Article
Microbiology
Dennis Maletich Junqueira, Caroline Tochetto, Tavis K. Anderson, Danielle Gava, Vanessa Haach, Mauricio E. Cantao, Amy L. Vincent Baker, Rejane Schaefer
Summary: This study analyzed a large number of H1N1pdm09 gene sequences from humans and swine globally between 2009 and 2022, and found that there was rapid transmission of the virus from humans to swine in Brazil during 2009-2011, but most of the infections in swine were self-limited with limited onward transmission. After 2012, there was a reduction in human-to-swine H1N1pdm09 transmissions in Brazil. The study highlights the dynamic interplay between human-to-swine transmission, antigenic drift, and the establishment of swine-to-swine transmission in shaping the evolution and persistence of H1N1pdm09 in swine populations.
FRONTIERS IN MICROBIOLOGY
(2023)
Editorial Material
Multidisciplinary Sciences
Martha I. Nelson, Elodie Ghedin
Summary: The evolutionary steps taken by the 1918 flu pandemic virus have been revealed through the analysis of lung samples stored in medical archives. Three genomes of the influenza A virus responsible for the global pandemic have been obtained, showing mutations that may have triggered the devastating second wave.
Article
Business, Finance
Di Gong, Tao Jiang, Liping Lu
Summary: This paper empirically analyzes the impact of pandemic on the contracting of bank loans. Using data on syndicated loans during the season of H1N1 Swine Flu, we find that more flu is associated with higher loan spreads and smaller loan size. The adverse impact of pandemic was alleviated by the approval of vaccines.
FINANCE RESEARCH LETTERS
(2021)
Article
Virology
Peter W. Cook, Thomas Stark, Joyce Jones, Rebecca Kondor, Natosha Zanders, Jeffrey Benfer, Samantha Scott, Yunho Jang, Alicia Janas-Martindale, Stephen Lindstrom, Lenee Blanton, John Schiltz, Rachel Tell, Richard Griesser, Peter Shult, Erik Reisdorf, Tonya Danz, Alicia Fry, John Barnes, Amy Vincent, David E. Wentworth, C. Todd Davis
Summary: The study discusses the transmission of seasonal influenza viruses between humans and pigs, leading to sustained circulation of human-like viruses in the U.S. swine population. Two cases of human infections with A(H1N1)pdm09 viruses originating from swine hosts are identified and classified as swine-origin variant influenza viruses. The study underscores the importance of developing techniques for distinguishing human-origin and swine-origin viruses for continued surveillance of influenza viruses.
JOURNAL OF VIROLOGY
(2021)
Article
Nursing
Deborah Johnson
Summary: The article tells the story of the author's grandmother, who was a nurse responding to the 1918 influenza pandemic. It highlights the important role nurses have played in public health crises, both then and now, as the world faces the COVID-19 pandemic.
AMERICAN JOURNAL OF NURSING
(2021)
Article
Immunology
Veronica A. Ferrando, Marcel E. Friedrich, Shrey Gandhi, Alexander Mellmann, Doerthe Masemann, Anmari Christersson, Darisuren Anhlan, Linda Brunotte, Monika Stoll, Timm Harder, Martin Beer, Yvonne Boergeling, Stephan Ludwig
Summary: Influenza A viruses, including the H1N1pdm09 virus, cause recurrent epidemics and occasional pandemics in humans. The reassortment of these viruses in swine and their ability to replicate in human lung tissue suggest a possible zoonotic potential. Reassortment frequently occurs in the PB1, PA, and NA segments, resulting in the generation of reassortants that can reach high titers in swine lung cells.
EMERGING MICROBES & INFECTIONS
(2023)
Article
Economics
Joel Floris, Laurent Kaiser, Harald Mayr, Kaspar Staub, Ulrich Woitek
Summary: Researchers used historical birth records from a maternity hospital in Bern, Switzerland to evaluate the impact of survivorship bias on the 1918 flu pandemic and other foetal health shocks. The results indicate that a careful consideration of survivorship bias is crucial for assessing the effects of these shocks.
