Article
Obstetrics & Gynecology
Alice Goisis, Maria Palma
Summary: The study found that parent-child relationships in families with adolescents born after medically assisted reproduction (MAR) using the parents' own gametes were similar to those in families with adolescents born after natural conception (NC). The only difference observed was that MAR mothers reported being closer to their children than NC mothers.
HUMAN REPRODUCTION
(2021)
Article
Cell Biology
Juan Ge, Congyang Li, Hongzheng Sun, Yongan Xin, Shuai Zhu, Yuan Liu, Shoubin Tang, Longsen Han, Zhenyue Huang, Qiang Wang
Summary: Maternal obesity leads to telomere shortening and defective telomeres in oocytes and early embryos, which in turn affects the development of embryos.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Yuriy Pichugin, Arne Traulsen
Summary: Multiple modes of asexual reproduction are observed in microbial organisms, and the transition between these modes, such as from unicellularity to multicellularity, can directly affect population growth rates. Mass conservation can limit the number of possible reproduction modes, while the interplay between cell shape and growth kinetics explains the characteristics of cell size and shape, as well as the evolution of reproductive strategies in multicellular species.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Biochemistry & Molecular Biology
Eugenia D. Namiot, Aleksandr Sokolov, Vladimir N. Chubarev, Vadim V. Tarasov, Helgi B. Schioth
Summary: Nanoparticles, particularly lipid-based ones, have played a crucial role in the development and manufacturing of the Pfizer and Moderna COVID-19 vaccines. They offer advantages such as reduced toxicity and increased bioavailability, and can be modified for specific tissues or cells. The number of clinical trials using nanoparticles for drug delivery is growing rapidly due to advancements in nanotechnology, biotechnology, and medicine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Reproductive Biology
Pierre Comizzoli, Olga Amelkina, Daniela R. Chavez, Tricia R. Rowlison, Pei-Chih Lee
Summary: In addition to companion animals and laboratory species, approximately 270 carnivore species play vital ecological roles in various ecosystems. However, the majority of these species are now threatened or endangered in the wild due to human activities. Protecting their natural habitats is crucial, but understanding carnivore reproduction, particularly in terms of sperm, oocyte, and embryo biology, is equally important for maintaining sustainable populations and conservation efforts. This review aims to provide the latest knowledge on the biology of sperm cells, oocytes, and early embryos across all carnivore families, highlighting the need for further research and the development of conservation strategies.
Article
Obstetrics & Gynecology
Alan Penzias, Ricardo Azziz, Kristin Bendikson, Marcelle I. Cedars, Tommaso Falcone, Karl Hansen, Micah Hill, Sangita Jin-dal, Suleena Kalra, Jennifer Mersereau, Richard Reindollar, Chevis N. Shannon, Anne Steiner, Cigdem Tanrikut, Hugh Taylor, Belinda Yauger
Summary: Based on data from the American Society for Reproductive Medicine and the Society for Assisted Reproductive Technology, the guidelines for the limits on the number of embryos to be transferred during in vitro fertilization cycles have been further refined by the American Society for Reproductive Medicine, aiming to promote singleton gestation and reduce the number of multiple pregnancies.
FERTILITY AND STERILITY
(2021)
Article
Parasitology
Emmanuel Pacia Hernandez, Kei Shimazaki, Hiroko Niihara, Rika Umemiya-Shirafuji, Kozo Fujisaki, Tetsuya Tanaka
Summary: Despite the absence of a blood meal, iron is transferred maternally through iron transport molecules like secreted ferritin (FER2) during embryogenesis. In this study, we tracked the movement of FER2 using indirect immunofluorescence and observed a shift from the germ layer to the appendages during late embryogenesis. Additionally, FER2 was found in the middle part of the legs of the embryo, providing insights into both iron processing events and organogenesis in ticks.
