Article
Biotechnology & Applied Microbiology
Changhui Sun, Kuan Zhang, Yi Zhou, Lin Xiang, Changcai He, Chao Zhong, Ke Li, Qiuxia Wang, Chuanpeng Yang, Qian Wang, Congping Chen, Dan Chen, Yang Wang, Chuanqiang Liu, Bin Yang, Hualin Wu, Xiaoqiong Chen, Weitao Li, Jing Wang, Peizhou Xu, Pingrong Wang, Jun Fang, Chengcai Chu, Xiaojian Deng
Summary: The study identified a novel gene, OsLHY, in rice that may be involved in regulating the circadian clock. OsLHY influences flowering time through the OsGI-Hd1 pathway and plays a role in fine-tuning the critical day length (CDL) by directly regulating OsGI. This study illustrates a new regulatory mechanism between the circadian clock and photoperiodic flowering.
PLANT BIOTECHNOLOGY JOURNAL
(2021)
Article
Plant Sciences
Xingwei Wang, Yanfei Hu, Wei Wang
Summary: This study compares the circadian characteristics of Arabidopsis and soybean, revealing notable differences and contrasting biological activities under circadian regulation.
Review
Biochemistry & Molecular Biology
Honglv Jiang, Xiaohui Wang, Jingjing Ma, Guoqiang Xu
Summary: Circadian rhythm is a 24-hour cycle that regulates biological functions and activities in organisms. The circadian clock is controlled by a feedback loop involving core clock proteins and accessory factors. Recent research reveals that CLOCK exhibits lysine acetyltransferase activities, impacting the biological functions of core clock proteins and downstream gene expression. This review explores the role of acetylation in circadian rhythm and discusses the interactions between lysine acetylation and other posttranslational modifications.
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
(2023)
Review
Plant Sciences
Luis Cervela-Cardona, Benjamin Alary, Paloma Mas
Summary: A fundamental principle shared by all organisms is the conversion of nutrients into energy, requiring precise spatiotemporal programming. Cellular metabolism can adapt to external time, relying on the circadian clock. The circadian clock plays a prevalent role in controlling the timing of mitochondrial activity and cellular energy in Arabidopsis thaliana, with evidence showing metabolic signals can feedback to the clock.
FRONTIERS IN PLANT SCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Hang Zhao, Di Xu, Tian Tian, Fanying Kong, Ke Lin, Shuo Gan, Haisen Zhang, Gang Li
Summary: ELF3 and ELF4 are key negative regulators in plant circadian clock control, forming complexes to repress the transcription of multiple clock-related genes, affecting growth and flowering. They are also involved in thermomorphogenesis and shade responses, and form complexes with other proteins for transcriptional repression.
Article
Plant Sciences
Takahiro N. Uehara, Saori Takao, Hiromi Matsuo, Ami N. Saito, Eisuke Ota, Azusa Ono, Kenichiro Itami, Toshinori Kinoshita, Takafumi Yamashino, Junichiro Yamaguchi, Norihito Nakamichi
Summary: A novel synthetic small molecule called TU-892 has been found to affect the amount of PRR7 protein, leading to lengthening of the circadian clock period in plants. The study showed that TU-892 treatment upregulates the expression of CCA1 gene and reduces the amount of PRR7 protein. This novel clock modulator provides new tools and avenues for studying the circadian clock in plants.
PLANT AND CELL PHYSIOLOGY
(2023)
Article
Plant Sciences
Yongtao Yu, Sergi Portoles, Yi Ren, Guangyu Sun, Xiao-Fang Wang, Huihui Zhang, Shaogui Guo
Summary: The F-box protein ZEITLUPE (ZTL) negatively regulates ABA signaling in Arabidopsis thaliana during early seedling growth and stomatal closure induced by ABA. ZTL interacts with and ubiquitinates its substrate CHLH/ABAR to modulate CHLH stability. ABA induces ZTL phosphorylation and CHLH degradation, suggesting a reciprocal regulation mechanism between ABA signaling and the circadian clock.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Yang Cheng, Yuhao Chi, Linying Sun, Guang-Zhong Wang
Summary: This study analyzed rhythmic gene expression in eight different species and identified four common distribution patterns. The findings suggest that the maintenance of reduced energetic costs constrains the evolution of rhythmic gene expression and that the peaks of rhythmic expression are influenced by selective pressure. The results indicate that selective pressure from circadian regulation efficiently removes unnecessary gene products from the transcriptome, significantly impacting its evolutionary path.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Titouan Bonnot, Dawn H. Nagel
Summary: Plants regulate their transcriptome in response to heat stress by modulating gene expression through the circadian clock, highlighting potential regulatory nodes for improving heat stress tolerance.
