Article
Cell Biology
Weiwei Liu, Yang Yi, Chuanfu Zhang, Baojuan Zhou, Lin Liao, Wenrui Liu, Jing Hu, Qiming Xu, Jie Chen, Jianrao Lu
Summary: This study reveals the crucial role of TRIM6 in renal fibrosis, which is associated with the mTORC1 pathway and NF-κB p50. Knockdown of TRIM6 can alleviate fibrosis and inhibit EMT and ER processes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Wenjuan Wang, Zhaohan Zhang, Minghui Zhao, Yu Wang, Yuze Ge, Lin Shan
Summary: CXXC5 interacts with CRL4B and NuRD complexes, regulating the transcriptional repression process and promoting tumor cell proliferation.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2023)
Article
Endocrinology & Metabolism
Shuaibin Wang, Chao Zhang, Zhifang Xu, Michael H. Chen, Haiyan Yu, Lizhong Wang, Runhua Liu
Summary: The study compared the impact of different signaling nodes in the PI3K/AKT/mTOR pathway on prostate cancer initiation and progression using genetically engineered mouse models. The results suggest that these signaling nodes have differential roles in prostate cancer, but the underlying molecular mechanisms remain unclear.
Article
Multidisciplinary Sciences
Rossana Segreto, Hoda Bazafkan, Julia Millinger, Martina Schenk, Lea Atanasova, Maria Doppler, Christoph Bueschl, Melanie Boeckstaens, Silvia Soto Diaz, Ulrike Schreiner, Fabiano Sillo, Raffaella Balestrini, Rainer Schuhmacher, Susanne Zeilinger
Summary: Trichoderma atroviride, a well-known mycoparasite used for plant protection, shows tightly regulated mycoparasitic activity involving production of enzymes and metabolites, influenced by TOR1 activity. Genetic manipulation affecting TOR pathway components in T. atroviride alters various cellular functions, highlighting the importance of TOR signaling in its antagonistic activity.
Article
Multidisciplinary Sciences
Yugang Zhang, Zhewang Lin, Julia Zhu, Miao Wang, Hening Lin
Summary: Diphthamide, a modification unique to translation elongation factor 2 (EF2), suppresses -1 frameshifting in translation and affects the TORC1/mTORC1 signaling pathway. In yeast, diphthamide deficiency inhibits the translation of TORC1-activating proteins.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Plant Sciences
Manuel J. Mallen-Ponce, Maria Esther Perez-Perez, Jose L. Crespo
Summary: Microalgae are photosynthetic microorganisms widely distributed on Earth and they play an important role in oxygen production and food chains. Recent studies have identified a protein called TOR, which regulates cell growth and nutrient sensing in microalgae. Conservation of TOR signaling pathway has been found in diverse microalgae.
JOURNAL OF EXPERIMENTAL BOTANY
(2022)
Article
Biochemistry & Molecular Biology
David L. Dai, S. M. Naimul Hasan, Geoffrey Woollard, Yazan M. Abbas, Stephanie A. Bueler, Jean-Philippe Julien, John L. Rubinstein, Mohammad T. Mazhab-Jafari
Summary: The study successfully purified endogenous pTSC using a recombinant antigen binding fragment, revealing the potential formation of large oligomers. Samples extracted from pig brains showed protein particles and filaments with conformational flexibility, indicating the polymerization of endogenous pTSC into filamentous superstructures.
Article
Biochemistry & Molecular Biology
Bei Liu, Jiaxi Zhang, Xue Meng, Shelly M. Xie, Fang Liu, Heli Chen, Demin Yao, Minglei Li, Minghui Guo, Haitao Shen, Xianghong Zhang, Lingxiao Xing
Summary: This study reveals that ETV4 activates mTORC1 in non-small cell lung cancer cells by controlling HK1 expression and glycolysis-lactate production. Furthermore, G3BP2 and HDAC6 play important roles in inhibiting mTORC1 through regulating TSC2. Therefore, the HDAC6-G3BP2 complex might represent a critical adaptive mechanism for cell survival under low-lactate challenges.
Article
Multidisciplinary Sciences
Pike-See Cheah, Shilpa Prabhakar, David Yellen, Roberta L. Beauchamp, Xuan Zhang, Shingo Kasamatsu, Roderick T. Bronson, Elizabeth A. Thiele, David J. Kwiatkowski, Anat Stemmer-Rachamimov, Bence Gyorgy, King-Hwa Lin, Masao Kaneki, Bakhos A. Tannous, Vijaya Ramesh, Casey A. Maguire, Xandra O. Breakefield
Summary: Tuberous sclerosis complex is caused by the loss of tumor suppressor genes TSC1 or TSC2, which encodes hamartin and tuberin respectively. Gene therapy using adeno-associated virus vectors carrying a condensed form of human tuberin has shown potential in treating life-threatening TSC2 lesions. The survival of a mouse model with TSC2 was extended and brain pathology reduced after a single intravenous injection of AAV9-cTuberin.
