Review
Environmental Sciences
Kyung Joo Lee, Kyungho Choi
Summary: In this systematic review, the authors examined the presence and potential effects of DINP and DIDP, two plasticizers used as alternatives to DEHP, in various environmental media, foods, consumer products, and human populations. The results indicate that DINP and DIDP are widely present in indoor environments, diets, and children's products. While the levels of DINP exposure were found to be relatively lower compared to DEHP, it still exhibited similar endocrine disruption potentials, particularly among males and pregnant women. There are knowledge gaps regarding the exposure of DIDP in the human population.
CRITICAL REVIEWS IN ENVIRONMENTAL SCIENCE AND TECHNOLOGY
(2023)
Article
Environmental Sciences
Xianxu Li, Na Li, Can Wang, Anyu Wang, Wenjia Kong, Peipei Song, Jun Wang
Summary: This study investigated the occurrence of phthalic acid esters (PAEs) in protected agriculture soils and assessed their potential health risks to humans. The results showed that DEHP and DBP were the most abundant PAEs found in the soils, while DMP and DEP were not detected. Health risk assessment revealed that children have higher health risks compared to adults.
BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
(2022)
Article
Environmental Sciences
Bablu Prasad, Kumar Suranjit Prasad, Hemen Dave, Aditee Das, Gargi Asodariya, Nisha Talati, Sunita Swain, Shruti Kapse
Summary: This study reports on the distribution and human exposure extent of phthalate esters (PAEs) globally, using computed indices. The results reveal heterogenous global distribution of PAEs, with indoor environments being the main source of exposure for humans. Urban populations have significantly higher exposure compared to rural populations. Furthermore, the study examines the distribution and exposure likelihood of PAEs in different environmental compartments based on calculated indices, and their correlation with human development index (HDI), gross national income (GNI), and particulate matter exposure.
ENVIRONMENTAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Hui Huang, Bei-Di Lan, Yu-Jing Zhang, Xiao-Juan Fan, Min-Cui Hu, Guo-Qiang Qin, Fei-Ge Wang, Yue Wu, Tao Zheng, Jun-Hui Liu
Summary: This study investigated the inhibition of human important SULTs by phthalate monoesters. The results showed that several phthalate monoesters strongly inhibited certain SULT isoforms, providing insights into the risk of phthalate monoester exposure.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Environmental Sciences
Chih-Feng Chen, Yun-Ru Ju, Yee Cheng Lim, Ming-Huang Wang, Anil Kumar Patel, Reeta Rani Singhania, Chiu-Wen Chen, Cheng-Di Dong
Summary: Phthalate esters (PAEs) are widely used in plastic products and easily released into the environment, leading to their ubiquity. A study in Kaohsiung, Taiwan, investigated the impact of heavy rainfall on PAEs concentrations in surface sediments of the Salt River, revealing potential ecological risks to aquatic organisms. The study showed that heavy rainfall can cause more serious pollution in sediments and increase the exposure risk of PAEs to aquatic organisms.
Article
Biotechnology & Applied Microbiology
Jianqiang Sun, Haofeng Zhu, Xindong Yang, Yan Zheng, Tianchi Sun, Honglei Xu, Jiaqi Meng, Anping Zhang
Summary: Phthalate esters (PAEs) are commonly found in agricultural soil and crops due to the use of plastic films containing PAEs. This study investigated the enzyme-catalyzed reaction kinetics of seven selected PAE congeners in water and soil to evaluate the effects of enzymes on PAE degradation. The results showed that the length of the alkyl chain had a significant impact on the enzymatic degradation of PAEs, with longer alkyl chains being more recalcitrant to degradation. Additionally, the reaction rates and half-lives were correlated with the logKow value of PAEs, which is influenced by the molecular structure. These findings have important implications for the remediation and assessment of PAE contamination in water and soil.
