Article
Engineering, Environmental
Dingxiang Wang, Jiahao He, Jun Ma, Jing Zhang, Timothy J. Strathmann
Summary: Permanganate and ferrate oxidations are widely used advanced treatment processes to degrade organic components in secondary effluents from municipal wastewater treatment plants. However, these reactions are sensitive to the dissolved effluent organic matter (EfOM) and do not mineralize it but change its molecular composition.
Article
Environmental Sciences
Carlos Silva, Anabela Cachada, Fernando J. M. Goncalves, Christina Nannou, Dimitra Lambropoulou, Carla Patinha, Nelson Abrantes, Joana Luisa Pereira
Summary: The study investigated three wastewater treatment plants of different sizes and urbanization degrees, and found differences in contamination patterns and sources. Sediment analysis provides important historical information about contamination, especially in flowing recipient ecosystems.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Engineering, Environmental
Cindy Weng, Marlena M. Hinkle, William A. Mitch
Summary: In this study, a reductive electrochemical reactor with a stainless-steel cathode was used to degrade chloramine disinfectant residuals in municipal wastewater effluents. High degradation rates and efficiencies were achieved with a 304-grade stainless-steel cathode and a cathode with a high surface area. The electricity cost associated with this method could be comparable to the cost of purchasing sodium bisulfite in areas with low electricity costs.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Engineering, Environmental
Zhi-Wei Lin, Emma F. Shapiro, Francisco J. Barajas-Rodriguez, Arsen Gaisin, Mohamed Ateia, John Currie, Damian E. Helbling, Rosa Gwinn, Aaron I. Packman, William R. Dichtel
Summary: Trace organic contaminants (TrOCs) pose significant challenges to wastewater treatment, and cross-linked beta-cyclodextrin (beta-CD) polymers show promise in removing TrOCs from complex water matrices.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Engineering, Chemical
Kunal Gupta, Shankararaman Chellam
Summary: The study found that pre-chlorination has complex effects on membrane fouling during wastewater reclamation, altering the characteristics of EfOM and leading to different fouling trends.
JOURNAL OF MEMBRANE SCIENCE
(2021)
Article
Engineering, Environmental
Joseph P. Smith, Thomas J. Boyd, Jennifer Cragan, Matthew C. Ward
Summary: Municipal wastewater effluent discharges can negatively impact local ecosystems and human health by introducing contaminants to receiving waters. Gadolinium and dissolved rubidium/strontium ratios have been identified as potential conservative tracers for tracking wastewater-sourced pollutants in urbanized freshwater systems, providing a cost-effective alternative to traditional tracers. Studies have shown that these tracers could be valuable tools in investigating wastewater impacts in different geological settings.
Article
Engineering, Environmental
Li Chen, Wanyi Fu, Yu Tan, Xihui Zhang
Summary: This study focuses on organic micropollutants in secondary effluents from municipal wastewater treatment plants, identifying various micropollutants and evaluating an advanced treatment process for their removal. It was found that a combination of ozonation, ceramic membrane filtration, and biological active carbon filtration achieved remarkable removal efficiencies of pharmaceuticals, personal care products, endocrine disrupting chemicals, and odorous compounds in the effluents.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Engineering, Environmental
Shixin Zhang, Zhen Lei, Mawuli Dzakpasu, Qian Li, Yu-You Li, Rong Chen
Summary: Anaerobic membrane bioreactors (AnMBRs) show promising applications in treating municipal wastewater, effectively removing chemicals with strong electron-donating functional groups and highly hydrophobic compounds. Adsorption and biodegradation are key processes for TrOCs removal, and combining membrane separation technologies with bioreactor technology can enhance removal efficiency. Operating conditions play a critical role in AnMBRs performance, and addressing challenges and future perspectives can lead to wider adoption and improved TrOCs removal.