Article
Biochemistry & Molecular Biology
Mirja Tamara Prentzell, Ulrike Rehbein, Marti Cadena Sandoval, Ann-Sofie De Meulemeester, Ralf Baumeister, Laura Brohee, Bianca Berdel, Mathias Bockwoldt, Bernadette Carroll, Suvagata Roy Chowdhury, Andreas von Deimling, Constantinos Demetriades, Gianluca Figlia, Mariana Eca Guimaraes de Araujo, Alexander M. Heberle, Ines Heiland, Birgit Holzwarth, Lukas A. Huber, Jacek Jaworski, Magdalena Kedra, Katharina Kern, Andrii Kopach, Viktor Korolchuk, Ineke van't Land-Kuper, Matylda Macias, Mark Nellist, Wilhelm Palm, Stefan Pusch, Jose Miguel Ramos Pittol, Michele Reil, Anja Reintjes, Friederike Reuter, Julian R. Sampson, Chloe Scheldeman, Aleksandra Siekierska, Eduard Stefan, Aurelio A. Teleman, Laura E. Thomas, Omar Torres-Quesada, Saskia Trump, Hannah D. West, Peter de Witte, Sandra Woltering, Teodor E. Yordanov, Justyna Zmorzynska, Christiane A. Opitz, Kathrin Thedieck
Summary: The study found that Ras GTPase-activating protein-binding proteins 1 and 2 are core components of stress granules and play a key role at the cytoplasmic surface of lysosomes. They anchor the tuberous sclerosis complex protein complex to lysosomes in a non-redundant manner, suppressing the activation of mTORC1. Deficiency in G3BP1 can lead to phenotypes related to mTORC1 hyperactivity, and low G3BP1 levels in tumors enhance mTORC1-driven cell motility and correlate with poor outcomes in patients. Additionally, inhibition of G3bp1 in zebrafish affects neuronal development and function.
Article
Cell Biology
Sean R. Williamson, Ondrej Hes, Kiril Trpkov, Aditi Aggarwal, Abhishek Satapathy, Sourav Mishra, Shivani Sharma, Ankur Sangoi, Liang Cheng, Mahmut Akgul, Muhammad Idrees, Albert Levin, Sudha Sadasivan, Pilar San Miguel Fraile, Joanna Rogala, Eva Comperat, Daniel M. Berney, Stela Bulimbasic, Jesse K. McKenney, Shilpy Jha, Nakul Y. Sampat, Sambit K. Mohanty
Summary: Low-grade oncocytic tumour (LOT) of the kidney is a potential novel tumour type with distinct morphological, immunohistochemical, and genetic characteristics. Tumours in this study were found to have alterations in genes related to the tuberous sclerosis/MTOR pathway, as well as PIK3CA. Further research is needed to determine the clinical implications and differences from other renal cancers.
Article
Reproductive Biology
Jiao Jiao Zhang, Ya Qi Li, Yu Sha Wang, Liang Chen, Xian Zhong Wang
Summary: Metformin inhibits Sertoli cell proliferation, while 17β-estradiol weakens its inhibitory effects. The regulation is possibly mediated by the AMPK/TSC2/mTOR signaling pathway.
Article
Plant Sciences
Cintia Pereyra, Rodrigo Parola, Ana Paula Lando, Marianela Rodriguez, Giselle Maria Astrid Martinez-Noel
Summary: Sugars are both energy sources and central molecular signals that regulate growth, development, and response to environmental stresses. Different types and concentrations of sugars have different effects on TOR signaling, with sucrose, glucose, and to a lesser extent fructose inducing root apical meristem reactivation and TOR activity. High concentration of glucose does not induce RAM or kinase activity, while sucrose-induced TOR activity requires auxin signaling.
JOURNAL OF PLANT GROWTH REGULATION
(2023)
Review
Biochemistry & Molecular Biology
Francisco Gutierrez-Santiago, Francisco Navarro
Summary: Ribosomes are vital for protein production, and their biogenesis is regulated by cellular energy status and stress signals. In eukaryotic cells, stress signals and newly-synthesized ribosomes require transcription by RNA polymerases. The Target of Rapamycin pathway in eukaryotes influences RNA polymerase transcription to ensure proper ribosome production. This review focuses on how TOR regulates transcription in Saccharomyces cerevisiae and the coordination of three RNA polymerases.