ENVIRONMENTAL TECHNOLOGY & INNOVATION
(2022)
Article
Environmental Sciences
Juan Wu, Rongfei Qu, Qianwen Wang, Xindong Yang, Haofeng Zhu, Anping Zhang, Jianqiang Sun
Summary: This study investigates the impact of interregional food trade on dietary exposure to phthalate esters (PAEs) in China. The results show that interregional food trade promotes the transfer of PAEs between regions and alters the potential risk to the local population.
ENVIRONMENTAL POLLUTION
(2022)
Article
Environmental Sciences
Liqun Zhang, Ren Ren, Huali He, Shaoying Liu
Summary: The migration of 16 phthalate esters (PAEs) in seven different types of water pipes and filter materials was investigated. It was found that the migration of PAEs from plastic pipes into water increases with higher water temperature, lower pH, and longer leaching time. The chronic daily intake of PAEs through drinking water was higher for children aged < 1-12 years than other population groups. The carcinogenic risk of DEHP through drinking water was negligible for most groups, but acceptable for young children aged 1-2 years.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Zhentao Tang, Zhiguo Gong, Wei Jia, Wenxuan Shen, Qingrong Han, Fang Fang, Cheng Peng
Summary: This study investigated the occurrence and risk assessment of phthalate esters (PAEs) in imported plant oils in western China. The results showed that PAEs were ubiquitous contaminants in these oils, with potential health risks.
Article
Environmental Sciences
Nai-Xian Feng, Yu-Xi Feng, Qi-Feng Liang, Xin Chen, Lei Xiang, Hai-Ming Zhao, Bai-Lin Liu, Gang Cao, Yan-Wen Li, Hui Li, Quan-Ying Cai, Ce-Hui Mo, Ming Hung Wong
Summary: A novel bacterium Pseudomonas sp. YJB6 isolated from PAEs-contaminated soil showed strong DBP-degrading activity and could completely degrade DBP within a short period. YJB6 presented a complex and complete degradation pathway for DBP, with high degradation rates and reusability when immobilized.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Review
Environmental Sciences
Wei-Hsiang Chang, Samuel Herianto, Ching-Chang Lee, Hsin Hung, Hsiu-Ling Chen
Summary: Phthalate esters can have various health effects on humans, including impacts on sperm quality and development of ADHD symptoms in children. However, the association between PAEs and cardiovascular diseases, thyroid diseases, respiratory diseases, and other health issues lacks consistent evidence.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Environmental Sciences
Chao Bao, Jia Lv, Jian-rong Chen, Guo-zhang Wei, Nuo Liu, Yi-tao Wang, Zheng Ding, Wei-bo Liu, Xiu-de Li, Hong-juan Cao, Jie Sheng, Kai-yong Liu, Jun He, Fang-biao Tao, Qu-nan Wang
Summary: This study examines the relationship between phthalate exposure, chronic inflammation, and depressive symptoms in the elderly population. The results showed that higher levels of certain phthalates were positively correlated with depressive symptoms. Additionally, chronic inflammation partially mediated the association between phthalate exposure and depressive symptoms in the elderly.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Environmental Sciences
Yanru Huo, Zexiu An, Mingxue Li, Jianfei Sun, Jinchan Jiang, Yuxin Zhou, Maoxia He
Summary: This study comprehensively investigates the ozonolysis mechanism and toxicity of low-molecular-weight phthalate acid esters (PAEs) using quantum chemistry calculations and computational toxicology. The results show a pattern in the ozonation reaction rate constants and highlight the potential risks of PAEs and their degradation products.
ENVIRONMENTAL POLLUTION
(2022)
Article
Environmental Sciences
Yulin Chen, Yile Wang, Yang Tan, Chunxia Jiang, Tianyi Li, Yuyi Yang, Zulin Zhang
Summary: This study investigated the pollution characteristics of phthalate esters (PAEs) in sediments of the Yangtze River, and found that DEHP could potentially be used as an indicator for microplastics (MPs). DEHP, DIBP, and DBP posed high risks at the monitoring sites.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Elise Lorre, Federica Bianchi, Irma Vybernaite-Lubiene, Jovita Mezine, Mindaugas Zilius
Summary: This study investigated the external sources and seasonal variation of eight plasticizers in the Curonian Lagoon, focusing on their partitioning between dissolved and particulate phases. The results were combined with hydrological inputs to estimate the lagoon's role in regulating pollutant transport to the sea. Plasticizers were detected in all samples, with DEHP being the most abundant and mainly associated with particulate matter. DnBP and DiBP were also found, predominantly in the dissolved phase. Meteorological conditions played a significant role in the distribution of PAEs, with high concentrations during the river ice-covered season and heavy rainfall events.