JOURNAL OF WATER PROCESS ENGINEERING
(2021)
Article
Engineering, Environmental
Rongwei Zhong, Hu Li, Yangyang Wang, Ying Zhang, Jian Zhou, Tiecheng Wang
Summary: Plasma oxidation was used to remove antibiotic resistance genes (ARGs) and inhibit pathogenic bacteria in municipal wastewater treatment plants (MWTP). The experimental results showed that plasma treatment effectively removed various ARGs and decreased the diversity and richness of microbial communities. Plasma treatment also resulted in reduced gene expression related to ARGs and inhibited the transmission risks of ARGs and pathogenicity in MWTP effluent.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Marine & Freshwater Biology
S. Hanson, K. Steeves, T. Bagatim, N. Hogan, S. Wiseman, A. Hontela, J. P. Giesy, P. D. Jones, M. Hecker
Summary: The unique hydrological and climatic conditions in the southern Canadian Prairies put surface water systems at an elevated risk from contaminants in municipal wastewater effluents. This study focused on the health effects and molecular mechanisms in fathead minnow populations in Wascana Creek, revealing a general deterioration in health and reproductive status downstream of the effluent fallout. Chemical analysis identified pharmaceuticals and personal care products present at concentrations posing a risk to aquatic organisms, indicating Wascana Creek as an ecosystem at risk.
AQUATIC TOXICOLOGY
(2021)
Article
Environmental Sciences
Elizangela Pinheiro Costa, Maria Clara Vieira Martins Starling, Camila C. Amorim
Summary: This work provides a bibliographic review on the simultaneous removal of contaminants of emerging concern (CECs) and disinfection in domestic wastewater matrices, highlighting the recent attention to removing CECs and pathogens simultaneously. The study employs a combination of bibliometric analysis and systemic approach to select five highly cited papers and authors, revealing the need for further exploration in depth for new technologies.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Environmental Sciences
Sicong Yao, Massimiliano Fabbricino, Ludovico Pontoni, Marco Race, Francesco Parrino, Luigi Savignano, Gerardino D'Errico, Yao Chen
Summary: The concept of natural organic matter of anthropogenic origin is introduced, and its characteristics and interaction with chemical pollutants are investigated using various analytic methodologies. The results indicate that the presence of AOM can significantly influence the fate, transport, and toxicity of pollutants in the environment.
Article
Environmental Sciences
Linhua Fan, Arash Mohseni, Jonathan Schmidt, Ben Evans, Ben Murdoch, Li Gao
Summary: The experimental results from two wastewater treatment plants in Melbourne showed that both the conventional wastewater lagoon system and the activated sludge-lagoon system were effective in removing microplastic pollutants. The high removal efficiency of the lagoon system was due to its lengthy wastewater detention time, while the activated sludge-lagoon system further removed microplastics through post-secondary treatment. These low-energy, low-cost wastewater treatment systems have the potential for controlling microplastic pollution.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Engineering, Environmental
Pengxiao Zhou, Zhong Li, Wael El-Dakhakhni, Shirley Anne Smyth
Summary: This study uses machine learning models to predict the effluent BPA concentration at municipal WWTPs in Canada and analyzes the interdependencies among influencing factors of BPA removal. The results show that these models can provide reasonable predictions and have advantages in dealing with data sparsity and imbalance. The study identifies important factors for BPA removal and finds that primary treatment plants are unlikely to remove BPA, while secondary or tertiary treatment can achieve BPA removal.
JOURNAL OF WATER PROCESS ENGINEERING
(2022)
Article
Environmental Sciences
Emma Undeman, Kristina Rasmusson, Ilga Kokorite, Matti T. Leppanen, Martin M. Larsen, Ksenia Pazdro, Grzegorz Siedlewicz
Summary: This study compiled data on chemical substances in the effluents from wastewater treatment plants in the Baltic Sea region, assessed the differences between countries, and estimated the inputs of micropollutants to the Baltic Sea catchment. The study provides useful data for environmental risk assessments and pressure analysis, but also highlights the need for broader monitoring of micropollutants in wastewater.
