Article
Engineering, Multidisciplinary
Riwang Li, Yuhui Zhang, Zhen Lin, Qiqi Lei, Yi Liu, Xinyang Li, Mingxian Liu, Gang Wu, Simin Luo, Huajun Wang, Xiaofei Zheng, Lihua Li, Ningjian Ao, Zhengang Zha
Summary: Injectable biocompatible thiolated chitosan (CSSH) hydrogel with pH-response was designed for accurate treatment of tumor cells and tissue reconstruction. Modified halloysite nanotubes (HNTs) improved the mechanical strength of hydrogels and slow the release of doxorubicin (DOX). The drug-loaded gel effectively inhibited tumor growth and recurrence, and repaired defect tissue after tumor resection.
COMPOSITES PART B-ENGINEERING
(2021)
Article
Polymer Science
Seyed Mohammadjafar Mousavi, Mirzaagha Babazadeh, Mahboob Nemati, Moosa Es'haghi
Summary: This study developed nanocomposites using reversible addition fragmentation chain transfer polymerization to address limitations in doxorubicin loading. The release behavior of DOX from the nanocomposites was found to be pH-dependent, with a high drug loading efficiency of 81%.
Review
Materials Science, Biomaterials
Sreejan Manna, Arnab Seth, Prajna Gupta, Gouranga Nandi, Ria Dutta, Subrata Jana, Sougata Jana
Summary: Chitosan has gained attention as a biomaterial carrier in pharmaceutical and biomedical research due to its nontoxic behavior, biodegradability, and biocompatibility. Chemical modifications of chitosan derivatives, such as trimethyl chitosan and thiolated chitosan, have improved its efficacy as a drug carrier and are widely studied for controlled and target-specific drug delivery. Chitosan derivatives also have applications in wound healing, hyperthermia therapy, tissue engineering, and bioadhesives.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Pharmacology & Pharmacy
Andreia Almeida, Nazende Guenday-Tuereli, Bruno Sarmento
Summary: Nanomedicines are increasingly being explored for their potential in addressing public health issues by pharmaceutical industry. However, standardizing and approving nanomedicines is still a significant challenge. This study demonstrated the successful scale-up production of two chitosan derivatives in pharmaceutical industry, showing the feasibility of producing polymers and polymeric micelles closer to the bedside.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Nanoscience & Nanotechnology
Qing Hu, Jiayi Yao, Xiaoqin Wang, Yanfang Wang, Xiaoling Fu, Ju Ma, Han Lin, Jiaqi Xu, Longhua Shen, Xiangbin Yu
Summary: This study reports a multifunctional nanocarrier with a pH-sensitive liposome shell and a dendritic core for targeted co-delivery of PD-L1 siRNA and DOX. The nanocarrier showed suitable particle size, good stability, and pH-sensitive drug release. In vitro and in vivo experiments demonstrated that the nanocarrier effectively inhibited cell proliferation, reduced PD-L1 expression, and exhibited high accumulation at the tumor site. It holds promise as a codelivery nanoplatform to improve the treatment of various solid tumors.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Review
Polymer Science
Andre Jiang, Rajkumar Patel, Bandana Padhan, Supriya Palimkar, Padmaja Galgali, Arindam Adhikari, Imre Varga, Madhumita Patel
Summary: The development of biobased polymer packaging films has gained attention due to the environmental hazards of petroleum-based, nonbiodegradable packaging materials. Chitosan is a popular biopolymer for food packaging due to its biocompatibility, biodegradability, antibacterial properties, and ease of use. This review summarizes chitosan composites that exhibit active packaging, improving food storage conditions and extending shelf life, by incorporating active compounds such as essential oils and phenolic compounds. Additionally, composites with polysaccharides and various nanoparticles are also discussed. This review provides valuable information for selecting an enhanced composite with chitosan and offers directions for the development of novel biodegradable food packaging materials.
Article
Biochemistry & Molecular Biology
Prem Prakash Sharma, Shakshi Bhardwaj, Aaftaab Sethi, Vijay K. Goel, Maria Grishina, Poonam, Brijesh Rathi
Summary: Chitosan has shown intriguing applications in biomedical science due to its biodegradability, biocompatibility, minimal toxicity, cost-effectiveness, and easy synthesis. It can serve as a drug carrier for biomedical applications.
