Article
Cell Biology
Yue Zhu, Xinzhi Peng, Qianlei Zhou, Langping Tan, Cheng Zhang, Shaojian Lin, Miaoyun Long
Summary: This study revealed that the expression of six transmembrane epithelial antigen of the prostate 2 (STEAP2) is downregulated in papillary thyroid cancer (PTC) tissues. Low STEAP2 expression is associated with aggressive clinicopathological characteristics and poor prognosis in PTC patients. The METTL3-mediated STEAP2 N6-methyladenosine (m6A) modification plays a critical tumor-suppressive role in PTC progression. The METTL3-STEAP2 axis may serve as a potential therapeutic molecular target against PTC.
CELL DEATH & DISEASE
(2022)
Article
Cell Biology
Jennifer L. Hope, Dennis C. Otero, Eun-Ah Bae, Christopher J. Stairiker, Ashley B. Palete, Hannah A. Faso, Michelle Lin, Monique L. Henriquez, Sreeja Roy, Hyungseok Seo, Xue Lei, Eric S. Wang, Savio Chow, Roberto Tinoco, Gregory A. Daniels, Kevin Yip, Alexandre Rosa Campos, Jun Yin, Peter D. Adams, Anjana Rao, Linda M. Bradley
Summary: PSGL-1 is a T cell-intrinsic checkpoint regulator that acts upstream of PD-1 and requires co-ligation with the TCR to attenuate T cell activation and drive terminal T cell exhaustion. PSGL-1 directly restrains TCR signaling via Zap70 and maintains expression of the Zap70 inhibitor Sts-1. Deficiency of PSGL-1 empowers CD8+ T cells to respond to low-affinity TCR ligands and inhibit the growth of PD-1-blockade-resistant melanoma.
Article
Biochemical Research Methods
Ze Zhang, Danyi Xiong, Xinlei Wang, Hongyu Liu, Tao Wang
Summary: Tessa is a tool that integrates TCR with gene expression of T cells to estimate the effect of TCRs on T cell phenotypes. It can predict the functional dichotomization of T cells and weakening in tumor contexts.
Article
Immunology
Zhong Fang, Yi Zhang, Zhaoqin Zhu, Cong Wang, Yao Hu, Xiuhua Peng, Dandan Zhang, Jun Zhao, Bisheng Shi, Zhongliang Shen, Min Wu, Chunhua Xu, Jieliang Chen, Xiaohui Zhou, Youhua Xie, Hui Yu, Xiaonan Zhang, Jianhua Li, Yunwen Hu, Maya Kozlowski, Antonio Bertoletti, Zhenghong Yuan
Summary: HBV exposure in children usually leads to chronic infection and the detection of HBsAg-specific CD8(+) T cells is rare. This study found that mMDSCs migrate to the thymus and eliminate HBsAg-specific CD8(+) thymocytes, resulting in specific tolerance to HBV.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Article
Immunology
Hongyan Ren, Tianyu Zhang, Yongren Wang, Qi Yao, Ziyu Wang, Luyao Zhang, Lixin Wang
Summary: Research has shown that DRibbles can efficiently induce proliferation and activation of human B cells, leading to the production of chemokines, cytokines and hematopoietic growth factors. Human B cells can effectively phagocytose DRibbles and cross-present antigens to activate memory T cells. These findings suggest the potential for clinical application of B-DRibbles vaccines.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Yangyang Wang, Kuo Qu, Wenting Lu, Peiyan Zhao, Zhe Wang, Cuiyun Cui, Ye Liu, Ming Yang, Yongli Yu, Liying Wang
Summary: Neutrophils play a crucial role in immune responses, and it has been found that they can regulate antibody reactions induced by vaccines at immunization sites. Inhibiting BAFF in neutrophils can weaken B cell activation and antibody production.
Review
Cell Biology
Chieh Yang, John Nguyen, Yun Yen
Summary: This article provides a summary of the adverse effects of CAR-T cell therapies, including cytokine release syndrome, immune effector cell-associated neurotoxicity syndrome, and CAR T-cell associated HLH. It discusses the pathophysiology, symptoms, grading, and diagnosis systems, as well as management strategies. The article also gives an overview of measures and modifications currently being explored to limit toxicity in CAR-T cells.
JOURNAL OF BIOMEDICAL SCIENCE
(2023)
Article
Nutrition & Dietetics
Sheng-Jie Shiue, Chao-Ling Cheng, Han-Shiang Shiue, Chun-Nan Chen, Sheng-Wei Cheng, Li-Wei Wu, Ganbolor Jargalsaikhan, Tze-Sian Chan, Hsin-Yi Lin, Ming-Shun Wu
Summary: This study found that oral Arthrospira as an add-on therapy can reduce HBsAg levels in CHB patients and improve immune function by promoting the activation of B cells, T cells, and NK cells.