Article
Biochemistry & Molecular Biology
Jimena Leyria, Ian Orchard, Angela B. Lange
Summary: Insulin signaling in insects, such as the blood-gorging triatomine R. prolixus, plays a crucial role in metabolism, growth, and reproduction, with a direct effect on ovarian follicles and egg production. The up-regulation of insulin/ToR signaling transcripts in unfed insects suggests a heightened sensitivity to respond rapidly to nutrient levels, while the pathway is only activated in fed insects. This study demonstrates a mechanism by which nutritional signaling regulates reproductive performance in insects, offering potential implications for the development of biocontrol methods.
INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2021)
Article
Evolutionary Biology
Erin R. Butterfield, Christopher J. Howe, R. Ellen R. Nisbet
GENOME BIOLOGY AND EVOLUTION
(2016)
Article
Biochemistry & Molecular Biology
R. E. R. Nisbet, J. L. McKenzie
MOLECULAR AND BIOCHEMICAL PARASITOLOGY
(2016)
Article
Biochemistry & Molecular Biology
Richard G. Dorrell, Christen M. Klinger, Robert J. Newby, Erin R. Butterfield, Elisabeth Richardson, Joel B. Dacks, Christopher J. Howe, Ellen R. Nisbet, Chris Bowler
MOLECULAR BIOLOGY AND EVOLUTION
(2017)
Article
Microbiology
R. Ellen R. Nisbet, Davy P. Kurniawan, Harrison D. Bowers, Christopher J. Howe
Article
Agriculture, Dairy & Animal Science
M. A. Bower, M. Whitten, R. E. R. Nisbet, M. Spencer, K. M. Dominy, A. M. Murphy, R. Cassidy, E. Barrett, E. W. Hill, M. Binns
JOURNAL OF ANIMAL BREEDING AND GENETICS
(2013)
Article
Microbiology
Erin R. Butterfield, Christopher J. Howe, R. Ellen R. Nisbet
Article
Genetics & Heredity
Richard G. Dorrell, James Drew, R. Ellen R. Nisbet, Christopher J. Howe
Article
Microbiology
Richard G. Dorrell, R. Ellen R. Nisbet, Adrian C. Barbrook, Stephen J. L. Rowden, Christopher J. Howe
Article
Biology
Isabel C. Nimmo, Adrian C. Barbrook, Imen Lassadi, Jit Ern Chen, Katrin Geisler, Alison G. Smith, Manuel Aranda, Saul Purton, Ross F. Waller, R. Ellen R. Nisbet, Christopher J. Howe
Article
Cell Biology
Joanna L. Hicks, Imen Lassadi, Emma F. Carpenter, Madeleine Eno, Alexandros Vardakis, Ross F. Waller, Christopher J. Howe, R. Ellen R. Nisbet
CELLULAR MICROBIOLOGY
(2019)
Article
Biochemical Research Methods
Drahomira Faktorova, R. Ellen R. Nisbet, Jose A. Fernandez Robledo, Elena Casacuberta, Lisa Sudek, Andrew E. Allen, Manuel Ares, Cristina Areste, Cecilia Balestreri, Adrian C. Barbrook, Patrick Beardslee, Sara Bender, David S. Booth, Francois-Yves Bouget, Chris Bowler, Susana A. Breglia, Colin Brownlee, Gertraud Burger, Heriberto Cerutti, Rachele Cesaroni, Miguel A. Chiurillo, Thomas Clemente, Duncan B. Coles, Jackie L. Collier, Elizabeth C. Cooney, Kathryn Coyne, Roberto Docampo, Christopher L. Dupont, Virginia Edgcomb, Elin Einarsson, Pia A. Elustondo, Fernan Federici, Veronica Freire-Beneitez, Nastasia J. Freyria, Kodai Fukuda, Paulo A. Garcia, Peter R. Girguis, Fatma Gomaa, Sebastian G. Gornik, Jian Guo, Vladimir Hampl, Yutaka Hanawa, Esteban R. Haro-Contreras, Elisabeth Hehenberger, Andrea Highfield, Yoshihisa Hirakawa, Amanda Hopes, Christopher J. Howe, Ian Hu, Jorge Ibanez, Nicholas A. T. Irwin, Yuu Ishii, Natalia Ewa Janowicz, Adam C. Jones, Ambar Kachale, Konomi Fujimura-Kamada, Binnypreet Kaur, Jonathan Z. Kaye, Eleanna Kazana, Patrick J. Keeling, Nicole King, Lawrence A. Klobutcher, Noelia Lander, Imen Lassadi, Zhuhong Li, Senjie Lin, Jean-Claude Lozano, Fulei Luan, Shinichiro Maruyama, Tamara Matute, Cristina Miceli, Jun Minagawa, Mark Moosburner, Sebastian R. Najle, Deepak Nanjappa, Isabel C. Nimmo, Luke Noble, Anna M. G. Novak Vanclova, Mariusz Nowacki, Isaac Nunez, Arnab Pain, Angela Piersanti, Sandra Pucciarelli, Jan Pyrih, Joshua S. Rest, Mariana Rius, Deborah Robertson, Albane Ruaud, Inaki Ruiz-Trillo, Monika A. Sigg, Pamela A. Silver, Claudio H. Slamovits, G. Jason Smith, Brittany N. Sprecher, Rowena Stern, Estienne C. Swart, Anastasios D. Tsaousis, Lev Tsypin, Aaron Turkewitz, Jernej Turnsek, Matus Valach, Valerie Verge, Peter von Dassow, Tobias von der Haar, Ross F. Waller, Lu Wang, Xiaoxue Wen, Glen Wheeler, April Woods, Huan Zhang, Thomas Mock, Alexandra Z. Worden, Julius Lukes