ENVIRONMENTAL RESEARCH
(2023)
Review
Chemistry, Analytical
Yao Chen, Zheng Zhou, Shu Zhu, Zhonghua Ni, Nan Xiang
Summary: The rapid development of microfluidic technologies has provided a promising tool for single-cell analysis, enabling a deeper understanding of the physiological and pathological states of cells. This review provides a comprehensive overview of the recent advances in label-free microfluidics for analyzing the biophysical properties of single cells, and discusses their applications in cell identification, disease diagnosis, and drug resistance studies.
MICROCHEMICAL JOURNAL
(2022)
Article
Chemistry, Analytical
Dezhi Tang, Lin Jiang, Wenlai Tang, Nan Xiang, Zhonghua Ni
Summary: This paper proposes a cost-effective portable microfluidic impedance cytometer (MIC) for broadband impedance analysis of cells using maximum length sequence (MLS) and viscoelastic focusing. Results show that MIC has the potential for rapid detection of circulating tumor cells.
Article
Food Science & Technology
Nan Xiang, Hui Xie, Liuwei Qin, Min Wang, Xinbo Guo, Wen Zhang
Summary: This study investigated the discrepancies in volatiles of the popular grape variety 'Red Globe' cultivated in two regions with different climates. The study found that climate conditions influenced fatty acid derivatives and terpenoids in grapes, and specific transcription factors were correlated to these compounds. The study also revealed variations in fruit maturity and volatile formations, and suggested the involvement of specific transcription factors in volatile accumulations.
Article
Agriculture, Multidisciplinary
Bing Zhang, Tianxiang Wen, Nan Xiang, Yihan Zhao, Xinbo Guo
Summary: Ultrasonic pretreatment was found to increase the accumulation of tocopherols and carotenoids in maize seedlings but decrease tocotrienol synthesis. The carotenoid content reached its highest level at 8 minutes of ultrasonic pretreatment, while tocopherol initially dropped but began to rise after 8 minutes. The predominant component of tocochromanols in maize seedlings shifted from gamma-tocotrienol to alpha-tocopherol after ultrasonic pretreatment.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Review
Chemistry, Analytical
Lin Jiang, Hang Yang, Weiqi Cheng, Zhonghua Ni, Nan Xiang
Summary: Circulating tumor cells (CTCs) are important biomarkers in liquid biopsy, and their number and heterogeneity play a crucial role in cancer diagnosis and personalized medicine. However, due to their low abundance, conventional methods can only detect CTCs at the population level. Therefore, droplet microfluidics, as a high-throughput and sensitive single-cell analysis platform, becomes a significant tool for quantitative detection and heterogeneity analysis of CTCs.
Article
Biochemical Research Methods
Hang Yang, Lin Jiang, Kefan Guo, Nan Xiang
Summary: We developed a manually operated device based on a static droplet array (SDA) for the synthesis of nonspherical microparticles. The device utilized an improved SDA structure and reversible bonding between PDMS for large-scale synthesis and rapid extraction. We investigated the effects of flow rate, SDA well size, and shape on droplet generation and found that it was insensitive to flow rate. The device was capable of producing monodisperse droplets by manual pushing of the syringe. Additionally, we successfully integrated four different SDA structures in one device and achieved synthesis and extraction of nonspherical microparticles with various shapes and materials.
