Article
Multidisciplinary Sciences
Ke-Huan K. Chow, Mark W. Budde, Alejandro A. Granados, Maria Cabrera, Shinae Yoon, Soomin Cho, Ting-Hao Huang, Noushin Koulena, Kirsten L. Frieda, Long Cai, Carlos Lois, Michael B. Elowitz
Summary: By utilizing the intMEMOIR system, researchers have developed a method to record cell lineage information that can be read out in situ. This system allows for lineage reconstruction in both mouse and fly cells, as well as simultaneous analysis of clonal history, spatial position, and gene expression. These results establish a foundation for microscopy-readable lineage recording and analysis in diverse systems.
Article
Multidisciplinary Sciences
Bin Yang, Tomomi Karigo, David J. Anderson
Summary: Mating and aggression are innate social behaviours controlled by subcortical circuits. The bed nucleus of the stria terminalis (BNSTpr) receives sex-specific olfactory cues from the medial amygdala and projects to hypothalamic nuclei that control mating and aggression. BNSTpr neurons shape sex- and behavior-specific neural representations in the hypothalamus, controlling the transition from appetitive to consummatory phases of male social behaviors.
Article
Multidisciplinary Sciences
Stephen X. Zhang, Ethan H. Glantz, Lauren E. Miner, Dragana Rogulja, Michael A. Crickmore
Summary: Sexual transition in male Drosophila is controlled by hormonal changes, which inhibit the activity of courtship-motivating circuit elements rather than constructing new neural circuits. Hormonal changes gate the transition to sexuality by permitting activity in latent motivational circuit elements in otherwise asexual males, similar to mammalian adolescence.
Editorial Material
Biochemistry & Molecular Biology
Ansgar Bueschges, Charalampos Mantziaris
Summary: New research reveals that mechanosensitive neurons in the lateral spinal cord of adult zebrafish can sense lateral bending and inhibit neighboring neurons and central rhythm-generating networks. The tight interplay between central and peripheral neural mechanisms has never been observed before.
Article
Ecology
Arielle M. Cooley, Suzanne Schmitz, Eduardo J. Cabrera, Mitchell Cutter, Maxwell Sheffield, Ian Gingerich, Gabriella Thomas, Calvin N. M. Lincoln, Virginia H. Moore, Alexandra E. Moore, Sarah A. Davidson, Nikhil Lonberg, Eli B. Fournier, Sophia M. Love, Galen Posch, Matthew B. Bihrle, Spencer D. Mayer, Kuenzang Om, Lauren Wilson, Casey Q. Doe, Chantalle E. Vincent, Elizabeth R. T. Wong, Ilona Wall, Jarred Wicks, Stephon Roberts
Summary: The experiment showed differences in light preference within and between two sister species of Drosophila, with overall support for the hypothesis that lighter pigmentation is correlated with a greater preference for environmental light. Additional research is needed to corroborate these findings and evaluate conflicting results, particularly the consistent effect of sex within and between species.
ECOLOGY AND EVOLUTION
(2021)
Article
Biochemistry & Molecular Biology
Jose M. Duhart, Joseph R. Buchler, Sho Inami, Kyle J. Kennedy, B. Peter Jenny, Dinis J. S. Afonso, Kyunghee Koh
Summary: Sleep is essential, and animals may sacrifice sleep for other behaviors. A study on flies shows that female flies have reduced sleep after mating, and this is influenced by diet and sleep deprivation. Specific neurons are involved in modulating postmating sleep and there are complex interactions between sleep, reproduction, and diet.
Article
Biology
Carson Fulgham, Austin P. Dreyer, Anita Nasseri, Asia N. Miller, Jacob Love, Madison M. Martin, Daniel A. Jabr, Sumit Saurabh, Daniel J. Cavanaugh
Summary: Research in fruit flies shows that the generation of feeding rhythms is dependent on molecular clock function in ventrolateral clock neurons in the central brain. The speed of molecular clock oscillations in these neurons dictates the period length of feeding rhythms. Central brain clock cells play a primary role in dictating the timing of feeding behavior, while peripheral tissue clocks also contribute to the regulation of feeding rhythms.
