Review
Biochemistry & Molecular Biology
Gabriel Ichim, Benjamin Gibert, Sahil Adriouch, Catherine Brenner, Nathalie Davoust, Solange Desagher, David Devos, Svetlana Dokudovskaya, Laurence Dubrez, Jerome Estaquier, Germain Gillet, Isabelle Guenal, Philippe P. Juin, Guido Kroemer, Patrick Legembre, Romain Levayer, Stephen Manon, Patrick Mehlen, Olivier Meurette, Olivier Micheau, Bernar Mignotte, Florence Nguyen-Khac, Nikolay Popgeorgiev, Jean-Lu Poyet, Muriel Priault, Jean-Ehrlan Ricci, Franck B. Riquet, Santos A. Susin, Magal Suzanne, Pierre Vacher, Ludivine Walter, Bertran Mollereau
Summary: Since the Nobel Prize was awarded more than twenty years ago for discovering the core apoptotic pathway in C. elegans, researchers around the world have conducted extensive research on apoptosis and various other forms of regulated cell death. Although there are still many aspects of regulated cell death that need to be clarified in specific cell subtypes and disease conditions, the last decade has seen the description of multiple cell death modalities, some of which have been successfully used in clinical therapy. To keep research into cell death alive, francophone researchers from several institutions in France and Belgium established the French Cell Death Research Network (FCDRN), which is at the forefront of emerging topics in cell death research. These research efforts will enhance our mechanistic knowledge of regulated cell death and its therapeutic applications in the coming years.
Article
Multidisciplinary Sciences
Rasool Erfani, Cameron Carmichael, Thea Sofokleous, Qiuyu Wang
Summary: Plasma therapy is an exciting and novel cancer treatment method that can be influenced by treatment time and different parameters. Changing the polarity of the reactor can alter the plasma discharge regime, thereby directly affecting the treatment effectiveness. This treatment method can induce cell death, which is not completely counteracted by N-acetyl cysteine. Gene expression analysis also identified key genes associated with plasma-induced cell death.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Multidisciplinary
Yiheng Dai, Tianyu Li, Zhiheng Zhang, Yizheng Tan, Shuojiong Pan, Luo Zhang, Huaping Xu
Summary: This study demonstrates a novel oxidative polymerization reaction in cells triggered by intracellular ROS, selectively inducing apoptosis in cancer cells. The polymerization products disrupt intracellular antioxidant systems, leading to increased oxidative stress, further promoting oxidative polymerization and activating apoptosis pathways related to ROS. The anticancer efficacy and biosafety of this strategy are proven in vitro and in vivo, suggesting a new possibility for chemists to manipulate cellular behavior through artificial chemical reactions.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Review
Biochemistry & Molecular Biology
Tapan Behl, Rashita Makkar, Aayush Sehgal, Sukhbir Singh, Neelam Sharma, Gokhan Zengin, Simona Bungau, Felicia Liana Andronie-Cioara, Mihai Alexandru Munteanu, Mihaela Cristina Brisc, Diana Uivarosan, Ciprian Brisc
Summary: The human body is complex and comprises various living cells and extracellular material forming tissues, organs, and organ systems. While most human cells turnover regularly, postmitotic nerve cells have the exceptional ability to regenerate and sustain throughout an individual's life to safeguard the central nervous system's functioning. Neurodegenerative diseases, such as Parkinson's and Alzheimer's disease, result from factors like oxidative stress, cell death, and neuroinflammation, causing neuronal degradation and impacting the quality of life for millions worldwide.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Analytical
Minggang Tian, Baoli Dong, Zheming Zhang, Junling Yin, Weiying Lin
Summary: A new fluorescent probe mPTP-F has been successfully designed to monitor the opening of mPTP in cellular native status. This probe can serve as an important tool for studying areas such as ischemia-reperfusion injury and cell apoptosis.
ANALYTICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Juan A. Montero, Carlos Ignacio Lorda-Diez, Juan M. Hurle
Summary: This paper proposes a new perspective on the regulation of programmed cell death (PCD) in developing systems based on epigenetics. It challenges the traditional view that PCD is solely controlled by specific gene-encoded signals, arguing that the signals and local tissue interactions responsible for embryonic tissue growth and differentiation play a significant role in PCD. The study suggests that cells retain an epigenetic profile sensitive to DNA damage, resulting in their subsequent elimination.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Antonio Rego, Antonio Ribeiro, Manuela Corte-Real, Susana Rodrigues Chaves
Summary: Acetic acid and hydrogen peroxide are common stimuli to induce apoptosis in yeast. A simple method was developed to explore the timing of plasma membrane disruption and secondary necrosis in non-viable cells after apoptosis.
