Article
Food Science & Technology
Alf Aagaard, Philippe Berny, Pierre-Francois Chaton, Ana Lopez Antia, Emily McVey, Maria Arena, Gabriella Fait, Alessio Ippolito, Alberto Linguadoca, Rachel Sharp, Anne Theobald, Theodorus Brock, European Food Safety Authority EFSA
Summary: The European Commission has requested EFSA to update the Guidance on the risk assessment for birds and mammals. This guidance provides instructions on how to assess the risk of plant protection products containing pesticide active substances to birds and mammals in compliance with Regulation (EU) 1107/2009. The updated document outlines a tiered risk assessment scheme covering dietary exposure, secondary poisoning, and exposure through contaminated water intake.
Article
Veterinary Sciences
Kelsey Briggs, Darrell R. Kapczynski
Summary: Avian influenza viruses (AIVs) primarily exist in migratory waterfowl, but many of these viruses have the ability to jump from birds to mammals. This study compared the mutations in the PB2 gene of different AIV subtypes in different species and found that these mutations are common in human viruses.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Review
Physiology
Kang Nian Yap, Yufeng Zhang
Summary: The study compared the characteristics of erythrocytes in birds and mammals, finding no difference in MCHC levels but differences in MCV. It is suggested that birds and mammals may employ different strategies to solve a common problem.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Joseph Rufo, Peiran Zhang, Ruoyu Zhong, Luke P. Lee, Tony Jun Huang
Summary: Newly developed acoustic technologies have the potential to address critical challenges in biomedicine, such as activation of ion channels and development of biofabrication protocols.
NATURE COMMUNICATIONS
(2022)
Article
Agricultural Engineering
Hehu Zhang, Yanfei Li, Ruyue Xie, Ying Zhu, Suan Shi, Zengling Yang, Lujia Han
Summary: A novel 3D in-situ visualization method was established in this study to qualitatively and semi-quantitatively characterize Pb (II) adsorption profiles in crop residue-derived char particles. Utilizing X-ray micro-CT imaging and the K-means clustering algorithm, the distribution of Pb (II) adsorption in different char particles was demonstrated.
BIORESOURCE TECHNOLOGY
(2022)
Article
Environmental Sciences
Valerio Orioli, Alessandra Caffi, Flavio Marchetto, Olivia Dondina, Luciano Bani
Summary: The European Pesticide Registration requires a risk assessment for nontarget organisms according to EU Regulation. European Authorities have developed Guidance Documents for risk assessment using exposure scenarios for required organisms typical for terrestrial crops. An analytical framework was developed to calculate species frequency and tested in a portion of the largest rice-cultivated area of Europe.
INTEGRATED ENVIRONMENTAL ASSESSMENT AND MANAGEMENT
(2022)
Article
Pharmacology & Pharmacy
Hossein Salimi-Moosavi, Marcus Soto
Summary: The aim of this research was to develop a reliable non-radiometric method to measure residual blood in tissue without the need for perfusion or radiometric measurements. The study found that perfusion method was ineffective in removing blood from tissue and introduced variability in determining tissue drug exposure. Hemoglobin measurement was also found to be an unreliable approach. An alternative method using RBDR was developed, which showed comparable results to radiometric measurements in determining tissue blood volume.
Article
Multidisciplinary Sciences
Anne Cathrine Linder, Henriette Lyhne, Bjarke Laubek, Dan Bruhn, Cino Pertoldi
Summary: This study aims to model collision risk by investigating flight behavioral traits and other influencing factors, and to study the specificity of species through a case study. The results indicate that these traits can be used to predict collision risk and identify high-risk species.
Article
Environmental Sciences
Gustavo Souza Santos, Mariana Coletty Artal, Mario del Giudice Paniago, Ana P. Paola Cione, Fabio Casallanovo, Eamonn Farrelly, Steven Kragten, Jonathan D. Maul
Summary: This study investigates the utilization of freshly drilled dry bean fields by birds and mammals in Brazilian Cerrado and Atlantic Forest sites. The results demonstrate that off-crop areas exhibit greater species richness, abundance, and diversity compared to in-crop areas. Dry bean fields are generally unattractive habitats for birds and mammals, with most observed species either not granivorous or too small to feed on dry bean seeds.
