Review
Biochemistry & Molecular Biology
Kah Kheng Goh, Chun-Hsin Chen, Hsien-Yuan Lane
Summary: Schizophrenia is characterized by abnormal behavior, and dysregulation of oxytocin may play a role in its expression. Studies have shown potential clinical benefits of oxytocin in improving the psychopathology of patients with schizophrenia. Oxytocin has the potential to be a therapeutic agent for schizophrenia and may have implications for future treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Psychology, Clinical
Kah Kheng Goh, Nobuhisa Kanahara, Yi-Hang Chiu, Mong-Liang Lu
Summary: Childhood trauma is associated with schizophrenia and social dysfunction, while oxytocin and the OXTR gene may play a role in regulating social behavior. This study found significant differences in childhood trauma exposure, social functioning, and oxytocin levels among patients with schizophrenia, with certain OXTR SNPs being associated with increased risk for the disorder. The results suggest that oxytocin and its receptor gene could be potential targets for interventions to improve social functioning in individuals with a history of childhood trauma and schizophrenia, although more research is needed to fully understand their effects and applications in this population.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Behavioral Sciences
Ellen R. Bradley, Marlene Tai, Michael Hankin, Joshua D. Woolley
Summary: While oxytocin has been shown to improve mentalizing in men with schizophrenia, it did not have the same effect in women with schizophrenia in this study, suggesting potential sex-specific effects. Higher doses of anti-dopaminergic medication were associated with a decreased response to oxytocin, consistent with previous findings in men.
HORMONES AND BEHAVIOR
(2021)
Article
Psychiatry
Kah Kheng Goh, Mong-Liang Lu
Summary: The study suggests that oxytocin levels are associated with social cognition and social dysfunction in patients with schizophrenia. Patients with schizophrenia have more deficits in social cognition and social dysfunction, along with lower plasma oxytocin levels. Plasma oxytocin levels are positively correlated with affective Theory of Mind (ToM) in patients with schizophrenia, and the effects of oxytocin on social functioning are partially mediated by affective ToM.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Psychiatry
Michael J. Spilka, William R. Keller, Robert W. Buchanan, James M. Gold, James I. Koenig, Gregory P. Strauss
Summary: This study investigated the relationship between plasma oxytocin (OT) levels and social cognition in individuals with schizophrenia (SZ). The results showed that lower plasma OT levels were associated with decreased accuracy in facial emotion recognition, indicating a potential role of endogenous OT in social cognitive abilities in SZ. However, there was no association between OT levels and visual attention to salient facial features. These findings highlight the importance of understanding the association between endogenous OT and social cognition in SZ for the improvement of OT-focused therapies.
ACTA PSYCHIATRICA SCANDINAVICA
(2022)
Article
Biochemistry & Molecular Biology
Jessica L. Andrews, Andrew Zalesky, Shalima Nair, Ryan P. Sullivan, Melissa J. Green, Christos Pantelis, Kelly A. Newell, Francesca Fernandez
Summary: The study reveals that the Lingo-1 gene and methylation are associated with cognitive dysfunction and white matter integrity in schizophrenia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biology
Don Wei, Sherab Tsheringla, James C. McPartland, A. Z. A. Stephen Azariah Allsop
Summary: Social behaviour is crucial to human life, but many psychiatric conditions are associated with deficits in social function. Currently, there are no FDA-approved treatments for social dysfunction. This article proposes a network-based framework that combines pharmacology, psychotherapy, non-invasive brain stimulation, and social skills training to target trans-diagnostic social impairment. The use of oxytocin and endocannabinoids within this framework is discussed as an illustrative strategy. The framework provides actionable treatment strategies for neuropsychiatric social impairment.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2022)
Article
Psychiatry
Vijaya Lakshmi Valaparla, Ritu Nehra, Urvakhsh Meherwan Mehta, Sandeep Grover
Summary: The study found that in patients with schizophrenia, all domains of social cognition and neurocognition show significant improvement during the remission phase, except for the Wisconsin card sorting test (WCST) in neurocognition and the social perception index in social cognition.
