Article
Materials Science, Ceramics
Liang Zhou, Yulin Zhang, Defu Zeng, Ting Shu, Shi Wang
Summary: Mesoporous poly-N-isopropylacrylamide-hydroxyapatite composite microspheres (PNIPAM-m-HAP) were synthesized in this study, showing biocompatibility, pH and thermo-responsiveness, which can effectively control the release of doxorubicin.
JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Nicolas Jackson, Andrea C. C. Ortiz, Alejandro Jerez, Javier Morales, Francisco Arriagada
Summary: Stimuli-responsive nanomaterials have been studied as a promising strategy for anticancer therapy, with pH-responsive silica nanocarriers being particularly effective in controlled drug delivery in acidic tumor microenvironments. The design of the nanocarrier and drug release mechanisms play a crucial role in optimizing efficacy, and this study provides new insights into the behavior of a hydrophobic drug released from a pH-sensitive nanosystem.
Article
Pharmacology & Pharmacy
Noyel Ghosh, Mousumi Kundu, Sumit Ghosh, Abhishek Kumar Das, Samhita De, Joydeep Das, Parames C. Sil
Summary: Cancer is a global disease and the use of phytochemicals with inherent anticancer efficacy is important. Nanotechnology is essential to enhance the bioavailability and therapeutic efficacy of these phytochemicals. In this study, folic acid conjugated polyacrylic acid capped mesoporous silica nanoparticles were used for targeted delivery of chrysin to breast cancer cells. Chrysin loaded nanoparticles showed increased cytotoxicity and induced apoptosis in the cancer cells. Furthermore, in tumor-bearing mice, the nanoparticles enhanced the anti-neoplastic effects of chrysin. This study highlights the potential of chrysin and the importance of nanotechnology in biomedical research.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Mengru Chen, Yunyun Chen, Yanbao Zhao, Xueyan Zou, Lei Sun
Summary: In this study, three types of mesoporous silica nanoparticles with different aspect ratios were prepared. The samples showed that aspect ratio affects specific surface area, cell uptake rate, and drug loading capacity. The MS3 sample, with higher cell uptake rate and specific surface area, was used as a carrier for drug delivery system, displaying redox/pH-responsive and sustained release behavior.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Oncology
Ran Li, Ruifang Gao, Yingjiao Zhao, Fang Zhang, Xiangyu Wang, Bing Li, Lu Wang, Lixin Ma, Jie Du
Summary: Oral squamous cell carcinoma (OSCC) is the most common type of cancer in the oral and maxillofacial regions, but its treatment remains challenging. In this study, a GRPR-targeted nano-graphene oxide (NGO) nanoprobe drug delivery system was developed to improve the treatment of OSCC.
FRONTIERS IN ONCOLOGY
(2022)
Article
Chemistry, Analytical
Ziqi Li, Weimin Wan, Ziwei Bai, Bo Peng, Xi Wang, Liu Cui, Zhaoyun Liu, Kui Lin, Jian Yang, Jia Hao, Fei Tian
Summary: Currently, developing responsive hydrophobic drug delivery systems centered on magnetic nanoparticles is a promising approach for efficient drug delivery to living cells. In this study, a pH-responsive nanoplatform for targeted hydrophobic drug delivery was successfully constructed using a SET-LRP method. The nanoplatform showed high biocompatibility and low cytotoxicity, and exhibited pH-responsive release behaviors under different pH values. Furthermore, it effectively targeted and inhibited the growth of HepG2 cells, and allowed for continuous intracellular imaging. These findings represent a significant advancement in the field of clinical hydrophobic drug delivery platforms.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Oncology
Jian Song, Bingbing Xu, Hui Yao, Xiaofang Lu, Yang Tan, Bingyang Wang, Xing Wang, Zheng Yang
Summary: The study demonstrated a pH-responsive PEGylated doxorubicin prodrug that could achieve high drug loading and pH-responsive drug release within tumor cells, with good stability. Furthermore, the nanoparticles showed similar cytotoxicity to MCF-7 tumor cells as free DOX drug, and were able to encapsulate small DOX drugs with enhanced therapeutic effects.
FRONTIERS IN ONCOLOGY
(2021)
Article
Engineering, Environmental
Yingjian Ma, Yinmin Wang, Rui Zhao, Zhijie Wang, Shuang Li, Meng Yu, Sen Pang, Xinyu Guo, Yong Xu, Xuemin Wu
Summary: Using advanced functional materials and technologies to construct new, efficient, and controlled-release pesticide formulations can effectively improve the target utilization of pesticides and reduce their impact on nontarget organisms and the surrounding environment. The study presents a strategy for preparing pH-responsive nanodrug delivery systems that can release pesticides rapidly in acidic environments. The results show that the nanodrug delivery system has longer-lasting fungicidal activity and lower impact on non-target organisms and the environment. Moreover, it can provide trace elements required by plants to promote crop growth without disturbing normal growth.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2023)
Article
Chemistry, Multidisciplinary
Enhui Liang, Zhihao Guo, Zhuang Hu, Zhangpei Chen, Aikebaier Reheman, Jiwei Wang, Jianshe Hu
Summary: The tailor-made polycarbonate-doxorubicin conjugate self-assembles into nanoparticles with high drug loading and pH-dependent drug release, showing potential for safe and effective drug delivery. These expandable nanoparticles exhibit good stability, avoid early drug leakage, and demonstrate significant inhibition of tumor cells.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Xinyuan Zhou, Anwei Zhou, Zihan Tian, Weiwei Chen, Yurui Xu, Xinghai Ning, Kerong Chen
Summary: In this study, a smart nanorobot named Zinger was developed for enhancing zinc-promoted photodynamic therapy (PDT). The nanorobot selectively triggered intracellular zinc overload and photodynamic effect in cancer cells, enhancing the treatment outcomes. It also showed high efficacy in overcoming various treatment barriers and effectively killing cancer cells in complex circumstances.
Article
Polymer Science
Ngoc-Hang Truong-Thi, Ngoc Hoi Nguyen, Dinh Tien Dung Nguyen, Tuan Ngan Tang, Thi Hiep Nguyen, Dai Hai Nguyen
Summary: In this study, a drug delivery system based on mesoporous silica nanoparticles modified with heparin was fabricated to achieve sustainable and pH-responsive release of Platinum-based drugs. The modified nanoparticles showed high uniform spherical shape with a diameter of 89.03 +/- 4.49 nm, and had a loading capacity of cisplatin twice as the bare nanoparticles. The amount of drug released in tumor microenvironment (pH 5.8) was significantly higher than that released in physiological environment (pH 7.4). Cell toxicity assay confirmed the biocompatibility of the modified nanoparticles on MCF-7 cells. These results suggest that the heparin-modified nanoparticles have great potential as nanocarriers for chemotherapy with effectively loading ability and sustained release of Platinum-based drugs with pH response.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Biotechnology & Applied Microbiology
Mingyue Jiang, Le Chen, Bo Chen, Qinghua Yu, Xianming Zhang, Weihong Jing, Limei Ma, Tao Deng, Zhangyou Yang, Chao Yu
Summary: In this study, a novel type of polymeric micelles with intracellular K+-responsive controlled-release properties for curcumin (CUR) delivery was designed and developed. These polymeric micelles showed significant CUR release in simulated intracellular fluid in response to the intracellular K+ concentration, leading to high cellular uptake and excellent intracellular drug release. The findings provide a new strategy for designing targeted drug delivery systems for CUR delivery in cancer treatment.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Jialang Zhuang, Siqi Chen, Ye Hu, Fan Yang, Qin Huo, Ni Xie
Summary: The study developed tumor-targeted and redox-responsive mesoporous silica nanoparticles (MSNs) for the co-delivery of Doxorubicin and siTIE2 to improve the treatment of metastatic breast cancer. The controlled release of drugs within cells was achieved through redox-sensitive disulfide bonds, resulting in enhanced therapeutic effects in vitro and in vivo, including lower IC50 values and improved anti-tumor and anti-metastatic effects.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Engineering, Biomedical
Haidi Guan, Zhongwei Xu, Qinghua Liu, Qianshan Tan, Yihui Chen, Shuaishuai Chen, Jingfeng Wu, Fengchao Wang, Jixi Zhang, Lihua Sun, Weidong Xiao
Summary: Repurposing clinically approved drugs to construct novel nanomedicines is an attractive therapeutic approach, especially in the treatment of inflammatory bowel disease (IBD). This study developed a pH-responsive nanomedicine based on mesoporous polydopamine nanoparticles (MPDA NPs) for the selective enrichment of anti-inflammatory drugs and reactive oxygen species (ROS) scavenging at the site of inflammation. The nanomedicine (PAA@MPDA-SAP NPs) showed efficient drug loading of sulfasalazine (SAP) and demonstrated excellent biocompatibility and anti-inflammatory repair ability in in vitro and in vivo experiments. Overall, this work provides a theoretical basis for the development of nanomedicines for IBD therapy.
MATERIALS TODAY BIO
(2023)
Review
Chemistry, Multidisciplinary
Yuzhe Sun, Edward Davis
Summary: The translation mentioned that achieving the promise of stimuli-responsive drug delivery systems for cancer treatment involves challenges like avoiding premature clearance, accumulating in tumors, and exhibiting appropriate payload release. However, the expanding toolbox of design tools from proof-of-concept studies each year helps address these requirements. Recent advances in targeting and stimuli-responsiveness, as well as challenges and potential solutions are discussed to assist researchers in overcoming interdisciplinary knowledge barriers and speeding up development in cancer therapy.
Article
Engineering, Environmental
Shuaihang Zhu, Zhiwei Lei, Yuejie Dou, Ching-Wen Lou, Jia-Horng Lin, Jiwei Li
Summary: Solar desalination is a green energy process for water treatment. This study developed a self-floating fabric evaporator with excellent photothermal properties and antibacterial performance, showing promising potential for water purification.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Virology
Jiwei Li, Xiangmin Zhang, Bowen Bai, Mengmeng Zhang, Weiwei Ma, Yuezhi Lin, Xiaojun Wang, Xue-Feng Wang
Summary: Nuclear export of viral transcripts is regulated by a post-transcriptional transactivator, Rev, shared by all lentiviruses. EIAV encodes a novel viral protein, Grev, which mediates the expression of the viral protein Mat by binding to the first exon of mat mRNAs via the CRM1 pathway. Grev and Rev have similar functions but also exhibit distinct differences in their regulatory mechanisms.
JOURNAL OF VIROLOGY
(2022)
Review
Materials Science, Multidisciplinary
Jiwei Li, Yujie Feng, Weichao Chen, Shaohua Zhang, Jianwei Ma, Shaojuan Chen, Shangpeng Liu, Chengbo Cao, Yuankai Zhang
Summary: This review focuses on the structural design and antibacterial mechanisms of electroactive materials, including electrochemical materials, conductive materials, piezoelectric materials, and micro-batteries/galvanic couples. It also describes the biomedical applications of electroactive antibacterial materials in various areas such as bone tissue engineering, wound healing, medical catheters, oral healthcare, and wearable devices. The future challenges and perspectives associated with electroactive antibacterial materials are discussed. In summary, electroactive materials offer a promising platform for fighting bacterial infections and play a crucial role in the field of biomedicine.
PROGRESS IN MATERIALS SCIENCE
(2023)
Article
Multidisciplinary Sciences
Tao Xue, Mingkun Tong, Jiajianghui Li, Ruohan Wang, Tianjia Guan, Jiwei Li, Pengfei Li, Hengyi Liu, Hong Lu, Yanshun Li, Tong Zhu
Summary: Gestational exposure to ambient fine particles (PM2.5) increases the risk of stillbirth, particularly in low- and middle-income countries. Through combining state-of-the-art estimates on stillbirths and multiple exposure-response functions, the authors evaluated the burden of PM2.5-related stillbirths in 137 countries.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Applied
Yanhui Kong, Wenjing Zhang, Tian He, Xue Yang, Wanghua Bi, Jiwei Li, Wenzhe Yang, Weichao Chen
Summary: In this study, a bilayered asymmetric nanofibrous membrane was prepared, with a hydrophilic chitosan/chitosan oligosaccharide (COS) nanofibrous membrane as the bottom layer and a hydrophobic polycaprolactone (PCL) nanofibrous membrane as the top layer. Results showed that incorporating COS improved the wettability of the CS membrane and increased the antibacterial effects against Escherichia coli and Staphylococcus aureus. The PCL layer prevented water and bacteria adhesion. This wettable membrane has the potential to serve as a new antibacterial dressing for wound healing.
CARBOHYDRATE POLYMERS
(2023)
Article
Biophysics
Na Yi, Mengyue Wang, Li Song, Fan Feng, Jiwei Li, Ruyi Xie, Zhihui Zhao, Weichao Chen
Summary: In this study, a high-performance calcium alginate/carbon polymer dots/forsythin (CA/CPDs/FT) composite nanofibrous membrane was developed for the preparation of biological dressings with antibacterial and antioxidant properties. The addition of carbon polymer dots improved the nanofiber morphology and mechanical strength of the membrane. The CA/CPDs/FT membrane exhibited satisfactory antibacterial and antioxidant properties due to the natural characteristics of forsythin. Furthermore, the composite membrane had excellent hygroscopicity exceeding 700%. In vitro and in vivo experiments demonstrated that the CA/CPDs/FT nanofibrous membrane effectively prevented bacterial invasion, scavenged free radicals, and promoted wound healing. Its good hygroscopicity and antioxidation characteristics are beneficial for the clinical application of high-exudate wounds.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Astronomy & Astrophysics
Jiwei Li, Liangliang Su, Lei Wu, Bin Zhu
Summary: In this work, ionization signals are considered as an important approach for detecting light dark matter, specifically focusing on sub-GeV inelastic dark matter. The study utilizes non-relativistic effective field theory to derive constraints on the spin-dependent DM-electron scattering and DM-nucleus Migdal scattering. The results suggest that the exclusion limits of DM-proton/neutron and DM-electron scattering cross sections are much stronger for exothermic inelastic dark matter than for endothermic inelastic dark matter.
JOURNAL OF COSMOLOGY AND ASTROPARTICLE PHYSICS
(2023)
Review
Nanoscience & Nanotechnology
Shaohua Zhang, Na Wang, Qian Zhang, Renzheng Guan, Zhenghai Qu, Lirong Sun, Jiwei Li
Summary: This review introduces the applications of electroactive materials in antiviral face masks. It first discusses the mechanisms for preventing viral infection or inactivating viruses by electroactive materials, and then describes in detail the use of static, conductive, triboelectric, and microbattery-based materials in masks. Finally, it summarizes the problems of various electroactive antiviral materials and discusses the prospects for their future development.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Construction & Building Technology
Debo Zhao, Jiewei Zhang, Zenghui Ye, Jianbo Fei, Jiwei Li
Summary: In this study, the tensile behaviors of LRS-FRP laminates were investigated through quasi-static tests at different scales and high-speed tests at varying strain rates. The results showed that size effect and resin matrix had significant influences on the tensile behaviors. The strain rate effects on the strength were analyzed, and empirical formulas and a constitutive model were established for LRS-FRP.
CONSTRUCTION AND BUILDING MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Ling Li, Qian Zhao, Fan Feng, Chenglin Li, Tiantian Wang, Weichao Chen, Xiaochuan Ren, Yuesheng Huang, Jiwei Li
Summary: This study developed a Janus dressing (TPU/Cotton) by directly electrospinning thermoplastic polyurethane (TPU) nanofiber on cotton microfibers, which can drain excess exudate unidirectionally. Ag/Zn dot electrodes were deposited on the TPU layer to produce an electric field that penetrates the wound when activated by wound exudate. Hydro-activated Ag/Zn's electrical stimulation (ES) promotes fibroblast cell migration and exhibits strong antibacterial activity. In vivo experiments showed that exudate management coupled with ES accelerates wound healing by promoting re-epithelization, collagen deposition, and vascularization. Additionally, the Ag/Zn@TPU/Cotton dressing demonstrates excellent biocompatibility in vitro cytotoxicity experiments. This research provides insights for developing next-generation wound dressings with self-activated electrical stimulation and exudate management.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Article
Chemistry, Multidisciplinary
Liguo Yang, Chenglin Li, Xuefang Wang, Xiangyan Zhang, Yongxin Li, Shangpeng Liu, Jiwei Li
Summary: Developing functional dressings that promote cellular activities and monitor healing progress is gaining attention. Ag/Zn electrodes were deposited on a PLA nanofibrous membrane, generating electric stimulation (ES) when wetted by wound exudate. The dressing showed antibacterial activity and promoted wound healing through electrostatic effect and metal ion release. Additionally, an integrated sensor monitored wound temperature in real-time. This work suggests a new strategy for designing functional wound dressings.
Article
Computer Science, Artificial Intelligence
Xiaofei Sun, Yuxian Meng, Xiang Ao, Fei Wu, Tianwei Zhang, Jiwei Li, Chun Fan
Summary: This study proposes a new framework to address two challenges in measuring sentence similarity. The framework is based on the core idea that the meaning of a sentence should be defined by its contexts and measures sentence similarity by comparing the probabilities of generating two sentences given the same context. Experimental results show significant performance improvements over existing baselines in both supervised and unsupervised settings.
TRANSACTIONS OF THE ASSOCIATION FOR COMPUTATIONAL LINGUISTICS
(2022)
Proceedings Paper
Computer Science, Artificial Intelligence
Leilei Gan, Jiwei Li, Tianwei Zhang, Xiaoya Li, Yuxian Meng, Fei Wu, Yi Yang, Shangwei Guo, Chun Fan
Summary: This paper investigates a new strategy in textual backdoor attacks that does not require an external trigger and ensures correctly labeled poisoned samples. The proposed approach utilizes a sentence generation model based on genetic algorithm to generate poisoned clean-labeled examples, and extensive experiments demonstrate its effectiveness and the difficulty of defense due to its triggerless and clean-labeled nature.
NAACL 2022: THE 2022 CONFERENCE OF THE NORTH AMERICAN CHAPTER OF THE ASSOCIATION FOR COMPUTATIONAL LINGUISTICS: HUMAN LANGUAGE TECHNOLOGIES
(2022)
Proceedings Paper
Computer Science, Artificial Intelligence
Yuxian Meng, Xiaoya Li, Xiayu Zheng, Fei Wu, Xiaofei Sun, Tianwei Zhang, Jiwei Li
Summary: This paper presents Fast kNN-MT, a machine translation approach that improves decoding efficiency by constructing a smaller data store, enabling practical use of kNN-MT systems in real-world applications.
FINDINGS OF THE ASSOCIATION FOR COMPUTATIONAL LINGUISTICS (ACL 2022)
(2022)
Proceedings Paper
Computer Science, Artificial Intelligence
Minghuan Tan, Yong Dai, Duyu Tang, Zhangyin Feng, Guoping Huang, Jing Jiang, Jiwei Li, Shuming Shi
Summary: In this study, researchers explore the use of Chinese GPT for improving pinyin input methods. They find that a frozen GPT achieves state-of-the-art performance on perfect pinyin, but the performance drops significantly when dealing with abbreviated pinyin. To address this issue, they propose two strategies and create a dataset for evaluation. The results demonstrate that their approach improves the performance on abbreviated pinyin across various domains.
PROCEEDINGS OF THE 60TH ANNUAL MEETING OF THE ASSOCIATION FOR COMPUTATIONAL LINGUISTICS (ACL 2022), VOL 1: (LONG PAPERS)
(2022)
