Article
Medicine, General & Internal
Bernard Moerdler, Matan Krasner, Elazar Orenbuch, Avi Grad, Benjamin Friedman, Eliezer Graber, Efrat Barbiro-Michaely, Doron Gerber
Summary: Contemporary personalized cancer diagnostic approaches face multiple challenges. Researchers have developed a system called PTOLEMI, which is based on Python and utilizes machine learning algorithms and microfluidic technology to rapidly and accurately analyze cancer patient samples, enabling point-of-care diagnostics and providing a more granular understanding of cellular dynamics for personalized treatment options.
Review
Endocrinology & Metabolism
Svenja Noelting, Nicole Bechmann, David Taieb, Felix Beuschlein, Martin Fassnacht, Matthias Kroiss, Graeme Eisenhofer, Ashley Grossman, Karel Pacak
Summary: Pheochromocytomas/paragangliomas have high heritability, with 70% of patients falling into 3 main molecular clusters with distinct phenotypes and clinical behaviors. Personalized management strategies are essential for accurate diagnosis and effective treatment in different clusters.
Article
Oncology
Maxim Sorokin, Marianna Zolotovskaia, Daniil Nikitin, Maria Suntsova, Elena Poddubskaya, Alexander Glusker, Andrew Garazha, Alexey Moisseev, Xinmin Li, Marina Sekacheva, David Naskhletashvili, Alexander Seryakov, Ye Wang, Anton Buzdin
Summary: RNA sequencing analysis of tumor FFPE materials may be helpful for personalizing prescriptions of targeted therapeutics in CRC. The Oncobox drug efficiency score is an effective biomarker that can predict treatment outcomes, especially for bevacizumab.
Article
Health Care Sciences & Services
Pune N. Paque, Christopher Herz, Daniel B. Wiedemeier, Konstantinos Mitsakakis, Thomas Attin, Kai Bao, Georgios N. Belibasakis, John P. Hays, Joel S. Jenzer, Wendy E. Kaman, Michal Karpisek, Philipp Korner, Johannes R. Peham, Patrick R. Schmidlin, Thomas Thurnheer, Florian J. Wegehaupt, Nagihan Bostanci
Summary: This study identified four salivary biomarkers crucial for predicting caries accurately and developed an RF model for classification and prediction of caries progression. The high correlation between RF prediction and clinical classification was observed, indicating a new approach for caries identification.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Chemistry, Multidisciplinary
Faezeh Ghorbanizamani, Hichem Moulahoum, Emine Guler Celik, Suna Timur
Summary: The growing demand for personalized treatments and constant vital signs observation has led to the development of implantable biosensors that can temporarily or permanently be introduced into the human body. However, ensuring reliable functionality in the complex environment of the human body remains a critical challenge.
APPLIED SCIENCES-BASEL
(2023)
Review
Biochemistry & Molecular Biology
Laura Secli, Guido Leoni, Valentino Ruzza, Loredana Siani, Gabriella Cotugno, Elisa Scarselli, Anna Morena D'Alise
Summary: Personalized cancer vaccines aim to stimulate potent and tumor-specific immune responses against specific neoantigens in each patient, while minimizing adverse events. Recent advancements in technology for identifying neoantigens and novel vaccine delivery platforms have renewed interest in personalized cancer vaccines. Viral vectors have emerged as a preferred technology due to efficient production processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, General & Internal
Karla Jaimes Merazzo, Joseba Totoricaguena-Gorrino, Eduardo Fernandez-Martin, F. Javier del Campo, Eva Baldrich
Summary: Smartphones are becoming more versatile thanks to the sensors and actuators packed in them, enabling new applications beyond their original purpose. Personalized diagnostics is an area where mobile devices can have a significant impact, with potential for more advanced applications in the future. However, current technologies have not fully exploited the capabilities of mobile devices for personalized diagnostics.