APPLIED ECONOMICS LETTERS
(2022)
Article
Microbiology
Alexey Markin, Giovana Ciacci Zanella, Zebulun W. Arendsee, Jianqiang Zhang, Karen M. Krueger, Phillip C. Gauger, Amy L. Vincent L. Baker, Tavis K. Anderson
Summary: Research reveals that the 2009 H1N1 influenza virus has the ability to cross species barriers and frequently spread between humans and swine. The virus undergoes genetic and antigenic changes in swine populations, posing a zoonotic threat to humans. The study confirms a correlation between human and swine cases of H1N1 influenza, and the burden of the virus in humans directly impacts its detection in pigs. Additionally, it was found that the persistence of the virus in swine is mainly due to spillovers from human-to-swine transmission. These findings underscore the risk of influenza transmission between humans and swine.
Article
Virology
Helen E. Everett, Pauline M. van Diemen, Mario Aramouni, Andrew Ramsay, Vivien J. Coward, Vincent Pavot, Laetitia Canini, Barbara Holzer, Sophie Morgan, Mark E. J. Woolhouse, Elma Tchilian, Sharon M. Brookes, Ian H. Brown, Bryan Charleston, Sarah Gilbert
Summary: This study evaluated the efficacy of different vaccines in reducing nasal shedding in pigs following pH1N1 virus challenge and their transmission to naive, directly in-contact pigs. Vaccines containing homologous HA significantly reduced virus shedding, yet transmission still occurred to susceptible cohoused recipients. The findings are crucial for informing disease surveillance and control strategies and determining necessary vaccine coverage for disease moderation or herd protection.
JOURNAL OF VIROLOGY
(2021)
Article
Multidisciplinary Sciences
Hyesun Jang, Ted M. Ross
Summary: The study found that the humoral response to trivalent seasonal influenza virus vaccines was influenced by rapid antigenic switching of H1 HA. While successful induction of antibodies against H1N1 and H3N2 vaccine components was observed, a strong immune response against CA/09 H1N1 influenza virus negatively influenced the induction of novel humoral responses to other vaccine strains.
Article
Management
Emilio Gutierrez, Adrian Rubli
Summary: This study examines the impact of hospital congestion on in-hospital mortality using data from a large public hospital system in Mexico, leveraged the shock in hospitalizations induced by the 2009 H1N1 pandemic, and found that congestion led to an increase in non-ARI in-hospital mortality. The effects were nonlinear in the size of the local outbreak, and supply-side policies such as improving patient assignment and strategically increasing hospital capacity could mitigate some of the negative impacts.
MANAGEMENT SCIENCE
(2021)
Review
Virology
Gloria Perez-Rubio, Marco Antonio Ponce-Gallegos, Bruno Andre Dominguez-Mazzocco, Jaime Ponce-Gallegos, Roman Alejandro Garcia-Ramirez, Ramces Falfan-Valencia
Summary: Research has shown that genetic susceptibility to Influenza A virus infection is influenced by multiple pathways, including innate immune response, complement activation, and variants in inflammatory response genes. Specific gene polymorphisms such as SNPs play key roles in host immune responses, affecting viral replication and host response, representing important factors in genetic susceptibility to IAV infection.
Article
Microbiology
Hailiang Sun, Yongcui Wang, Hanlin Liu, Zifeng Pang, Xinxin Cui, Rui Zhao, Yanwei Liu, Xiaoyun Qu, Mian Huang, Changwen Ke, Ming Liao
Summary: This study analyzed the evolution, replication, and transmission of H1N1 influenza A virus in China from 2009 to 2020. The predominant clades were 6B.1 and 6B.2, with different proportions in different regions. The evolution trend in China diverged from that in North America after 2015. Pdm09 viruses from Guangdong in 2016-2017 showed efficient replication and transmission ability.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Ravina, Paramjeet Singh Gill, Jagriti Narang, Ashok Kumar, Hari Mohan
Summary: The recent emergence of respiratory viruses such as COVID-19 and swine flu has emphasized the importance of robust and bedside detection methods. In this study, cloning was used to develop a biosensor for H1N1 pdm09 detection, which showed high sensitivity and specificity. This development is significant for reducing morbidity and mortality associated with these viruses.
Article
Chemistry, Analytical
Meena Yadav, Rajat Arora, Monika Dhanda, Geeta Singh, Hari Mohan, Suman Lata
Summary: In this study, an electrochemical biosensor based on TiO2-guanine nanocomposite was developed for the detection of H1N1 swine flu virus. The modified biosensor showed high sensitivity, low limit of detection, and broad linear range for H1N1 virus detection. It also exhibited good stability and specificity against different infectious pathogens, and could be used for rapid detection of H1N1 swine flu virus in real samples.