Article
Nanoscience & Nanotechnology
Sandeep Kumar Kalva, Ana Sanchez-Iglesias, Xose Luis Dean-Ben, Luis M. Liz-Marzan, Daniel Razansky
Summary: The rapid volumetric tracking of gold nanoagents in mice at a suborgan level using single-sweep volumetric optoacoustic tomography (sSVOT) allows for high spatial resolution and sub-picomolar sensitivity. This new method opens up new avenues for the development and characterization of diagnostic and therapeutic nanoagents.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Pharmacology & Pharmacy
Hinojal Zazo, Clara I. Colino, Carmen Gutierrez-Millan, Andres A. Cordero, Matthias Bartneck, Jose M. Lanao
Summary: This study developed a specific PBPK model to simulate the biodistribution of stavudine in rats after administration of a 40 nm gold nanoparticle-based drug delivery system. Higher biodistribution of stavudine into HIV reservoirs and modifications in pharmacokinetic parameters were observed compared to stavudine solution. This PBPK model approach may aid in pre-clinical extrapolation to other administration routes or species of stavudine gold nanoparticles.
Article
Radiology, Nuclear Medicine & Medical Imaging
Milou E. Noltes, Maximilian Bader, Madelon J. H. Metman, Jasper Vonk, Pieter J. Steinkamp, Jan Kukacka, Henriette E. Westerlaan, Rudi A. J. O. Dierckx, Bettien M. van Hemel, Adrienne H. Brouwers, Gooitzen M. van Dam, Dominik Juestel, Vasilis Ntziachristos, Schelto Kruijff
Summary: This study examines the potential of multispectral optoacoustic tomography (MSOT) for risk stratification of thyroid nodules. The findings show a correlation between vascular patterns and thyroid malignancy, and identify malignant features in MSOT images that are verified by histopathology. However, mean oxygen saturation does not provide significant differences between benign and malignant thyroid nodules. Recommendations are made to consider optoacoustic features and chromophore quantification together for malignancy risk assessment.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Chemistry, Multidisciplinary
Qi Li, Charles J. Zeman, Zhuoran Ma, George C. Schatz, X. Wendy Gu
Summary: This study reports rod-shaped icosahedral nanoclusters with bright NIR-II PL, quantum yields up to approximately 8%, and a peak emission wavelength of 1520 nm. The central Au atom in the nanoclusters is found to enhance overall PL efficiency and make NIR-II emission brighter. A framework is developed to analyze underlying transitions in metal nanoclusters based on experimentally defined absorption coefficients.
Article
Acoustics
Ingo Ganzleben, Daniel Klett, Wiebke Hartz, Lisa Gotzfried, Francesco Vitali, Markus F. Neurath, Maximilian J. Waldner
Summary: Timely diagnosis of severe anemia is crucial, but reliable non-invasive diagnostic tools are currently lacking. This study used advanced Multispectral Opto-acoustic Tomography (MSOT) to measure hemoglobin concentration and identified patients requiring transfusion based on a strong positive correlation between MSOT-signal intensity and hemoglobin concentration.
Article
Chemistry, Multidisciplinary
Shang-Fu Yuan, Cong-Qiao Xu, Wen-Di Liu, Jing-Xuan Zhang, Jun Li, Quan-Ming Wang
Summary: This study presents the construction of a linear silver supercluster based on Ag-13 units and reveals its stability and electron coupling mechanism. The quantum size effect explains the enhancement of metal-related absorption intensity and the red shift phenomenon.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Polymer Science
Wafaa E. Soliman, Heba S. Elsewedy, Nancy S. Younis, Pottathil Shinu, Lamis E. Elsawy, Heba A. Ramadan
Summary: The characterization and application of gold nanoparticles (Au-NPs) in antimicrobial and wound healing activities were investigated in this study. The results showed that Au-NPs possessed appropriate particle size and rod-shaped particles, exhibiting efficient antimicrobial behavior against different bacterial strains. Furthermore, Au-NPs demonstrated promising wound healing activity in diabetic animals.
Article
Chemistry, Multidisciplinary
Jie Kong, Dayujia Huo, Jialong Jie, Yanzhen Wu, Yan Wan, Yongbo Song, Meng Zhou
Summary: The excited state dynamics of Au-25 nanoclusters are influenced by the addition of single electrons, with different decay lifetimes observed for different charge states. The presence of a single electron results in an additional decay process, and the charge state significantly affects the initial dipole moment orientation. These findings are important for understanding the role of charge state on the optical properties of metal nanoclusters.
