Review
Clinical Neurology
Andrea Ballesio, Andrea Zagaria, Davide Gusmeo Curti, Rosalyn Moran, Peter J. Goadsby, Ivana Rosenzweig, Caterina Lombardo
Summary: The brain-derived neurotrophic factor (BDNF) is considered a transdiagnostic biomarker for mental disorders and is associated with emotional and cognitive functioning. A systematic review and meta-analysis of case-control studies were conducted to examine the levels of peripheral BDNF in individuals with insomnia. The results showed that subjects with insomnia had lower BDNF levels compared to healthy controls. However, the interpretation of the results should be cautious due to the small sample size, cross-sectional nature of the measurement, and high heterogeneity of the included data.
SLEEP MEDICINE REVIEWS
(2023)
Review
Medicine, General & Internal
Michal Piotrkowicz, Marlena Janoska-Jazdzik, Tytus Koweszko, Agata Szulc
Summary: Psychotherapy has been shown to lead to changes in brain structure and function, with BDNF identified as a potential research target. Limited studies indicate that BDNF concentration levels may increase after psychotherapy, but the impact of BDNF gene methylation status remains to be explored.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Clinical Neurology
Jessica A. Harder, Raina N. Fichorova, Akanksha Srivastava, Aleta Wiley, Katherine E. Burdick, Joseph J. Locascio, Hadine Joffe
Summary: This study found that BDNF levels are positively correlated with the severity of mood symptoms in women with perimenopausal depression symptoms, resembling the pattern seen in hormonally-sensitive PMDD. This suggests the presence of a hormonally-sensitive mood disorder biomarker profile distinct from that of major depression.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Younjung Lee, Kye-Hyun Kim, Bun-Hee Lee, Yong-Ku Kim
Summary: The study found that pregnancy and postpartum depression can affect BDNF concentration, and the BDNF concentration in the postpartum depression-recovery group significantly increased at 6 weeks postpartum.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Review
Biology
Massimo Fioranelli, Maria Grazia Roccia, Bianca Przybylek, Maria Luisa Garo
Summary: This systematic review examines the bidirectional relationship between cardiovascular disease (CVD) and depression, with a focus on the potential role of low serum BDNF levels in the development of either disease in the presence of the other. The results suggest a strong association between low serum BDNF levels and the risk of post-stroke depression, but there is limited research on altered serum BDNF levels and other types of CVD, therefore the inverse association between depression and CVD cannot be proven.
Review
Biochemistry & Molecular Biology
Anna Mosiolek, Magdalena Pietrzak, Maria Tabisz, Wiktoria Wojtaszek, Michalina Zabielska, Agnieszka Ostrowska, Pawel Szwed, Jadwiga Mosiolek, Agata Szulc
Summary: This systematic review evaluates the effect of broadly defined cognitive behavioral therapy (CBT) on the levels of brain-derived neurotrophic factor (BDNF) in psychiatric patients. Ten randomized-controlled trials were included, and the results suggest that BDNF levels may be considered as an indicator of cognitive function outcomes in psychotherapy, but no correlation was observed for mindfulness-based practices aimed at reducing stress or improving quality of life.
Review
Neurosciences
Gianmarco De Felice, Mario Luciano, Alessia Boiano, Giulia Colangelo, Pierluigi Catapano, Bianca Della Rocca, Maria Vita Lapadula, Elena Piegari, Claudia Toni, Andrea Fiorillo
Summary: This review examines the role of brain-derived neurotrophic factor (BDNF) in bipolar disorder (BD) and investigates its potential as a biomarker for BD. The results show a decrease in circulating levels of BDNF during acute phases of BD compared to healthy controls, which increase after effective therapy. The Val66Met polymorphism is associated with features typically linked to worse outcomes. While more research is needed, BDNF appears to be a promising biomarker for BD.