PARASITES & VECTORS
(2023)
Review
Biochemistry & Molecular Biology
Ha Yeong Choi, Ji-Eun Chang
Summary: The development of targeted therapies has revolutionized cancer treatment, offering improved efficacy with reduced side effects. This review focuses on targeted therapy in lung cancer, colorectal cancer, and prostate cancer, highlighting key molecular targets and FDA-approved drugs. Mutations in EGFR and ALK genes are significant targets in lung cancer, with drugs like osimertinib and crizotinib inhibiting these pathways. For colorectal cancer, targeting VEGF and EGFR with drugs like bevacizumab and cetuximab significantly improves outcomes. AR targeting with drugs like enzalutamide, apalutamide, and darolutamide is pivotal in prostate cancer. The review also discusses promising targets like MET, ROS1, BRAF, and PARP, along with ongoing clinical trials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Leigh M. Vanderloo, Shelley M. Vanderhout, Erika Tavares, Jonathon Maguire, Sharon Straus, Catherine S. Birken
Summary: Collaborating with parents in research design and implementation can provide valuable feedback and support, leading to improvements in research methods and quality. This approach of involving parents in research design is crucial for enhancing parent engagement, improving the relevance and acceptability of the study.
Review
Oncology
Shigeto Nishikawa, Tomoo Iwakuma
Summary: Mutations in the tumor suppressor p53 occur in about 50% of human cancers, leading to impaired tumor suppressive function and oncogenic activities of mutant p53. Various approaches, including restoration of wild-type p53 conformation, rescue of p53 nonsense mutations, depletion of mutant p53 proteins, and induction of p53 synthetic lethality or targeting of vulnerabilities imposed by p53 mutations, have been used to target p53 mutations in the development of cancer therapies. This review article summarizes the mechanisms of action and activities of clinically available FDA-approved drugs and drugs in clinical trials that target p53 mutations for suppressing cancer progression.
Article
Geography
Josie Hamper, Manuela Perrotta
Summary: New biomedical imaging technologies have opened up new possibilities for assisted reproduction by allowing embryologists to observe the development of human embryos. This article critically examines the impact of encounters with embryo imagery on the relationships between people and reproductive bioinformation, and advances geographical approaches to understanding assisted reproductive technologies and their visual representations.
SOCIAL & CULTURAL GEOGRAPHY
(2023)
Article
Endocrinology & Metabolism
Wang-Yu Cai, Xi Luo, Erxidi Chen, Houyi Lv, Kaiyou Fu, Xiao-Ke Wu, Jian Xu
Summary: Serum lipid levels are associated with treatment outcomes in women undergoing assisted reproduction. Higher levels of HDL-C are related to more oocytes retrieved, while lower levels of TC, LDL-C, and TG are independently predictive of clinical pregnancy.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Reproductive Biology
R. H. F. Hunter, F. Lopez-Gatius
Summary: Rowson's research has had a significant impact in farm animal research, with his contributions to reproduction remaining important worldwide. His studies enabled the widespread application of artificial insemination and non-surgical embryo transfer techniques, providing a major boost to the breeding industry.
Article
Biochemistry & Molecular Biology
Hyo-Gu Kang, Sanghoon Lee, Pil-Soo Jeong, Min Ju Kim, Soo-Hyun Park, Ye Eun Joo, Sung Hyun Park, Bong-Seok Song, Sun-Uk Kim, Min Kyu Kim, Bo-Woong Sim
Summary: The study found that supplementation of 0.1 μM lycopene enhanced embryonic development in pigs by regulating oxidative stress and mitochondria-dependent apoptosis.
Review
Health Care Sciences & Services
Tatiane Bomfim Ribeiro, Charles L. Bennett, Luis Enrique Colunga-Lozano, Ana Paula Vieira Araujo, Iztok Hozo, Benjamin Djulbegovic
Summary: This study aimed to analyze the characteristics of single-arm trials (SAT), evaluate the transparency in presenting historical control by the FDA, and assess confirmatory randomized controlled trials (RCTs). The findings showed that 47% of FDA-AA approvals were based on SAT, with 52% of treatments converting into regular approval and 46% based on confirmatory RCTs using overall survival (OS) as an outcome. Improved transparency in reporting historical controls is necessary.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2023)