Article
Neurosciences
Marina Betancor, Laura Moreno-Martinez, Oscar Lopez-Perez, Alicia Otero, Adelaida Hernaiz, Tomas Barrio, Juan Jose Badiola, Rosario Osta, Rosa Bolea, Inmaculada Martin-Burriel
Summary: TTC, as a neuroprotective molecule, shows significant neuroprotective effects in murine models of prion diseases, reducing apoptosis, regulating autophagy, and increasing neuronal survival, although it does not extend survival time in these models.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Marina Betancor, Sonia Perez-Lazaro, Alicia Otero, Belen Marin, Inmaculada Martin-Burriel, Kaj Blennow, Juan Jose Badiola, Henrik Zetterberg, Rosa Bolea
Summary: This study evaluated the changes of neurogranin (Ng) and neurofilament light chain (NfL) at both protein and gene expression levels in the central nervous system (CNS) of preclinical and clinical scrapie-affected sheep. The levels of Ng and NfL decreased as the disease progressed, while the concentrations of NfL in cerebrospinal fluid (CSF) increased. These proteins may serve as biomarkers for neurodegeneration in preclinical cases of scrapie.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Daniele Armocida, Carla Letizia Busceti, Francesca Biagioni, Francesco Fornai, Alessandro Frati
Summary: The complex carcinogenesis of glial tumors involves many genetic and epigenetic phenomena. Cellular prion protein (PrPC) and autophagy play important roles in cell death and tumorigenesis, and their interaction is involved in glioma carcinogenesis. Despite limited research on their combined activity, understanding their molecular mechanisms and pathways can provide valuable insights into the origin and treatment of glioma. This study explores the role of PrPC in autophagy processes and its interplay with glioma tumorigenesis, providing a basis for future research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Tuane C. R. G. Vieira, Caroline A. Barros, Renato Domingues, Tiago Fleming Outeiro
Summary: The discovery of prions challenges dogmas and revolutionizes our understanding of protein-misfolding diseases. The concept of self-propagation via protein conformational changes applies to other proteins, such as alpha-synuclein, in Parkinson's disease and other synucleinopathies. The transfer of alpha-synuclein between cells may involve receptor-mediated transport, with the cellular prion protein playing a crucial role. Understanding the interaction between alpha-synuclein and the cellular prion protein is important for synucleinopathies.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Neurosciences
Joanna E. Pankiewicz, Anita M. Lizinczyk, Leor A. Franco, Jenny R. Diaz, Mitchell Marta-Ariza, Martin J. Sadowski
Summary: Prion diseases are fatal neurodegenerative diseases associated with self-replication and spread of PrPSc. Microglia play a crucial role in the pathogenesis, with apoE controlling their activation. ApoE deficiency exacerbates neurodegeneration by affecting clearance of PrPSc and dying neurons by microglia.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Bryan A. Killinger, Lee L. Marshall, Diptaman Chatterjee, Yaping Chu, Jose Bras, Rita Guerreiro, Jeffrey H. Kordower
Summary: This study used biotinylation by antibody recognition (BAR) to label pathological alpha-synuclein and performed mass spectrometry analysis on Lewy pathology (LP). It identified 261 enriched proteins in synucleinopathy brains and revealed PD as the most significant pathway. BAR has the potential to help understand LP in primary human tissue and animal models.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Chemistry, Multidisciplinary
Ziyao Long, Jiafeng Ruan, Shuyang Li, Jiaming Hu, Renzong Hu, Fang Fang, Fei Wang, Yun Song, Dalin Sun
Summary: Recent studies have improved the energy density of all-solid-state batteries using inorganic solid electrolytes. However, the commercialization process is still delayed due to intrinsic limitations, particularly the lack of focus on fast-charging capability. This study introduces a novel strategy of using liquid metal to trigger capacitive behavior in all-solid-state batteries, and demonstrates its effectiveness in multiple active materials.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Immunology
Vanessa Dominique Lobognon, Jean-Eric Alard
Summary: Periodontal diseases are inflammatory conditions caused by bacterial invasion and host defenses. Antimicrobial peptides (AMPs) play a critical role in the immune response, targeting microbes and modulating immune cells such as B-cells. Understanding the interaction between AMPs and B-cells could shed light on their recruitment, differentiation, and involvement in periodontal defense and destruction.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Pujarini Dash, Soumya R. Mohapatra, Sanghamitra Pati
Summary: Multimorbidity, the simultaneous presence of two or more chronic diseases, poses a significant challenge to healthcare due to the complexity of managing multiple treatment modalities for different diseases. Understanding common etiological factors and pathways may reduce the risk of developing multimorbidity.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Virology
Sonia M. Vallabh, Dan Zou, Rose Pitstick, Jill O'Moore, Janet Peters, Derek Silvius, Jasna Kriz, Walker S. Jackson, George A. Carlson, Eric Vallabh Minikel, Deborah E. Cabin
Summary: There is an urgent need to develop drugs for prion disease, and the choice of animal models to support drug development programs is a subject of debate. This study tested the efficacy of the small molecule anle138b in multiple mouse models of prion disease. The results showed that anle138b doubled the survival of mice infected with the RML strain of prions and suppressed astrogliosis. However, in mouse models with genetic prion disease, it was challenging to identify a clear disease endpoint to measure therapeutic efficacy.
JOURNAL OF VIROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yeong-Gon Choi, Byungki Jang, Jeong-Ho Park, Min-Woo Choi, Gong Yeal Lee, Dae Jin Cho, Hong Youp Kim, Hae Kyoung Lim, Won Jae Lee, Eun-Kyoung Choi, Yong-Sun Kim
Summary: Conversion of PrPC into PrPSc and PRNP mutations are definite causes of prion diseases, which are untreatable and fatal. This study investigated the efficacy of the c-Abl tyrosine kinase inhibitor radotinib in prion models and found that it inhibited PrPSc deposition and improved survival time in hamsters.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Psychiatry
Milica M. Borovcanin, Katarina Vesic
Summary: Recent studies have revealed a connection between schizophrenia and breast cancer, possibly driven by immunological mechanisms. IL-33 and sST2 play key roles in the pathogenesis of both diseases and could serve as targets for treatment.
WORLD JOURNAL OF PSYCHIATRY
(2021)
Article
Neurosciences
Natallia Makarava, Olga Mychko, Jennifer Chen-Yu Chang, Kara Molesworth, Ilia Baskakov
Summary: The study found that in neurodegenerative diseases, the degree of astrocyte activation and disturbance in physiological pathways may have a significant impact on the rapid progression of the disease.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2021)
Review
Biochemistry & Molecular Biology
Timothy Sampson
Summary: Microbial amyloids are associated with neurodegenerative diseases and may contribute to amyloid pathologies through interactions with host amyloid proteins.
Article
Engineering, Environmental
Johannes Morfeldt, Wasim Shoman, Daniel J. A. Johansson, Sonia Yeh, Sten Karlsson
Summary: This research investigates the impact of different charging conditions on carbon footprints, including dynamic on-road charging through an electric road system (ERS). The study uses a prospective life cycle analysis framework to estimate carbon footprints of vehicles, fuels, and infrastructure, and models vehicle stock turnover and optimal battery capacity based on Swedish real-world driving patterns. The findings suggest that implementing ERS on selected high-traffic roads, combined with stationary charging, can significantly reduce carbon emissions, even if only a small percentage of vehicles adopt optimized battery capacities.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)