Article
Plant Sciences
Hikari Ikeda, Taiga Uchikawa, Yohei Kondo, Nozomu Takahashi, Takuma Shishikui, Masaaki K. Watahiki, Akane Kubota, Motomu Endo
Summary: Plants adapt to environmental changes through circadian clocks, and this study found that root hair elongation in Arabidopsis is controlled by both light and the circadian clock. Genes encoding major components of the central oscillator regulate the rhythmicity of root hair length. Grafting experiments showed that TOC1 in shoots is responsible for the generation of root hair rhythmicity.
PLANT AND CELL PHYSIOLOGY
(2023)
Article
Plant Sciences
Takahiro N. Uehara, Takashi Nonoyama, Kyomi Taki, Keiko Kuwata, Ayato Sato, Kazuhiro J. Fujimoto, Tsuyoshi Hirota, Hiromi Matsuo, Akari E. Maeda, Azusa Ono, Tomoaki T. Takahara, Hiroki Tsutsui, Takamasa Suzuki, Takeshi Yanai, Steve A. Kay, Kenichiro Itami, Toshinori Kinoshita, Junichiro Yamaguchi, Norihito Nakamichi
Summary: This study demonstrates the necessity of CDKC;2 in maintaining the circadian period in Arabidopsis. Through chemical biology and genetic approaches, it was found that CDKC;2 maintains transcriptional activity by phosphorylating the C-terminal domain of RNA polymerase II, affecting clock gene expression and period length.
PLANT AND CELL PHYSIOLOGY
(2022)
Article
Plant Sciences
Mitsuhiko Muroya, Haruka Oshima, Shoko Kobayashi, Aya Miura, Yohei Miyamura, Hajime Shiota, Kiyoshi Onai, Masahiro Ishiura, Katsushi Manabe, Shinsuke Kutsuna
Summary: This study revealed that plant flower movements are regulated by the circadian clock, with wild-type flowers exhibiting regular opening and closing patterns, while mutant flowers show different closing speeds. Flower closing is controlled by the clock, while the opening process may also be influenced by other light-sensing pathways.
PLANT AND CELL PHYSIOLOGY
(2021)
Article
Plant Sciences
Min Gao, Chong Zhang, William Angel, Owen Kwak, Jessica Allison, Linda Wiratan, Amelia Hallworth, Julie Wolf, Hua Lu
Summary: This research elucidates the transcriptional control mechanism of the master clock protein CCA1 on the downstream target gene GRP7, and its impact on pathogen defense. The study demonstrates that CCA1 physically associates with the promoter of GRP7 and regulates its circadian expression, leading to altered defense signaling and pathogen responses.
JOURNAL OF EXPERIMENTAL BOTANY
(2023)
Review
Endocrinology & Metabolism
Ferdinando Fusco, Nicola Longo, Marco De Sio, Davide Arcaniolo, Giuseppe Celentano, Marco Capece, Roberto La Rocca, Francesco Mangiapia, Gianluigi Califano, Simone Morra, Carmine Turco, Gianluca Spena, Lorenzo Spirito, Giovanni Maria Fusco, Luigi Cirillo, Luigi De Luca, Luigi Napolitano, Vincenzo Mirone, Massimiliano Creta
Summary: The impact of circadian desynchrony on spermatogenesis is significant but current evidence is insufficient due to study heterogeneity.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Yue Yu, Zhanming Li
Summary: This study analyzes literature from the Web of Science core database and draws a knowledge graph using CiteSpace to explore the research frontiers between light and circadian rhythm. The study focuses on the regulation of light in the circadian rhythm of poultry, explores the effects of light on poultry growth and immunity, and analyzes the regulatory effect of light on melatonin levels.
APPLIED SCIENCES-BASEL
(2023)
Article
Plant Sciences
Shijia Zhang, Huili Liu, Li Yuan, Xiaojing Li, Lingbao Wang, Xiaodong Xu, Qiguang Xie
Summary: The study identified that CCA1 alpha and CCA1 beta protein variants respond to light and temperature cues, with higher temperatures promoting CCA1 beta protein production. The levels of CCA1 proteins peak in the morning and the detection of CCA1 beta is dependent on specific conditions at 22 degrees Celsius.
