Article
Agriculture, Dairy & Animal Science
Annemiek Maaskant, Isabel Janssen, Inge M. Wouters, Frank J. C. M. Eerdenburg, Edmond J. Remarque, Jan A. M. Langermans, Jaco Bakker
Summary: Indoor air quality is important for the health and wellbeing of animals. A study on group-housed macaques at a research center in the Netherlands evaluated the indoor air quality and found that the concentrations of inhalable dust and endotoxins did not exceed recommended limits. However, caretakers were exposed to higher levels than the animals and steps should be taken to reduce their exposure.
Article
Construction & Building Technology
Samuel J. Cochran, Luis Acosta, Adnan Divjan, Angela R. Lemons, Andrew G. Rundle, Rachel L. Miller, Edward Sobek, Brett J. Green, Matthew S. Perzanowski, Karen C. Dannemiller
Summary: There is significant seasonal variation in total fungal concentration and concentration of select allergenic species. Indoor relative humidity and temperature may underlie these associations.
BUILDING AND ENVIRONMENT
(2022)
Article
Construction & Building Technology
Liu Sun, J. David Miller, Keith Van Ryswyk, Amanda J. Wheeler, Marie-Eve Heroux, Mark S. Goldberg, Gary Mallach
Summary: The study found that household characteristics such as the presence of carpeting, low floor cleaning frequency, older home age, high indoor relative humidity, and pets are positively associated with the presence of indoor biocontaminants. On the other hand, high floor cleaning frequency and use of dehumidifiers are negatively associated with the presence of indoor biocontaminants. In addition, mold odor is positively associated with older home age, past water damage, and visible mold growth.
Article
Environmental Sciences
Lihui Huang, Yaqi Qiao, Shunxi Deng, Xiaoke Wang, Weiping Zhao, Yang Yue
Summary: Exposure to phthalates in dust samples collected from residences in Beijing showed concentrations significantly influenced by season and residence time. Phthalates were highest in dust on plastic surfaces, with polar organic components potentially playing a key role in their fate and transport. Additionally, factors like air humidity, indoor PM2.5 concentrations, and household lifestyle also impacted the levels of phthalates in dust.
Article
Construction & Building Technology
Jianping Cao, Yuqing Zhu, Xinyi Huang, Li Zhang, Xuanhao Wang, Chuang Geng, Haibao Huang
Summary: House dust serves as an important medium for the transfer and storage of semi-volatile organic compounds (SVOCs) in indoor environments. The dust loading, or weight of dust per surface area, has been identified as a key factor influencing the transport of SVOCs into dust. This study proposes a mass transfer model that differentiates between SVOC diffusion distances in monolayer and multilayer dusts, providing a comprehensive understanding of dust loading effects. The model shows good agreement with measurements and allows for the determination of characteristic parameters of SVOCs in house dust. This study enhances our understanding of SVOC transport into house dust and enables accurate exposure assessment of indoor SVOCs.
BUILDING AND ENVIRONMENT
(2023)
Article
Environmental Sciences
Pauline Loison, Xavier Simon, Philippe Duquenne
Summary: This article provides an expert opinion on the influence of the filter used for the measurement of airborne endotoxins. It reveals the lack of sufficient data and the need for further experimental studies to determine the appropriate filter type for endotoxin measurements.
WATER AIR AND SOIL POLLUTION
(2023)
Article
Biochemistry & Molecular Biology
Jiraphorn Issara-Amphorn, Cong Phi Dang, Wilasinee Saisorn, Kavee Limbutara, Asada Leelahavanichkul
Summary: The presence of Candida in BiN mice accelerated the gut translocation of β-glucan, leading to enhanced cell energy status and pro-inflammatory macrophage responses. This research suggests a potential role of gut fungi and β-glucan in exacerbating systemic inflammation in acute uremia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Helle Vibeke Andersen, Marie Frederiksen
Summary: The study investigated human exposure pathways to PCB in a high-rise estate in Denmark by conducting an experiment on the sorption of PCB from air to settled house dust. Different origin house dust samples were exposed to elevated air concentrations of PCB in a vacant apartment, and most samples reached equilibrium for PCB congeners after 40 days. The measured partition coefficients were in agreement with literature values, and comparisons with predicted estimates showed good correlation with some overestimation. Additionally, dust-air ratios from field investigations confirmed the results from the exposure experiment, indicating near steady state conditions for PCB congeners in the dust.
