Review
Biochemistry & Molecular Biology
Marcelle Mehu, Chandrakala Aluganti Narasimhulu, Dinender K. Singla
Summary: Atherosclerosis is a chronic disease characterized by damage to the intima, inflammatory cell recruitment, and lipid accumulation followed by calcification and plaque rupture. Inflammation is believed to play a crucial role in the development and progression of the disease. This paper discusses the various types of inflammatory cells involved in atherosclerosis and their significance in the disease's development and progression. Understanding the role of these cells at different stages of the disease provides valuable insights for targeted therapy.
Article
Public, Environmental & Occupational Health
Sudha Ramachandra Rao, Grace A. Chitra, G. Elavarasu, P. Kamaraj, Kanagasabai Kaliaperumal, Prabhdeep Kaur
Summary: This study found a high prevalence of biomass fuel and mosquito coil use in rural areas of India, and it was associated with poor respiratory health. Therefore, community education and the promotion of cleaner fuels and alternative mosquito control methods are important for reducing indoor air pollution and improving respiratory health.
JOURNAL OF PUBLIC HEALTH
(2022)
Article
Immunology
Hoa Le Mai, Nicolas Degauque, Marine Lorent, Marie Rimbert, Karine Renaudin, Richard Danger, Clarisse Kerleau, Gaelle Tilly, Anais Vivet, Sabine Le Bot, Florent Delbos, Alexandre Walencik, Magali Giral, Sophie Brouard
Summary: This study found that kidney allograft rejection is associated with an imbalance between immune cells with effector/memory functions and those with regulatory properties, manifested as a decrease in the percentage of circulating B cells and an increase in the ratio of CD28-CD8+ T cells to Tregs.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
In-Hong Kang, Uday K. Baliga, Shilpak Chatterjee, Paramita Chakraborty, Seungho Choi, Nathan Buchweitz, Hong Li, Yongren Wu, Hai Yao, Shikhar Mehrotra, Meenal Mehrotra
Summary: Recent studies have shown that T lymphocytes and regulatory T cells regulate the functions of osteoclasts and osteoblasts, restoring Treg numbers can reduce the inflammatory environment and enhance bone remodeling in OI.
Article
Immunology
Lindsey E. Padgett, Paola M. Marcovecchio, Claire E. Olingy, Daniel J. Araujo, Kathleen Steel, Huy Q. Dinh, Ahmad Alimadadi, Yanfang Peipei Zhu, Melissa A. Meyer, William B. Kiosses, Graham D. Thomas, Catherine C. Hedrick
Summary: CD16(+) nonclassical monocytes play a crucial role in anti-cancer immunity by modulating CD8(+) T cell activation. In E2-deficient mice lacking nonclassical monocytes, there is a decrease in the frequency of CD8(+) effector memory and effector T cells in the lungs and lung-draining lymph nodes during early metastatic seeding. This is associated with a depletion of nonclassical monocytes and reduced CCL21 expression in endothelial cells.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Astrid Fabri, Khalil Kandara, Remy Coudereau, Morgane Gossez, Paul Abraham, Celine Monard, Martin Cour, Thomas Rimmele, Laurent Argaud, Guillaume Monneret, Fabienne Venet
Summary: The study analyzed the impact of IL-10 production in septic patients' whole blood, revealing monocytes and CD4+ T cells as the main IL-10 producers associated with global immunosuppression in septic shock. Further research is needed to determine the pathophysiological mechanisms leading to increased IL-10 production in monocytes and CD4+ T cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Katherine Kelda Gomes de Castro, Pedro Henrique Lopes da Silva, Luciana Nahar dos Santos, Julia Monteiro Pereira Leal, Mylena Masseno de Pinho Pereira, Iris Maria Peixoto Alvim, Danuza Esquenazi
Summary: The study found that Treg cells decrease during leprosy reactional episodes, indicating an enhanced immune response. Changes in cytokine profile were also observed during reactional episodes.
FRONTIERS IN MEDICINE
(2022)
Article
Multidisciplinary Sciences
Zohreh Amoozgar, Jonas Kloepper, Jun Ren, Rong En Tay, Samuel W. Kazer, Evgeny Kiner, Shanmugarajan Krishnan, Jessica M. Posada, Mitrajit Ghosh, Emilie Mamessier, Christina Wong, Gino B. Ferraro, Ana Batista, Nancy Wang, Mark Badeaux, Sylvie Roberge, Lei Xu, Peigen Huang, Alex K. Shalek, Dai Fukumura, Hye-Jung Kim, Rakesh K. Jain
Summary: In this study, researchers found that treatment with an agonistic anti-GITR antibody converts tumor infiltrating regulatory T cells to effector cells, overcoming resistance to PD1 blockade in preclinical models of GBM.