PLANT CELL REPORTS
(2021)
Article
Medicine, Research & Experimental
Shelly R. Nason, Jessica Antipenko, Natalie Presedo, Stephen E. Cunningham, Tanya H. Pierre, Teayoun Kim, Jodi R. Paul, Cassie Holleman, Martin E. Young, Karen L. Gamble, Brian Finan, Richard DiMarchi, Chad S. Hunter, Alexei Kharitonenkov, Kirk M. Habegger
Summary: The study suggests that glucagon mediates weight loss through FGF21 signaling and central KLB. Central KLB is shown to be an important regulator in GCGR-mediated weight loss, while also playing a role in metabolic improvements. These findings have implications for future treatments of obesity and metabolic syndrome.
Article
Clinical Neurology
Jeanne F. Duffy, Sabra M. Abbott, Helen J. Burgess, Stephanie J. Crowley, Jonathan S. Emens, Lawrence J. Epstein, Karen L. Gamble, Brant P. Hasler, David A. Kristo, Roneil G. Malkani, Shadab A. Rahman, S. Justin Thomas, James K. Wyatt, Phyllis C. Zee, Elizabeth B. Klerman
Summary: This White Paper presents the results of a workshop co-sponsored by the Sleep Research Society (SRS) and the Society for Research on Biological Rhythms (SRBR) to identify gaps in diagnosis and treatment, and areas of high-priority research in circadian rhythm sleep-wake disorders. CRSWD are caused by alterations in the circadian time-keeping system and may affect a large number of individuals in the United States.
Article
Multidisciplinary Sciences
Jennifer A. Davis, Jodi R. Paul, Stefani D. Yates, Elam J. Cutts, Lori L. McMahon, Jennifer S. Pollock, David M. Pollock, Shannon M. Bailey, Karen L. Gamble
Summary: Changing meal timing can rescue the cognitive and hippocampal impairments induced by HFD, even without altering body composition and total caloric intake. This suggests that short-term time-restricted feeding is an effective intervention for HFD-induced cognitive deficits and hippocampal dysfunction.
Article
Endocrinology & Metabolism
Chao Huang, Robert F. Rosencrans, Raluca Bugescu, Cristiano P. Vieira, Ping Hu, Yvonne Adu-Agyeiwaah, Karen L. Gamble, Ana Leda F. Longhini, Patrick M. Fuller, Gina M. Leinninger, Maria B. Grant
Summary: Hypothalamic inflammation and sympathetic nervous system hyperactivity are key features of metabolic syndrome and type 2 diabetes. Reduction of somatostatinergic (SST) neurons in the hypothalamus may contribute to disease progression, leading to brain inflammation and metabolic dysfunction. This study demonstrates that selectively depleting SST neurons can mimic several aspects of type 2 diabetes in relevant tissues.
Review
Biochemistry & Molecular Biology
Xiaodong Xu, Li Yuan, Xin Yang, Xiao Zhang, Lei Wang, Qiguang Xie
Summary: This review summarizes recent studies on the plant circadian system, including molecular mechanisms, internal and external time cues, and physiological regulation. The circadian clock in plants is highly sensitive to timing cues such as light, temperature, and nutrients, and it regulates independent rhythms in different tissues, affecting processes like growth and immune response.
JOURNAL OF INTEGRATIVE PLANT BIOLOGY
(2022)
Article
Plant Sciences
Lei Liu, Xiaoyun Li, Li Yuan, Guofang Zhang, Hui Gao, Xiaodong Xu, Hongtao Zhao
Summary: This study identifies XCT as a key spliceosomal component associated with multiple splicing factors. Inactivation of XCT leads to defects in Alt 3'ss recognition, resulting in significant alterations in the 3' splice sites of LHY and TIC and a shortened circadian period.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Derrick Cumberbatch, Tetsuya Mori, Jie Yang, Dehui Mi, Paige Vinson, C. David Weaver, Carl Hirschie Johnson
Summary: The use of intrinsic fluorescence as a detection method has limitations due to the interference caused by the intrinsic fluorescence of samples. To address this issue, researchers have developed a bioluminescence resonance energy transfer (BRET) Ca2+ sensor, called CalfluxCTN. This sensor is able to accurately detect changes in intracellular Ca2+ concentrations even in the presence of fluorescent compounds, and can identify agonists and antagonists in chemical libraries containing fluorescent compounds.