Review
Chemistry, Analytical
Yao Chen, Kefan Guo, Lin Jiang, Shu Zhu, Zhonghua Ni, Nan Xiang
Summary: Cell deformability plays a crucial role in cellular processes and functions, and its measurement at the single-cell level is highly sought after in biomedicine for various applications. Microfluidics has emerged as a promising tool for single-cell deformability analysis, offering advantages such as reduced complexity and reagent consumption. This review discusses recent advances in microfluidic technologies for single-cell deformability analysis, including different methods of stress generation and their respective applications, advantages, and disadvantages. Future research directions are also explored, such as improving detection performance and integration of detection technologies.
Article
Chemistry, Analytical
Nan Xiang, Zhonghua Ni
Review
Biochemical Research Methods
Shu Zhu, Yaohui Fang, Kefan Guo, Zhonghua Ni, Nan Xiang
Summary: Conventional cancer diagnosis requires invasive tissue biopsy, causing severe harm to patients. Liquid biopsy, with its minimal invasiveness, has shown potential for real-time cancer diagnosis but still cannot replace tissue biopsy in most settings. This paper discusses the challenges and limitations of existing liquid biopsy instruments, as well as the opportunities and future progression of next-generation tools. Ultimately, the goal is to integrate liquid biopsy into clinical workflows and establish it as a validated and reliable tool for cancer diagnosis.
Article
Materials Science, Multidisciplinary
Nan Xiang, Lin Li, Hua Wang, Jiang Qian, Tonghua Wang
Summary: Graphene oxide-polyvinyl alcohol mixed matrix membranes were prepared on the surface of polysulfone membranes for the dehydration of alcohols through pervaporation. The concentration and size of graphene oxide nanosheets were found to affect the separation performance of the membranes.
JOURNAL OF MATERIALS SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Yao Chen, Chen Ni, Lin Jiang, Zhonghua Ni, Nan Xiang
Summary: An inertial multi-force deformability cytometry (IMFDC) is developed for high-throughput, high-accuracy, and high-applicability tumor cell mechanotyping. The IMFDC is able to evaluate the deformability of different cells and identify cell types. The multiple-parameters-based machine learning model achieves high discrimination accuracy and throughput. The IMFDC has important applications in clinical cancer diagnosis.
Article
Food Science & Technology
Yaoyao Cheng, Nan Xiang, Honglin Chen, Yihan Zhao, Lixia Wang, Xuzhen Cheng, Xinbo Guo
Summary: This study aimed to investigate the regulatory mechanisms of white, blue, and red lights on carotenoid and tocopherol biosynthesis in mung bean sprouts. Results showed that these lights stimulated the increase of carotenoids and tocopherols in sprouts, with the best yield observed under white light. Genes involved in carotenoid and tocopherol biosynthesis exhibited high expression levels under light quality conditions. These findings provide insights into light-mediated regulation and fortification of carotenoids and tocopherols, as well as guidance for future agricultural cultivation of mung bean sprouts.
FOOD CHEMISTRY: MOLECULAR SCIENCES
(2023)
Article
Chemistry, Analytical
Yao Chen, Lin Jiang, Xiaozhe Zhang, Zhonghua Ni, Nan Xiang
Summary: This article introduces an efficient label-free sorting and mechanical phenotyping method for tumor cells, which utilizes a viscoelastic-sorting integrated deformability cytometer (VSDC) to sort, extract, and analyze the mechanical properties of tumor cells. Machine learning algorithms are used to distinguish tumor cells from white blood cells.
ANALYTICAL CHEMISTRY
(2023)
Article
Biochemical Research Methods
Zheng Zhou, Chen Ni, Zhixian Zhu, Yao Chen, Zhonghua Ni, Nan Xiang
Summary: Cell mechanical properties can be used as label-free markers to indicate cell states and disease processes. This study proposes a high-throughput adjustable deformability cytometry system that combines three-dimensional elasto-inertial focusing and a virtual fluidic channel to enable fast mechanical phenotyping of various cell sizes.
Article
Biochemical Research Methods
Nan Xiang, Zhonghua Ni
Summary: Inertial microfluidics is a technique that utilizes hydrodynamic effects induced at finite Reynolds numbers to passively manipulate particles, cells, or fluids. It offers advantages such as high-throughput processing, simple channel geometry, and label-free and external field-free operation. It has gained increasing interest and is widely used in single-cell detection and analysis for sample preparation. Although there have been achievements in the field, improvements can still be made in the performance and outcomes of inertial microfluidics with a better understanding of the physical mechanisms and the development of novel channels, integration strategies, and commercial instruments. Enhanced inertial microfluidic platforms may be a new foundation for advancing biomedical research and disease diagnosis.