Article
Biochemistry & Molecular Biology
Elena Chiavacci, Sara Bagnoli, Alessandro Cellerino, Eva Terzibasi Tozzini
Summary: Neurotrophins play a crucial role in the differentiation, survival, neurite outgrowth, and plasticity of neurons. Abnormal neurotrophin-signaling is associated with neuropathies, neurodegenerative disorders, and age-related cognitive decline. BDNF is the most highly expressed neurotrophin in the brain, particularly in the hippocampus and cerebral cortex.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
L. M. C. Puhlmann, R. Linz, S. L. Valk, P. Vrticka, R. Vos de Wael, A. Bernasconi, N. Bernasconi, B. Caldairou, I Papassotiriou, G. P. Chrousos, B. C. Bernhardt, T. Singer, V Engert
Summary: The study found no significant relationship between serum BDNF levels and hippocampal structure volumes in healthy middle-aged adults, and age does not moderate this relationship.
Article
Biochemistry & Molecular Biology
Ivana Vecurkovska, Jana Maslankova, Vladimira Tomeckova, Jana Kat'uchova, Terezia Kiskova, Lucia Frohlichova, Maria Marekova, Marek Stupak
Summary: The determination of the tissue BDNF/MMP-9 ratio can be used as a prognostic biomarker for colorectal cancer. This ratio significantly decreases with the progression of the disease in living patients, but shows an opposite trend in deceased individuals. Lower BDNF/MMP-9 ratio levels may predict favorable prognosis in patients.
Article
Biochemistry & Molecular Biology
Alexandros Tsimpolis, Maria Kokkali, Aris Logothetis, Konstantinos Kalafatakis, Ioannis Charalampopoulos
Summary: Novel research studies have discovered complex interactions between glucocorticoid hormones and brain-derived neurotrophic factor, regulating crucial physiological processes in neuronal cells. This study investigated the acute effects of glucocorticoid stimulation on gene expression of BDNF and TrkB in astrocytes, revealing a biphasic response characterized by an initial rapid upregulation and subsequent downregulation of BDNF mRNA under the influence of glucocorticoid receptors. These findings demonstrate a rhythmic regulation of the neurotrophin system based on glucocorticoid levels, indicating the intricate trophic responses to temporal hormonal mechanisms in the brain microenvironment.
Article
Biochemistry & Molecular Biology
Maria S. Gavrish, Mark D. Urazov, Tatiana A. Mishchenko, Victoria D. Turubanova, Ekaterina A. Epifanova, Victoria G. Krut', Alexey A. Babaev, Maria V. Vedunova, Elena Mitroshina
Summary: The role of neurotrophic factors BDNF and GDNF in maintaining brain resistance to hypoxia and promoting recovery of neural networks is being actively studied. This study aimed to evaluate the effects of overexpressing BDNF and GDNF using viral vectors in modeling hypoxia. The results showed increased survival rate of mice under hypoxic conditions, indicating that overexpression of neurotrophic factors may be a potential neuroprotection method.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
David Azoulay, Mira Naamad, Dafna Frydman, Ellen Broide, Ari Zimran, Galia Stemer, Shoshana Revel-Vilk
Summary: This study investigated the relationship between BDNF levels and platelet activity and bleeding tendency in patients with Gaucher disease. The results showed that serum BDNF levels were positively correlated with platelet count and moderately correlated with platelet P-selectin expression. Patients with multiple bleeding manifestations had lower serum BDNF levels. Splenectomized patients had significantly elevated plasma BDNF levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
David Gustafsson, Andrea Klang, Sebastian Thams, Elham Rostami
Summary: BDNF plays a crucial role in neural repair and regeneration, making it a focus of TBI research. Studies have shown varied effects on BDNF expression based on different experimental setups and interventions. Clinical research emphasizes the significance of BDNF polymorphism in outcomes, highlighting its protective role.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Rheumatology
Cristina Iannuccelli, Bruno Lucchino, Chiara Gioia, Giulio Dolcini, Jole Rabasco, Teresa Venditto, Francesco Ioppolo, Valter Santilli, Fabrizio Conti, Manuela Di Franco
Summary: This study evaluated the influence of gender on the clinical manifestations of fibromyalgia and investigated BDNF serum levels as a potential biomarker. The results showed that women with fibromyalgia had more prominent pain, fatigue, and other common symptoms, while men were more likely to have neuropsychiatric symptoms. BDNF levels showed good accuracy in distinguishing fibromyalgia patients from healthy controls.
CLINICAL RHEUMATOLOGY
(2022)