期刊
SCIENCE OF THE TOTAL ENVIRONMENT
卷 414, 期 -, 页码 98-102出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.scitotenv.2011.11.001
关键词
Air pollution; Placenta/birth weight ratio; Geographic Information System; Placenta; Reproductive health; Pregnancy
资金
- ESRI Japan Corp.
- Grants-in-Aid for Scientific Research [23790663] Funding Source: KAKEN
Exposure to air pollution has been demonstrated to increase the risk of preterm birth and low birth weight. We examined whether proximity to major roads (as a marker of exposure to air pollution) is associated with increased placenta/birth weight ratio (as a biomarker of the placental transport function). Data on parental characteristics and birth outcomes were extracted from the database maintained by a major hospital in Shizuoka Prefecture, Japan. We restricted the analysis to mothers who delivered liveborn single births from 1997 to 2008 (n = 14,189). Using geocoded residential information, each birth was classified according to proximity to major roads. We examined the association between proximity to major roads and the placenta/birth weight ratio, using multiple linear regression. Proximity to major roads was associated with higher placenta/birth weight ratio. After adjusting for potential confounders, living within 200 m of a major road increased the ratio by 0.48% (95% CI = 0.15 to 0,80). In addition, proximity to major roads was associated with lower placenta weight and birth weight. These observed associations were stronger among participants living closer to major roads. Exposure to traffic-related air pollution is associated with higher placenta/birth weight ratio. Impaired placental oxygen and nutrient transport function might be a mechanism for explaining the observed association between air pollution and low birth weight as well as preterm birth. (C) 2011 Elsevier B.V. All rights reserved.
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