Article
Oncology
Ajay Bansal, Robert Montgomery, Eduardo Vilar
Summary: The CAPP2 study investigators reported on the long-term effects of resistant starch (RS) on the incidence of colorectal cancer and other Lynch syndrome-related tumors. The study found that RS had no effect on colorectal cancer incidence, but it reduced the numbers of other Lynch syndrome-related tumors, mainly upper gastrointestinal cancers. Despite limitations in the secondary analysis, the study filled an important gap in the field of cancer interception in non-colorectal Lynch syndrome-related tumors and should serve as the basis for future RS trials in Lynch syndrome.
CANCER PREVENTION RESEARCH
(2022)
Review
Clinical Neurology
Bastiaan R. Bloem, Erik Post, Deborah A. Hall
Summary: The Rune Labs Kinematics System, a smartwatch-based monitoring system, has been cleared by the FDA to remotely track motor impairments in Parkinson's disease. While this new digital approach shows promise, further validation studies are needed to determine its clinical significance and use in research.
ANNALS OF NEUROLOGY
(2023)
Review
Food Science & Technology
Yue Zhang, Miao Zeng, Xiaolu Zhang, Qun Yu, Wenyun Zeng, Bin Yu, Jiali Gan, Shiwu Zhang, Xijuan Jiang
Summary: Apples and their products have beneficial effects on human health due to their high phytochemical content. They can protect against cardiovascular diseases, cancer, mild cognitive impairment, and promote hair growth, healing of burn wounds, improve oral health, prevent niacin-induced skin flushing, relieve UV-induced skin pigmentation, and improve symptoms of atopic dermatitis and cedar hay fever among others.
FOOD SCIENCE & NUTRITION
(2023)
Article
Communication
Robin L. Nabi, Stefanie Demetriades, Nathan Walter, Li Qi
Summary: This research replicated initial studies on media prescriptions and explored the process through which the effect of reducing perceived stress might emerge. Findings showed that exposure to positively-valenced media generated amusement and hope, which led to a reduction in perceived stress over time. The research highlights the potential of media as a useful coping tool, especially during stressful times.
HEALTH COMMUNICATION
(2023)
Review
Pharmacology & Pharmacy
David G. Menter, Robert S. Bresalier
Summary: Chemoprevention refers to the use of natural or synthetic agents to reverse, suppress, or prevent the progression or recurrence of cancer. Aspirin has shown potential in preventing precursor lesions and cancers, although most clinical data are inferential. The biological targets of aspirin include cyclooxygenases, with newly recognized molecular and cellular interactions suggesting additional modifiable functional targets. This review focuses on pharmacological developments and innovations in biopharmacology for a better understanding of aspirin's role in cancer chemoprevention.
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY
(2023)
Review
Dentistry, Oral Surgery & Medicine
Jonathan Deng, Vaidehi Misra, Neehal Vilash, Wendi Wu, Cindy Hua, Kate Son, Federica Canfora, Fabian Y. S. Kong, Rita Paolini, Michael Mccullough, Antonio Celentano
Summary: This article reviews the evidence on the anticancer effects of coffee constituents and discusses their potential therapeutic use for oral squamous cell carcinoma (OSCC). The results indicate that coffee constituents have positive effects on inhibiting cancer cell proliferation and influencing apoptotic mechanisms. However, there is currently a lack of literature on the specific utilization of coffee constituents for the treatment of oral cancers.
JOURNAL OF ORAL PATHOLOGY & MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Eduard Tiganescu, Markus Alexander Laemmermann, Yannick Ney, Ahmad Yaman Abdin, Muhammad Jawad Nasim, Claus Jacob
Summary: Reactive sulfur species (RSS) play important roles in the biological activities and health benefits in animals and humans. Volatile sulfur compounds (VSCs), as a type of organic sulfur compounds (OSCs), have different functions in various organisms.