Article
Environmental Sciences
Toshimi Nakajima, Mao Kuragano, Makoto Yamada, Ryo Sugimoto
Summary: This study compared the contribution of submarine groundwater discharge (SGD) to river nutrient budgets at nearshore and embayment scales, and found that SGD-derived nutrients become more important at larger spatial scales.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Fan Liu, Lei Zhang, Chongyang Zhang, Ziguang Chen, Jingguang Li
Summary: NO2 emissions from wall-mounted gas stoves used for household heating have become a significant source of indoor pollution in Chinese urban areas. The high indoor concentration of NO2 poses potential health risks to residents. It is urgently necessary to establish relevant regulations and implement emission reduction technologies to reduce NO2 emissions from wall-mounted gas stoves.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Letter
Environmental Sciences
Hans Peter H. Arp, Raoul Wolf, Sarah E. Hale, Sivani Baskaran, Juliane Gluege, Martin Scheringer, Xenia Trier, Ian T. Cousins, Harrie Timmer, Roberta Hofman-Caris, Anna Lennquist, Andre D. Bannink, Gerard J. Stroomberg, Rosa M. A. Sjerps, Rosa Montes, Rosario Rodil, Jose Benito Quintana, Daniel Zahn, Herve Gallard, Tobias Mohr, Ivo Schliebner, Michael Neumann
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Philomina Onyedikachi Peter, Binessi Edouard Ifon, Francois Nkinahamira, Kayode Hassan Lasisi, Jiangwei Li, Anyi Hu, Chang-Ping Yu
Summary: This study investigates the relationship between dissolved organic matter (DOM) and Rare Earth Elements (REEs) in sediments from Yundang Lagoon, China. The results show four distinct fluorescent components, with protein-like substances being the most prevalent. Additionally, the total fluorescence intensity and LREE concentrations exhibit a synchronized increase from Outer to Inner to Songbai Lake core sediments. The findings demonstrate a strong correlation between DOM content and pollution levels.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Surya Gupta, Pasquale Borrelli, Panos Panagos, Christine Alewell
Summary: The objective of this study is to incorporate soil hydraulic properties into the erodibility factor (K) of USLE-type models. By modifying and improving the existing equations for soil texture and permeability, the study successfully included information on saturated hydraulic conductivity (Ksat) into the calculation of K factor. Using the Random Forest machine learning algorithm, two independent K factor maps with different spatial resolutions were generated. The results show that the decrease in K factor values has a positive impact on the modeling of soil erosion rates.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Jesmin Akter, Wendy J. M. Smith, Yawen Liu, Ilho Kim, Stuart L. Simpson, Phong Thai, Asja Korajkic, Warish Ahmed
Summary: The choice of workflow in wastewater surveillance has a significant impact on SARS-CoV-2 concentrations, while having minimal effects on HF183 and no effect on HAdV 40/41 concentrations. Certain components in the workflow can be interchangeable, but factors such as buffer type, chloroform, and homogenization speed can affect the recovery of viruses and bacteria.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Yu Luo, Xueting Yang, Diwei Wang, Hongmei Xu, Hongai Zhang, Shasha Huang, Qiyuan Wang, Ningning Zhang, Junji Cao, Zhenxing Shen
Summary: Atmospheric PM2.5, which can generate reactive oxygen species (ROS), is associated with cardiorespiratory morbidity and mortality. The study found that both the mass concentration of PM2.5 and the DTT activity were higher during the heating season than during the nonheating season. Combustion sources were the primary contributors to DTT activity during the heating season, while secondary formation dominated during the nonheating season. The study also revealed that biomass burning had the highest inherent oxidation potential among all sources investigated.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Erin L. Murphy, Leah R. Gerber, Chelsea M. Rochman, Beth Polidoro