Article
Nanoscience & Nanotechnology
Cheng-Han Ho, Yan-Cheng Lin, Wei-Chen Yang, Ender Ercan, Yun-Chi Chiang, Bi-Hsuan Lin, Chi-Ching Kuo, Wen-Chang Chen
Summary: With the increasing amount of data generated, the demand for photomemory capable of multibit data storage has grown rapidly to improve storage capacity. A study focused on developing an organic-molecule-based electret with an elaborate nanostructure to enable multibit data storage in a stable memory device. The researchers synthesized a series of star-shaped rod-coil molecules and investigated their molecular architecture-morphology relationships. They found that the memory devices based on these rod-coil molecules exhibited high memory ratios and rapid multilevel photoresponses, attributed to the favorable energy-level alignment, isolated nanostructure, and face-on orientation of one specific molecule. This study provides a new strategy for designing high-performance phototransistor memory by tailoring nanostructures in organic-molecule-based electrets using a star-shaped rod-coil architecture.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Kuo Li, Dan Li, Cheng-Hsuan Li, Pengfei Zhuang, Chunmei Dai, Xiangka Hu, Dahao Wang, Yuanye Liu, Xifan Mei, Vincent M. Rotello
Summary: Studies have shown that ultra-small noble metal nanoclusters have comprehensive therapeutic effects for wound healing, promoting cell proliferation and migration while decreasing inflammation.
Article
Chemistry, Multidisciplinary
Katarina Kozics, Monika Sramkova, Kristina Kopecka, Patricia Begerova, Alena Manova, Zora Krivosikova, Zuzana Sevcikova, Aurelia Liskova, Eva Rollerova, Tibor Dubaj, Victor Puntes, Ladislava Wsolova, Peter Simon, Jana Tulinska, Alena Gabelova
Summary: The study demonstrates potential toxic effects of tissue accumulation of PEG-AuNPs, primarily manifesting as cellular changes in the liver and spleen, but with unclear long-term effects.
Article
Nanoscience & Nanotechnology
Daniil Nozdriukhin, Sandeep Kumar Kalva, Weiye Li, Alexey Yashchenok, Dmitry Gorin, Daniel Razansky, Xose Luis Dean-Ben
Summary: By utilizing a new type of monodisperse silica-core microparticles with a multilayered structure of carbon nanotubes and gold nanoparticles, we have successfully visualized and tracked individual core-shell particles flowing through mouse brain vasculature using a high-frame-rate optoacoustic tomography system. This opens up new opportunities for mapping blood flow velocity, enhancing resolution and visibility of optoacoustic images, and developing new biosensing assays.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Pharmacology & Pharmacy
Elnaz Yaghini, Elisa Tacconi, Andrew Pilling, Paula Rahman, Joe Broughton, Imad Naasani, Mohammed R. S. Keshtgar, Alexander J. MacRobert, Oscar Della Pasqua
Summary: The study investigated the in vivo biodistribution and potential toxicity of QDs in mice, developing a population PK model and using a multi-compartment PK model to describe blood and organ disposition characteristics. QDs were primarily taken up by the liver and spleen and excreted via hepatobiliary and urinary pathways, with distribution into liver and spleen occurring rapidly post-injection and a long elimination profile observed.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Biochemical Research Methods
Alejandra Hernandez Pichardo, James Littlewood, Arthur Taylor, Bettina Wilm, Raphael Levy, Patricia Murray
Summary: Tracking the fate of therapeutic cell types is crucial for evaluating their safety and effectiveness. Bioluminescence imaging (BLI) is effective but lacks spatial resolution, so a bimodal imaging approach that combines BLI with high-resolution techniques is necessary. In this study, the effectiveness of combining multispectral optoacoustic tomography (MSOT) or micro-computed tomography (micro-CT) with BLI was compared for tracking gold nanorod-labeled human mesenchymal stromal cells (MSCs). MSOT was found to be more sensitive than micro-CT in tracking the labeled cells in vivo, and when combined with BLI, it effectively tracked the fate of MSCs in mice depending on the route of administration.