INTEGRATED ENVIRONMENTAL ASSESSMENT AND MANAGEMENT
(2023)
Article
Biotechnology & Applied Microbiology
Li-Jun Peng, Yue-Bo Zhou, Mei Geng, Ekaterina Bourova-Flin, Florent Chuffart, Wei-Na Zhang, Tao Wang, Meng-Qing Gao, Meng-Ping Xi, Zhong-Yi Cheng, Jiao-Jiao Zhang, Yuan-Fang Liu, Bing Chen, Saadi Khochbin, Jin Wang, Sophie Rousseaux, Jian-Qing Mi
Summary: By discovering 18 genes associated with shorter survival, we have developed a prognostic classifier for T-ALL patients that can improve therapeutic decisions. Additionally, our study has revealed specific biological characteristics of aggressive T leukemic cells, providing insights for better understanding and management of the disease.
Article
Engineering, Environmental
Abhay Guleria, Rahul Singh, Sumedha Chakma, Volker Birke
Summary: This study conducted an ecological and human health risk assessment of the subsurface environment near chromite ore processing residue (COPR) dumping sites in Northern India. It found considerable to very high contamination of soil near the Rania contaminant site, with a serious threat to human health. Urgent remediation action is recommended to ensure human health safety.
PROCESS SAFETY AND ENVIRONMENTAL PROTECTION
(2022)
Article
Public, Environmental & Occupational Health
Kosuke Inoue, Susan Athey, Yusuke Tsugawa
Summary: In medicine, using a machine-learning based high-benefit approach to treat high-risk patients can improve population health outcomes and is more effective than the traditional high-risk approach. Researchers found that treating patients with blood pressure over 130 mmHg using the high-benefit approach had better outcomes compared to the traditional high-risk approach. These findings suggest that the high-benefit approach has the potential to maximize treatment effectiveness.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Multidisciplinary Sciences
Yohannes Tesfaye Endale, Argaw Ambelu, Geremew G. Sahilu, Bernd Mees, Gijs Du Laing
Summary: This study investigated the lead contamination level in drinking water in Addis Ababa, Ethiopia, and found that over 50% of the samples exceeded the WHO guideline for lead concentration. The study also revealed that children are more vulnerable to lead exposure compared to adults, with significant spatial variation of lead concentration among different city locations.
Article
Biochemical Research Methods
Jingsha Zhang, Wenhao Li, Ke Zhang, Congcong Huo, Gongcheng Xu, Zengyong Li
Summary: This study evaluated the cerebral blood flow autoregulation function of subjects with different stroke risk levels and used the coupling strength between cerebral oxygen and blood pressure as a predictive index. The results showed that the coupling strength was significantly higher in the high-risk group and the prediction model achieved an average accuracy of 0.80.
JOURNAL OF BIOPHOTONICS
(2023)
Article
Chemistry, Multidisciplinary
Lining Xu, Xudong Wang, Ruixia Wang, Sijin Liu, Ming Xu
Summary: This study focuses on using macrophages as a shuttle to deliver sub-5 nm PEGylated gold nanoparticles to tumors, while reducing the accumulation of nanoparticles in the brain. The study demonstrates that sub-5 nm gold nanoparticles can be rapidly exocytosed from live macrophages, leading to the release of free nanoparticles in the blood circulation. To overcome this issue, the researchers engineer macrophages to obtain half-dead and dead macrophages. Although the efficiency of engineered macrophages for delivering nanoparticles to tumors is slightly lower than that of free nanoparticles, this approach can significantly reduce the accumulation of nanoparticles in the brain.