Article
Immunology
Catherine A. Nicholas, Mia J. Smith
Summary: The COVID-19 pandemic and advances in single-cell analysis have led to the development of highly effective vaccines and treatments due to new methods and years of research. While initially focused on infection models, these tools also hold promise for autoimmune diseases. Targeting self-reactive B cells without depleting non-pathogenic B cells is crucial for effective treatment. Single-cell RNA sequencing (scRNA-seq) can help identify pathogenic self-reactive B cells and aid in the development of precision targeted therapies.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biology
Stanca M. Ciupe, Naveen K. Vaidya, Jonathan E. Forde
Summary: Experimental studies have shown a non-monotonic relationship between the inoculum dose of hepatitis B virus and infection outcome, with different doses leading to different CD8 T-cell dynamics and infection outcomes. The mathematical model developed in this study explains and predicts how the inoculum dose affects the timing and quality of CD8 T-cell response, providing insights for the design of immune cell-based interventions.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2021)
Article
Oncology
Stefano Vergani, Davide Bagnara, Andreas Agathangelidis, Anita Kar Yun Ng, Gerardo Ferrer, Andrea N. Mazzarello, Florencia Palacios, Sophia Yancopoulos, Xiao-Jie Yan, Jaqueline C. Barrientos, Kanti R. Rai, Kostas Stamatopoulos, Nicholas Chiorazzi
Summary: CLL patients often have unique leukemic cells with similar IGHV-IGHD-IGHJ gene rearrangements and BCRs. Our study found similar CLL-like sequences in normal B-lymphocyte populations, suggesting that specific subpopulations of normal B cells may be the origin of CLL-SLS. Although most CLL-SLS were antigen-experienced, CLL-SLS with matching IGHV-mutation status varied among normal B-cell subpopulations.
FRONTIERS IN ONCOLOGY
(2023)
Article
Cell Biology
Elliott D. SoRelle, Joanne Dai, Nicolas M. Reinoso-Vizcaino, Ashley P. Barry, Cliburn Chan, Micah A. Luftig
Summary: In this study, a genome-wide multistate model of B cell fates upon Epstein-Barr virus (EBV) infection was constructed using single-cell transcriptomics. The model was validated using single-cell data from human tonsils and provides detailed perspectives on the cellular landscape during oncogenic viral infection. The findings have implications for understanding EBV-host dynamics, B cell fates, and lymphomagenesis.
Article
Immunology
Wanli Song, Xueying Li, Hongyu Cao, Tiantong Wang, Yuhan Sun, Qingjie Fan, Danish Zahid, Ming Li, Wenzhe Li
Summary: Taurine, a special sulphur-containing amino acid, has been found to regulate B-cell receptor (BCR)-mediated signal transduction and activate B cells. It also increases IgG production in mice after ovalbumin immunization. Taurine binds specifically to IgG2a-BCR and enhances B-cell activation by interacting with the variable regions of BCR.
Article
Cell Biology
Abhishek Bedi, Kate Choi, Connor Keane, Madison Bolger-Munro, Ashley R. Ambrose, Michael R. Gold
Summary: The study reveals that WAVE2 plays a crucial role in B lymphocytes by participating in actin cytoskeleton remodeling, cell spreading, BCR signal amplification, and immune response.
Article
Immunology
Xiaoyu He, Jiayi Zhao, Abidan Adilijiang, Peicheng Hong, Pengda Chen, Xinyong Lin, Jun Xie, Ying Du, Yun Liu, Lianghua Lin, Hyun Yong Jin, Yazhen Hong, Wen-Hsien Liu, Changchun Xiao
Summary: Using CRISPR/Cas9-mediated functional analysis and mouse genetics approaches, this study found that the activation-induced RNA helicase Dhx33 plays a critical role in coupling B-cell activation with growth and proliferation. Dhx33-deficient B cells exhibited impaired B-cell development, germinal center reactions, plasma cell differentiation, and antibody production.