Correction
Biochemical Research Methods
Drahomira Faktorova, R. Ellen R. Nisbet, Jose A. Robledo, Elena Casacuberta, Lisa Sudek, Andrew E. Allen, Manuel Ares, Cristina Areste, Cecilia Balestreri, Adrian C. Barbrook, Patrick Beardslee, Sara Bender, David S. Booth, Francois-Yves Bouget, Chris Bowler, Susana A. Breglia, Colin Brownlee, Gertraud Burger, Heriberto Cerutti, Rachele Cesaroni, Miguel A. Chiurillo, Thomas Clemente, Duncan B. Coles, Jackie L. Collier, Elizabeth C. Cooney, Kathryn Coyne, Roberto Docampo, Christopher L. Dupont, Virginia Edgcomb, Elin Einarsson, Pia A. Elustondo, Fernan Federici, Veronica Freire-Beneitez, Nastasia J. Freyria, Kodai Fukuda, Paulo A. Garcia, Peter R. Girguis, Fatma Gomaa, Sebastian G. Gornik, Jian Guo, Vladimir Hampl, Yutaka Hanawa, Esteban R. Haro-Contreras, Elisabeth Hehenberger, Andrea Highfield, Yoshihisa Hirakawa, Amanda Hopes, Christopher J. Howe, Ian Hu, Jorge Ibanez, Nicholas A. T. Irwin, Yuu Ishii, Natalia Ewa Janowicz, Adam C. Jones, Ambar Kachale, Konomi Fujimura-Kamada, Binnypreet Kaur, Jonathan Z. Kaye, Eleanna Kazana, Patrick J. Keeling, Nicole King, Lawrence A. Klobutcher, Noelia Lander, Imen Lassadi, Zhuhong Li, Senjie Lin, Jean-Claude Lozano, Fulei Luan, Shinichiro Maruyama, Tamara Matute, Cristina Miceli, Jun Minagawa, Mark Moosburner, Sebastian R. Najle, Deepak Nanjappa, Isabel C. Nimmo, Luke Noble, Anna M. G. Vanclova, Mariusz Nowacki, Isaac Nunez, Arnab Pain, Angela Piersanti, Sandra Pucciarelli, Jan Pyrih, Joshua S. Rest, Mariana Rius, Deborah Robertson, Albane Ruaud, Inaki Ruiz-Trillo, Monika A. Sigg, Pamela A. Silver, Claudio H. Slamovits, G. Smith, Brittany N. Sprecher, Rowena Stern, Estienne C. Swart, Anastasios D. Tsaousis, Lev Tsypin, Aaron Turkewitz, Jernej Turnsek, Matus Valach, Valerie Verge, Peter von Dassow, Tobias von der Haar, Ross F. Waller, Lu Wang, Xiaoxue Wen, Glen Wheeler, April Woods, Huan Zhang, Thomas Mock, Alexandra Z. Worden, Julius Lukes
Article
Evolutionary Biology
Barnaby Slater, Darius Kosmutzky, R. Ellen R. Nisbet, Christopher J. Howe
Summary: This study presents a comprehensive analysis of the evolutionary relationship between members of the cytochrome c(6) family in photosynthetic organisms. The phylogenetic analyses suggest that cytochromes c(6B) and c(6C) are likely orthologs that arose from a duplication of cytochrome c(6), and propose renaming cytochrome c(6)C as cytochrome c(6B). The study also provides evidence that cytochrome c6A likely originated from cytochrome c(6B) rather than by an independent duplication of cytochrome c(6), and proposes a new model for the evolution of the cytochrome c(6) family.
GENOME BIOLOGY AND EVOLUTION
(2021)
Article
Microbiology
Paula MacGregor, Vishvanath Nene, R. Ellen R. Nisbet
Editorial Material
Biochemistry & Molecular Biology
Christopher J. Howe, R. Ellen R. Nisbet, Adrian C. Barbrook
Summary: Many chloroplast-bearing plants and algae have lost their photosynthetic activity during evolution but retained their chloroplasts for other functions. Dinoflagellate algae, in particular, have lost half of their photosynthetic machinery but retained the other half, which provides a unique mechanism for light perception.