Article
Agronomy
Mieke Verbeeck, Eva Houben, Pieterjan De Bauw, Tovohery Rakotoson, Roel Merckx, Erik Smolders
Summary: Rainfed rice in sub-Saharan Africa faces the challenges of drought and phosphorus deficiency. This study examined the response of different rice genotypes to variable water stress under conditions of phosphorus deficiency. The results showed that the effects of phosphorus supply on shoot weight were greater than the effects of water supply. Reduced water supply did not enhance phosphorus stress, and the stress response varied among genotypes. Root biomass production and root efficiency were found to be important factors in combating the combined stresses of water and phosphorus. The study confirmed the superior performance of the genotypes Chhomrong Dhan and FOFIFA 172 found in the field.
Editorial Material
Biotechnology & Applied Microbiology
Silvio Matassa, Pascal Boeckx, Jos Boere, Jan Willem Erisman, Miao Guo, Raffaele Manzo, Francis Meerburg, Stefano Papirio, Ilje Pikaar, Korneel Rabaey, Diederik Rousseau, Jerald Schnoor, Peter Smith, Erik Smolders, Stefan Wuertz, Willy Verstraete
Summary: Nitrogen is crucial for the production of nutritious feeds and foods, but the production and use of fertilizer nitrogen pose a major threat to environmental health and sustainability. It is important to promote consumer acceptance and awareness of proteins produced by highly effective microorganisms as an alternative to proteins obtained from plants and animals with low nitrogen efficiencies. Additionally, recovering and upgrading used nitrogen from secondary resources and integrating biological nitrogen fixation into feed and food supply chains are promising solutions for a more sustainable agriculture.
MICROBIAL BIOTECHNOLOGY
(2023)
Article
Environmental Sciences
D. Arguello, E. Chavez, E. Gutierrez, M. Pittomvils, J. Dekeyrel, H. Blommaert, E. Smolders
Summary: The effects of soil amendments on cadmium concentrations in cacao beans were tested in two established cacao orchards in Ecuador. Lime application decreased leaf cadmium concentrations in acidic soil, while compost application decreased leaf cadmium concentrations in neutral soil. The compost + lime treatment should be further tested in field scale to accelerate cadmium mitigation effects.
Editorial Material
Environmental Sciences
Cristina Palacios-Mateo, Ke Meng, Lucia Legaz-Pol, Erik Steen Redeker, Esperanza Huerta-Lwanga, Lars M. Blank
Summary: Plastic mulch films and biofertilizers have increased crop yields but also led to microplastic contamination in agricultural soils. Researchers propose using hydrolytic enzymes for bioremediation, optimizing them for natural soil conditions and assessing their effects on soil organisms and ecosystems.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Environmental Sciences
Margot Vanheukelom, Lieve Sweeck, May Van Hees, Nancy Weyns, Jos Van Orshoven, Erik Smolders
Summary: Current radiocesium (137Cs) models for predicting 137Cs transfer from soil to plants are inadequate and do not consider the mineralogy of the clay fraction. This study conducted a pot cultivation experiment to test the hypothesis that information on mineralogy can improve predictions. The results showed that the transfer factor (TF) of 137Cs varied significantly across different clay groups and doses, and was best predicted by the soil solution 137Cs and K concentrations. X-ray diffraction (XRD) analysis of phyllosilicate groups provided the strongest predictive power for 137Cs bioavailability in plant substrates.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Ruth Vanderschueren, Lena Wantiez, Hester Blommaert, Julia Flores, Eduardo Chavez, Erik Smolders
Summary: The pathways of cadmium (Cd) loading into cacao beans (nibs) have been investigated using a stable isotope (108Cd) pulse-chase experiment. The results suggest that Cd is likely transported from the stem, branches, or mature leaves to the nibs through phloem-mediated redistribution, rather than directly through the xylem.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Florian Lauryssen, Jari Struyve, Philippe Crombe, Elliot Van Maldegem, Erik Smolders
Summary: This study estimated the reference conditions of total dissolved phosphorus (TDP) and found that disturbed samples had higher phosphorus concentrations compared to reference samples. The study suggests that soil or sediments in old forests can be used to identify reference conditions.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Lei Xia, Toon van Dael, Benoit Bergen, Erik Smolders
Summary: Fe rich by-product from drinking water treatment plants can be used to immobilise phos-phorus (P) in sediment and reduce eutrophication risks. The immobilisation efficiency of the by-product was investigated in relation to pH and sulphate (SO4) concentration. The study found that the addition of the by-product significantly reduced P release from sediment, but its long-term effectiveness may be reduced in low pH water.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Horticulture
Esther Geukens, Annelies Haegeman, Jef Van Meulder, Katrijn Van Laere, Erik Smolders, Tom Ruttink, Leen Leus
Summary: Knowledge of genetic identity, genetic relationships, ploidy level, and chromosome numbers in a collection of Ilex accessions has been determined. Genetic fingerprinting revealed high intra-specific genetic diversity in Ilex crenata, and the species was separated into three clades based on genome sizes. These findings can be utilized for selective breeding to enhance genetic diversity.
