期刊
SCIENCE OF THE TOTAL ENVIRONMENT
卷 425, 期 -, 页码 214-222出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.scitotenv.2012.03.022
关键词
Deciduous teeth; Dentine; Lead; Exposure history; Laser ablation ICP-MS; Dental histology
资金
- Department of Medical Services, Ministry of Public Health, Thai Government
- School of Dental Sciences
- Institute of Health and Society
Data are presented to demonstrate that the circumpulpal dentine of deciduous teeth can be used to reconstruct a detailed record of childhood exposure to lead. By combining high spatial resolution laser ablation ICP-MS with dental histology, information was acquired on the concentration of lead in dentine from in utero to several years after birth, using a true time template of dentine growth. Time corrected lead analyses for pairs of deciduous molars confirmed that between-tooth variation for the same child was negligible and that meaningful exposure histories can be obtained from a single, multi-point ablation transect on longitudinal sections of individual teeth. For a laser beam of 100 mu m diameter, the lead signal for each ablation point represented a time span of 42 days. Simultaneous analyses for Sr, Zn and Mg suggest that the incorporation of Pb into dentine (carbonated apatite) is most likely controlled by nanocrystal growth mechanisms. The study also highlights the importance of discriminating between primary and secondary dentine and the dangers of translating lead analyses into blood lead estimates without determining the age or duration of dentine sampled. Further work is in progress to validate deciduous teeth as blood lead biomarkers. (C) 2012 Elsevier B.V. All rights reserved.
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