MARINE POLLUTION BULLETIN
(2022)
Editorial Material
Biochemistry & Molecular Biology
Yibo Hu, Louis Bernatchez
Article
Biochemistry & Molecular Biology
Quentin Rougemont, Amanda Xuereb, Xavier Dallaire, Jean-Sebastien Moore, Eric Normandeau, Eric B. Rondeau, Ruth E. Withler, Donald M. Van Doornik, Penelope A. Crane, Kerry A. Naish, John Carlos Garza, Terry D. Beacham, Ben F. Koop, Louis Bernatchez
Summary: This study investigated the genomic basis of local adaptation in Coho salmon across North America and found that migration distance is the primary selective factor. Several candidate genetic variations associated with long-distance migration and altitude were also identified.
Article
Ecology
Hugo Cayuela, Staffan Jacob, Nicolas Schtickzelle, Rik Verdonck, Herve Philippe, Martin Laporte, Michele Huet, Louis Bernatchez, Delphine Legrand
Summary: Phenotypic plasticity refers to the ability of one genotype to produce different phenotypes in different environments, and transgenerational plasticity allows the transmission of this environmentally-induced variation across generations. In this study, using a ciliate model-species, the researchers found that phenotypic traits related to dispersal are plastic and can be inherited over at least 35 generations. The fitness costs and benefits associated with these changes can also be passed on to further generations.
Article
Genetics & Heredity
Anne-Laure Ferchaud, Claire Merot, Eric Normandeau, Jiannis Ragoussis, Charles Babin, Haig Djambazian, Pierre Berube, Celine Audet, Margaret Treble, Wojciech Walkusz, Louis Bernatchez
Summary: A chromosome-level reference genome for Greenland Halibut was successfully assembled using single-molecule sequencing and chromatin conformation capture sequencing data. The study revealed that Greenland Halibut possesses a male heterogametic XY system for sex determination, similar to other teleost fishes, and identified several candidate genes potentially involved in this process. Additionally, the study suggested a putative Y-autosomal fusion may be associated with reduced recombination during the early steps of sex chromosome evolution in flatfishes.
G3-GENES GENOMES GENETICS
(2022)
Article
Fisheries
Anthony Fontaine, Mackenzie Anne Clifford Martyniuk, Camille Garnier, Patrice Couture
Summary: For many years, mining companies have been exploiting the mineral resources of Northern Quebec, but there is still limited research on the effects of toxic stress on fish health in subarctic environments. This study investigated the effects of manganese and selenium bioaccumulation on fish in lakes near mining activities. The results showed that high concentrations of manganese and selenium caused oxidative stress and DNA damage in fish, highlighting the variability of fish responses to contaminated areas.
CANADIAN JOURNAL OF FISHERIES AND AQUATIC SCIENCES
(2023)
Article
Environmental Sciences
Roxanne Berube, Camille Garnier, Molly Lefebvre-Raine, Charles Gauthier, Normand Bergeron, Gaelle Triffault-Bouchet, Valerie S. Langlois, Patrice Couture
Summary: Atlantic salmon is an important species for culture and economy in Canada, Scandinavia, and Western Europe, but its vulnerability to habitat contamination and destruction poses a threat to its population. This study compares the effects of diluted bitumen and conventional oil on Atlantic salmon embryos and finds that dilbit causes higher mortality and malformations. Early developmental stage is the most sensitive to oil exposure, affecting gene expression and enzymatic activity related to detoxification and DNA repair.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Environmental Sciences
Chris J. Brauer, Jonathan Sandoval-Castillo, Katie Gates, Michael P. Hammer, Peter J. Unmack, Louis Bernatchez, Luciano B. Beheregaray
Summary: Under climate change, species without the ability to shift their range rely on genetic variation for adaptation. Genomic vulnerability studies often overlook hybridization as a source of adaptive variation. This study found that hybrid populations of rainbowfish showed reduced vulnerability to climate change compared to pure narrow endemics, highlighting the importance of hybrid populations and adaptive introgression in the evolutionary rescue of species with narrow environmental ranges.