Article
Medicine, General & Internal
Silvia Corcione, Luisa Chasseur, Tommaso Lupia, Nour Shbaklo, Silvia Scabini, Claudia Filippini, Simone Mornese Pinna, Stefania Morra di Celle, Rossana Cavallo, Francesco Giuseppe De Rosa
Summary: This study aimed to evaluate the performance and accuracy of (1,3)-beta-D-glucan (BDG) at different cut-offs in diagnosing candidemia in internal medicine patients. The results showed that a cut-off value of 150 pg/mL for BDG maintained the best balance between sensitivity, specificity, and negative predictive value, strengthening the association between BDG and the development of candidemia. Analyzing BDG > 150 pg/mL along with Candida score > 2 and Charlson score > 4 further increased the strength of association between BDG, clinical scores, and the development of candidemia. The overall clinical evaluation considering BDG values > 150 pg/mL, Candida score > 2, and Charlson score > 4 seemed to predict the need for empiric antifungal treatment more accurately.
Article
Environmental Sciences
Sivakumar Subpiramaniyam, Gowri Manogari Boovaragamoorthy, Thamaraiselvi Kaliannan, Kadirvelu Krishna, Sung-Chul Hong, Pyong-In Yi, Seong-Ho Jang, Jeong-Min Suh
Summary: The study revealed significant differences in the concentration of elements in foliar dust and tamarind leaves between urban, suburban, and rural areas, possibly influenced by local construction activities and heavy transportation. Comprehensive studies are needed to confirm these findings.
Article
Environmental Sciences
Jenny Lexen, Maria Bernander, Ian Cotgreave, Patrik L. Andersson
Summary: Studies have shown that human exposure to SVOCs in car cabins is influenced by both air and dust concentrations. It is suggested to broaden the scope of research to include all relevant exposure routes for a more comprehensive assessment of human exposure.
ENVIRONMENT INTERNATIONAL
(2021)
Review
Construction & Building Technology
James D. Johnston, Ashlin E. Cowger, K. Scott Weber
Summary: Evaporative cooling is an energy-efficient form of air conditioning that can provide a comfortable indoor environment in dry climates. However, studies have shown that it may have negative impacts on human health, such as bringing outdoor air pollutants indoors or increasing indoor bioaerosol levels. Additionally, evaporative coolers may create a beneficial microbial environment that offers immunological protection against allergies and asthma in early life.
Article
Chemistry, Multidisciplinary
Pengfei Zuo, Feng Gong, Yixia Yang, Xinghu Ji, Zhike He
Summary: A specific and sensitive method combining aptamer recognition and tyramide signal amplification technology was proposed for in situ fluorescence imaging of fungi. The method allows rapid observation of fungi and provides morphology and diagnostic information, making it a promising detection tool.