ASIAN JOURNAL OF PSYCHIATRY
(2021)
Article
Behavioral Sciences
Keisuke Noto, Akihito Suzuki, Toshinori Shirata, Yoshihiko Matsumoto, Haruka Muraosa, Kaoru Goto, Koichi Otani
Summary: This study found that OXTR gene polymorphism interacts significantly with AC parenting to influence harm avoidance scores, without a significant main effect on any personality traits.
BRAIN AND BEHAVIOR
(2021)
Article
Neurosciences
Junping Wang, Peng Zhang, Wei Li, Qin Wen, Feng Liu, Jiayuan Xu, Qiang Xu, Dan Zhu, Zhaoxiang Ye, Chunshui Yu
Summary: Evidence suggests that the OXTR gene influences autism spectrum disorders (ASDs), which are characterized by deficits in prosocial behaviors linked to the personality trait of reward dependence (RD). Higher OXTR-PRSASDS was associated with lower RD and smaller GMV in the right posterior insula and putamen. The GMV in this region positively correlated with RD and mediated the relationship between OXTR-PRSASDS and RD, showing spatial correlation with OXTR gene expression.
Review
Psychology, Multidisciplinary
Alvaro Cavieres, Pablo Lopez-Silva
Summary: Disturbances in social cognition are a core feature of schizophrenia. This paper discusses the lack of attention given to the domain of social perception and proposes a more precise definition for the concept. Drawing on resources from ecological psychology and phenomenology, the authors suggest that social perception refers to low-level pre-reflective processes involved in the awareness of interpersonal interactions. They argue that people with schizophrenia have difficulties perceiving social situations as opportunities for engagement, and therefore, the term should be used to capture this neglected domain in social cognition.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Psychiatry
Yusuke Nakata, Nobuhisa Kanahara, Atsushi Kimura, Tomihisa Niitsu, Hideki Komatsu, Yasunori Oda, Miwako Nakamura, Masatomo Ishikawa, Tadashi Hasegawa, Yu Kamata, Atsushi Yamauchi, Kazuhiko Inazumi, Hiroshi Kimura, Yuki Shiko, Yohei Kawasaki, Masaomi Iyo
Summary: This study compared TRS, remitted schizophrenia, and ASD patients, finding that oxytocin concentrations in TRS patients were positively correlated with cognitive and social cognitive abilities, while no significant correlation was found in the RemSZ and ASD groups. The single nucleotide polymorphism Rs53576 on the oxytocin receptor gene affected social cognition abilities in the schizophrenia group, suggesting that oxytocin system dysfunction may be involved in the cognitive deficits in TRS patients. These results also indicate potential early neurodevelopmental abnormalities in TRS patients based on shared biological features with ASD patients.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Review
Behavioral Sciences
Julia S. Krimberg, Francisco S. Lumertz, Rodrigo Orso, Thiago W. Viola, Rosa Maria M. de Almeida
Summary: Social isolation stress is associated with negative developmental outcomes and may be related to the oxytocinergic system. Decreased OXTR levels are associated with behavioral alterations such as increased aggression and anxiety-like behavior, hyperactivity, and diminished social behaviors and memory. Administration of synthetic oxytocin or its agonists can partially decrease these behavioral alterations.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Psychiatry
Matteo Cella, Ottilie Sedgwick, Megan Lawrence, Nina Grant, Dimosthenis Tsapekos, Lauren Harrison, Til Wykes
Summary: This study evaluates the impact of a social cognition intervention on social cognition and social functioning outcomes in people with schizophrenia, and explores the mechanisms of affect and physiological arousal driving these changes. The results show that the intervention can improve social quality by reducing negative affect, but an increase in social behavior may take longer to manifest.