Review
Environmental Sciences
Maarten van Doorn, Debby van Rotterdam, Gerard Ros, Gerwin F. Koopmans, Erik Smolders, Wim de Vries
Summary: Current P fertilizer recommendations must be revised to balance crop yield, water quality, and finite P resources. Current soil P tests do not provide the necessary insights. The oxalate extraction method shows promise as an agri-environmental soil test as it measures the total pool of P and the maximum P sorption capacity. These insights are crucial for assessing crop response, P loss risk, and the judicious use of finite P reserves.
CRITICAL REVIEWS IN ENVIRONMENTAL SCIENCE AND TECHNOLOGY
(2023)
Article
Environmental Sciences
Andreas Fettweis, Simon Hansul, Karel De Schamphelaere, Erik Smolders
Summary: This article investigates the effects of metal mixtures and species interactions on biological communities and finds that the sensitivity of communities depends on the correlation of sensitivities among single species to single metals. The results suggest that functional endpoints are less sensitive than structural endpoints under metal mixture stress, indicating functional redundancy. Antagonistic metal mixture interactions found in single species can also exhibit antagonistic and synergistic effects in communities. Additionally, the interactions of metal mixtures in communities gradually shift from antagonism to non-interactions with increasing correlation of single-species sensitivities among the single metals. Overall, functional redundancy can lead to reduced biodiversity, and synergisms can emerge at the community level without any synergisms on the single-species level.
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
(2023)
Article
Environmental Sciences
Benoit Bergen, Claudia Moens, Anneleen De Winter, Franne Ricou, Erik Smolders
Summary: This study measured the leaching of cadmium and uranium in undisturbed unsaturated soils and quantified the contribution of colloids through proper solution sampling methods. The results showed that colloid facilitated transport had a significant impact on the migration of uranium, while its effect on cadmium was relatively small.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Business, Finance
Jose Luis Vazquez-deCastro, Eduardo Chavez, Ramon Espinel, Stan Hendrix, Erik Smolders, Miet Maertens
Summary: By studying cocoa farmers in Ecuador, we find that the European Union's restrictions on cadmium content in cocoa-derived products could result in significant economic costs for farmers. If compliance strategies are not implemented to minimize welfare loss, the potential total economic cost at the producer level in Ecuador could be very large.
Article
Biochemistry & Molecular Biology
Tony Kayembe-Kitenge, Celestin Banza Lubaba Nkulu, Sebastien Mbuyi Musanzayi, Toni Lubala Kasole, Leon Kabamba Ngombe, Paul Musa Obadia, Daan Van Brusselen, Daniel Kyanika Wa Mukoma, Taty Muta Musambo, Augustin Mutombo Mulangu, Patient Nkulu Banza, P. D. M. C. Katoto, Erik Smolders, Benoit Nemery, Tim Nawrot
Summary: This first study on maternal and neonatal cobalt concentrations in the African Copperbelt provides strong evidence of a high transfer of cobalt from mother to fetus.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2023)
Article
Chemistry, Applied
Hester Blommaert, Geraldine Sarret, Eduardo Chavez, Erik Smolders, Ruth Vanderschueren
Summary: This study used X-ray absorption spectroscopy and speciation calculations to investigate changes in cadmium speciation during cacao bean fermentation. The results showed that fermentation can decrease the concentration of cadmium in the beans and change the cadmium complexation, especially in high cadmium beans.