CHINESE CHEMICAL LETTERS
(2023)
Article
Biotechnology & Applied Microbiology
Eva Lena F. Estensmo, Synnove Smebye Botnen, Sundy Maurice, Pedro M. Martin-Sanchez, Luis Morgado, Ingeborg Bjorvand Engh, Klaus Hoiland, Inger Skrede, Havard Kauserud
Summary: The study analyzed the indoor mycobiomes of 125 daycare centers in Norway, revealing that indoor fungal composition is influenced by various factors including indoor and outdoor conditions, geographic location, and building features. Yeasts and molds were found to dominate the indoor mycobiomes, indicating a potential impact on children's health and emphasizing the importance of further research in this area.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2022)
Article
Environmental Sciences
Reiji Kojima, Ryoji Shinohara, Megumi Kushima, Sayaka Horiuchi, Sanae Otawa, Kunio Miyake, Hiroshi Yokomichi, Yuka Akiyama, Tadao Ooka, Zentaro Yamagata
Summary: The association between endotoxin and allergic rhinitis is inconclusive. This study found that in a non-farming setting, both endotoxin and house dust mite allergens in dust were associated with an increased risk of house dust mite sensitization, but not with allergic rhinitis.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Construction & Building Technology
Christine Niemeier-Walsh, Patrick H. Ryan, Jarek Meller, Nicholas J. Ollberding, Atin Adhikari, Reshmi Indugula, Tiina Reponen
Summary: Respiratory microbiome research is less explored compared to other microbiomes, with limited knowledge on the relationship between environmental and respiratory microbiomes. This study compared mycobiomes and bacteriomes in home dust, saliva, and sputum samples from adolescents, revealing differences in diversity and distribution of major taxa between sample types. Future research should investigate the biological significance of taxa in each sample based on microbial ecology and health associations.
Article
Engineering, Chemical
Lian Zhou, Maosheng Yao, Xiang Zhang, Bicheng Hu, Xinyue Li, Haoxuan Chen, Lu Zhang, Yun Liu, Meng Du, Bochao Sun, Yunyu Jiang, Kai Zhou, Jie Hong, Na Yu, Zhen Ding, Yan Xu, Min Hu, Lidia Morawska, Sergey A. Grinshpun, Pratim Biswas, Richard C. Flagan, Baoli Zhu, Wenqing Liu, Yuanhang Zhang
Summary: The study found that some COVID-19 patients have SARS-CoV-2 in their exhaled breath, while medical equipment and surfaces may still be contaminated, and air samples may also contain the virus. Throat swab diagnosis has a failure rate when safely discharging COVID-19 patients, and breath samples can be used as a supplement to ensure public safety.
JOURNAL OF AEROSOL SCIENCE
(2021)
Letter
Allergy
Jonathan A. Bernstein, Umesh Singh, Marepalli B. Rao, Karen Berendts, Xiang Zhang, Diya Mutasim
Article
Environmental Sciences
Atin Adhikari, Jingjing Yin
Summary: The study found that the effects of ozone, PM2.5, and five meteorological factors on COVID-19 new cases are significant with lag9-lag13 days, and variables with moving averages >14 days are less reliable for summarizing cumulative lag effects. Future studies should consider further lag day checks to better understand the progression of COVID-19 in relation to meteorological factors and ambient air pollutants.
Article
Chemistry, Medicinal
Summon Koul, Suresh Kurhade, Sandeep Bhosale, Keshav Naik, Videsh Salunkhe, Sudhir Ravula, Prasad Punde, Ravikumar Velayutham, Atul Tiwari, Daniela Ahl, Srividya Malkapuram, Vamsi Mudagala, Amol Raje, Dhananjay Umrani, Suhas Tambe, Poonam Patil, Umesh Singh, Debnath Bhuniya, Narayanan Hariharan, Kasim Mookhtiar
Summary: A series of novel spirocyclic DGAT1 inhibitors containing the oxadiazole motif were designed and synthesized, with several compounds exhibiting potent DGAT1 inhibitory activity. Optimization of the series resulted in the identification of five lead compounds with excellent in-vitro activity against human DGAT1. All compounds showed good druggability and stability, and one compound significantly reduced plasma triglyceride levels in-vivo, indicating DGAT1 inhibition.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2022)
Article
Chemistry, Multidisciplinary
Sudha Shankar, Deeti Jyothi, Junaid Ur Rahim, Purna Chandra Pal, Umesh Prasad Singh, Rajkishor Rai
Summary: This study investigates the conformation of achiral alpha/beta hybrid peptides through X-ray crystallography. Peptides P1 and P2 exhibit different folded conformations and hydrogen bond orientation, while no hydrogen bond is observed in peptide P3. The study also reveals differences in torsional preferences of the achiral alpha/beta peptides compared to chiral ones.