JOURNAL OF BIOPHOTONICS
(2023)
Article
Engineering, Electrical & Electronic
Mohanna Etemadi, Saeed Golmohammadi, Abolfazl Akbarzadeh, Seyed Hossein Rasta, Yashar Sarbaz
Summary: Plasmonic nanoprobes based on GNSs with different morphology were designed and embedded in human skin tissue, showing high refractive index sensitivity and effective figure of merit enhancement. The results indicate that the performance of GNSs is dependent on their shape and size as well as the dielectric constant of the surrounding medium.
OPTICAL AND QUANTUM ELECTRONICS
(2021)
Article
Chemistry, Multidisciplinary
Jiantian Zhang, Wei Xu, Liming Wang, Zhaoqiang Zheng, Fucai Liu, Peng Yu, Guowei Yang
Summary: Band engineering can effectively tune the properties of materials, leading to improved performance. In this study, the first two-dimensional quaternary quantum dots (CIPS) were successfully fabricated using the lithium intercalation method. By forming lithium-induced phosphorus and sulfur vacancies, the band structure of CIPS was tuned, resulting in stronger optical absorbance and higher conductivity. The CIPS quantum dots exhibited outstanding optoelectronic performances in broadband photodetection, retaining excellent photoresponse on flexible substrates and in imaging applications.
CRYSTAL GROWTH & DESIGN
(2023)
Article
Food Science & Technology
Xiaoying Lin, Hongxin Xie, Yanfei Zhang, Xue Tian, Liwei Cui, Nianqiu Shi, Liming Wang, Jiating Zhao, Lihui An, Jing Wang, Bai Li, Yu-Feng Li
Summary: This study evaluated the LD50 of different sizes of nano-sized PET (nPET) in mice and studied the health effects of single exposure to these nPETs. It was found that the toxicity and health effects were size-dependent, with smaller nPETs causing more damage. The study also found that nPET disrupted gut microbiome and metabolome, particularly lipid metabolism, and had adverse effects on weight, organ function, and mortality in mice. This is the first report on the systematic toxicity of nPET and further studies are needed to understand the long-term effects.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Agriculture, Multidisciplinary
Hongxin Xie, Xue Tian, Lina He, Jincheng Li, Liwei Cui, Xin Cong, Bochong Tang, Yi Zhang, Zhiying Guo, Aiyu Zhou, Dongliang Chen, Liming Wang, Jiating Zhao, Yong-Liang Yu, Bai Li, Yu-Feng Li
Summary: Spatial metallomics was used to visualize the distribution and speciation of selenium in a single seed of Cardamine violifolia in Enshi, China. The study found that methylated selenium species were mainly located in the seed coat, providing the first visual evidence of their in situ distribution in C. violifolia seeds. This research deepens our understanding of selenium tolerance in C. violifolia and could have implications for studying tolerance of heavy metals/metalloids in other hyperaccumulators.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Wenting Cheng, Wanjun Zhang, Xiaowen Xia, Jianzhong Zhang, Mingyue Wang, Yanting Li, Xin Li, Yuxin Zheng, Jing Liu, Rong Zhang, Jinglong Tang
Summary: Inhaled carbon black nanoparticles (CBNPs) are internalized by alveolar macrophages, leading to pulmonary inflammation and subsequent circulatory inflammation and damage to cerebrovascular tight junctions. The Wnt/beta-catenin signaling pathway is closely associated with cerebrovascular endothelial cell impairment. Inflammation in the lungs and circulatory system plays a significant role in the domino effect of inhaled CBNPs.
