart Ellenbroek, Juerg Messer, Axel Pahler, Julie K. Andersen, Rene Wyler, Andrea M. Cesura
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2017)
Article
Cell Biology
Dmitri Leonoudakis, Anand Rane, Suzanne Angeli, Gordon J. Lithgow, Julie K. Andersen, Shankar J. Chinta
MEDIATORS OF INFLAMMATION
(2017)
Article
Neurosciences
Banibrata Das, Subramanian Rajagopalan, Gnanada S. Joshi, Liping Xu, Dan Luo, Julie K. Andersen, Sokol V. Todi, Aloke K. Dutta
Review
Clinical Neurology
Manish Chamoli, Shankar J. Chinta, Julie K. Andersen
JOURNAL OF NEURAL TRANSMISSION
(2018)
Article
Neurosciences
Anand Rane, Subramanian Rajagopalan, Manuj Ahuja, Bobby Thomas, Shankar J. Chinta, Julie K. Andersen
Article
Toxicology
Georgia Woods, Julie K. Andersen
TOXICOLOGICAL SCIENCES
(2018)
Article
Cell Biology
Shankar J. Chinta, Georgia Woods, Marco Demaria, Anand Rane, Ying Zou, Amanda McQuade, Subramanian Rajagopalan, Chandani Limbad, David T. Madden, Judith Campisi, Julie K. Andersen
Article
Biochemistry & Molecular Biology
Mrudang Shah, Subramanian Rajagopalan, Liping Xu, Chandrashekhar Voshavar, Yevgeniya Shurubor, Flint Beal, Julie K. Andersen, Aloke K. Dutta
JOURNAL OF NEUROCHEMISTRY
(2014)
Article
Cell & Tissue Engineering
Samantha Haller, Subir Kapuria, Rebeccah R. Riley, Monique N. O'Leary, Katherine H. Schreiber, Julie K. Andersen, Simon Melov, Jianwen Que, Thomas A. Rando, Jason Rock, Brian K. Kennedy, Joseph T. Rodgers, Heinrich Jasper