Review
Medicine, General & Internal
Navya Sakhamuri, Sreekartthik Athiyaman, Bhawna Randhi, Sai Dheeraj Gutlapalli, Jingxiong Pu, Maheen F. Zaidi, Maithily Patel, Lakshmi Malvika Atluri, Natalie A. Gonzalez, Michael Alfonso
Summary: Heart failure is a clinical syndrome caused by the deterioration of ventricular function. It is a major cause of hospitalization and poses a significant health and economic burden. The inhibition of the neprilysin enzyme and activation of the natriuretic peptide system can effectively prevent cardiac remodeling and improve the treatment of heart failure.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Humanities, Multidisciplinary
Xenia Matschke, Marc Oliver Rieger
Summary: Based on a survey conducted in Germany, we found that the majority of respondents plan to continue wearing face masks in certain situations even after the COVID-19 pandemic. This willingness is strongly influenced by the perception that there is valuable knowledge to be gained from East Asians' handling of pandemics, regardless of the perceived protection provided by wearing masks. This finding suggests a positive side effect of the current crisis, as face masks have been empirically proven to help prevent the spread of respiratory diseases.
HUMANITIES & SOCIAL SCIENCES COMMUNICATIONS
(2022)
Article
Family Studies
Xiaoyue Wang, Ruibo Xie, Wan Ding, Min Jiang, Weijian Li
Summary: This study aims to explore the independent and joint developmental trajectories of childhood depression and neuroticism, as well as the relationship between different types of maltreatment. The findings reveal heterogeneous developmental trajectories for childhood depression/neuroticism and highlight the importance of considering the heterogeneity in children's development. The study also uncovers associations between different types of maltreatment and the independent/joint developmental trajectories of depression and neuroticism.
CHILDREN AND YOUTH SERVICES REVIEW
(2022)
Article
Geosciences, Multidisciplinary
Petar Milanovic
Summary: The distribution and flow of groundwater in karstified rocks can be extremely complex and not readily predictable, leading to costly failures in dam and reservoir construction due to inadequate investigation and interpretation of karst processes. Despite expensive and often ineffective remedial works, the construction of water storage reservoirs is crucial for socio-economic development in many karst regions, requiring the challenge to be accepted. Best practices for site selection of dams and reservoirs in various geological and hydrogeological settings are defined based on field experience in Europe and Asia, emphasizing the recognition of certainty or uncertainty in crucial parameters such as geological structure, groundwater regime, and depth of karstification.
HYDROGEOLOGY JOURNAL
(2021)
Article
History & Philosophy Of Science
Benjamin Elzinga
Summary: In the 1940s, Gilbert Ryle argued that knowing how to do something requires not only being well-regulated but also self-regulated. He believed that self-regulation is essential both in looking back and looking forward. This contradicts common intuitions about know-how. After reviewing the empirical literature on learning, I update Daniel Dennett's Tower of Generate-and-Test and identify a Rylean intuition about intelligence, arguing that self-regulation in a forward-looking sense is necessary for know-how.
Review
Food Science & Technology
Ayodeji B. Oyenihi, Zinash A. Belay, Asanda Mditshwa, Oluwafemi J. Caleb
Summary: Apples are rich in micronutrients and polyphenols, which can help in mitigating micronutrient deficiencies and chronic diseases such as diabetes, cancer, and cardiovascular diseases. Maintaining the quality of apples after harvest is important to fully gain health benefits. Postharvest treatments and hurdle techniques can effectively preserve the bioactive components and ensure the safety of stored apples. Optimizing postharvest management strategies to extend the storage life of apples is crucial for improving consumers' overall health.
JOURNAL OF FOOD SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Martina Trentini, Federica Zanotti, Elena Tiengo, Francesca Camponogara, Margherita Degasperi, Danilo Licastro, Luca Lovatti, Barbara Zavan
Summary: The constant dialogue between the plant world and the animal world has a significant impact on human health, and apple exosomes have been found to possess anti-inflammatory effects in human cells and influence cell proliferation and death.
Review
Economics
Keyi Li, Paula Lorgelly, Sarah Jasim, Tiyi Morris, Manuel Gomes
Summary: The impact of unemployment on health and social care utilization varies across different care settings, with a stronger association found in mental health services. Unemployed individuals are about 30% more likely to use health services compared to those employed, mainly driven by mental health service use. Factors such as financial pressure, health insurance, social network, disposable time, and depression/anxiety play a role in this association.
EUROPEAN JOURNAL OF HEALTH ECONOMICS
(2023)