CELLULAR & MOLECULAR IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Elena Andrada, Maria Almena, Julia Saez de Guinoa, Sara V. Merino-Cortes, Rosa Liebana, Raquel Arcos, Silvia Carrasco, Yolanda R. Carrasco, Isabel Merida
Article
Multidisciplinary Sciences
Eloy F. Robles, Maria Mena-Varas, Laura Barrio, Sara V. Merino-Cortes, Peter Balogh, Ming-Qing Du, Takashi Akasaka, Anton Parker, Sergio Roa, Carlos Panizo, Idoia Martin-Guerrero, Reiner Siebert, Victor Segura, Xabier Agirre, Laura Macri-Pellizeri, Beatriz Aldaz, Amaia Vilas-Zornoza, Shaowei Zhang, Sarah Moody, Maria Jose Calasanz, Thomas Tousseyn, Cyril Broccardo, Pierre Brousset, Elena Campos-Sanchez, Cesar Cobaleda, Isidro Sanchez-Garcia, Jose Luis Fernandez-Luna, Ricardo Garcia-Munoz, Esther Pena, Beatriz Bellosillo, Antonio Salar, Maria Joao Baptista, Jesus Maria Hernandez-Rivas, Marcos Gonzalez, Maria Jose Terol, Joan Climent, Antonio Ferrandez, Xavier Sagaert, Ari M. Melnick, Felipe Prosper, David G. Oscier, Yolanda R. Carrasco, Martin J. S. Dyer, Jose A. Martinez-Climent
NATURE COMMUNICATIONS
(2016)
Article
Biochemistry & Molecular Biology
Elena Andrada, Maria Almena, Julia Saez de Guinoa, Sara V. Merino-Cortes, Rosa Liebana, Raquel Arcos, Silvia Carrasco, Yolanda R. Carrasco, Isabel Merida
Article
Biochemistry & Molecular Biology
Laura Martinez-Munoz, Jose Miguel Rodriguez-Frade, Ruben Barroso, Carlos Oscar S. Sorzano, Juan A. Torreno-Pina, Cesar A. Santiago, Carlo Manzo, Pilar Lucas, Eva M. Garcia-Cuesta, Enric Gutierrez, Laura Barrio, Javier Vargas, Graciela Cascio, Yolanda R. Carrasco, Francisco Sanchez-Madrid, Maria F. Garcia-Parajo, Mario Mellado
Article
Cell & Tissue Engineering
Laura Barrio, Victor Delgado Cuevas, Ramon Menta, Pablo Mancheno-Corvo, Olga delaRosa, Wilfried Dalemans, Eleuterio Lombardo, Yolanda R. Carrasco
Article
Biochemistry & Molecular Biology
Mercedes Perez-Olivares, Alfonsina Trento, Sara Rodriguez-Acebes, Daniel Gonzalez-Acosta, David Fernandez-Antoran, Sara Roman-Garcia, Dolores Martinez, Tania Lopez-Briones, Carlos Torroja, Yolanda R. Carrasco, Juan Mendez, Ignacio Moreno de Alboran
Article
Immunology
Sabine Konradi, Nighat Yasmin, Denise Haslwanter, Michele Weber, Bernhard Gesslbauer, Michael Sixt, Herbert Strobl
EUROPEAN JOURNAL OF IMMUNOLOGY
(2014)
Correction
Biochemistry & Molecular Biology
Laura Martinez-Munoz, Jose Miguel Rodriguez-Frade, Ruben Barroso, Carlos Oscar S. Sorzano, Juan A. Torreno-Pina, Cesar A. Santiago, Carlo Manzo, Pilar Lucas, Eva M. Garcia-Cuesta, Enric Gutierrez, Laura Barrio, Javier Vargas, Graciela Cascio, Yolanda R. Carrasco, Francisco Sanchez-Madrid, Maria F. Garcia-Parajo, Mario Mellado
Article
Immunology
Sara Roman-Garcia, Sara V. Merino-Cortes, Sofia R. Gardeta, Marjolein J. W. de Bruijn, Rudi W. Hendriks, Yolanda R. Carrasco
FRONTIERS IN IMMUNOLOGY
(2018)
Review
Cell Biology
Yolanda R. Carrasco
JOURNAL OF LEUKOCYTE BIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Sara V. Merino-Cortes, Sofia R. Gardeta, Sara Roman-Garcia, Ana Martinez-Riano, Judith Pineau, Rosa Liebana, Isabel Merida, Ana-Maria Lennon Dumenil, Paolo Pierobon, Julien Husson, Balbino Alarcon, Yolanda R. Carrasco
Article
Immunology
Alexey V. Sarapulov, Petar Petrov, Sara Hernandez-Perez, Vid Sustar, Elina Kuokkanen, Lena Cords, Rufus V. M. Samuel, Marika Vainio, Marco Fritzsche, Yolanda R. Carrasco, Pieta K. Mattila
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Cell Biology
Laura Barrio, Sara Roman-Garcia, Ester Diaz-Mora, Ana Risco, Rodrigo Jimenez-Saiz, Yolanda R. Carrasco, Ana Cuenda
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2020)
Editorial Material
Allergy
Irene Soleto, Rodrigo Jimenez-Saiz, Yolanda R. Carrasco
Article
Biophysics
Alexandra Zak, Sara Violeta Merino-Cortes, Anais Sadoun, Farah Mustapha, Avin Babataheri, Stephanie Dogniaux, Sophie Dupre-Crochet, Elodie Hudik, Hai-Tao He, Abdul Barakat, Yolanda R. Carrasco, Yannick Hamon, Pierre-Henri Puech, Claire Hivroz, Oliver Nusse, Julien Husson
Summary: The study found that leukocytes become significantly stiffer and more viscous when stimulated by microbeads mimicking target cells, with these mechanical changes starting within seconds and rapidly evolving over minutes. The elastic and viscous properties of leukocytes evolve in parallel, maintaining a specific ratio that constitutes a mechanical signature unique to each cell type.
BIOPHYSICAL JOURNAL
(2021)