Summary: Plastic pollution has devastating consequences for marine organisms. This study uses a trait-based framework to develop a vulnerability index for marine mammals, seabirds, and sea turtles in Hawai'i. The index ranks 63 study species based on their vulnerability to macroplastic pollution, providing valuable information for species monitoring and management priorities.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Kenji Maurice, Amelia Bourceret, Sami Youssef, Stephane Boivin, Liam Laurent-Webb, Coraline Damasio, Hassan Boukcim, Marc-Andre Selosse, Marc Ducousso
Summary: Growing pressure from climate change and agricultural land use is destabilizing soil microbial community interactions. Little is known about microbial community resistance and adaptation to disturbances, hindering our understanding of recovery latency and implications for ecosystem functioning. This study found that anthropic disturbance and natural disturbance have different effects on the topology and stability of soil microbial networks.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Yunhao Li, Yali Feng, Haoran Li, Yisong Yao, Chenglong Xu, Jinrong Ju, Ruiyu Ma, Haoyu Wang, Shiwei Jiang
Summary: Deep-sea mining poses a serious threat to marine ecosystems and human health by disturbing sediment and transmitting metal ions through the food chain. This study developed a new regenerative adsorption material, OMN@SA, which effectively removes metal ions. The adsorption mechanism and performance of the material for metal ion fixation were investigated.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Antonio Medici, Margherita Lavorgna, Marina Isidori, Chiara Russo, Elena Orlo, Giovanni Luongo, Giovanni Di Fabio, Armando Zarrelli
Summary: Valsartan, a widely used antihypertensive drug, has been detected in high concentrations in surface waters due to its unchanged excretion and incomplete degradation in wastewater treatment plants. This study investigated the degradation of valsartan and identified 14 degradation byproducts. The acute and chronic toxicity of these byproducts were evaluated in key organisms in the freshwater trophic chain.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Jiang Lin, Lianbao Chi, Qing Yuan, Busu Li, Mingbao Feng
Summary: This study investigated the photodegradation behavior and product formation of two representative pharmaceuticals in simulated estuary water. The study found that the formed transformation products of these pharmaceuticals have potential toxicity on marine organisms, including oxidative stress and damage to cellular components.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Hua Fang, Dongdong Jiang, Ye He, Siyi Wu, Yuehong Li, Ziqi Zhang, Haoting Chen, Zixin Zheng, Yan Sun, Wenxiang Wang
Summary: This study revealed that exposure to lower levels of air pollutants led to decreased pregnancy rates, with PM10, NO2, SO2, and CO emerging as the four most prominent pollutants. Individuals aged 35 and above exhibited heightened susceptibility to pollutants.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Ali Shaan Manzoor Ghumman, Rashid Shamsuddin, Amin Abbasi, Mohaira Ahmad, Yoshiaki Yoshida, Abdul Sami, Hamad Almohamadi
Summary: In this study, inverse vulcanized polysulfides (IVP) were synthesized by reacting molten sulfur with 4-vinyl benzyl chloride, and then functionalized using N-methyl D-glucamine (NMDG). The functionalized IVP showed a high mercury adsorption capacity and a machine learning model was developed to predict the amount of mercury removed. Furthermore, the functionalized IVP can be regenerated and reused, providing a sustainable and cost-effective adsorbent.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Rita Bonfiglio, Renata Sisto, Stefano Casciardi, Valeria Palumbo, Maria Paola Scioli, Erica Giacobbi, Francesca Servadei, Gerry Melino, Alessandro Mauriello, Manuel Scimeca
Summary: This study investigated the presence of aluminum in human colon cancer samples and its potential association with biological processes involved in cancer progression. Aluminum was found in tumor areas of 24% of patients and was associated with epithelial to mesenchymal transition (EMT) and cell death. Additional analyses revealed higher tumor mutational burden and mutations in genes related to EMT and apoptosis in aluminum-positive colon cancers. Understanding the molecular mechanisms of aluminum toxicity may improve strategies for the management of colon cancer patients.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