PSYCHIATRY RESEARCH
(2023)
Article
Neurosciences
Kristina Hennig-Fast, Dominik Meissner, Carolin Steuwe, Sandra Dehning, Janusch Blautzik, Dirk W. Eilert, Peter Zill, Norbert Mueller, Thomas Meindl, Maximilian Reiser, Hans-Juergen Moeller, Peter Falkai, Martin Driessen, Anna Buchheim
Summary: This study compared attachment patterns and oxytocin levels between male schizophrenic patients and male healthy controls using fMRI. The results showed a higher proportion of insecure attachment and lower oxytocin levels in schizophrenic patients. Neural activation in memory and self-related brain regions was increased in schizophrenic patients during the activation of the attachment system.
Review
Pharmacology & Pharmacy
Jacob T. Brown, Jeffrey R. Bishop, Katrin Sangkuhl, Erika L. Nurmi, Daniel J. Mueller, Jean C. Dinh, Andrea Gaedigk, Teri E. Klein, Kelly E. Caudle, James T. McCracken, Jose de Leon, J. Steven Leeder
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2019)
Letter
Medicine, General & Internal
Jean Kim, Michael Davis, Tiffany Farchione
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2019)
Letter
Psychiatry
Yvonne S. Yang, Michael C. Davis, Jonathan K. Wynn, Gerhard Hellemann, Michael F. Green, Stephen R. Marder
SCHIZOPHRENIA RESEARCH
(2019)
Article
Neurosciences
Xiang-Zhen Kong, Premika S. W. Boedhoe, Yoshinari Abe, Pino Alonso, Stephanie H. Ameis, Paul D. Arnold, Francesca Assogna, Justin T. Baker, Marcelo C. Batistuzzo, Francesco Benedetti, Jan C. Beucke, Irene Bollettini, Anushree Bose, Silvia Brem, Brian P. Brennan, Jan Buitelaar, Rosa Calvo, Yuqi Cheng, Kang Ik K. Cho, Sara Dallaspezia, Damiaan Denys, Benjamin A. Ely, Jamie Feusner, Kate D. Fitzgerald, Jean-Paul Fouche, Egill A. Fridgeirsson, David C. Glahn, Patricia Gruner, Deniz A. Gursel, Tobias U. Hauser, Yoshiyuki Hirano, Marcelo Q. Hoexter, Hao Hu, Chaim Huyser, Anthony James, Fern Jaspers-Fayer, Norbert Kathmann, Christian Kaufmann, Kathrin Koch, Masaru Kuno, Gerd Kvale, Jun Soo Kwon, Luisa Lazaro, Yanni Liu, Christine Lochner, Paulo Marques, Rachel Marsh, Ignacio Martinez-Zalacain, David Mataix-Cols, Sarah E. Medland, Jose M. Menchon, Luciano Minuzzi, Pedro S. Moreira, Astrid Morer, Pedro Morgado, Akiko Nakagawa, Takashi Nakamae, Tomohiro Nakao, Janardhanan C. Narayanaswamy, Erika L. Nurmi, Joseph O'Neill, Jose C. Pariente, Chris Perriello, John Piacentini, Fabrizio Piras, Federica Piras, Christopher Pittenger, Y. C. Janardhan Reddy, Oana Georgiana Rus-Oswald, Yuki Sakai, Joao R. Sato, Lianne Schmaal, H. Blair Simpson, Noam Soreni, Carles Soriano-Mas, Gianfranco Spalletta, Emily R. Stern, Michael C. Stevens, S. Evelyn Stewart, Philip R. Szeszko, David F. Tolin, Aki Tsuchiyagaito, Daan van Rooij, Guido A. van Wingen, Ganesan Venkatasubramanian, Zhen Wang, Je-Yeon Yun, Paul M. Thompson, Dan J. Stein, Odile A. van den Heuvel, Clyde Francks
BIOLOGICAL PSYCHIATRY
(2020)
Editorial Material
Psychiatry
Erika L. Nurmi
BRAZILIAN JOURNAL OF PSYCHIATRY
(2020)
Article
Substance Abuse
Edythe D. London, Kyoji Okita, Kaitlin R. Kinney, Andrew C. Dean, Megan N. McClintick, Elizabeth J. Rizor, Maritza C. Johnson, Tarannom Mahmoudie, Arthur L. Brody, Erika L. Nurmi, Lauren C. Seaman, Judah Farahi, Nathaniel Ginder, Mark A. Mandelkern
DRUG AND ALCOHOL DEPENDENCE
(2020)
Article
Multidisciplinary Sciences
Ruishan Liu, Shemra Rizzo, Samuel Whipple, Navdeep Pal, Arturo Lopez Pineda, Michael Lu, Brandon Arnieri, Ying Lu, William Capra, Ryan Copping, James Zou
Summary: The study found that using a data-driven approach to broaden trial eligibility criteria can increase the number of eligible patients and decrease the hazard ratio of overall survival. Many patients who were initially not eligible under the trial criteria could potentially benefit from the treatments.
