Review
Biochemistry & Molecular Biology
Jia Song, Jie Lv, Jiamiao Jin, Zhichao Jin, Tingting Li, Jian Wu
Summary: 1,2,3-Triazolium salts have shown great potential in medicine and agriculture, with remarkable antibacterial, antifungal, anticancer, and antileishmanial properties. They can also be used to produce antibacterial nano- and fiber-based materials. This review summarizes various synthetic strategies for obtaining 1,2,3-triazolium salts and discusses their structures and biological activities in pharmaceuticals, pesticides, and functional materials. The structure-activity relationship of these salts with different biological activities is analyzed. Additionally, the potential applications and prospects of 1,2,3-triazolium salts in agriculture, medicine, and industrial synthesis are presented.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Physical
Vineetha Telma D'Souza, Janardhana Nayak, Desmond Edward D'Mello, P. Dayananda
Summary: Triazoles and quinoline compounds have been well studied for their biological activities. In this study, a novel series of compounds were synthesized and screened for antimicrobial activities, with some showing significantly higher bioactivities compared to normal drugs.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Biochemistry & Molecular Biology
Reem I. Al-Wabli, Mona A. Alsulami, Sarah I. Bukhari, Nadine M. S. Moubayed, Maha S. Al-Mutairi, Mohamed I. Attia
Summary: A series of new indole-triazole conjugates were designed and synthesized for evaluation as new antimicrobial candidates, showing good to moderate activity against most tested Gram-negative strains and potent activity against Candida tropicalis, with one compound exhibiting the strongest activity against Candida albicans.
Article
Chemistry, Physical
Priyanka Yadav, C. P. Kaushik, Mukesh Kumar, Anil Kumar
Summary: A series of Phthalimide/Naphthalimide containing 1,2,3-triazole hybrids were synthesized through Click reaction. The compounds were characterized using various spectral techniques and the structure of compound 6b was confirmed by Single Crystal X-ray Crystallography. The synthesized hybrids showed excellent antimicrobial potency, particularly compound 6e, which demonstrated strong antimicrobial activity against all tested strains due to the presence of a nitro group on the phenyl ring. Molecular docking studies confirmed the binding conformation of compound 6e with E. coli topoisomerase II DNA gyrase B.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Organic
Marcin Budny, Anna Kozakiewicz, Andrzej Wolan
Summary: The synthesis of 1,2,4-triazolium tetrafluoroborates under electrochemical conditions is reported in this study. By converting starting materials to their corresponding cationic forms using HBF4, sufficient conductivity is achieved in MeOH, CD3OD, and EtOH without the need for additional supporting electrolyte. The fungicide triticonazole is successfully transformed into an O-methylated intermediate in 42% yield on a gram scale.
Article
Chemistry, Medicinal
Connor A. Lejcher, Eric M. Villa, James T. Fletcher
Summary: This study presents 1,3,4-trisubstituted-1,2,3-triazolium salts exhibiting antimicrobial properties as well as visible emission characteristics. By incorporating various aryl units at the N1 position, visible emission properties were imparted to the salts with significant Stokes shifts. The hydrophobic aryl units showed impact on the minimum inhibitory concentration (MIC) values against bacteria and yeast, which could be adjusted by substituent variation to maintain bioactivity.
MEDICINAL CHEMISTRY RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Jia Song, Juan Zou, Jiamiao Jin, Jie Lv, Chengli Mou, Yonggui Robin Chi
Summary: 1,2,4-Triazolium salts are precursors of N-heterocyclic carbenes (NHCs), which have been extensively used as effective catalysts and ligands for both asymmetric and non-enantioselective reactions. They are also quaternary ammonium compounds (QACs) with amphipathic properties. The bioactivities of 1,2,4-triazolium salt derivatives against various bacteria, fungi, cancer cells, and other pathogens in the past 30 years have been summarized, along with the structure-activity relationship (SAR) of these salts. The future development and applications of triazolium salts as agrichemicals or human drugs are discussed.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Physical
Nada Y. Tashkandi, Zahra M. Al-Amshany, Nasser A. Hassan
Summary: A series of compounds with potential antibacterial and antifungal activities were designed and synthesized, among which derivative 12 showed superior antibacterial activity against G-positive Bacillus cereus, and all compounds exhibited appreciable antifungal activity.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Chemistry, Multidisciplinary
Ashruba B. Danne, Mukund Deshpande, Jaiprakash N. Sangshetti, Vijay M. Khedkar, Bapurao B. Shingate
Summary: This study describes the design of a small library of new 1,2,3-triazole-appended bis-pyrazoles using a molecular hybridization approach, which show broad-spectrum antifungal activity with excellent minimum inhibitory concentration values against various fungal strains. Additionally, the compounds also exhibit promising antioxidant activity.
Article
Chemistry, Multidisciplinary
Yueheng Li, Zhixing Huang, Guangquan Mo, Wei Jiang, Chengwei Zheng, Pengju Feng, Zhixiong Ruan
Summary: In this study, an electrochemical thiocyanation/cyclization of aldehyde hydrazones was developed under external oxidant-free and catalyst-free conditions, utilizing commercially available and inexpensive sodium thiocyanate as a dual role reagent and electrolyte. This strategy provides expedient access to functionalized sulfur-containing triazolium inner salts with ample scope and diverse functional group tolerance. Based on mechanistic studies, a reaction mechanism was proposed.