NATURE COMMUNICATIONS
(2021)
Article
Cardiac & Cardiovascular Systems
Guoshuai Feng, Geetika Bajpai, Pan Ma, Andrew Koenig, Andrea Bredemeyer, Inessa Lokshina, Lulu Lai, Irmgard Foerster, Florian Leuschner, Daniel Kreisel, Kory J. Lavine
Summary: This study identified CCL17 as a proinflammatory mediator in CCR2(+) macrophages and dendritic cells, and suggested that inhibiting CCL17 could promote Treg recruitment and suppress myocardial inflammation.
Article
Immunology
Andreja Natasa Kopitar, Jernej Repas, Larisa Janzic, Masa Bizjak, Tina Tajnsek Vesel, Nina Emersic, Mojca Zajc Avramovic, Alojz Ihan, Tadej Avcin, Mojca Pavlin
Summary: Although children seem to be less susceptible to COVID-19, some of them develop a rare but serious hyperinflammatory condition called multisystem inflammatory syndrome in children (MIS-C). The status of convalescent patients in the months after acute MIS-C is still unclear, especially the question of persistence of changes in specific subpopulations of immune cells.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Jessica G. Lee, Kathleen E. Jaeger, Yoichi Seki, Yi Wei Lim, Christina Cunha, Aleksandra Vuchkovska, Alexander J. Nelson, Anya Nikolai, Dan Kim, Michael Nishimura, Katherine L. Knight, Paula White, Makio Iwashima
Summary: The study reveals that a subset of CD14(+) monocytes can generate regulatory Foxp3(+) T-bet(+) T cells from umbilical cord blood, which suppress T-cell proliferation and ameliorate graft-versus-host disease. Additionally, adult peripheral blood monocytes are capable of inducing Foxp3(+) T cells, but their induction is inhibited by lymphoid cells from adult peripheral blood in neonates. This suggests a novel immunoregulatory role of monocytes in generating regulatory T cells with implications for both neonates and adults.
Review
Biochemistry & Molecular Biology
Michel Y. Braun
Summary: T cells, particularly T lymphocytes of the immune system, exhibit characteristics of proliferation and mobility in tissues and organs, requiring metabolic plasticity to fulfill their immune function. This review focuses on the various mechanisms that allow T cells to adapt their metabolism to different real-life circumstances, such as exiting quiescence, differentiating into effector cells, and participating in immune memory formation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Gara Arteaga-Henriquez, Jorge Lugo-Marin, Laura Gisbert, Imanol Setien-Ramos, Monica Martinez-Gallo, Ricardo Pujol-Borrell, Josep Antoni Ramos-Quiroga
Summary: Individuals with Autism spectrum disorder (ASD) exhibit differences in immune cell levels and inflammation markers compared to typically developing (TD) controls.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Geriatrics & Gerontology
Raffaello Pellegrino, Roberto Paganelli, Angelo Di Iorio, Stefania Bandinelli, Antimo Moretti, Giovanni Iolascon, Eleonora Sparvieri, Domiziano Tarantino, Toshiko Tanaka, Luigi Ferrucci
Summary: Aging is characterized by chronic low-level inflammation and is associated with geriatric syndromes such as sarcopenia and frailty. Leukocyte-derived ratios, specifically neutrophil-to-lymphocyte ratio (NL-ratio) and monocyte-to-lymphocyte ratio (ML-ratio), may be implicated in age-related mechanisms that affect body composition and muscle strength. Further studies are needed to determine their usefulness for early detection of sarcopenia, myosteatosis, and frailty in older adults.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Development Studies
YuJung Julia Lee, Zakir Husain, Mousumi Dutta
Summary: Reliance on biomass fuel is still high in many developing countries, such as India. Shifting to clean fuel has recognized benefits for women, including time-saving, improved health, and a better environment. However, the additional benefits of empowerment for women from this shift remain understudied.