Article
Medicine, General & Internal
Devin Incerti, Shemra Rizzo, Xiao Li, Lisa Lindsay, Vincent Yau, Dan Keebler, Jenny Chia, Larry Tsai
Summary: Analyzed data from over 17,000 COVID-19 hospitalized patients to develop a prognostic model for mortality. Found age to be the most critical predictor, with demographic and comorbidity factors showing minimal impact on model performance. The model had good discrimination and calibration, indicating potential for prognosis assessment. No overfitting detected as similar results were obtained in both training and test sets.
Article
Medicine, Research & Experimental
Lin Xu, Ashok Krishna, Sharron Stewart, Katherine Shea, Rebecca Racz, James L. Weaver, Donna A. Volpe, Nageswara R. Pilli, Suresh Narayanasamy, Jeffry Florian, Vikram Patel, Murali K. Matta, Marc B. Stone, Hao Zhu, Michael C. Davis, David G. Strauss, Rodney Rouse
Summary: This study utilized a nonclinical in vivo model to assess the impact on respiration of non-benzodiazepine sedative psychotropic drugs when used concurrently with opioids. It found that paroxetine, trazodone, and quetiapine given with oxycodone significantly increased arterial partial pressure of carbon dioxide, potentially due to pharmacokinetic interactions. The study identified drug-drug interaction effects depressing respiration in an animal model when quetiapine or paroxetine were co-administered with oxycodone, highlighting the importance of further clinical pharmacodynamic drug interaction studies.
CTS-CLINICAL AND TRANSLATIONAL SCIENCE
(2021)
Article
Medicine, General & Internal
Lisa Lindsay, Matthew H. Secrest, Shemra Rizzo, Daniel S. Keebler, Fei Yang, Larry Tsai
Summary: This study identified sociodemographic and clinical factors associated with COVID-19 test positivity and provided real-world evidence demonstrating high antibody test concordance among viral-positive patients. Factors associated with increased odds of viral and antibody positivity included male sex, Hispanic or non-Hispanic black or Asian race/ethnicity, uninsured or Medicaid insurance, and Northeast residence. Pediatric patients had reduced odds of a positive viral test but increased odds of a positive antibody test compared with those aged 18-34 years old.
Article
Biochemistry & Molecular Biology
Ruishan Liu, Shemra Rizzo, Sarah Waliany, Marius Rene Garmhausen, Navdeep Pal, Zhi Huang, Nayan Chaudhary, Lisa Wang, Chris Harbron, Joel Neal, Ryan Copping, James Zou
Summary: This study conducted a large-scale computational analysis on real-world data of over 40,000 US cancer patients. By studying mutation profiles, treatment sequences, and outcomes, the study identified 458 mutations that predict patient survival in specific cancer therapies, such as immunotherapies, chemotherapy agents, and targeted therapies. The study also investigated mutation-mutation interactions that affect the outcomes of targeted therapies.
