Article
Neurosciences
Jeffrey M. Kenzie, Deepthi Rajashekar, Bradley G. Goodyear, Sean P. Dukelow
Summary: Around 50% of stroke patients have deficits in proprioception, but our understanding of the neurological mechanisms behind these deficits is limited. This study used resting-state functional magnetic resonance imaging (fMRI) to investigate changes in functional brain networks associated with proprioception deficits in stroke patients. The results showed reduced connectivity in specific brain regions, including the supplementary motor area and the supramarginal gyrus, in stroke patients compared to healthy controls. Functional connectivity of these regions, as well as the primary somatosensory cortex and the parietal opercular area, was significantly associated with proprioceptive function. The parietal lobe of the lesioned hemisphere was identified as an important node for proprioception after stroke, and evaluating the functional connectivity of this region could help predict recovery. The study also identified potential targets for therapeutic neurostimulation to aid in stroke recovery.
HUMAN BRAIN MAPPING
(2023)
Article
Health Care Sciences & Services
Tsutomu Takahashi, Daiki Sasabayashi, Yoichiro Takayanagi, Atsushi Furuichi, Mikio Kido, Tien Viet Pham, Haruko Kobayashi, Kyo Noguchi, Michio Suzuki
Summary: This study found a high prevalence of duplicated HG patterns in patients with schizophrenia and schizotypal disorder, with no significant difference between the two groups. Different HG gyrification patterns may be associated with symptom severity and antipsychotic medication dosage in patients.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Psychiatry
Tsutomu Takahashi, Daiki Sasabayashi, Yoichiro Takayanagi, Atsushi Furuichi, Haruko Kobayashi, Kyo Noguchi, Michio Suzuki
Summary: This study found a higher prevalence of duplicated Heschl's gyrus (HG) pattern, especially on the right side, in schizophrenia patients with deficit syndrome. The HG pattern was not associated with clinical variables, but correlated with higher scores for Proxy for the Deficit Syndrome. These findings suggest that neurodevelopmental pathology of the HG may contribute to enduring negative symptoms in schizophrenia.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Psychiatry
Fan Yang, Huan Ma, Jing Yuan, Yujun Wei, Li Xu, Yan Zhang, Chuanyuan Kang, Jianzhong Yang
Summary: The study identified significant differences in cognitive function, ReHo patterns in the cerebrum and cerebellum between chronic schizophrenia patients and normal controls. However, these changes in regional activity did not show significant correlations with clinical symptoms.
PSYCHIATRY RESEARCH
(2021)
Article
Psychology, Clinical
Daniel Berge, Tyler A. Lesh, Jason Smucny, Cameron S. Carter
Summary: This study using rs-fMRI found evidence of abnormal thalamocortical connectivity in individuals with recent-onset psychosis. These abnormal connections were stable over a 1-year period and did not worsen over time.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Computer Science, Artificial Intelligence
Mingliang Wang, Jiashuang Huang, Mingxia Liu, Daoqiang Zhang
Summary: This study proposes a temporal dynamics learning (TDL) method for network-based brain disease identification using rs-fMRI time-series data. By integrating network feature extraction and classifier training into a unified framework, it addresses the issues of previous studies paying less attention to the evolution of global network structures over time and treating feature extraction and training as separate tasks.
MEDICAL IMAGE ANALYSIS
(2021)
Article
Computer Science, Artificial Intelligence
Nan Wang, Dongren Yao, Lizhuang Ma, Mingxia Liu
Summary: The proposed MC-NFE method divides training data into ASD and HC groups, models inter-site heterogeneity within each category, and uses a nested SVD method to extract FC features for ASD detection. Experimental results show that MC-NFE outperforms several state-of-the-art methods in detecting ASD, with discriminative FCs mainly located in the default mode network, salience network, and cerebellum region.
MEDICAL IMAGE ANALYSIS
(2022)
Article
Behavioral Sciences
Weiwei Chang, Zongxia Lv, Xiaomin Pang, Liluo Nie, Jinou Zheng
Summary: This study investigated local brain abnormalities in patients with temporal lobe epilepsy presenting as ictal panic. The results showed a significant decrease in ReHo value in the right middle frontal gyrus and a significant increase in DC value in the left middle temporal gyrus in the group with ictal panic.