CARBOHYDRATE RESEARCH
(2022)
Article
Chemistry, Physical
Abdul Rehman, Mehr Un Nisa, Muhammad Usman, Zahoor Ahmad, Tanveer Hussain Bokhari, Hafiz Muhammad Abd Ur Rahman, Aamir Rasheed, Laraib Kiran
Summary: The challenge of improving the solubility of hydrophobic organic compounds can be addressed using micellar solutions of surfactants. Research has shown that a blend of different surfactants can synergistically enhance the dye partitioning, leading to improved stability and solubility of the dye in water. The processes of surfactant micellization, counterion binding, and dye partitioning have been found to be spontaneous.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Chemistry, Physical
Xiudong Liu, Huofei Zhou, Weiting Yu, Xin Xiong, Rumen Krastev, Xiaojun Ma
Summary: The study successfully prepared polymeric micelle-like nanoparticles capable of delivering DOX by modifying chitosan to HT-CS-DCA, and further demonstrated the inhibitory activity of these nanoparticles on MCF-7 cells.
Article
Chemistry, Applied
Garima Agrawal, Ankita Dhiman, Dimpy Bhardwaj, Kajal Goswami
Summary: In this study, redox-sensitive DH-ChSt MGs were developed for controlled release of insecticide and capturing heavy metal ions. The DH-ChSt MGs exhibited high loading and encapsulation efficiency for imi-dacloprid insecticide, and prolonged release under reducing conditions. DH-ChSt MGs also showed enhanced foliar adhesion and efficient binding of Fe3+. MTT assay confirmed the non-toxicity of DH-ChSt MGs, and their capability to bind heavy metal ions makes them a promising platform for agriculture application.
CARBOHYDRATE POLYMERS
(2023)
Article
Food Science & Technology
Natalia Wronska, Nadia Katir, Marta Nowak-Lange, Abdelkrim El Kadib, Katarzyna Lisowska
Summary: The study found that biomaterials made from food processing waste as an alternative to plastic packaging have good biodegradability and can be efficiently degraded by microorganisms in soil. The application of these biodegradable films can help reduce environmental pollution.
Article
Chemistry, Applied
Maocheng Ji, Jianyong Li, Fangyi Li, Xiaojie Wang, Jia Man, Jianfeng Li, Chuanwei Zhang, Sixian Peng
Summary: By adding ramie fibre and lignin to the chitosan-based film, significant improvements in mechanical, water resistance, thermal, and antioxidant properties were observed. The composite films showed better food preservation effects, indicating the great potential of chitosan-based films in food packaging.
CARBOHYDRATE POLYMERS
(2022)
Review
Pharmacology & Pharmacy
Jiaqi Weng, Alain Durand, Stephane Desobry
Summary: This article reviews the state of the art in using chitosan (CS) for preparing particulate carriers for drug delivery applications. It discusses the relationship between targeted controlled activity, preparation process, and release kinetics, focusing on matrix particles and capsules. The article emphasizes the relationship between the size/structure of CS-based particles and drug release kinetics, and reviews various techniques for characterizing particle properties. Mathematical models play a crucial role in understanding release mechanisms and identifying key structural characteristics, leading to the development of a novel design strategy for drug delivery devices.
Article
Polymer Science
Regina R. Vildanova, Svetlana F. Petrova, Sergey V. Kolesov, Vitaliy V. Khutoryanskiy
Summary: Preparation of stable hydrogels using charge-complementary polyelectrolyte chains offers practical advantages over the use of organic crosslinking agents. This study utilizes natural polyelectrolytes-chitosan and pectin-with their biocompatibility and biodegradability. Different molecular weights of pectin are used to prepare hydrogels with varying rheological characteristics and swelling kinetics. These polyelectrolyte hydrogels can release the cytostatic drug cisplatin over an extended period, potentially improving the effectiveness of cancer treatment.
Article
Chemistry, Physical
Balint Basa, Geza Jakab, Nikolett Kallai-Szabo, Bence Borbas, Viktor Fulop, Emese Balogh, Istvan Antal
Summary: The emergence of additive manufacturing, specifically 3D printing, has the potential to revolutionize the pharmaceutical industry by enabling personalized drug manufacturing. This study focused on investigating the behavior of PVA under different dissolution conditions and explored its potential as a drug delivery carrier.