SUSTAINABLE DEVELOPMENT
(2023)
Article
Environmental Sciences
Christopher O. Olopade, Elizabeth Frank, Emily Bartlett, Donee Alexander, Anindita Dutta, Tope Ibigbami, Damilola Adu, John Olamijulo, Ganiyu Arinola, Theodore Karrison, Oladosu Ojengbede
ENVIRONMENT INTERNATIONAL
(2017)
Article
Environmental Sciences
Anindita Dutta, Katherine Brito, Galina Khramstova, Ariel Mueller, Sireesha Chinthala, Donee Alexander, Damilola Adu, Tope Ibigbami, John Olamijulo, Abayomi Odetunde, Kehinde Adigun, Liese Pruitt, Olufunmilayo Olopade, Oladosu Ojengbede, Sarosh Rana, Christopher O. Olopade
SCIENCE OF THE TOTAL ENVIRONMENT
(2017)
Article
Environmental Sciences
Donee A. Alexander, Amanda Northcross, Theodore Karrison, Oludare Morhasson-Bello, Nathaniel Wilson, Omolola M. Atalabi, Anindita Dutta, Damilola Adu, Tope Ibigbami, John Olamijulo, Dayo Adepoju, Oladosu Ojengbede, Christopher O. Olopade
ENVIRONMENT INTERNATIONAL
(2018)
Article
Environmental Sciences
Anindita Dutta, Galina Khramtsova, Katherine Brito, Donee Alexander, Ariel Mueller, Sireesha Chinthala, Damilola Adu, Tope Ibigbami, John Olamijulo, Abayomi Odetunde, Kehinde Adigun, Liese Pruitt, Ian Hurley, Olufunmilayo Olopade, Oladosu Ojengbede, Sarosh Rana, Christopher O. Olopade
SCIENCE OF THE TOTAL ENVIRONMENT
(2018)
Article
Green & Sustainable Science & Technology
Alicia Ozier, Dana Charron, Sarah Chung, Vivek Sarma, Anindita Dutta, Kirstie Jagoe, Joe Obueh, Harry Stokes, Chidochashe L. Munangagwa, Michael Johnson, Christopher O. Olopade
ENERGY FOR SUSTAINABLE DEVELOPMENT
(2018)
Article
Environmental Sciences
Tianjia Guan, Maosheng Yao, Junxia Wang, Yanhua Fang, Songhe Hu, Yan Wang, Anindita Dutta, Junnan Yang, Yusheng Wu, Min Hu, Tong Zhu
ATMOSPHERIC ENVIRONMENT
(2014)
Article
Environmental Sciences
Bidisha Mukherjee, Anindita Dutta, Saswati Chowdhury, Sanghita Roychoudhury, Manas Ranjan Ray
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2014)
Article
Environmental Sciences
Ganiyu Olatunbosun Arinola, Anindita Dutta, Oluwafemi Oluwole, Christopher O. Olopade
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2018)
Article
Environmental Sciences
Anindita Dutta, Mariam Alaka, Tope Ibigbami, Dayo Adepojuc, Samuel Adekunle, John Olamijulo, Babatunde Adedokun, Oluwafunmilade Deji-Abiodun, Ryan Chartier, Oladosu Ojengbede, Christopher O. Olopade
Summary: The study found that increased postnatal HAP exposure may result in poorer lung function in children. However, there were no significant associations between prenatal or postnatal PM2.5 exposure levels and other oscillometry parameters, indicating a specific relationship between postnatal HAP exposure and children's lung function.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Environmental Sciences
Anindita Dutta, Donee Alexander, Theodore Karrison, Oludare Morhasson-Bello, Nathaniel Wilson, Omolola Mojisola Atalabi, Damilola Adu, Tope Ibigbami, Samuel Adekunle, Dayo Adepoju, John Olamijulo, Omolola Akinwunmi, Oluniyi S. Afolabi, Oluwafunmilade Deji-Abiodun, Babatunde Adedokun, Briseis Aschebrook-Kilfoy, Oladosu Ojengbede, Christopher O. Olopade
Summary: This study investigated the effects of a cookstove intervention on fetal biometric parameters and intrauterine growth restriction in pregnant Nigerian women exposed to household air pollution. The results showed no significant differences in fetal growth trajectories between the intervention and control groups. Larger studies in a setting of low ambient air pollution are needed to further explore the impact of transitioning to cleaner fuels on intrauterine growth.
ENVIRONMENTAL HEALTH
(2021)
Article
Multidisciplinary Sciences
Oluwafunmilade Deji-Abiodun, Babatunde Adedokun, Donee Alexander, Anindita Dutta, Tope Ibigbami, John Olamijulo, Dayo Adepoju, Samuel Adekunle, Oladosu Ojengbede, Christopher O. Olopade
Summary: This study investigated the impact of maternal psychological distress on fetal biometric parameters in pregnant Nigerian women exposed to household air pollution. The results showed that psychological distress negatively affected fetal biometric parameters, and women using ethanol stoves had lower psychological distress compared to those using kerosene/firewood. These findings emphasize the importance of implementing measures to alleviate maternal distress and reduce exposure to household air pollution during pregnancy from a public health perspective.
