期刊
RSC ADVANCES
卷 5, 期 4, 页码 2592-2601出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4ra11224e
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资金
- PCCA [131/2012]
- Sectoral Operational Programme Human Resources Development of the Ministry of European Funds [POSDRU/159/1.5/S/132395]
The adsorption and in vitro release properties of the poorly soluble cytostatic agent DL-aminoglutethimide (AGT) on pristine MCM-41, 3-aminopropyl and a novel N-propyl-2-sulfanylacetamide functionalized MCM41 material were studied. The mesostructured supports and hybrid samples were characterized by smalland wide-angle X-ray diffraction, FT-IR spectroscopy, thermogravimetric and calorimetric analyses, SEM-EDX and N-2 adsorption-desorption isotherms. The drug uptake was found to be strongly influenced by its ionization state and solution pH. Drug release experiments show a spectacular increase in the dissolution rate of the therapeutic agent for all hybrid samples, indicating that aminoglutethimide encapsulation into the mesopores of MCM-41-type supports is a viable strategy for dissolution rate enhancement. Using a knowledge-based logit hydrogen bonding propensity model to assess the relative strengths of drug-support supramolecular interactions, we have proposed that a Si-OH center dot center dot center dot Cl-AGT(+) mechanism is responsible for the increased drug adsorption in acid media and release rate enhancement at physiological pH.
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