Article
Environmental Sciences
Toshimi Nakajima, Mao Kuragano, Makoto Yamada, Ryo Sugimoto
Summary: This study compared the contribution of submarine groundwater discharge (SGD) to river nutrient budgets at nearshore and embayment scales, and found that SGD-derived nutrients become more important at larger spatial scales.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Fan Liu, Lei Zhang, Chongyang Zhang, Ziguang Chen, Jingguang Li
Summary: NO2 emissions from wall-mounted gas stoves used for household heating have become a significant source of indoor pollution in Chinese urban areas. The high indoor concentration of NO2 poses potential health risks to residents. It is urgently necessary to establish relevant regulations and implement emission reduction technologies to reduce NO2 emissions from wall-mounted gas stoves.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Letter
Environmental Sciences
Hans Peter H. Arp, Raoul Wolf, Sarah E. Hale, Sivani Baskaran, Juliane Gluege, Martin Scheringer, Xenia Trier, Ian T. Cousins, Harrie Timmer, Roberta Hofman-Caris, Anna Lennquist, Andre D. Bannink, Gerard J. Stroomberg, Rosa M. A. Sjerps, Rosa Montes, Rosario Rodil, Jose Benito Quintana, Daniel Zahn, Herve Gallard, Tobias Mohr, Ivo Schliebner, Michael Neumann
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Philomina Onyedikachi Peter, Binessi Edouard Ifon, Francois Nkinahamira, Kayode Hassan Lasisi, Jiangwei Li, Anyi Hu, Chang-Ping Yu
Summary: This study investigates the relationship between dissolved organic matter (DOM) and Rare Earth Elements (REEs) in sediments from Yundang Lagoon, China. The results show four distinct fluorescent components, with protein-like substances being the most prevalent. Additionally, the total fluorescence intensity and LREE concentrations exhibit a synchronized increase from Outer to Inner to Songbai Lake core sediments. The findings demonstrate a strong correlation between DOM content and pollution levels.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Surya Gupta, Pasquale Borrelli, Panos Panagos, Christine Alewell
Summary: The objective of this study is to incorporate soil hydraulic properties into the erodibility factor (K) of USLE-type models. By modifying and improving the existing equations for soil texture and permeability, the study successfully included information on saturated hydraulic conductivity (Ksat) into the calculation of K factor. Using the Random Forest machine learning algorithm, two independent K factor maps with different spatial resolutions were generated. The results show that the decrease in K factor values has a positive impact on the modeling of soil erosion rates.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Jesmin Akter, Wendy J. M. Smith, Yawen Liu, Ilho Kim, Stuart L. Simpson, Phong Thai, Asja Korajkic, Warish Ahmed
Summary: The choice of workflow in wastewater surveillance has a significant impact on SARS-CoV-2 concentrations, while having minimal effects on HF183 and no effect on HAdV 40/41 concentrations. Certain components in the workflow can be interchangeable, but factors such as buffer type, chloroform, and homogenization speed can affect the recovery of viruses and bacteria.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Yu Luo, Xueting Yang, Diwei Wang, Hongmei Xu, Hongai Zhang, Shasha Huang, Qiyuan Wang, Ningning Zhang, Junji Cao, Zhenxing Shen
Summary: Atmospheric PM2.5, which can generate reactive oxygen species (ROS), is associated with cardiorespiratory morbidity and mortality. The study found that both the mass concentration of PM2.5 and the DTT activity were higher during the heating season than during the nonheating season. Combustion sources were the primary contributors to DTT activity during the heating season, while secondary formation dominated during the nonheating season. The study also revealed that biomass burning had the highest inherent oxidation potential among all sources investigated.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Erin L. Murphy, Leah R. Gerber, Chelsea M. Rochman, Beth Polidoro