NATURE CLIMATE CHANGE
(2023)
Article
Environmental Sciences
N. Indiketi, E. Lhoste, M. C. Grenon, M. Gagnon, E. Veilleux, G. Triffault-Bouchet, P. Couture
Summary: Diluted bitumen (dilbit), an unconventional oil produced by the oil sands industry in Canada, has unknown effects on benthic organisms despite existing knowledge on hydrocarbon toxicity. The current provisional threshold values in Quebec for chronic and acute effects have not been tested for heavy unconventional oils like dilbit, indicating a need for further research.
ENVIRONMENTAL POLLUTION
(2023)
Article
Ecology
Florent Sylvestre, Claire Merot, Eric Normandeau, Louis Bernatchez
Summary: Differences between sexes in trait fitness optima can contribute to genetic diversity through balancing selection, but detecting such conflicts is challenging. Recent studies have found that duplications on sexual chromosomes can create misleading signals of intralocus sexual conflicts. In this study, we investigated intralocus sexual conflicts in three-spined sticklebacks and found only two regions that showed potential conflicts and signals of balancing selection. These results suggest that most intralocus sexual conflicts are transient and do not drive long-term balancing selection.
Article
Parasitology
Chloe Suzanne Berger, Berenice Bougas, Guillaume Cote, Jean-Francois Dumont, Louis Bernatchez
Summary: The ability to systematically detect parasitic infection, even without visible signs, is crucial for accurate conservation policies. In particular, the nematode Anguillicola crassus poses a potential threat to eel populations. The authors present a real-time PCR-based method to detect A. crassus infection in both final and intermediate hosts. By using this method, they were able to detect the DNA of A. crassus in both zooplankton and individual swim bladders. This method allows for early detection of A. crassus infection in nature, going beyond previous protocols.
PARASITOLOGY RESEARCH
(2023)
Article
Environmental Sciences
Sebastien Ryskie, Etienne Belanger, Carmen M. Neculita, Patrice Couture, Eric Rosa
Summary: The efficiency of ozone microbubbles combined with lime precipitation on contaminant removal and its impact on toxicity for Daphnia magna were evaluated in this study. Results showed that ozone treatment had high removal efficiency for NH3-N, but abnormal toxicity issues were observed without metals pre-treatment.
Article
Environmental Sciences
Lisa M. Crawford, James Gelsleichter, Alisa L. Newton, Lisa A. Hoopes, Cheng-Shiuan Lee, Nicholas S. Fisher, Douglas H. Adams, Maeva Giraudo, Anne E. Mcelroy
Summary: The ecology and life-histories of white sharks make them susceptible to mercury bioaccumulation, but the health consequences of mercury exposure are not well-studied. This study measured mercury levels in muscle and plasma of white sharks in the Northwest Atlantic and found a positive correlation between mercury levels and shark precaudal length. The study also found that some individuals had higher selenium:mercury ratios, suggesting potential protective effects of selenium.
MARINE POLLUTION BULLETIN
(2023)
Review
Genetics & Heredity
Louis Bernatchez, Anne-Laure Ferchaud, Chloe Suzanne Berger, Clare J. Venney, Amanda Xuereb
Summary: With global climate change causing drastic changes in environmental conditions, it is crucial to understand how organisms respond and adapt to these changes. Recent advancements in genomic, transcriptomic, and epigenomic technologies provide unprecedented insights into the evolutionary processes and molecular mechanisms of adaptation. This review summarizes the methods that utilize omics tools to investigate, monitor, and predict the responses of species and communities to global climate change, highlighting the need for holistic, multi-omics approaches.