Article
Toxicology
Lin Xu, Ashok Chockalingam, Sharron Stewart, Katherine Shea, Murali K. Matta, Suresh Narayanasamy, Nageswara R. Pilli, Donna A. Volpe, James Weaver, Hao Zhu, Michael C. Davis, David G. Strauss, Rodney Rouse
TOXICOLOGY REPORTS
(2020)
Correction
Clinical Neurology
Je-Yeon Yun, Premika S. W. Boedhoe, Chris Vriend, Neda Jahanshad, Yoshinari Abe, Stephanie H. Ameis, Alan Anticevic, Paul D. Arnold, Marcelo C. Batistuzzo, Francesco Benedetti, Jan C. Beucke, Irene Bollettini, Anushree Bose, Silvia Brem, Anna Calvo, Yuqi Cheng, Kang Ik K. Cho, Valentina Ciullo, Sara Dallaspezia, Damiaan Denys, Jamie D. Feusner, Jean-Paul Fouche, Monica Gimenez, Patricia Gruner, Derrek P. Hibar, Marcelo Q. Hoexter, Hao Hu, Chaim Huyser, Keisuke Ikari, Norbert Kathmann, Christian Kaufmann, Kathrin Koch, Luisa Lazaro, Christine Lochner, Paulo Marques, Rachel Marsh, Ignacio Martinez-Zalacain, David Mataix-Cols, Jose M. Menchon, Luciano Minuzzi, Pedro Morgado, Pedro Moreira, Takashi Nakamae, Tomohiro Nakao, Janardhanan C. Narayanaswamy, Erika L. Nurmi, Joseph O'Neill, John Piacentini, Fabrizio Piras, Federica Piras, Y. C. Janardhan Reddy, Joao R. Sato, H. Blair Simpson, Noam Soreni, Carles Soriano-Mas, Gianfranco Spalletta, Michael C. Stevens, Philip R. Szeszko, David F. Tolin, Ganesan Venkatasubramanian, Susanne Walitza, Zhen Wang, Guido A. van Wingen, Jian Xu, Xiufeng Xu, Qing Zhao, Paul M. Thompson, Dan J. Stein, Odile A. van den Heuvel, Jun Soo Kwon
Article
Clinical Neurology
Je-Yeon Yun, Premika S. W. Boedhoe, Chris Vriend, Neda Jahanshad, Yoshinari Abe, Stephanie H. Ameis, Alan Anticevic, Paul D. Arnold, Marcelo C. Batistuzzo, Francesco Benedetti, Jan C. Beucke, Irene Bollettini, Anushree Bose, Silvia Brem, Anna Calvo, Yuqi Cheng, Kang Ik K. Cho, Valentina Ciullo, Sara Dallaspezia, Damiaan Denys, Jamie D. Feusner, Jean-Paul Fouche, Monica Gimenez, Patricia Gruner, Derrek P. Hibar, Marcelo Q. Hoexter, Hao Hu, Chaim Huyser, Keisuke Ikari, Norbert Kathmann, Christian Kaufmann, Kathrin Koch, Luisa Lazaro, Christine Lochner, Paulo Marques, Rachel Marsh, Ignacio Martinez-Zalacain, David Mataix-Cols, Jose M. Menchon, Luciano Minuzzi, Pedro Morgado, Pedro Moreira, Takashi Nakamae, Tomohiro Nakao, Janardhanan C. Narayanaswamy, Erika L. Nurmi, Joseph O'Neill, John Piacentini, Fabrizio Piras, Federica Piras, Y. C. Janardhan Reddy, Joao R. Sato, H. Blair Simpson, Noam Soreni, Carles Soriano-Mas, Gianfranco Spalletta, Michael C. Stevens, Philip R. Szeszko, David F. Tolin, Ganesan Venkatasubramanian, Susanne Walitza, Zhen Wang, Guido A. van Wingen, Jian Xu, Xiufeng Xu, Qing Zhao, Paul M. Thompson, Dan J. Stein, Odile A. van den Heuvel, Jun Soo Kwon
Meeting Abstract
Psychiatry
D. Mueller, M. Maciukiewicz, A. K. Tiwari, C. C. Zai, I. Gorbovskaya, C. P. Laughlin, E. L. Nurmi, J. A. Liebermann, H. Y. Meltzer, J. L. Kennedy
EUROPEAN PSYCHIATRY
(2019)