Letter
Allergy
Debajyoti Ghosh, Rashid Karim, Xiang Zhang, Umesh Singh, Jonathan A. Bernstein
Article
Allergy
Susamita Kesh, Umesh Singh, Jonathan A. Bernstein
Summary: This study retrospectively analyzed the clinical characteristics and treatment responses of 13 patients with AAE. The results showed that using TXA as prophylaxis significantly reduced AE attacks. However, it is worth noting that potential adverse effects of TXA should be taken into consideration.
ALLERGY AND ASTHMA PROCEEDINGS
(2022)
Article
Environmental Sciences
Victoria Clower, Melanie Sparrow, Atin Adhikari
Summary: River landings are commonly visited public grounds, but they often suffer from litter and trash problems. This study measured air and water quality in the Ogeechee River basin and found that areas with more trash had higher pollution levels, particularly in Rocks River Landing and Little Lotts Creek.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Environmental Sciences
Omolola Okunromade, Jingjing Yin, Clara Ray, Atin Adhikari
Summary: Poor air quality and environmental pollution are major factors leading to cancers around the world. This study aimed to explore the trends and correlations between air pollutants and cancers in sub-Saharan African countries. The results revealed a significant increase in cancer rates and air pollutant levels during 2005-2020 in some sub-Saharan countries.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Allergy
Umesh Singh, Jonathan A. Bernstein
Summary: Through the comparison of DEGs in RNA-seq and miR-NA-seq data, the biological pathways and regulators of HAE attacks were identified. The study found that the PLAUR gene was constitutively over-expressed in HAE-Type-1 patients and associated with severe AE. Additionally, beta1/beta3-integrin cell surface interactions and IL-6-mediated signaling played important roles in HAE attacks. Furthermore, mRNA AKT2 regulated by miR-184A was also associated with HAE attacks.
CLINICAL AND TRANSLATIONAL ALLERGY
(2022)
Article
Materials Science, Multidisciplinary
Sumit Chaudhary, R. N. Rai, Deeti Jyothi, Umesh Prasad Singh
Summary: In this study, an environment friendly solid state synthesis method was used to successfully synthesize a molecular complex, 2-(3-Hydroxyphenyl)-2,3-dihydroquinazolin-4(1H)-one (ANHB), with the highest yield. The compositional behavior of composites in the entire range was determined by analyzing the phase diagram of anthranilamide (AN) 3-hydroxybenzaldehyde (HB) system, which identified the formation of two eutectics and a molecular complex. The novelty and structural behavior of ANHB were studied using various techniques such as FTIR, NMR, UV-vis, fluorescence, DSC, and PXRD. The thermodynamic properties of the eutectics and complex were characterized using the heat of fusion values obtained from DSC. The single crystal XRD (SCXRD) and atomic packing studies confirmed that ANHB crystallizes in a centro-symmetric triclinic space group P 1 with two molecules in the asymmetric unit and four molecules in the unit cell. The synthesized complex exhibited fluorescence emission in the visible region.
Article
Microbiology
Atin Adhikari, Pratik Banerjee, Taylor Thornton, Daleniece Higgins Jones, Caleb Adeoye, Sonam Sherpa
Summary: The USA is one of the top cotton-producing countries globally and cotton farming is commonly practiced in Georgia. Cotton harvesting can contribute to airborne microbial exposures, but the use of respirators or masks can help reduce this exposure. However, the OSHA Respiratory Protection Standard does not apply to agricultural workplaces, and the effectiveness of N95 respirators against airborne microorganisms and antibiotic resistance genes during cotton harvesting has not been tested. This study addressed these gaps by sampling airborne microorganisms on cotton farms and evaluating the protection provided by N95 respirators. The findings showed that cotton harvesting can release antibiotic resistance genes into the farm air, and the tested N95 respirators did not offer sufficient protection against microorganisms and antibiotic resistance genes during cotton harvesting.
Article
Pediatrics
Oyindamola Akinso, Atin Adhikari, Jingjing Yin, Joanne Chopak-Foss, Gulzar Shah
Summary: This study examined the knowledge, attitudes, and practice behaviors of caregivers in the management of asthma in children under 5 years of age in Nigeria. The findings showed that most caregivers have poor knowledge of proper asthma-management practices. However, there is a positive association between higher income and proper asthma-care behavior.
