Review
Biochemistry & Molecular Biology
Ali A. A. Akhiani, Anna Martner
Summary: Activation of NADPH oxidases (NOX) and the resulting formation of reactive oxygen species (ROS) play important roles in antimicrobial defense and oncogenesis. Enhanced NOX activity has been linked to the activation of oncogenic cascades such as the phosphoinositide 3-kinase (PI3K) signaling pathway, which is upregulated in various malignancies. This review examines the role of PI3K in regulating NOX-induced ROS formation in cancer.
Review
Food Science & Technology
Heui Min Lim, See-Hyoung Park
Summary: Cancer and diabetes mellitus are life-threatening diseases that share common risk factors. Conventional treatments for these diseases have limitations such as side effects, economic burdens, and patient compliance. Phytochemicals from edible plants, with their antioxidant and pro-oxidant properties, have emerged as alternative therapeutic options. These naturally occurring compounds have beneficial effects and can regulate cell proliferation, differentiation, cell cycle arrest, and apoptosis, offering preventive and therapeutic effects against cancer and diabetes. This article summarizes recent studies on the antioxidant or pro-oxidant effects and underlying mechanisms of flavonoids, alkaloids, and saponins in cancer or diabetic models.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Engineering, Biomedical
Xiaohua Zheng, Yilan Jin, Xiao Liu, Tianqing Liu, Weiqi Wang, Haijun Yu
Summary: Reactive species-based cancer therapies have gained significant attention for their simplicity, controllability, and efficacy. Utilizing nanomaterials for photo-controlled generation of highly reactive radical species is a promising approach for cancer treatment, showing potential synergistic effects with other therapeutic modalities.
BIOACTIVE MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Min Zhang, Zan Dai, Shevanuja Theivendran, Zhengying Gu, Liang Zhao, Hao Song, Yannan Yang, Chengzhong Yu
Summary: The article discusses the application of nanotechnology in regulating reactive species in cancer immunotherapy, emphasizing the design principles based on the mechanism of action of reactive species in different bio-targets.
Review
Chemistry, Analytical
Marialaura Marchetti, Luca Ronda, Monica Cozzi, Stefano Bettati, Stefano Bruno
Summary: This review provides an overview of genetically encoded biosensors for real-time measurements of intracellular oxygen and reactive oxygen species (ROS) concentrations. Oxygen sensing relies on oxygen-dependent mechanisms and direct binding, while ROS sensing involves ROS-induced chemical reactions and conformational changes. Real-time measurement of oxygen and ROS concentrations is critical for investigating physiological and pathological conditions.
Review
Chemistry, Inorganic & Nuclear
Hanjie Zhang, Zhuo Mao, Yong Kang, Wen Zhang, Lin Mei, Xiaoyuan Ji
Summary: This review provides a detailed description and analysis of the latest advances in redox regulation-based nanotherapies, focusing on the basic material chemistry of nanomaterials and how they can generate or scavenge ROS to improve anticancer therapeutic effects. Key issues and core technologies in the development of ROS-based nanotherapies are also discussed.
COORDINATION CHEMISTRY REVIEWS
(2023)
Review
Chemistry, Multidisciplinary
Yujie Dai, Yiming Ding, Linlin Li
Summary: Nanozymes possess high catalytic activity and stability, making them advantageous in generating or eliminating reactive oxygen species (ROS) for potential applications in disease therapy. Researchers are exploring catalytic mechanisms and strategies to design nanozyme-based platforms for cancer therapy, pathogen infection, neurodegenerative diseases, and more. Challenges and future opportunities for the development and application of nanozymes are also being discussed.
CHINESE CHEMICAL LETTERS
(2021)
Article
Chemistry, Multidisciplinary
Hong-Gui Xu, Margot Schikora, Miroslav Sisa, Steffen Daum, Insa Klemt, Christina Janko, Christoph Alexiou, Galyna Bila, Rostyslav Bilyy, Wenjie Gong, Michael Schmitt, Leopold Sellner, Andriy Mokhir
Summary: Novel ER-targeted prodrugs have been developed with activation only in cancer cells, demonstrating anticancer efficacy and cancer cell specificity. These prodrugs induce ER stress, attenuate mitochondrial membrane potential, and generate mitochondrial ROS leading to cell death via necrosis. Activation of the new prodrugs has also been demonstrated in the Nemeth-Kellner lymphoma murine model.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Biochemistry & Molecular Biology
Marilisa Galasso, Simona Gambino, Maria Grazia Romanelli, Massimo Donadelli, Maria Teresa Scupoli
Summary: This study discusses the role of catalase in cancer, emphasizing its dichotomous role in cancer and providing a comprehensive description of the regulatory mechanisms associated with catalase at multiple levels.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Medicine, Research & Experimental
Fabiola Lili Sarmiento-Salinas, Andrea Perez-Gonzalez, Adilene Acosta-Casique, Adrian Ix-Ballote, Alfonso Diaz, Samuel Trevino, Nora Hilda Rosas-Murrieta, Lourdes Millan-Perez-Pena, Paola Maycotte
Summary: Cancer is a major global cause of death, with the role of reactive oxygen species (ROS) in cancer development and progression being extensively studied. However, conflicting evidence exists regarding the specific impact of ROS on cancer, which may vary depending on the type of cancer and stage of tumorigenesis. Recent research has focused on exploring the diverse aspects of ROS interaction with cancer at different stages of cancer progression.
Review
Plant Sciences
Piyush Mathur, Durgesh Kumar Tripathi, Frantisek Balus, Soumya Mukherjee
Summary: With the rapid industrial development, the production and release of various heavy metals and metalloids in the environment pose threats to crop production and global food security. Plants respond to heavy metal and metalloid stress by synthesizing auxin plant hormone to enhance resilience. Auxin interacts with other biomolecules such as nitric oxide, carbon monoxide, ethylene, salicylic acid, and abscisic acid to protect plants from oxidative stress.
ENVIRONMENTAL AND EXPERIMENTAL BOTANY
(2022)
Review
Biotechnology & Applied Microbiology
Danling Cheng, Xiaoying Wang, Xiaojun Zhou, Jingchao Li
Summary: Immunotherapy is a promising strategy for cancer treatment, but it faces challenges of low immune responses and immune-related adverse events. Sonodynamic therapy combined with immunotherapy can enhance antitumor immunity, and research on nanosonosensitizers for ROS generation is ongoing.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Yang Zhang, Mengqiu Hao, Xuyang Yang, Su Zhang, Junhong Han, Ziqiang Wang, Hai-Ning Chen
Summary: Colorectal cancer often requires adjuvant therapies to reduce tumor burden, and the efficacy of these therapies is significantly influenced by reactive oxygen species (ROS). ROS-mediated colorectal cancer adjuvant therapies involve multiple mechanisms, and preliminary clinical trials have shown the potential of ROS-manipulating therapy in enhancing treatment outcomes.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Review
Chemistry, Multidisciplinary
Yingbo Li, Jie Yang, Xilin Sun
Summary: Advancements in nanotechnology for cancer therapy have led to the development of nanomaterials that specifically generate cytotoxic reactive oxygen species (ROS) in tumor cells. These materials disturb the redox balance in tumor cells, leading to oxidative damage of DNA and proteins.
FRONTIERS IN CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Juliana Cazarin, Corinne Dupuy, Denise Pires de Carvalho
Summary: Radioiodine therapy is a standard and effective treatment for differentiated thyroid cancers, but some patients develop resistance to this treatment due to cell dedifferentiation leading to NIS repression. Oxidative stress may play a crucial role in thyroid cancer, affecting NIS expression and function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)