Article
Biochemical Research Methods
Li-Fei Wu, De-Ping Wang, Jing Shen, Li-Juan Gao, Ying Zhou, Qing-Hua Liu, Ji-Min Cao
Summary: Lysine malonylation plays an important role in cardiac remodeling, particularly in relation to isocitrate dehydrogenase 2 (IDH2).
JOURNAL OF PROTEOMICS
(2022)
Article
Chemistry, Multidisciplinary
Qingyun Yang, Yingxiao Gao, Xia Liu, Yihang Xiao, Mingxuan Wu
Summary: A new method for editing the N-tail of histone H3 using sortase mediated metathesis (SMM) is reported. This method expands the application scope of sortase and offers a strategy for precise editing of PTMs of cellular histone H3.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Biochemical Research Methods
Yanzheng Meng, Lin Zhang, Laizhi Zhang, Ziyu Wang, Xuanwen Wang, Chan Li, Yu Chen, Shipeng Shang, Lei Li
Summary: CysModDB is an integrated platform designed to facilitate the study of cysteine posttranslational modifications (PTMs). It brings together comprehensive CysPTM resources and analysis tools, providing researchers with online computational and analytical tools for CysPTM site prediction, gene enrichment, and sequence feature investigation.
BRIEFINGS IN BIOINFORMATICS
(2022)
Review
Immunology
C. Diskin, T. A. J. Ryan, L. A. J. O'Neill
Summary: Immunometabolism has become a focus for immunologists, with metabolic changes in immune cells playing a crucial role in specific immune responses. Post-translational modifications of proteins by metabolites, such as those from glycolysis and Krebs cycle pathways, as well as lipids, amino acids, and polyamines, have been found to alter cell phenotype and modulate immunity and inflammation. The potential use of these findings in developing therapeutics for immune-related diseases is being explored.
Article
Biochemistry & Molecular Biology
Michael A. Sirover
Summary: GAPDH is a moonlighting protein with distinct activities, and its posttranslational modifications play a crucial role in regulating its diverse functions and subcellular localization.
Article
Multidisciplinary Sciences
Yeonjin Ko, Mannkyu Hong, Seungbeom Lee, Manoj Kumar, Lara Ibrahim, Kayla Nutsch, Caroline Stanton, Braddock Sandoval, Phillip Sondermann, Maya L. Bulos, Jonathan Iaconelli, Arnab K. Chatterjee, R. Luke Wiseman, Peter G. Schultz, Michael J. Bollong
Summary: sAKZ692, a small molecule, activates the transcriptional activity of NRF2 in cells by inhibiting the pyruvate kinase enzyme. This leads to the accumulation of glyceraldehyde 3-phosphate, which modifies cysteine residues of KEAP1, resulting in increased NRF2-dependent transcription.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Fisheries
Jinzhao Lu, Xiaochen Fang, Haiying Liang, Zhijie Guo, Hexin Zou
Summary: By analyzing the lysine acetylome of P. f. martensii, it was found that there were significant differences in acetylation in response to allograft. The differentially acetylated proteins mainly involved cytoskeleton, response to stimulus, metabolism, and enriched pathways like aminoacyl-tRNA biosynthesis, salmonella infection, and longevity regulating pathway.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Suze Ma, Heng Chen, He Li, Xinjian Ji, Zixin Deng, Wei Ding, Qi Zhang
Summary: The study reveals a enzyme named three-residue cyclophane forming enzyme (3-CyFE) exhibiting remarkable catalytic promiscuity, producing cyclophane and aminomalonate. Bioinformatic analysis indicates that 3-CyFEs have evolved from a common ancestor with anaerobic sulfatase maturases (anSMEs) and share a similar set of catalytic residues.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Biochemistry & Molecular Biology
Gemma Serra-Bardenys, Sandra Peiro
Summary: Oxidoreductases catalyze oxidation-reduction reactions and constitute a large and diverse group of enzymes. Carbonylation, particularly in lysine residues, is a significant oxidative modification in proteins that can impact protein structure and function.
Article
Engineering, Mechanical
Zhuosheng Lu, Meiru Liu, Lixia Duan
Summary: This paper investigates the electrical activities of a special class of neurons within the brainstem pre-Botzinger complex, particularly focusing on the generation of mixed bursting. The study reveals that intracellular calcium oscillations originating from the dendrite can drive the occurrence of mixed bursting, and analyzes the dynamical mechanisms behind these activities through numerical simulations. Insights provided by this work can enhance understanding of compound kinetics scenarios within the pre-BotC.
NONLINEAR DYNAMICS
(2021)
Review
Biochemistry & Molecular Biology
Yifei Wang, Man Tong
Summary: The posttranslational modifications (PTMs) of proteins play a critical role in protein regulation, enhancing proteome functional diversity and participating in complicated biological processes. In cancer biology, PTMs have been shown to interact with pro-tumorigenic signaling pathways, contributing to neoplastic transformation, tumor recurrence, and resistance to therapy. Cancer stemness, which maintains tumor cell self-renewal and differentiation, is essential in cancer development and therapy resistance. Understanding the PTM profile for modulating cancer stemness has shed light on the underlying mechanisms and potential therapeutic targets for gastrointestinal cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Lise Boon, Estefania Ugarte-Berzal, Erik Martens, Pierre Fiten, Jennifer Vandooren, Rik Janssens, Marfa Blanter, Karen Yu, Mieke Boon, Sofie Struyf, Paul Proost, Ghislain Opdenakker
Summary: Citrullination of MMPs by PADs is a novel posttranslational modification that may impact their activities and functions. Citrullinated MMP-9 exhibits increased affinity for gelatin and more efficient activation compared to control MMP-9. Furthermore, other MMPs such as MMP-1 can also be efficiently citrullinated by PADs.