Article
Environmental Sciences
Wanjun Zhang, Yaxian Pang, Wenting Cheng, Tao Wang, Yanting Li, Xin Li, Jianzhong Zhang, Xiaowen Xia, Yuxin Zheng, Rong Zhang, Jinglong Tan
Summary: This study aimed to investigate the association between indoor coal burning and atherosclerotic cardiovascular diseases. It was found that prolonged exposure to indoor coal burning increased the risk of carotid atherosclerosis.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Review
Materials Science, Biomaterials
Xiaoyan Li, Xiaocui Guo, Mingdi Hu, Rong Cai, Chunying Chen
Summary: Messenger RNA (mRNA) has shown great potential for the treatment of diseases, but there are still challenges in its clinical translation due to issues like uneven distribution, low transfection efficiency, and poor biosafety. This review discusses the design of nanoparticles, particularly lipid nanoparticles, and strategies to improve mRNA delivery by manipulating nano-bio interactions and overcoming biological barriers. Regulating nano-bio interactions could be a significant breakthrough in improving mRNA delivery efficiency, and this review provides new insights for the design of nanoparticle-mediated mRNA delivery systems.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Materials Science, Biomaterials
Xiaoyu Wang, Xuejing Cui, Junguang Wu, Lin Bao, Chunying Chen
Summary: Through integrating tissue imaging, 16s rRNA gene sequencing, and metabolomics techniques, we found that silver nanoparticles and silver nanowires have an impact on the gut microbiota structure in mice. The gut microbiota showed resilience after short-term exposure, but the gut metabolites significantly changed after long-term exposure. This study provides new evidence for the adverse effects of silver nanomaterials on biological hosts.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Review
Materials Science, Biomaterials
Qiaolin Liu, Yuliang Zhao, Huige Zhou, Chunying Chen
Summary: This review summarizes the application of stimuli-responsive nanomaterials in ferroptosis for cancer therapy and proposes future perspectives in the field.
REGENERATIVE BIOMATERIALS
(2023)
Review
Environmental Sciences
Hongxin Xie, Xue Tian, Xiaoying Lin, Rui Chen, Saima Hameed, Liming Wang, Yong-Liang Yu, Bai Li, Yu-Feng Li
Summary: This review summarizes the biological effects of nanoplastics (NPs) in vivo (plants and animals) and in vitro (cells). NPs can be ingested and accumulated in organisms, affecting growth, development, and reproduction at each trophic level. Factors such as surface charges, size, exposure dose, and exposure time impact the biological effects of NPs. More research is needed on the risk assessment of commonly used plastics in daily life, such as polyethylene terephthalate (PET), for better understanding of the potential harm caused by NPs.
REVIEWS OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
(2023)
Review
Nanoscience & Nanotechnology
Xiumin Li, Yalin Cong, Muhammad Ovais, Mateus Borba Cardoso, Saima Hameed, Rui Chen, Mingli Chen, Liming Wang
Summary: Drug-resistant bacteria and highly infectious viruses are major threats to global health, and novel strategies are urgently needed to address this challenge. Copper-based nanoparticles (CBNPs) have exhibited broad antimicrobial capacity and have gained increasing attention. This review describes the functionalization of CBNPs, their antibacterial and antiviral activity, applications, as well as toxicity, biodistribution, and persistence. The limitations of current studies and potential solutions are also briefly discussed. This review will guide the rational design of functional nanomaterials for antimicrobial applications.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2023)
Review
Chemistry, Physical
Jinhui Lin, Xinlian Wang, Dongqi Ni, Yandong Chen, Chunying Chen, Ying Liu
Summary: Cancer poses a significant threat to human health, and traditional treatments such as chemotherapy and radiotherapy are suboptimal and cause significant side effects. Gene therapy offers improved targeting and reduced side effects, and the use of nanocarriers like liposomes enables effective delivery of gene therapy agents. However, combining gene therapy with other therapies using nanocarriers can lead to synergistic therapeutic effects. This review highlights various ways to combine gene therapy with other therapies and emphasizes the role of nanoplatforms in mediating these combined therapies.
Review
Chemistry, Multidisciplinary
Guanyu Liu, Lin Bao, Chunying Chen, Jianfu Xu, Xuejing Cui
Summary: A growing number of nanomaterials are being used in food-related fields and therapeutics. These nanoparticles can cross the intestinal barrier and enter the adjacent mesentery, where their fate is determined by the intricate structure and function of the mesentery. Understanding the interaction between nanomaterials and the mesentery is crucial for the development of safer products and more effective nanomedicines for intestinal disorders.
Article
Environmental Sciences
Jianzhong Zhang, Xinmin Jiang, Xin Li, He Sun, Mingyue Wang, Wanjun Zhang, Haonan Li, Hongmei Wang, Min Zhuang, Lin Zhang, Lin Lu, Jinglong Tang
Summary: Chlorhexidine, a commonly used guanidine disinfectant, may cause lung injury and fibrosis. Inhalation of chlorhexidine aerosol can induce an inflammatory response and activate pathways related to extracellular matrix deposition. Furthermore, chlorhexidine exposure may induce fibrosis-like injury by enhancing mucus secretion.
