Editorial Material
Biochemistry & Molecular Biology
Matthew D. Disney
Summary: In recent decades, there has been growing interest in RNA modifications and their biological functions. A recent study published in Cell describes the discovery of glycoRNAs on the surface of cells. Like proteins and lipids, conserved non-coding RNAs are now found to be functionalized with carbohydrates.
Review
Medicine, Research & Experimental
Ming Yang, Wei Chen, Liyu He, Di Liu, Li Zhao, Xi Wang
Summary: This study reviews the molecular mechanism of necroptosis and discusses its role in the pathogenesis of various diseases. Additionally, it summarizes several inhibitors of necroptosis and discusses the potential of targeting necroptosis as a therapeutic strategy for various diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Microbiology
Greco Hernandez
Summary: The definition and understanding of life have become complex with the development of scientific research. The progress in modern biology has challenged the traditional concept of life, suggesting the possibility of multiple forms of life.
FRONTIERS IN MICROBIOLOGY
(2022)
Editorial Material
Biochemistry & Molecular Biology
James C. A. Bardwell
Summary: In this study, Frydman and colleagues successfully visualized the folding process of tubulin by its chaperonin TRiC at near-atomic resolution, shedding light on the mechanism of protein folding.
Editorial Material
Multidisciplinary Sciences
Anna M. Stasto
Summary: Scientists have measured the size of the space occupied by a proton's mass and found it to be much smaller than previously believed. This discovery is significant as it helps in unraveling the intricate structure of this fundamental building block.
Review
Immunology
Chuiwen Deng, Qiufeng Xiao, Yunyun Fei
Summary: Sjogren's syndrome, a common chronic autoimmune disease, is associated with microbial dysbiosis. The alterations in the microbiota correlate with disease severity.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemical Research Methods
Kamil Kaminski, Jan Ludwiczak, Kamil Pawlicki, Vikram Alva, Stanislaw Dunin-Horkawicz
Summary: This study explores the feasibility of using protein language models and the pLM-BLAST tool to detect protein homology through sequence comparison. Benchmark tests show that pLM-BLAST maintains accuracy comparable to HHsearch while being faster, and it is able to compute local alignments, highlighting its potential for discovering previously undiscovered homologous relationships and improving protein annotation.
Article
Agronomy
James Steadham, Taylor Schulden, Bhanu Kalia, Dal-Hoe Koo, Bikram S. Gill, Robert Bowden, Inderjit Singh Yadav, Parveen Chhuneja, John Erwin, Vijay Tiwari, Nidhi Rawat
Summary: The article introduces a simple and powerful approach for high-resolution mapping of important genes from distant relatives of wheat, which can be used for eventual map-based cloning. By utilizing existing germplasm resources, this method opens up new possibilities for researchers to access and study important genes in tertiary gene pools of wheat.
THEORETICAL AND APPLIED GENETICS
(2021)
Article
Geography, Physical
Thammy E. Mottin, Roberto Iannuzzi, Fernando F. Vesely, Isabel P. Montanez, Neil Griffis, Rafael E. Canata, Leonardo M. Barao, Deise M. da Silveira, Aurora M. Garcia
Summary: The article describes a well-preserved in situ Brasilodendron-like lycopsid forest in an early Permian postglacial paleolandscape in western Gondwana. The death and burial of the lycopsids in life position may have been caused by crevasse splay progradation due to a major river flooding event.
PALAEOGEOGRAPHY PALAEOCLIMATOLOGY PALAEOECOLOGY
(2022)
Editorial Material
Biochemistry & Molecular Biology
Paola Binda, Maria Concetta Morrone
Summary: A new study has shown that our visual system does not shut down during eye movements, but instead selectively modulates sensitivity to specific stimuli.
Editorial Material
Hematology
Mark Leick, Yi-Bin Chen
Summary: In this study, McCurdy et al compare immune restoration after haploidentical and matched donor HCT, and find that high-dose PTCy-based GVHD prophylaxis is effective in immune recovery.
Review
Biochemistry & Molecular Biology
Silvia Marti-Martinez, Luis M. Valor
Summary: Huntington's disease is a neurodegenerative disorder caused by abnormal expansion of CAG repeats in the Huntingtin gene. It not only affects the central nervous system but also has a peripheral component. Precise diagnosis and evaluation of therapeutic response require the use of biomarkers with prognostic value.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Microbiology
Carl-Eric Wegner, Raphaela Stahl, Irina Velsko, Alex Huebner, Zandra Fagernaes, Christina Warinner, Robert Lehmann, Thomas Ritschel, Kai U. Totsche, Kirsten Kuesel
Summary: By adapting methods from microbial archaeology and paleogenomics, we recovered sufficient DNA from seven rock specimens for metagenomic analysis. Limestones serve as archives for genetic records of past microbial communities, including those sensitive to environmental stress, due to specific conditions facilitating long-term DNA preservation.
Review
Cell Biology
Xiao-Wei Chen, Guangjin Ding, Li Xu, Peng Li
Summary: China has seen significant economic growth and social progress, but also an increase in metabolic disorders such as diabetes. With the aging population, the prevalence of metabolic disorders is on the rise. Advances in metabolic research aim to contribute to understanding metabolism from lab to bedside.
Review
Environmental Sciences
Biswajita Pradhan, Prajna Paramita Bhuyan, Rabindra Nayak, Srimanta Patra, Chhandashree Behera, Jang-Seu Ki, Andrea Ragusa, Alexander S. Lukatkin, Mrutyunjay Jena
Summary: This review examines the changes in physicochemical and molecular characteristics of microalgae in response to heavy metals and metalloids stress and discusses the use of biotechnological methods to enhance their bioaccumulation and remediation capabilities.