Article
Public, Environmental & Occupational Health
Robin C. Puett, Lesliam Quiros-Alcala, Jessica A. Montresor-Lopez, Nedelina Tchangalova, Anindita Dutta, Devon Payne-Sturges, Jeff D. Yanosky
CURRENT EPIDEMIOLOGY REPORTS
(2019)
Article
Critical Care Medicine
Donee Alexander, Amanda Northcross, Nathaniel Wilson, Anindita Dutta, Rishi Pandya, Tope Ibigbami, Damilola Adu, John Olamijulo, Oludare Morhason-Bello, Theodore Karrison, Oladosu Ojengbede, Christopher O. Olopade
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2017)
Meeting Abstract
Critical Care Medicine
A. Dutta, G. Khramstova, K. Brito, S. Chinthala, S. Rana, C. O. Olopade
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2017)
Meeting Abstract
Critical Care Medicine
A. Dutta, K. Brito, G. Khramstova, S. Chinthala, S. Rana, C. O. Olopade
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2017)
Article
Environmental Sciences
Toshimi Nakajima, Mao Kuragano, Makoto Yamada, Ryo Sugimoto
Summary: This study compared the contribution of submarine groundwater discharge (SGD) to river nutrient budgets at nearshore and embayment scales, and found that SGD-derived nutrients become more important at larger spatial scales.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Fan Liu, Lei Zhang, Chongyang Zhang, Ziguang Chen, Jingguang Li
Summary: NO2 emissions from wall-mounted gas stoves used for household heating have become a significant source of indoor pollution in Chinese urban areas. The high indoor concentration of NO2 poses potential health risks to residents. It is urgently necessary to establish relevant regulations and implement emission reduction technologies to reduce NO2 emissions from wall-mounted gas stoves.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Letter
Environmental Sciences
Hans Peter H. Arp, Raoul Wolf, Sarah E. Hale, Sivani Baskaran, Juliane Gluege, Martin Scheringer, Xenia Trier, Ian T. Cousins, Harrie Timmer, Roberta Hofman-Caris, Anna Lennquist, Andre D. Bannink, Gerard J. Stroomberg, Rosa M. A. Sjerps, Rosa Montes, Rosario Rodil, Jose Benito Quintana, Daniel Zahn, Herve Gallard, Tobias Mohr, Ivo Schliebner, Michael Neumann
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Philomina Onyedikachi Peter, Binessi Edouard Ifon, Francois Nkinahamira, Kayode Hassan Lasisi, Jiangwei Li, Anyi Hu, Chang-Ping Yu
Summary: This study investigates the relationship between dissolved organic matter (DOM) and Rare Earth Elements (REEs) in sediments from Yundang Lagoon, China. The results show four distinct fluorescent components, with protein-like substances being the most prevalent. Additionally, the total fluorescence intensity and LREE concentrations exhibit a synchronized increase from Outer to Inner to Songbai Lake core sediments. The findings demonstrate a strong correlation between DOM content and pollution levels.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Surya Gupta, Pasquale Borrelli, Panos Panagos, Christine Alewell
Summary: The objective of this study is to incorporate soil hydraulic properties into the erodibility factor (K) of USLE-type models. By modifying and improving the existing equations for soil texture and permeability, the study successfully included information on saturated hydraulic conductivity (Ksat) into the calculation of K factor. Using the Random Forest machine learning algorithm, two independent K factor maps with different spatial resolutions were generated. The results show that the decrease in K factor values has a positive impact on the modeling of soil erosion rates.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Jesmin Akter, Wendy J. M. Smith, Yawen Liu, Ilho Kim, Stuart L. Simpson, Phong Thai, Asja Korajkic, Warish Ahmed
Summary: The choice of workflow in wastewater surveillance has a significant impact on SARS-CoV-2 concentrations, while having minimal effects on HF183 and no effect on HAdV 40/41 concentrations. Certain components in the workflow can be interchangeable, but factors such as buffer type, chloroform, and homogenization speed can affect the recovery of viruses and bacteria.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Yu Luo, Xueting Yang, Diwei Wang, Hongmei Xu, Hongai Zhang, Shasha Huang, Qiyuan Wang, Ningning Zhang, Junji Cao, Zhenxing Shen
Summary: Atmospheric PM2.5, which can generate reactive oxygen species (ROS), is associated with cardiorespiratory morbidity and mortality. The study found that both the mass concentration of PM2.5 and the DTT activity were higher during the heating season than during the nonheating season. Combustion sources were the primary contributors to DTT activity during the heating season, while secondary formation dominated during the nonheating season. The study also revealed that biomass burning had the highest inherent oxidation potential among all sources investigated.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Erin L. Murphy, Leah R. Gerber, Chelsea M. Rochman, Beth Polidoro
