Article
Multidisciplinary Sciences
Yueyi Sun, Oluwamayokun Oshinowo, David R. Myers, Wilbur A. Lam, Alexander Alexeev
Summary: Blood clot contraction plays a crucial role in wound healing and hemostasis. This study investigates the relationship between single platelet forces and macroscopic clot forces, providing insights into blood disorders associated with bleeding and thrombosis. The findings contribute to the development of platelet-based biomaterials and facilitate the understanding of clotting mechanisms.
Article
Chemistry, Multidisciplinary
Samuel J. Francis, Marco D. Torelli, Nicholas A. Nunn, Gowthami M. Arepally, Olga A. Shenderova
Summary: Thrombosis is a major health issue in the United States and there is a lack of understanding about its causes, progression, and response to anticoagulant therapy. This study demonstrates the use of fluorescent nanodiamond (FND) as a label for blood clots, which offers advantages over organic fluorophores, such as reduced photodegradation. The addition of tissue plasminogen activator (tPa) allows visualization of clot lysis, which is important for studying the resolution of deep vein thrombosis and pulmonary embolism.
Article
Engineering, Biomedical
Yueyi Sun, David R. Myers, Svetoslav V. Nikolov, Oluwamayokun Oshinowo, John Baek, Samuel M. Bowie, Tamara P. Lambert, Eric Woods, Yumiko Sakurai, Wilbur A. Lam, Alexander Alexeev
Summary: Researchers discovered that platelets utilize a new emergent behavior, asynchrono-mechanical amplification, to enhance material contraction and magnify contractile forces. This behavior, triggered by the heterogeneity in the timing of a population of actuators, indicates that cell heterogeneity plays an essential biophysical function in cell-matrix biomaterials.
Article
Biochemistry & Molecular Biology
Brandon J. DeOre, Paul P. Partyka, Fan Fan, Peter A. Galie
Summary: Fluid shear stress is an important factor in regulating vascular permeability, but the mechanisms underlying shear effects on the blood-brain barrier (BBB) are not well understood. This study investigates the impact of shear stress on BBB using an in vitro model and identifies specific molecular components involved in sensing and responding to shear stress. These findings enhance our understanding of the pathologies associated with changes in cerebral perfusion and suggest potential targets for barrier manipulation in vivo.
Article
Biophysics
Rebecca A. Risman, Ahmed Abdelhamid, John W. Weisel, Brittany E. Bannish, Valerie Tutwiler
Summary: This study investigates the influence of clot contraction on fibrinolysis and characterizes the process of external fibrinolysis using mathematical modeling and experimental methods. The results show that fibrin densification has the most significant impact on the rate of fibrinolysis. This study provides clinical insights for optimizing the timing and delivery of fibrinolysis agents.
BIOPHYSICAL JOURNAL
(2022)
Article
Immunology
Lorenzo Seneci, Christina N. Zdenek, Abhinandan Chowdhury, Caroline F. B. Rodrigues, Edgar Neri-Castro, Melisa Benard-Valle, Alejandro Alagon, Bryan G. Fry
Summary: The study identified significant species and ontogenetic differences in the coagulation effects of rattlesnake venom. Testing the neutralization of venoms from four medically important Mexican rattlesnake species with antivenom and enzyme-inhibitors revealed limitations in snakebite treatment and highlighted the need for further research. The study suggested potential adjunct treatments for specific species based on the mechanisms of venom-induced coagulation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Jia Li, Juan Zhao, Yangbo Xu, Antian Xu, Fuming He
Summary: This study investigates the effect of implant surface on blood-material interactions and subsequent BMSC cellular behaviors. The SLA surface induces earlier and stronger blood clot formation, and enhances the adhesion, proliferation, and migration of BMSCs. The SLA surface also shows higher levels of osteogenic-related genes, ALP activity, and calcium nodule formation. These findings highlight the importance of SLA titanium surfaces in influencing blood clot formation and coordinating surface-blood interactions and cell biological processes.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Editorial Material
Multidisciplinary Sciences
Chase P. Broedersz, Pierre Ronceray
Summary: This paper discusses how the Jarzynski equality updates the second law of thermodynamics by extending the physics of transformations from steam engines to molecular motors.
Article
Hematology
Fatemeh Shahneh, Alexandra Grill, Matthias Klein, Felix Frauhammer, Tobias Bopp, Katrin Schaefer, Verena K. Raker, Christian Becker
Summary: The cells and mechanisms involved in blood clot resorption are only partially known, with regulatory T cells playing a crucial role in regulating thrombolysis by controlling monocytes. The matricellular protein SPARC is shown to enhance monocyte activity and is crucial for blood clot resorption. Expanding Tregs within a therapeutic window can accelerate clot resorption.
Article
Biochemistry & Molecular Biology
Kayla Wood, Sam E. Stephens, Feng Xu, Alshaimaa Hazaa, James C. Meek, Hanna K. Jensen, Morten O. Jensen, Ranil Wickramasinghe
Summary: This study aims to create representative blood clots found in vivo and demonstrate a new method of removing them, in order to improve stroke treatment. The study used artificially created blood clots for experiments and evaluated the dissolution characteristics of different clot types.
Article
Dermatology
Zvi Landau, Katie Lyn Whitacre, Charles Leewood, Jessie Hawkins, Chinenye D. Wachuku
Summary: The management and treatment of pressure ulcers (PUs) are challenging due to various factors that make soft tissue vulnerable. Topical autologous blood clot therapy (TABCT) is an on-site treatment that helps recreate and repair the extracellular matrix (ECM) for wound healing. This study assessed the efficacy of TABCT compared to standard of care (SOC) in treating PUs. TABCT demonstrated effectiveness in reducing the area of PUs and promoting granulation tissue formation.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Chemistry, Analytical
Ming-Ya Hung, Chun-Kai Yang, Jiong-Hong Chen, Li-Han Lin, Hao-Ming Hsiao
Summary: Stroke is the second leading cause of death in the world, with ischemic stroke accounting for approximately 80% of cases. A unique blood clot retriever design was proposed for treating acute ischemic stroke, showing a retrieval rate of 79% and demonstrating the feasibility of the new design concept.
Article
Anesthesiology
Nina Moiseiwitsch, Kimberly A. Nellenbach, Laura A. Downey, David Boorman, Ashley C. Brown, Nina A. Guzzetta
Summary: The use of fibrinogen concentrate (FC) can effectively improve coagulation function after cardiopulmonary bypass (CPB) in neonates without adverse effects on the structure and degradation of fibrin clots.
ANESTHESIA AND ANALGESIA
(2023)
Article
Peripheral Vascular Disease
Lennart Kuck, Antony P. McNamee, Michael J. Simmonds
Summary: The study aimed to define the critical threshold of blood fluid properties to re-infused physically-impaired RBC. Addition of 1-5% rigidified RBC led to negative alterations in cellular deformability and high shear blood viscosity. High-resolution microscopy showed decreased capacity to form reversible aggregates and decreased aggregate size due to the presence of rigidified RBC.
MICROVASCULAR RESEARCH
(2022)
Article
Engineering, Biomedical
Qin Fan, Jinyu Bai, Huajian Shan, Ziying Fei, Hao Chen, Jialu Xu, Qingle Ma, Xiaozhong Zhou, Chao Wang
Summary: The study developed a blood clot delivery platform loaded with BMP-2 protein for enhanced bone regeneration in large-area bone defects. The platform can modulate the immune niche within the bone defect microenvironment in a controllable manner and accelerate bone repair through localized hyperthermia.
BIOACTIVE MATERIALS
(2021)