JOURNAL OF BIOLOGICAL RHYTHMS
(2021)
Article
Neurosciences
Lili Sun, Rui Han Jiang, Wen Jing Ye, Michael Rosbash, Fang Guo
Summary: A novel self-reinforcing loop within the circadian network and a new sleep-promoting neuropile have been identified in the fruit fly, which are both essential for maintaining normal sleep. These findings provide new insights into sleep research.
Article
Neurosciences
Wenlan Duan, Yihao Zhang, Xin Zhang, Jihua Yang, Heying Shan, Li Liu, Hongying Wei
Summary: Relative motion separates a camouflaged target from its background, leading to discrimination of a motion-defined object. R neurons in the Drosophila central complex, particularly the superior R neurons, play a crucial role in encoding motion features. These neurons receive visual signals from upstream TuBu neurons and their impairment affects tracking performance. Furthermore, the different responses of R neurons in the superior and inferior bulb to different bar stimuli suggest a functional division between the bulb subdomains. R4d neurons are found to be vital in tracking motion-defined bars.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Vikram Vijayan, Fei Wang, Kaiyu Wang, Arun Chakravorty, Atsuko Adachi, Hessameddin Akhlaghpour, Barry J. Dickson, Gaby Maimon
Summary: In this study, researchers have discovered that Drosophila have neurons called oviDNs that express a calcium signal related to decision-making in egg-laying. This signal reaches a peak level before the egg deposition and it is likely to reflect a behaviorally relevant rise-to-threshold process in the ventral nerve cord. Additionally, the study identifies a small recurrent circuit that is required for egg-laying and provides initial insight into the underlying circuit mechanism.
Article
Biochemistry & Molecular Biology
David D. Au, Alexander J. Foden, Soo Jee Park, Thanh H. Nguyen, Jenny C. Liu, Mary D. Tran, Olga G. Jaime, Zhaoxia Yu, Todd C. Holmes
Summary: Cryptochrome (CRY) is a light receptor in Drosophila that regulates light-induced circadian clock resetting. Different species, such as mosquitoes, show distinct behavioral responses to light, which can be affected by light exposure. CRY1 mediates species-specific behavioral and electrophysiological light responses in mosquitoes in a different manner compared to fruit flies.
Article
Neurosciences
Claire Wyart, Kin Ki Jim, Andrew E. Prendergast
Summary: The function of sensory cells in reporting the changes of the environment and internal physiology has been extensively studied in neuroscience. Recent research has shown that sensory cells can detect polymodal cues and evidence of pathogen invasion. This highlights the importance of interdisciplinary training in immunology, microbiology, and neuroscience.
Article
Biochemistry & Molecular Biology
Tuan Dat Le, Yoshihiro H. Inoue
Summary: Research has shown that sesamin exerts its anti-aging effects in Drosophila neurons by activating the Nrf2 transcription factor to suppress oxidative stress accumulation. Sesamin could be explored as a potential dietary supplement for preventing neurodegeneration associated with oxidative stress accumulation.
Article
Neurosciences
Sweta Agrawal, John C. Tuthill
Summary: Evolution has shaped flies to undergo multiple stages of development, resulting in distinct larval and adult body structures. Researchers have made progress in understanding the neural circuits involved in sensing and controlling movement in these different stages, finding both commonalities and differences.
CURRENT OPINION IN NEUROBIOLOGY
(2022)
Review
Neurosciences
Varun M. Bhave, Alexander R. Nectow
Summary: This review highlights the role of the brainstem's dorsal raphe nucleus (DRN) in regulating energy balance, showing how DRN neurons sense and respond to cues related to energy imbalance to induce appropriate alterations in energy intake and expenditure. Different populations within the DRN play distinct and often opposing roles in controlling energy balance, contributing to the overall extended circuit that regulates energy balance.
TRENDS IN NEUROSCIENCES
(2021)
