期刊
RSC ADVANCES
卷 5, 期 119, 页码 97975-97981出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5ra22307e
关键词
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资金
- National Natural Science Fund of China [51273217, 21474019]
- Science and Technology Developing Foundation of Shanghai [12JC1402600, 14441901500]
- National Science and Technology Major Project [2015AA033703]
A novel coordination-responsive block copolymer composed of polyether and polyester with selenium at the center was designed and synthesized for controlled drug delivery. The aqueous system of the new copolymer was a free-flowing solution at ambient temperature and turned into a semi-solid thermogel at body temperature. We demonstrate that the selenium-containing copolymer is capable of coordinating with the antitumor drug cisplatin. The efficient coordination between them significantly increased the loading capacity of cisplatin in the selenium-containing thermogel matrix, and the presence of glutathione in the release medium triggered the cisplatin release by coordination competition in a sustained release manner.
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