IGFBP7 Binds to the IGF-1 Receptor and Blocks Its Activation by Insulin-Like Growth Factors

Mammary tumors that become independent of the type I insulin-like growth factor receptor express elevated levels of platelet-derived growth factor receptors

(2012) Craig I Campbell et al.   BMC CANCER

ZEB2 Mediates Multiple Pathways Regulating Cell Proliferation, Migration, Invasion, and Apoptosis in Glioma

(2012) Songtao Qi et al.   PLoS One

Insulin-like growth factor receptor (IGF-1R) in breast cancer subtypes

(2011) Rinat Yerushalmi et al.   BREAST CANCER RESEARCH AND TREATMENT

Insulin-like growth factor-1 receptor gene expression is associated with survival in breast cancer: a comprehensive analysis of gene copy number, mRNA and protein expression

(2011) Peifen Fu et al.   BREAST CANCER RESEARCH AND TREATMENT

IGFBP7 reduces breast tumor growth by induction of senescence and apoptosis pathways

(2011) Tania Benatar et al.   BREAST CANCER RESEARCH AND TREATMENT

Small molecule inhibitors of the IGF-1R/IR axis for the treatment of cancer

(2011) Elizabeth Buck et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Metformin Induces Both Caspase-Dependent and Poly(ADP-ribose) Polymerase-Dependent Cell Death in Breast Cancer Cells

(2011) Y. Zhuang et al.   MOLECULAR CANCER RESEARCH

A tripartite complex composed of ETV6-NTRK3, IRS1 and IGF1R is required for ETV6-NTRK3-mediated membrane localization and transformation

(2011) C E Tognon et al.   ONCOGENE

Defining the pathway to insulin-like growth factor system targeting in cancer

(2010) Steven A. Rosenzweig et al.   BIOCHEMICAL PHARMACOLOGY

Insulin like growth factor binding protein-7 reduces growth of human breast cancer cells and xenografted tumors

(2010) Y. Amemiya et al.   BREAST CANCER RESEARCH AND TREATMENT

4E-BP1 Is a Key Effector of the Oncogenic Activation of the AKT and ERK Signaling Pathways that Integrates Their Function in Tumors

(2010) Qing-Bai She et al.   CANCER CELL

Synthetic Lethality Screens Reveal RPS6 and MST1R as Modifiers of Insulin-like Growth Factor-1 Receptor Inhibitor Activity in Childhood Sarcomas

(2010) J. C. Potratz et al.   CANCER RESEARCH

ETV6-NTRK3-Mediated Breast Epithelial Cell Transformation Is Blocked by Targeting the IGF1R Signaling Pathway

(2010) C. E. Tognon et al.   CANCER RESEARCH

Compensatory Insulin Receptor (IR) Activation on Inhibition of Insulin-Like Growth Factor-1 Receptor (IGF-1R): Rationale for Cotargeting IGF-1R and IR in Cancer

(2010) E. Buck et al.   MOLECULAR CANCER THERAPEUTICS

A Kinase-Independent Role for Unoccupied Insulin and IGF-1 Receptors in the Control of Apoptosis

(2010) J. Boucher et al.   Science Signaling

Calpain activation through galectin-3 inhibition sensitizes prostate cancer cells to cisplatin treatment

(2010) Y Wang et al.   Cell Death & Disease

Insulin Receptor Isoforms and Insulin Receptor/Insulin-Like Growth Factor Receptor Hybrids in Physiology and Disease

(2009) Antonino Belfiore et al.   ENDOCRINE REVIEWS

Efficacy of IGFBP7 for treatment of metastatic melanoma and other cancers in mouse models and human cell lines

(2009) N. Wajapeyee et al.   MOLECULAR CANCER THERAPEUTICS

Phosphorylated Insulin-Like Growth Factor-I/Insulin Receptor Is Present in All Breast Cancer Subtypes and Is Related to Poor Survival

(2008) J. H. Law et al.   CANCER RESEARCH

Oncogenic BRAF Induces Senescence and Apoptosis through Pathways Mediated by the Secreted Protein IGFBP7

(2008) Narendra Wajapeyee et al.   CELL

Two specific drugs, BMS-345541 and purvalanol A induce apoptosis of HTLV-1 infected cells through inhibition of the NF-kappaB and cell cycle pathways

(2008) Emmanuel Agbottah et al.   AIDS Research and Therapy

The role of insulin receptors and IGF-I receptors in cancer and other diseases

(2008) Francesco Frasca et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY