☆ 4.8 Article

Long-Acting Integrase Inhibitor Protects Macaques from Intrarectal Simian/Human Immunodeficiency Virus

SCIENCE (2014)

期刊

SCIENCE

卷 343, 期 6175, 页码 1151-1154

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AMER ASSOC ADVANCEMENT SCIENCE

DOI: 10.1126/science.1248707

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Multidisciplinary Sciences

资金

NIH [R0-AI100724, 1DP1-DA033263]
Tulane National Primate Research Center [2P51-OD11104-52]

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GSK1265744 (GSK744) is an integrase strand-transfer inhibitor that has been formulated as a long-acting (LA) injectable suitable for monthly to quarterly clinical administration. GSK744 LA was administered at two time points 4 weeks apart beginning 1 week before virus administration, and macaques were challenged weekly for 8 weeks. GSK744 LA, at plasma concentrations achievable with quarterly injections in humans, protected all animals against repeated low-dose challenges. In a second experiment, macaques were given GSK744 LA 1 week before virus administration and challenged repeatedly until infection occurred. Protection decreased over time and correlated with the plasma drug levels. With a quarterly dosing schedule in humans, our results suggest that GSK744 LA could potentially decrease adherence problems associated with daily preexposure prophylaxis (PrEP).

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