4.6 Article

Direct access to pyrimidines through organocatalytic inverse-electron-demand Diels-Alder reaction of ketones with 1,3,5-triazine

期刊

RSC ADVANCES
卷 5, 期 94, 页码 76759-76763

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ROYAL SOC CHEMISTRY
DOI: 10.1039/c5ra16995j

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资金

  1. National Natural Science Foundation of China [NSFC 21272043]
  2. Science and Technology Planning Project of Guangdong Province [2007A020300007-10, 2011B090400573]
  3. Guangdong Natural Science Foundation [S2011010004967]

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An organocatalytic inverse-electron-demand Diels-Alder reaction of ketones with 1,3,5-triazine through enamine catalysis has been developed. This method could furnish 4,5-disubstituted pyrimidines in good yields and high levels of regioselectivities.

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