Article
Pharmacology & Pharmacy
Zhifei Xu, Wentong Wu, Hao Yan, Yuhuai Hu, Qiaojun He, Peihua Luo
Summary: The tumor suppressor protein p53 plays a crucial role in controlling key biological functions and its mutation is associated with various diseases. Regulation of p53 stability is important for maintaining normal functions and targeting p53 for degradation could be a potential therapeutic strategy against cancer.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Oncology
Hongmei Jiang, Yixuan Wang, Jingjing Wang, Yafei Wang, Sheng Wang, Enyang He, Jing Guo, Ying Xie, Jingya Wang, Xin Li, Ziyi Peng, Mengqi Wang, Jian Hou, Zhiqiang Liu
Summary: This study discovered that the cytogenetic abnormality t(4;14) results in elevated levels of histone methyltransferase NSD2 in multiple myeloma patients. The study also found that Aurora A kinase phosphorylates NSD2 to enhance its methyltransferase activity, forming a positive regulatory loop that promotes chemoresistance. Targeting Aurora A pharmacologically sensitizes t(4;14) positive multiple myeloma to proteasome inhibitors. Overall, this research provides a new understanding of the mechanisms underlying chemoresistance in multiple myeloma and suggests a potential treatment strategy.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Andrea Zanotti, Joao P. L. Coelho, Dinah Kaylani, Gurdeep Singh, Marina Tauber, Manuel Hitzenberger, Donem Avci, Martin Zacharias, Robert B. Russell, Marius K. Lemberg, Matthias J. Feige
Summary: This study reveals a previously unknown function of the human signal peptidase complex (SPC) as a membrane protein quality control factor. The SPC cleaves membrane proteins at hidden cleavage sites when they fail to fold or assemble correctly, contributing to membrane protein homeostasis and cellular fitness.
Article
Biochemistry & Molecular Biology
Esha Sehanobish, Maria Dolores Chacon-Verdu, Antonio Sanchez-Amat, Victor L. Davidson
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2015)
Article
Biochemistry & Molecular Biology
Brian A. Dow, Victor L. Davidson
BIOCHEMICAL JOURNAL
(2016)
Article
Biochemistry & Molecular Biology
Zhongxin Ma, Heather R. Williamson, Victor L. Davidson
BIOCHEMICAL JOURNAL
(2016)
Article
Biochemistry & Molecular Biology
Esha Sehanobish, Jonatan C. Campillo-Brocal, Heather R. Williamson, Antonio Sanchez-Amat, Victor L. Davidson
Article
Biochemistry & Molecular Biology
Christian G. Roessler, Rakhi Agarwal, Marc Allaire, Roberto Alonso-Mori, Babak Andi, Jose F. R. Bachega, Martin Bommer, Aaron S. Brewster, Michael C. Browne, Ruchira Chatterjee, Eunsun Cho, Aina E. Cohen, Matthew Cowan, Sammy Datwani, Victor L. Davidson, Jim Defever, Brent Eaton, Richard Ellson, Yiping Feng, Lucien P. Ghislain, James M. Glownia, Guangye Han, Johan Hattne, Julia Hellmich, Annie Heroux, Mohamed Ibrahim, Jan Kern, Anthony Kuczewski, Henrik T. Lemke, Pinghua Liu, Lars Majlof, William M. McClintock, Stuart Myers, Silke Nelsen, Joe Olechno, Allen M. Orville, Nicholas K. Sauter, Alexei S. Soares, S. Michael Soltis, Heng Song, Richard G. Stearns, Rosalie Tran, Yingssu Tsai, Monarin Uervirojnangkoorn, Carrie M. Wilmot, Vittal Yachandra, Junko Yano, Erik T. Yukl, Diling Zhu, Athina Zouni
Article
Biochemistry & Molecular Biology
Manliang Feng, Zhongxin Ma, Breland F. Crudup, Victor L. Davidson
Article
Biochemistry & Molecular Biology
Victor L. Davidson
Article
Biochemistry & Molecular Biology
Andres Andreo-Vidal, Kyle J. Mamounis, Esha Sehanobish, Dante Avalos, Jonatan Cristian Campillo-Brocal, Antonio Sanchez-Amat, Erik T. Yukl, Victor L. Davidson
Article
Biochemistry & Molecular Biology
Dante Avalos, Sinan Sabuncu, Kyle J. Mamounis, Victor L. Davidson, Pierre Moenne-Loccoz, Erik T. Yukl
Article
Biochemistry & Molecular Biology
Zhongxin Ma, Victor L. Davidson
Article
Biochemistry & Molecular Biology
Kyle J. Mamounis, Dante Avalos, Erik T. Yukl, Victor L. Davidson
JOURNAL OF BIOLOGICAL CHEMISTRY
(2019)
Article
Biochemistry & Molecular Biology
Zhongxin Ma, Jan Abendroth, Garry W. Buchko, Kyle H. Rohde, Victor L. Davidson
BIOCHEMICAL JOURNAL
(2020)
Article
Biochemistry & Molecular Biology
Kyle J. Mamounis, Erik T. Yukl, Victor L. Davidson
JOURNAL OF BIOLOGICAL CHEMISTRY
(2020)
Article
Chemistry, Multidisciplinary
Zhongxin Ma, Maria Luiza Caldas Nogueira, Daniela Priscila Marchi-Salvador, Victor L. Davidson
Article
Biochemistry & Molecular Biology
Heather R. Williamson, Esha Sehanobish, Alan M. Shiller, Antonio Sanchez-Amat, Victor L. Davidson