Article
Biophysics
Norhan Badr ElDin, Mohamed K. Abd El-Rahman, Hala E. Zaazaa, Azza A. Moustafa, Said A. Hassan
Summary: The methacholine challenge test is considered the gold standard for diagnosing asthma, with recent research linking cholinesterase levels to the severity of COVID-19 pneumonia. A copper-based potentiometric sensor using graphene nanocomposites has been developed to track the degradation kinetics of MCH enzymatic reactions, offering potential applications in clinical settings.
BIOSENSORS & BIOELECTRONICS
(2021)
Review
Oncology
Miao Su, Zhe Zhang, Li Zhou, Chao Han, Canhua Huang, Edouard C. Nice
Summary: Cancer is a major global public health issue and personalized/precision medicine plays a crucial role in its diagnosis and treatment. Research focuses on cancer biomarkers, the impact of the microbiome, the application of emerging omics technologies, and future prospects.
Review
Biochemistry & Molecular Biology
Susan Morand, Monika Devanaboyina, Hannah Staats, Laura Stanbery, John Nemunaitis
Summary: Response to immunotherapy in ovarian cancer is limited, but stratification by tumor biomarkers may improve predictiveness. Future directions include utilizing these biomarkers to select ideal candidates, increasing the likelihood of success with immunotherapy in ovarian cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemical Research Methods
Casimir Bamberger, Jolene Diedrich, Salvador Martinez-Bartholome, John R. Yates
Summary: This study used a novel high-throughput mass spectrometric method to indirectly measure the accessibility of lysine ε-amine for chemical modification in the proteome, and determined the changes in the 3D proteome during malignant transformation. The results showed that different tumor genotypes reshape a limited set of effector proteins, and alterations in heat shock proteins are key predictors of anticancer drug efficacy.
JOURNAL OF PROTEOME RESEARCH
(2022)
Article
Engineering, Electrical & Electronic
Wonki Hong, Jungmin Lee, Won Gu Lee
Summary: A new stretchable finger-perimetric sensor has been developed to analyze the gripping force mechanism of chopsticks when taking food, showing a high accuracy of 97.7% in F1 score. This method can potentially benefit seniors' rehabilitation, children's dietary education, and personalized dietary monitoring and diagnosis.
SENSORS AND ACTUATORS A-PHYSICAL
(2022)
Article
Biophysics
Qinglai Meng, Shichao Liu, Jinhua Meng, Jiao Feng, Michael Mecklenburg, Lei Zhu, Lifang Zhou, Leif Bulow, Jianyi Liu, Dewei Song, Changxin Wu, Bin Xie
Summary: AMR poses a serious global health threat, with expression of 8-lactamase genes being a major mechanism for antibiotic resistance. A novel two-dimensional AMR profiling assay strategy was developed, allowing for simultaneous identification of multiple 8-lactamases in a single bacterial isolate with high sensitivity and accuracy.
BIOSENSORS & BIOELECTRONICS
(2021)
Review
Health Care Sciences & Services
Mohammad Raad, William Omar Contreras Lopez, Alireza Sharafshah, Marjan Assefi, Kai-Uwe Lewandrowski
Summary: This study systematically reviewed the latest research progress in cancer pain management, highlighting personalized medicine as one of the most promising strategies. By utilizing genomic and pharmacokinetic approaches, genes and variants associated with cancer pain can be identified, providing guidance for clinical personalized treatment.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Oncology
Shira Orr, Ling Huang, James Moser, Dina Stroopinsky, Omar Gandarilla, Cori DeCicco, Jessica Liegel, Cansu Tacettin, Adam Ephraim, Giulia Cheloni, Daniela Torres, Donald Kufe, Jacalyn Rosenblatt, Manuel Hidalgo, Senthil K. Muthuswamy, David Avigan
Summary: The study demonstrates that the use of personalized cancer vaccines can expand pancreatic cancer specific lymphocytes, leading to significant therapeutic effects in mouse models, including reducing tumor volume and prolonging survival.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)