Meeting Abstract
Allergy
Susamita Kesh, Umesh Singh, Jonathan Bernstein
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Environmental Sciences
Toshimi Nakajima, Mao Kuragano, Makoto Yamada, Ryo Sugimoto
Summary: This study compared the contribution of submarine groundwater discharge (SGD) to river nutrient budgets at nearshore and embayment scales, and found that SGD-derived nutrients become more important at larger spatial scales.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Fan Liu, Lei Zhang, Chongyang Zhang, Ziguang Chen, Jingguang Li
Summary: NO2 emissions from wall-mounted gas stoves used for household heating have become a significant source of indoor pollution in Chinese urban areas. The high indoor concentration of NO2 poses potential health risks to residents. It is urgently necessary to establish relevant regulations and implement emission reduction technologies to reduce NO2 emissions from wall-mounted gas stoves.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Letter
Environmental Sciences
Hans Peter H. Arp, Raoul Wolf, Sarah E. Hale, Sivani Baskaran, Juliane Gluege, Martin Scheringer, Xenia Trier, Ian T. Cousins, Harrie Timmer, Roberta Hofman-Caris, Anna Lennquist, Andre D. Bannink, Gerard J. Stroomberg, Rosa M. A. Sjerps, Rosa Montes, Rosario Rodil, Jose Benito Quintana, Daniel Zahn, Herve Gallard, Tobias Mohr, Ivo Schliebner, Michael Neumann
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Philomina Onyedikachi Peter, Binessi Edouard Ifon, Francois Nkinahamira, Kayode Hassan Lasisi, Jiangwei Li, Anyi Hu, Chang-Ping Yu
Summary: This study investigates the relationship between dissolved organic matter (DOM) and Rare Earth Elements (REEs) in sediments from Yundang Lagoon, China. The results show four distinct fluorescent components, with protein-like substances being the most prevalent. Additionally, the total fluorescence intensity and LREE concentrations exhibit a synchronized increase from Outer to Inner to Songbai Lake core sediments. The findings demonstrate a strong correlation between DOM content and pollution levels.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Surya Gupta, Pasquale Borrelli, Panos Panagos, Christine Alewell
Summary: The objective of this study is to incorporate soil hydraulic properties into the erodibility factor (K) of USLE-type models. By modifying and improving the existing equations for soil texture and permeability, the study successfully included information on saturated hydraulic conductivity (Ksat) into the calculation of K factor. Using the Random Forest machine learning algorithm, two independent K factor maps with different spatial resolutions were generated. The results show that the decrease in K factor values has a positive impact on the modeling of soil erosion rates.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Jesmin Akter, Wendy J. M. Smith, Yawen Liu, Ilho Kim, Stuart L. Simpson, Phong Thai, Asja Korajkic, Warish Ahmed
Summary: The choice of workflow in wastewater surveillance has a significant impact on SARS-CoV-2 concentrations, while having minimal effects on HF183 and no effect on HAdV 40/41 concentrations. Certain components in the workflow can be interchangeable, but factors such as buffer type, chloroform, and homogenization speed can affect the recovery of viruses and bacteria.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Yu Luo, Xueting Yang, Diwei Wang, Hongmei Xu, Hongai Zhang, Shasha Huang, Qiyuan Wang, Ningning Zhang, Junji Cao, Zhenxing Shen
Summary: Atmospheric PM2.5, which can generate reactive oxygen species (ROS), is associated with cardiorespiratory morbidity and mortality. The study found that both the mass concentration of PM2.5 and the DTT activity were higher during the heating season than during the nonheating season. Combustion sources were the primary contributors to DTT activity during the heating season, while secondary formation dominated during the nonheating season. The study also revealed that biomass burning had the highest inherent oxidation potential among all sources investigated.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Erin L. Murphy, Leah R. Gerber, Chelsea M. Rochman, Beth Polidoro