NATURE REVIEWS GENETICS
(2023)
Article
Biology
Swantje Enge, Claire Merot, Raimondas Mozuraitis, Violeta Apsegaite, Louis Bernatchez, Gerrit A. Martens, Sandra Radziute, Henrik Pavia, Emma L. Berdan
Summary: In this study, researchers found that a overdominant supergene in seaweed flies strongly modulates male traits but only weakly affects female traits. Gas chromatography-electroantennographic detection revealed that females can sense male traits and there may be differential perception between genotypes. Gene expression analysis showed that candidate genes for trait biosynthesis primarily showed differential expression in males, while odorant detection genes were differentially expressed in both sexes but showed high levels of divergence between supergene haplotypes. The reduced recombination between supergene haplotypes may have led to rapid divergence in mate preferences and increasing linkage between male traits and overdominant loci, helping to maintain the polymorphism despite deleterious effects in homozygotes.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2023)
Article
Environmental Sciences
Toshimi Nakajima, Mao Kuragano, Makoto Yamada, Ryo Sugimoto
Summary: This study compared the contribution of submarine groundwater discharge (SGD) to river nutrient budgets at nearshore and embayment scales, and found that SGD-derived nutrients become more important at larger spatial scales.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Fan Liu, Lei Zhang, Chongyang Zhang, Ziguang Chen, Jingguang Li
Summary: NO2 emissions from wall-mounted gas stoves used for household heating have become a significant source of indoor pollution in Chinese urban areas. The high indoor concentration of NO2 poses potential health risks to residents. It is urgently necessary to establish relevant regulations and implement emission reduction technologies to reduce NO2 emissions from wall-mounted gas stoves.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Letter
Environmental Sciences
Hans Peter H. Arp, Raoul Wolf, Sarah E. Hale, Sivani Baskaran, Juliane Gluege, Martin Scheringer, Xenia Trier, Ian T. Cousins, Harrie Timmer, Roberta Hofman-Caris, Anna Lennquist, Andre D. Bannink, Gerard J. Stroomberg, Rosa M. A. Sjerps, Rosa Montes, Rosario Rodil, Jose Benito Quintana, Daniel Zahn, Herve Gallard, Tobias Mohr, Ivo Schliebner, Michael Neumann
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Philomina Onyedikachi Peter, Binessi Edouard Ifon, Francois Nkinahamira, Kayode Hassan Lasisi, Jiangwei Li, Anyi Hu, Chang-Ping Yu
Summary: This study investigates the relationship between dissolved organic matter (DOM) and Rare Earth Elements (REEs) in sediments from Yundang Lagoon, China. The results show four distinct fluorescent components, with protein-like substances being the most prevalent. Additionally, the total fluorescence intensity and LREE concentrations exhibit a synchronized increase from Outer to Inner to Songbai Lake core sediments. The findings demonstrate a strong correlation between DOM content and pollution levels.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Surya Gupta, Pasquale Borrelli, Panos Panagos, Christine Alewell
Summary: The objective of this study is to incorporate soil hydraulic properties into the erodibility factor (K) of USLE-type models. By modifying and improving the existing equations for soil texture and permeability, the study successfully included information on saturated hydraulic conductivity (Ksat) into the calculation of K factor. Using the Random Forest machine learning algorithm, two independent K factor maps with different spatial resolutions were generated. The results show that the decrease in K factor values has a positive impact on the modeling of soil erosion rates.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Jesmin Akter, Wendy J. M. Smith, Yawen Liu, Ilho Kim, Stuart L. Simpson, Phong Thai, Asja Korajkic, Warish Ahmed
Summary: The choice of workflow in wastewater surveillance has a significant impact on SARS-CoV-2 concentrations, while having minimal effects on HF183 and no effect on HAdV 40/41 concentrations. Certain components in the workflow can be interchangeable, but factors such as buffer type, chloroform, and homogenization speed can affect the recovery of viruses and bacteria.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Yu Luo, Xueting Yang, Diwei Wang, Hongmei Xu, Hongai Zhang, Shasha Huang, Qiyuan Wang, Ningning Zhang, Junji Cao, Zhenxing Shen
Summary: Atmospheric PM2.5, which can generate reactive oxygen species (ROS), is associated with cardiorespiratory morbidity and mortality. The study found that both the mass concentration of PM2.5 and the DTT activity were higher during the heating season than during the nonheating season. Combustion sources were the primary contributors to DTT activity during the heating season, while secondary formation dominated during the nonheating season. The study also revealed that biomass burning had the highest inherent oxidation potential among all sources investigated.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Erin L. Murphy, Leah R. Gerber, Chelsea M. Rochman, Beth Polidoro