Article
Plant Sciences
Wei Li, Ying-Ying Tian, Jin-Yu Li, Li Yuan, Lin-Lin Zhang, Zhi-Ye Wang, Xiaodong Xu, Seth Jon Davis, Jian-Xiang Liu
Summary: Global warming affects plant growth and development, and plants adjust their internal circadian clock to adapt to the changing environment. This study reveals that the transcriptional repressor RVE5 fine-tunes the expression of ELF4, a circadian gene, by competing with the stronger transcriptional repressor CCA1 at a specific cis-element on the ELF4 promoter. This competition-attenuation mechanism provides a balancing system for regulating the level of ELF4 and thermoresponsive hypocotyl growth under warm-temperature conditions.
Article
Neurosciences
Lacy K. Goode, Allison R. Fusilier, Natalie Remiszewski, Jacob M. Reeves, Kavitha Abiraman, Matthew Defenderfer, Jodi R. Paul, Lori L. McMahon, Karen L. Gamble
Summary: This study investigated the influence of sex and time-of-day on hippocampal neurophysiology and memory in mice. The results showed that both time-of-day and sex had an impact on memory performance and hippocampal synaptic activity. The study emphasizes the importance of understanding how sex and circadian rhythms affect hippocampal physiology, which can improve the relevance of treatments and inform the timing of therapy.
Review
Peripheral Vascular Disease
Michelle L. Gumz, Daichi Shimbo, Marwah Abdalla, Ravi C. Balijepalli, Christian Benedict, Yabing Chen, David J. Earnest, Karen L. Gamble, Scott R. Garrison, Ming C. Gong, John B. Hogenesch, Yuling Hong, Jessica R. Ivy, Bina Joe, Aaron D. Laposky, Mingyu Liang, Eric J. MacLaughlin, Tami A. Martino, David M. Pollock, Susan Redline, Amy Rogers, R. Dan Rudic, Eva S. Schernhammer, George S. Stergiou, Marie-Pierre St-Onge, Xiaoling Wang, Jacqueline Wright, Young S. Oh
Summary: Healthy individuals experience variation in blood pressure over a 24-hour period, with higher levels during wakefulness and lower levels during sleep. Disruption of the blood pressure circadian rhythm has been associated with negative health outcomes such as cardiovascular disease, dementia, and chronic kidney disease. Current approaches to diagnosis and treatment do not adequately consider the circadian rhythmicity of blood pressure. This review summarizes findings from a workshop held by the National Heart, Lung, and Blood Institute to identify knowledge gaps and research opportunities related to the study of blood pressure circadian rhythm and chronotherapy for hypertension.
Article
Physiology
Megan K. Rhoads, Joshua S. Speed, Kaehler J. Roth, Dingguo Zhang, Chunhua Jin, Karen L. Gamble, David M. Pollock
Summary: Night shift work increases the risk of cardiovascular disease associated with an irregular eating schedule. High-salt intake disrupts the diurnal rhythm of renal sodium excretion. Limiting food intake to the inactive period in addition to high-salt feeding impairs circadian mechanisms associated with renal sodium excretion.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Li Yuan, Yingjun Yu, Mingming Liu, Yang Song, Hongmin Li, Junqiu Sun, Qiao Wang, Qiguang Xie, Lei Wang, Xiaodong Xu
Summary: The study reveals that a subfamily of zinc finger transcription factors, BBX, plays a critical role in fine-tuning circadian rhythms by interacting with PRRs to coordinate synchrony and inhibit the expression of morning-phased clock genes.
Article
Biochemistry & Molecular Biology
Li Yuan, Yue Hu, Shilin Li, Qiguang Xie, Xiaodong Xu
Summary: The study revealed the essential roles of PRR9 and 7 in regulating the circadian clock period and temperature response in plant roots, as well as their regulatory effects on specific gene expressions. Temperature plays a crucial role in the plant circadian clock regulation.
PLANT SIGNALING & BEHAVIOR
(2021)
Article
Plant Sciences
Li Yuan, Grace Z. Xie, Siyuan Zhang, Baozhu Li, Xianglong Wang, Yu Li, Tao Liu, Xiaodong Xu
Summary: The study investigated the role of soybean circadian clock genes in leaf water stress response, finding that the quadruple mutant had decreased leaf water loss under dehydration stress. Dehydration treatment delayed the peak expression of GmLCL genes by 4 hr, and the circadian clock in hairy roots also responded to ABA, leading to a free-running rhythm with shortened period. The findings suggest that GmLCLs act as negative regulators of ABA signaling in leaves during dehydration response.
PLANT CELL AND ENVIRONMENT
(2021)