Article
Engineering, Environmental
Chaoping Fu, Ruili Wei, Peiyao Xu, Shiwei Luo, Chunyang Zhang, Ranjith Kumar Kankala, Shibin Wang, Xinqing Jiang, Xinhua Wei, Liming Zhang, Aizheng Chen, Ruimeng Yang
Summary: In recent years, the use of diselenide-bridged polymeric nanocomposites for drug delivery, especially in enhanced anticancer therapy, has gained significant attention. However, the high sensitivity of diselenide bonds to various stimuli limits the fabrication of such nanocomposites with high performance efficiency. This study successfully demonstrated the fabrication of ICG-loaded diselenide-containing polymeric nanoparticles using a supercritical fluid-assisted rapid synthesis approach for ROS/GSH-responsive drug delivery, showing high drug loading and encapsulation efficiency.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Nanoscience & Nanotechnology
Ruili Wei, Yansong Dong, Yalan Tu, Shiwei Luo, Xinrui Pang, Wanli Zhang, Wang Yao, Wenjie Tang, Huikang Yang, Xinhua Wei, Xinqing Jiang, Youyong Yuan, Ruimeng Yang
Summary: The development of novel activatable photosensitizers with plasma membrane targeting ability is crucial for smart photodynamic therapy (PDT). This study combines a tumor acidity-activatable photosensitizer with a two-step bioorthogonal pretargeting strategy, effectively anchoring photosensitizers to the plasma membrane for enhanced therapeutic efficacy in anticancer therapy. The activation and click reaction-based localization of photosensitizers on tumor cells surface result in cytotoxic reactive oxygen species-induced cell membrane damage and apoptosis upon laser irradiation.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Applied
Shanshan Chen, Junjie Deng, Li-Ming Zhang
Summary: PAMAM-Cs-DCA nanoparticles exhibit good gene transfection efficiency and low cytotoxicity, successfully encapsulating the anticancer drug DOX and forming complexes with pDNA, while the co-delivery of DOX enhances transgene expression synergistically.
CARBOHYDRATE POLYMERS
(2021)
Article
Biotechnology & Applied Microbiology
Biyun Lan, Liming Zhang, Liqun Yang, Junfeng Wu, Na Li, Chenglin Pan, Xiaoyi Wang, Lexiang Zeng, Li Yan, Chuan Yang, Meng Ren
Summary: The hybrid hydrogel dressing developed for localized delivery of MMP-9 siRNA showed significant reduction in MMP-9 expression and improved diabetic wound closure in diabetic rats. The dressing exhibited negligible cytotoxicity in vitro and sustained release of siMMP-9 for up to 7 days. This delivery system offers a platform for in vivo delivery of siRNA for the treatment of various diseases.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Huikang Yang, Li-Ming Zhang
Summary: Novel hollow organic/inorganic hybrid nanoparticles based on dextran and poly(glutamate) were prepared with increased drug loading capacity and prolonged drug release time through the synthesis and functionalization process. Characteristics such as molecular structures, physicochemical properties, and self-assembly were analyzed, demonstrating good biocompatibility and enhanced drug delivery performance compared to their non-cross-linked counterparts.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Polymer Science
Ju-Zhen Yi, Kunhua Lin, Hao Wu, Xuhong Mao, Li-Ming Zhang, Liqun Yang
Summary: The hydrogel composed of CPUL-ConA was prepared with glucose-sensitivity and encapsulated acarbose effectively. The smart release of acarbose in gastrointestinal fluids was demonstrated to inhibit alpha-glucosidase activity and control blood glucose levels, with potential benefits for postprandial hyperglycemia and type 2 diabetes. Rheological analysis indicated the stability of the Acar/CPUL-ConA hydrogel under gastric and intestinal peristalsis, suggesting its potential therapeutic efficacy improvement.
JOURNAL OF APPLIED POLYMER SCIENCE
(2021)
Article
Materials Science, Characterization & Testing
Fu-An He, Li-Ming Zhang
Summary: MWCNTs/HDPE composites prepared by a masterbatch method exhibited better electrical, mechanical, and rheological properties, with in situ polymerized HDPE playing a key role in enhancing the reinforcing effects of MWCNTs and promoting crystallization of HDPE macromolecular chains.