Summary: Plastic pollution has devastating consequences for marine organisms. This study uses a trait-based framework to develop a vulnerability index for marine mammals, seabirds, and sea turtles in Hawai'i. The index ranks 63 study species based on their vulnerability to macroplastic pollution, providing valuable information for species monitoring and management priorities.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Kenji Maurice, Amelia Bourceret, Sami Youssef, Stephane Boivin, Liam Laurent-Webb, Coraline Damasio, Hassan Boukcim, Marc-Andre Selosse, Marc Ducousso
Summary: Growing pressure from climate change and agricultural land use is destabilizing soil microbial community interactions. Little is known about microbial community resistance and adaptation to disturbances, hindering our understanding of recovery latency and implications for ecosystem functioning. This study found that anthropic disturbance and natural disturbance have different effects on the topology and stability of soil microbial networks.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Yunhao Li, Yali Feng, Haoran Li, Yisong Yao, Chenglong Xu, Jinrong Ju, Ruiyu Ma, Haoyu Wang, Shiwei Jiang
Summary: Deep-sea mining poses a serious threat to marine ecosystems and human health by disturbing sediment and transmitting metal ions through the food chain. This study developed a new regenerative adsorption material, OMN@SA, which effectively removes metal ions. The adsorption mechanism and performance of the material for metal ion fixation were investigated.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Antonio Medici, Margherita Lavorgna, Marina Isidori, Chiara Russo, Elena Orlo, Giovanni Luongo, Giovanni Di Fabio, Armando Zarrelli
Summary: Valsartan, a widely used antihypertensive drug, has been detected in high concentrations in surface waters due to its unchanged excretion and incomplete degradation in wastewater treatment plants. This study investigated the degradation of valsartan and identified 14 degradation byproducts. The acute and chronic toxicity of these byproducts were evaluated in key organisms in the freshwater trophic chain.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Jiang Lin, Lianbao Chi, Qing Yuan, Busu Li, Mingbao Feng
Summary: This study investigated the photodegradation behavior and product formation of two representative pharmaceuticals in simulated estuary water. The study found that the formed transformation products of these pharmaceuticals have potential toxicity on marine organisms, including oxidative stress and damage to cellular components.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Hua Fang, Dongdong Jiang, Ye He, Siyi Wu, Yuehong Li, Ziqi Zhang, Haoting Chen, Zixin Zheng, Yan Sun, Wenxiang Wang
Summary: This study revealed that exposure to lower levels of air pollutants led to decreased pregnancy rates, with PM10, NO2, SO2, and CO emerging as the four most prominent pollutants. Individuals aged 35 and above exhibited heightened susceptibility to pollutants.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Ali Shaan Manzoor Ghumman, Rashid Shamsuddin, Amin Abbasi, Mohaira Ahmad, Yoshiaki Yoshida, Abdul Sami, Hamad Almohamadi
Summary: In this study, inverse vulcanized polysulfides (IVP) were synthesized by reacting molten sulfur with 4-vinyl benzyl chloride, and then functionalized using N-methyl D-glucamine (NMDG). The functionalized IVP showed a high mercury adsorption capacity and a machine learning model was developed to predict the amount of mercury removed. Furthermore, the functionalized IVP can be regenerated and reused, providing a sustainable and cost-effective adsorbent.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Rita Bonfiglio, Renata Sisto, Stefano Casciardi, Valeria Palumbo, Maria Paola Scioli, Erica Giacobbi, Francesca Servadei, Gerry Melino, Alessandro Mauriello, Manuel Scimeca
Summary: This study investigated the presence of aluminum in human colon cancer samples and its potential association with biological processes involved in cancer progression. Aluminum was found in tumor areas of 24% of patients and was associated with epithelial to mesenchymal transition (EMT) and cell death. Additional analyses revealed higher tumor mutational burden and mutations in genes related to EMT and apoptosis in aluminum-positive colon cancers. Understanding the molecular mechanisms of aluminum toxicity may improve strategies for the management of colon cancer patients.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)