Summary: Plastic pollution has devastating consequences for marine organisms. This study uses a trait-based framework to develop a vulnerability index for marine mammals, seabirds, and sea turtles in Hawai'i. The index ranks 63 study species based on their vulnerability to macroplastic pollution, providing valuable information for species monitoring and management priorities.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Kenji Maurice, Amelia Bourceret, Sami Youssef, Stephane Boivin, Liam Laurent-Webb, Coraline Damasio, Hassan Boukcim, Marc-Andre Selosse, Marc Ducousso
Summary: Growing pressure from climate change and agricultural land use is destabilizing soil microbial community interactions. Little is known about microbial community resistance and adaptation to disturbances, hindering our understanding of recovery latency and implications for ecosystem functioning. This study found that anthropic disturbance and natural disturbance have different effects on the topology and stability of soil microbial networks.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Yunhao Li, Yali Feng, Haoran Li, Yisong Yao, Chenglong Xu, Jinrong Ju, Ruiyu Ma, Haoyu Wang, Shiwei Jiang
Summary: Deep-sea mining poses a serious threat to marine ecosystems and human health by disturbing sediment and transmitting metal ions through the food chain. This study developed a new regenerative adsorption material, OMN@SA, which effectively removes metal ions. The adsorption mechanism and performance of the material for metal ion fixation were investigated.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Antonio Medici, Margherita Lavorgna, Marina Isidori, Chiara Russo, Elena Orlo, Giovanni Luongo, Giovanni Di Fabio, Armando Zarrelli
Summary: Valsartan, a widely used antihypertensive drug, has been detected in high concentrations in surface waters due to its unchanged excretion and incomplete degradation in wastewater treatment plants. This study investigated the degradation of valsartan and identified 14 degradation byproducts. The acute and chronic toxicity of these byproducts were evaluated in key organisms in the freshwater trophic chain.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Jiang Lin, Lianbao Chi, Qing Yuan, Busu Li, Mingbao Feng
Summary: This study investigated the photodegradation behavior and product formation of two representative pharmaceuticals in simulated estuary water. The study found that the formed transformation products of these pharmaceuticals have potential toxicity on marine organisms, including oxidative stress and damage to cellular components.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Hua Fang, Dongdong Jiang, Ye He, Siyi Wu, Yuehong Li, Ziqi Zhang, Haoting Chen, Zixin Zheng, Yan Sun, Wenxiang Wang
Summary: This study revealed that exposure to lower levels of air pollutants led to decreased pregnancy rates, with PM10, NO2, SO2, and CO emerging as the four most prominent pollutants. Individuals aged 35 and above exhibited heightened susceptibility to pollutants.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Ali Shaan Manzoor Ghumman, Rashid Shamsuddin, Amin Abbasi, Mohaira Ahmad, Yoshiaki Yoshida, Abdul Sami, Hamad Almohamadi
Summary: In this study, inverse vulcanized polysulfides (IVP) were synthesized by reacting molten sulfur with 4-vinyl benzyl chloride, and then functionalized using N-methyl D-glucamine (NMDG). The functionalized IVP showed a high mercury adsorption capacity and a machine learning model was developed to predict the amount of mercury removed. Furthermore, the functionalized IVP can be regenerated and reused, providing a sustainable and cost-effective adsorbent.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Rita Bonfiglio, Renata Sisto, Stefano Casciardi, Valeria Palumbo, Maria Paola Scioli, Erica Giacobbi, Francesca Servadei, Gerry Melino, Alessandro Mauriello, Manuel Scimeca
Summary: This study investigated the presence of aluminum in human colon cancer samples and its potential association with biological processes involved in cancer progression. Aluminum was found in tumor areas of 24% of patients and was associated with epithelial to mesenchymal transition (EMT) and cell death. Additional analyses revealed higher tumor mutational burden and mutations in genes related to EMT and apoptosis in aluminum-positive colon cancers. Understanding the molecular mechanisms of aluminum toxicity may improve strategies for the management of colon cancer patients.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