Article
Cell Biology
Jia-Heng Zhang, Shi-Yu Ni, Ya-Ting Tan, Jia Luo, Shu-Chao Wang
Summary: By conducting bibliometric analyses, this study explores the research trends and hotspots of Pin1 and cell death. The results indicate that the research on Pin1 and cell death has been increasing annually since 2001, but growth after 2014 appears to be stagnant. The cooperation between core institutions needs to be strengthened, and recently, Fujian Medical University in China has emerged as the institution with the highest citation count. Further research is required to understand the role of Pin1 in cell death and to identify new research hotspots. Future studies are likely to focus on disease treatment using Pin1 inhibitors, before breakthroughs are made in understanding the molecular mechanisms or signaling pathways.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Cell Biology
Chang Liu, Zecheng Jiang, Zhongjie Pan, Liang Yang
Summary: Atherosclerosis is a chronic inflammatory vascular disease, and macrophages play a significant role in its progression. Recent studies have highlighted the critical role of programmed cell death in macrophages in the development of vulnerable plaques in atherosclerosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Virology
Shannic-Le Kerr, Cynthia Mathew, Reena Ghildyal
Summary: Rhinoviruses are common causes of the common cold and can lead to more severe diseases in lower respiratory tract infections. These viruses hijack host cell pathways to suppress antiviral responses, and the mechanism of how they exit infected cells remains unclear.
Review
Neurosciences
Yan Zhang, Suliman Khan, Yang Liu, Ruiyi Zhang, Hongmin Li, Guofeng Wu, Zhouping Tang, Mengzhou Xue, V. Wee Yong
Summary: This review summarizes the knowledge of cell death induced by intracerebral hemorrhage (ICH), with a focus on apoptosis and necrosis. It also discusses the involvement of recently described modes of cell death including necroptosis, pyroptosis, ferroptosis, autophagy, and parthanatos in ICH. Treatment strategies to mitigate brain injury based on specific cell death pathways after ICH are also summarized.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Leo Razakamanantsoa, Neeraj R. Rajagopalan, Yasushi Kimura, Michele Sabbah, Isabelle Thomassin-Naggara, Francois H. Cornelis, Govindarajan Srimathveeravalli
Summary: Irreversible electroporation (IRE) can cause apoptosis, necrosis, oncosis, or pyroptosis. The mode of cell death following IRE is determined by intracellular ATP levels. Cell death after IRE is insensitive to caspase inhibition and is correlated with ATP loss, which cannot be rescued by ATP supplementation.
BIOELECTROCHEMISTRY
(2023)
Review
Cell Biology
Lawrence M. Schwartz
Summary: Cell death is a normal and essential component of development and homeostasis, but dysregulation of this process underlies most human diseases. Autophagy is a process mediated by the formation of double membrane vesicles, which allows cells to survive stresses and may also mediate cell death during development and pathogenesis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Siraj Pallichankandy, Faisal Thayyullathil, Anees Rahman Cheratta, Karthikeyan Subburayan, Ameer Alakkal, Mehar Sultana, Nizar Drou, Muhammad Arshad, Saeed Tariq, Sehamuddin Galadari
Summary: Oxeiptosis is a recently identified ROS-dependent cell death pathway that is caspase independent and non-inflammatory. This study demonstrates that sanguinarine induces oxeiptosis in human colorectal cancer cells through the activation of the KEAP1-PGAM5-AIFM1 signaling axis via hydrogen peroxide. Knockdown of key regulators in this pathway abolishes SNG-induced oxeiptosis, highlighting its importance in SNG-mediated cytotoxicity.
CELL DEATH DISCOVERY
(2023)
Article
Immunology
Wenhao Xu, Hai-Jia Tang, Aihetaimujiang Anwaier, Wangrui Liu, Xi Tian, Jiaqi Su, Shiyin Wei, Yuanyuan Qu, Hailiang Zhang, Dingwei Ye
Summary: This study evaluated the transcriptomic profile of cell death pathways in bladder cancer patients and found that patients with high cell-death index (CDI) had a higher risk of mortality. These high-risk patients also exhibited an immunoevasive tumor microenvironment characterized by increased tumor-associated macrophage infiltration and expression of immune checkpoints. These findings provide important clinical and immunological insights for the management of bladder cancer.
FRONTIERS IN IMMUNOLOGY
(2022)