Summary: Plastic pollution has devastating consequences for marine organisms. This study uses a trait-based framework to develop a vulnerability index for marine mammals, seabirds, and sea turtles in Hawai'i. The index ranks 63 study species based on their vulnerability to macroplastic pollution, providing valuable information for species monitoring and management priorities.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Kenji Maurice, Amelia Bourceret, Sami Youssef, Stephane Boivin, Liam Laurent-Webb, Coraline Damasio, Hassan Boukcim, Marc-Andre Selosse, Marc Ducousso
Summary: Growing pressure from climate change and agricultural land use is destabilizing soil microbial community interactions. Little is known about microbial community resistance and adaptation to disturbances, hindering our understanding of recovery latency and implications for ecosystem functioning. This study found that anthropic disturbance and natural disturbance have different effects on the topology and stability of soil microbial networks.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Yunhao Li, Yali Feng, Haoran Li, Yisong Yao, Chenglong Xu, Jinrong Ju, Ruiyu Ma, Haoyu Wang, Shiwei Jiang
Summary: Deep-sea mining poses a serious threat to marine ecosystems and human health by disturbing sediment and transmitting metal ions through the food chain. This study developed a new regenerative adsorption material, OMN@SA, which effectively removes metal ions. The adsorption mechanism and performance of the material for metal ion fixation were investigated.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Antonio Medici, Margherita Lavorgna, Marina Isidori, Chiara Russo, Elena Orlo, Giovanni Luongo, Giovanni Di Fabio, Armando Zarrelli
Summary: Valsartan, a widely used antihypertensive drug, has been detected in high concentrations in surface waters due to its unchanged excretion and incomplete degradation in wastewater treatment plants. This study investigated the degradation of valsartan and identified 14 degradation byproducts. The acute and chronic toxicity of these byproducts were evaluated in key organisms in the freshwater trophic chain.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Jiang Lin, Lianbao Chi, Qing Yuan, Busu Li, Mingbao Feng
Summary: This study investigated the photodegradation behavior and product formation of two representative pharmaceuticals in simulated estuary water. The study found that the formed transformation products of these pharmaceuticals have potential toxicity on marine organisms, including oxidative stress and damage to cellular components.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Hua Fang, Dongdong Jiang, Ye He, Siyi Wu, Yuehong Li, Ziqi Zhang, Haoting Chen, Zixin Zheng, Yan Sun, Wenxiang Wang
Summary: This study revealed that exposure to lower levels of air pollutants led to decreased pregnancy rates, with PM10, NO2, SO2, and CO emerging as the four most prominent pollutants. Individuals aged 35 and above exhibited heightened susceptibility to pollutants.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Ali Shaan Manzoor Ghumman, Rashid Shamsuddin, Amin Abbasi, Mohaira Ahmad, Yoshiaki Yoshida, Abdul Sami, Hamad Almohamadi
Summary: In this study, inverse vulcanized polysulfides (IVP) were synthesized by reacting molten sulfur with 4-vinyl benzyl chloride, and then functionalized using N-methyl D-glucamine (NMDG). The functionalized IVP showed a high mercury adsorption capacity and a machine learning model was developed to predict the amount of mercury removed. Furthermore, the functionalized IVP can be regenerated and reused, providing a sustainable and cost-effective adsorbent.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Rita Bonfiglio, Renata Sisto, Stefano Casciardi, Valeria Palumbo, Maria Paola Scioli, Erica Giacobbi, Francesca Servadei, Gerry Melino, Alessandro Mauriello, Manuel Scimeca
Summary: This study investigated the presence of aluminum in human colon cancer samples and its potential association with biological processes involved in cancer progression. Aluminum was found in tumor areas of 24% of patients and was associated with epithelial to mesenchymal transition (EMT) and cell death. Additional analyses revealed higher tumor mutational burden and mutations in genes related to EMT and apoptosis in aluminum-positive colon cancers. Understanding the molecular mechanisms of aluminum toxicity may improve strategies for the management of colon cancer patients.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