Summary: Plastic pollution has devastating consequences for marine organisms. This study uses a trait-based framework to develop a vulnerability index for marine mammals, seabirds, and sea turtles in Hawai'i. The index ranks 63 study species based on their vulnerability to macroplastic pollution, providing valuable information for species monitoring and management priorities.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Kenji Maurice, Amelia Bourceret, Sami Youssef, Stephane Boivin, Liam Laurent-Webb, Coraline Damasio, Hassan Boukcim, Marc-Andre Selosse, Marc Ducousso
Summary: Growing pressure from climate change and agricultural land use is destabilizing soil microbial community interactions. Little is known about microbial community resistance and adaptation to disturbances, hindering our understanding of recovery latency and implications for ecosystem functioning. This study found that anthropic disturbance and natural disturbance have different effects on the topology and stability of soil microbial networks.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Yunhao Li, Yali Feng, Haoran Li, Yisong Yao, Chenglong Xu, Jinrong Ju, Ruiyu Ma, Haoyu Wang, Shiwei Jiang
Summary: Deep-sea mining poses a serious threat to marine ecosystems and human health by disturbing sediment and transmitting metal ions through the food chain. This study developed a new regenerative adsorption material, OMN@SA, which effectively removes metal ions. The adsorption mechanism and performance of the material for metal ion fixation were investigated.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Antonio Medici, Margherita Lavorgna, Marina Isidori, Chiara Russo, Elena Orlo, Giovanni Luongo, Giovanni Di Fabio, Armando Zarrelli
Summary: Valsartan, a widely used antihypertensive drug, has been detected in high concentrations in surface waters due to its unchanged excretion and incomplete degradation in wastewater treatment plants. This study investigated the degradation of valsartan and identified 14 degradation byproducts. The acute and chronic toxicity of these byproducts were evaluated in key organisms in the freshwater trophic chain.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Jiang Lin, Lianbao Chi, Qing Yuan, Busu Li, Mingbao Feng
Summary: This study investigated the photodegradation behavior and product formation of two representative pharmaceuticals in simulated estuary water. The study found that the formed transformation products of these pharmaceuticals have potential toxicity on marine organisms, including oxidative stress and damage to cellular components.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Hua Fang, Dongdong Jiang, Ye He, Siyi Wu, Yuehong Li, Ziqi Zhang, Haoting Chen, Zixin Zheng, Yan Sun, Wenxiang Wang
Summary: This study revealed that exposure to lower levels of air pollutants led to decreased pregnancy rates, with PM10, NO2, SO2, and CO emerging as the four most prominent pollutants. Individuals aged 35 and above exhibited heightened susceptibility to pollutants.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Ali Shaan Manzoor Ghumman, Rashid Shamsuddin, Amin Abbasi, Mohaira Ahmad, Yoshiaki Yoshida, Abdul Sami, Hamad Almohamadi
Summary: In this study, inverse vulcanized polysulfides (IVP) were synthesized by reacting molten sulfur with 4-vinyl benzyl chloride, and then functionalized using N-methyl D-glucamine (NMDG). The functionalized IVP showed a high mercury adsorption capacity and a machine learning model was developed to predict the amount of mercury removed. Furthermore, the functionalized IVP can be regenerated and reused, providing a sustainable and cost-effective adsorbent.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Rita Bonfiglio, Renata Sisto, Stefano Casciardi, Valeria Palumbo, Maria Paola Scioli, Erica Giacobbi, Francesca Servadei, Gerry Melino, Alessandro Mauriello, Manuel Scimeca
Summary: This study investigated the presence of aluminum in human colon cancer samples and its potential association with biological processes involved in cancer progression. Aluminum was found in tumor areas of 24% of patients and was associated with epithelial to mesenchymal transition (EMT) and cell death. Additional analyses revealed higher tumor mutational burden and mutations in genes related to EMT and apoptosis in aluminum-positive colon cancers. Understanding the molecular mechanisms of aluminum toxicity may improve strategies for the management of colon cancer patients.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)