CHINESE JOURNAL OF CHEMISTRY
(2021)
Review
Chemistry, Multidisciplinary
Emer M. Foyle, Nicholas G. White
Summary: The use of 1,2,3-triazole and triazolium motifs to construct anion templated supramolecular structures has grown rapidly over the past decade, enabling a range of complex structures to be synthesized, especially in areas such as foldamers, polymers, and interlocked systems.
CHEMISTRY-AN ASIAN JOURNAL
(2021)
Article
Chemistry, Physical
Sana Saffour, Amal A. AL-Sharabi, Asaf Evrim Evren, Meral Yilmaz Cankilic, Leyla Yurttas
Summary: In this study, thirteen new compounds were synthesized and evaluated for their antifungal and antimicrobial activities. One compound exhibited the best activity and selectivity against Yersinia enterocolitica. Additionally, all compounds showed good activity against filamentous fungi.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Biochemistry & Molecular Biology
Zuleyha Almaz
Summary: This study synthesized diverse 1,2,3-triazole compounds and investigated their activities in antioxidant, antibacterial, and antifungal aspects. Compound 4 exhibited the best antimicrobial activity and antioxidant activity close to the standard compounds.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Chemistry, Organic
Tomas Horsten, Flip de Jong, Dries Theunissen, Mark Van der Auweraer, Wim Dehaen
Summary: This study explored the potential of 1,2,3-triazolium salts for the formation of water-soluble chromophores. The synthesis of water-soluble 1,2,3-triazolium BOPAHY dyes was achieved by a metal-free pathway.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
M. Ihsan Han, Ufuk Ince, Miyase Gozde Gunduz, S. Guniz Kucckguzel
Summary: The discovery of new antimicrobial molecules is crucial for combating drug-resistant infections. In this research, thiosemicarbazide-triazole derivatives were synthesized and screened for their antimicrobial activities. The compounds showed moderate antimicrobial effects, with 7j demonstrating the best antibacterial activity against a Staphylococcus aureus isolate.
CHEMISTRY & BIODIVERSITY
(2022)
Article
Chemistry, Multidisciplinary
Xin-Mei Peng, Kannekanti Vijaya Kumar, Guri L. V. Damu, Cheng-He Zhou
SCIENCE CHINA-CHEMISTRY
(2016)
Article
Biochemistry & Molecular Biology
Ling Zhang, Juan-Juan Chang, Shao-Lin Zhang, Guri L. V. Damu, Rong-Xia Geng, Cheng-He Zhou
BIOORGANIC & MEDICINAL CHEMISTRY
(2013)
Article
Chemistry, Medicinal
Yan Wang, Guri L. V. Damu, Jing-Song Lv, Rong-Xia Geng, Da-Cheng Yang, Cheng-He Zhou
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2012)
Article
Chemistry, Medicinal
Shao-Lin Zhang, Juan-Juan Chang, Gun L. V. Damu, Bo Fang, Xiang-Dong Zhou, Rong-Xia Geng, Cheng-He Zhou
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2013)
Article
Chemistry, Medicinal
Sheng-Feng Cui, Yu Ren, Shao-Lin Zhang, Xin-Mei Peng, Guri L. V. Damu, Rong-Xia Geng, Cheng-He Zhou
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2013)
Article
Chemistry, Medicinal
Guri L. V. Damu, Sheng-Feng Cui, Xin-Mei Peng, Qin-Mei Wen, Gui-Xin Cai, Cheng-He Zhou
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2014)
Review
Chemistry, Organic
Lingling Dai, Shengfeng Cui, Guri L. V. Damu, Chenghe Zhou
CHINESE JOURNAL OF ORGANIC CHEMISTRY
(2013)
Article
Chemistry, Organic
Hui-Zhen Zhang, Guri L. V. Damu, Gui-Xin Cai, Cheng-He Zhou
CURRENT ORGANIC CHEMISTRY
(2014)
Article
Pharmacology & Pharmacy
Xin-Mei Peng, Guri L. V. Damu, Cheng-He Zhou
CURRENT PHARMACEUTICAL DESIGN
(2013)
Article
Chemistry, Medicinal
Hui-Zhen Zhang, Guri L. V. Damu, Gui-Xin Cai, Cheng-He Zhou
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2013)
Review
Chemistry, Medicinal
Ling Zhang, Xin-Mei Peng, Guri L. V. Damu, Rong-Xia Geng, Cheng-He Zhou
MEDICINAL RESEARCH REVIEWS
(2014)
Article
Chemistry, Multidisciplinary
Guri L. Damu, Wang QingPeng, Zhang HuiZhen, Zhang YiYi, Lv JingSong, Zhou ChengHe
SCIENCE CHINA-CHEMISTRY
(2013)
Article
Biochemistry & Molecular Biology
Shao-Lin Zhang, Juan-Juan Chang, Guri L. V. Damu, Rong-Xia Geng, Cheng-He Zhou
Article
Chemistry, Multidisciplinary
S. Maddila, G. L. V. Damu, E. O. Oseghe, O. A. Abafe, C. Venakata Rao, P. Lavanya
JOURNAL OF THE KOREAN CHEMICAL SOCIETY-DAEHAN HWAHAK HOE JEE
(2012)