期刊
SCIENCE
卷 328, 期 5984, 页码 1394-1398出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1189176
关键词
-
资金
- Howard Hughes Medical Institute
- NIH [R37AI23081]
Gamma-interferon-inducible lysosomal thiolreductase (GILT) promotes major histocompatibility complex (MHC) class II-restricted presentation of exogenous antigens containing disulfide bonds. Here, we show that GILT also facilitates MHC class I-restricted recognition of such antigens by CD8(+) T cells, or cross-presentation. GILT is essential for cross-presentation of a CD8(+) T cell epitope of glycoprotein B (gB) from herpes simplex virus 1 (HSV-1) but not for its presentation by infected cells. Initiation of the gB-specific CD8(+) T cell response during HSV-1 infection, or cross-priming, is highly GILT-dependent, as is initiation of the response to the envelope glycoproteins of influenza A virus. Efficient cross-presentation of disulfide-rich antigens requires a complex pathway involving GILT-mediated reduction, unfolding, and partial proteolysis, followed by translocation into the cytosol for proteasomal processing.
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