期刊
RSC ADVANCES
卷 5, 期 110, 页码 90671-90681出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5ra16703e
关键词
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资金
- National Natural Science Foundation of China [21406080]
- Science and Technology Planning Project of Guangdong Province [2013B010404004]
- Fundamental Research Funds for the Central Universities of SCUT [D2154620, 2014ZG0003]
- Author of National Excellent Doctoral Dissertations of China [201169]
Temperature/pH dual-responsive hydrogels were prepared by the grafting copolymerization of xylan possessing different functional groups with N-isopropylacrylamide and acrylamide using N, N'-methylenebis-acrylamide as a cross-linker and 2,2-dimethoxy-2-phenylacetophenone as a photoinitiator via ultraviolet irradiation. The influence of xylan and glycidyl methacrylate-modified xylan (GMAX) as the raw materials on the mechanical properties of hydrogels was comparatively investigated. Hydrogels were characterized by SEM, FTIR, TGA and XRD. The prepared hydrogels demonstrated a rapid phase transition temperature around 35 degrees C. The cumulative release rate of acetylsalicylic acid for xylan-based hydrogels and GMAX-based hydrogels reached to 77.5% and 84.2% in the intestinal fluid, respectively. GMAX-based hydrogels had a drug encapsulation efficiency of 95.21% and low drug release rate in gastric fluid. NIH3T3 cells in GMAX-based hydrogels had the high cell viability by MTT essay. Therefore, GMAX-based hydrogels had the good biocompatibility which make them promising in biomedical applications, especially as intestinal-targeted drug carriers.
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