POLYMERS & POLYMER COMPOSITES
(2021)
Article
Engineering, Biomedical
Zechan Chen, Junbo Zhuang, Jiadong Pang, Zehao Liu, Penghao Zhang, Haijun Deng, Liming Zhang, Baoxiong Zhuang
Summary: A novel modification for single-walled carbon nanotubes (SWNTs) with amylose derivatives containing poly(L-lysine) dendrons (ADP@SWNT) is developed in this study. The ADP@SWNT complex exhibits good water dispersion stability and pDNA transfection capacity. It has been demonstrated to inhibit tumor growth and metastasis both in vitro and in vivo, and the anti-tumor effect can be enhanced by near-infrared irradiation.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2022)
Article
Pharmacology & Pharmacy
Huikang Yang, Nianhua Wang, Ruimeng Yang, Liming Zhang, Xinqing Jiang
Summary: Folic acid-decorated reduction-sensitive star polymeric nanoparticles were synthesized and used for tumor-targeted MRI and chemotherapy. The nanoparticles efficiently delivered drugs and superparamagnetic iron oxide particles into tumor cells through folate receptor-mediated endocytosis and disulfide bond cleavage.
Article
Multidisciplinary Sciences
Chaoping Fu, Weisen Huang, Xiaochang Lu, Shibin Wang, Liming Zhang, Aizheng Chen
Summary: Hydrogels are highly dense polymeric structures with softness, elasticity, and high water content, resembling biological tissues. Self-healing hydrogels that can prolong their life and improve durability, reliability, and safety have been designed. They can be classified into physical and chemical hydrogels based on the interactions between polymer chains. Physical hydrogels rely on non-covalent interactions, while chemical hydrogels rely on reversible covalent interactions.
CHINESE SCIENCE BULLETIN-CHINESE
(2022)
Article
Biochemical Research Methods
Heng-Cong Luo, Kai-Jin Mai, En Liu, Hui Chen, Yi-Juan Xie, Yong-Xiong Zheng, Rong Lin, Li-Ming Zhang, Ying Zhang
Summary: This study demonstrates the potential of a Dextran-PAMAM/siMMP-9 complex as a gene carrier for downregulating MMP-9 expression in diabetic foot ulcers. The complex effectively accelerated wound healing in diabetic rat models, indicating its promising regenerative capabilities for improving DFU healing.
BIOCONJUGATE CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Xuhong Mao, Lingli Long, Juncheng Shen, Kunhua Lin, Lin Yin, Juzhen Yi, Li-Ming Zhang, David Y. B. Deng, Liqun Yang
Summary: A novel cationic vitamin B-12-conjugated glycogen derivative was synthesized, which formed nanoparticles complexed with an acidic tea polysaccharide (TPSA). These nanoparticles exhibited targeted endocytosis for Caco-2 cells, potentially enhancing the absorption efficacy of tea polysaccharides through the small intestinal mucosa.
Article
Pharmacology & Pharmacy
Tian Zhang, Chaoping Fu, Ibrahim Alradwan, TinYo Yen, HoYin Lip, Ping Cai, Andrew M. Rauth, Liming Zhang, Xiao Yu Wu
Summary: A novel multifunctional biopolymer-anticancer drug combination nanomedicine has been designed to treat triple negative breast cancer (TNBC) and prevent its spontaneous metastasis. The nanomedicine significantly inhibits primary TNBC tumor growth and effectively prevents metastasis to other sites, showing promising potential in TNBC treatment.
ADVANCED THERAPEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Siyuan Li, Lin Yin, Juzhen Yi, Li-Ming Zhang, Liqun Yang
Summary: This study investigated the alpha-glucosidase inhibitory mechanism of theaflavin-3-gallate (TF-3-G) through spectroscopy and molecular docking analysis. The results showed that TF-3-G effectively quenched the intrinsic fluorescence of alpha-GC through static quenching and formed a stable complex through hydrophobic interactions. Molecular docking simulations suggested that TF-3-G may bind with the catalytic residues of alpha-GC, causing a change in its secondary structure. The inhibition of alpha-GC activity by TF-3-G was mainly attributed to the alteration of alpha-GC secondary structure caused by the complex formation.
JOURNAL OF FOOD BIOCHEMISTRY
(2021)