EPILEPSY & BEHAVIOR
(2022)
Article
Psychiatry
Shiral S. Gangadin, Wiepke Cahn, Thomas W. Scheewe, Hilleke E. Hulshoff Pol, Matthijs G. Bossong
Summary: Contemporary preclinical models suggest that abnormal functioning of a brain network involving the hippocampus, midbrain, and striatum is critical in schizophrenia. This study found that schizophrenia patients have lower functional connectivity in this network, particularly between the SUB and LS, and VTA and AS. Functioning of the hippocampus-midbrain-striatum network is significantly altered in the pathophysiology of schizophrenia.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Review
Neurosciences
Chrysoula Zouraraki, Penny Karamaouna, Stella G. Giakoumaki
Summary: Ample research findings suggest altered brain functioning in the schizophrenia spectrum. However, functional neuroimaging findings remain unclear for individuals with high schizotypal traits and diagnosed with schizotypal personality disorder (SPD). This systematic review aimed to identify neural abnormalities in task-related and resting-state conditions across these groups. The review found functional alterations in striatal, frontal, and temporal regions in individuals with high schizotypal traits, and default mode network abnormalities in SPD patients. Further research is needed to understand the neural correlates and compensatory mechanisms in these conditions.
Article
Neurosciences
Xianyu Cao, Huan Huang, Bei Zhang, Yuchao Jiang, Hui He, Mingjun Duan, Sisi Jiang, Ying Tan, Dezhong Yao, Chao Li, Cheng Luo
Summary: This study compared local neural synchronous spontaneous oscillation between SZ patients and healthy controls using a 2dReHo method. The findings showed abnormal 2dReHo in SZ patients across the cortical surface, different from the control group. Additionally, the study found significant correlations between certain brain regions related to neural synchronous oscillations and illness duration, as well as symptoms in SZ patients.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Article
Psychiatry
Tsutomu Takahashi, Daiki Sasabayashi, Yoichiro Takayanagi, Atsushi Furuichi, Mikio Kido, Mihoko Nakamura, Tien Viet Pham, Haruko Kobayashi, Kyo Noguchi, Michio Suzuki
Summary: The study revealed that first-episode schizophrenia patients showed lower gray matter volumes in the HG and PT compared to healthy controls, and had a higher prevalence of duplicated HG patterns. Additionally, different HG duplication patterns were associated with clinical symptoms in patients with schizophrenia.
SCHIZOPHRENIA RESEARCH
(2021)
Article
Psychiatry
Christina Isakoglou, Koen V. V. Haak, Thomas Wolfers, Dorothea L. L. Floris, Alberto Llera, Marianne Oldehinkel, Natalie J. J. Forde, Bethany F. M. Oakley, Julian Tillmann, Rosemary J. J. Holt, Carolin Moessnang, Eva Loth, Thomas Bourgeron, Simon Baron-Cohen, Tony Charman, Tobias Banaschewski, Declan G. M. Murphy, Jan K. K. Buitelaar, Andre F. F. Marquand, Christian F. F. Beckmann
Summary: Sensory atypicalities are common in autism spectrum disorders (ASD), but the functioning of the somatosensory region and its association with the ASD phenotype is not well understood. In this study, we examined the functional connectivity of the primary somatosensory cortex (S1) in autistic and neurotypical individuals. We found that the S1 connectopy is organized along a dorsoventral axis and is associated with adaptive functioning skills. Furthermore, the S1 connectopy showed differences between rest and emotion processing, indicating a task-modulating effect.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Neurosciences
Ioannis K. Gallos, Evangelos Galaris, Constantinos I. Siettos
Summary: This study utilized various manifold learning algorithms to construct functional connectivity networks from resting-state fMRI data of schizophrenia patients and healthy controls. The diffusion maps with cross correlation metric outperformed other combinations in terms of classification potential.
COGNITIVE NEURODYNAMICS
(2021)
Article
Neurosciences
Zhihong Lan, Shoujun Xu, Xiangrong Yu, Zhenjie Yu, Meng Li, Feng Chen, Yu Liu, Tianyue Wang, Yunfan Wu, Yungen Gan, Guihua Jiang
Summary: This study investigates the functional connectivity in single-sex children with autism spectrum disorders (ASDs) through resting-state functional magnetic resonance imaging (rs-fMRI), revealing enhanced connectivity in specific brain regions. The study suggests a possible relationship between atypical visual attention and poor learning ability in subjects with ASD.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Psychology, Clinical
Hannah J. Jones, Gemma Hammerton, Tayla McCloud, Lindsey A. Hines, Caroline Wright, Suzanne H. Gage, Peter Holmans, Peter B. Jones, George Davey Smith, David E. J. Linden, Michael C. O'Donovan, Michael J. Owen, James T. Walters, Marcus R. Munafo, Jon Heron, Stanley Zammit
Summary: This study found that genetic risk for schizophrenia is associated with patterns of cannabis use during adolescence, but not mediated through cognitive, emotional, and behavioral phenotypes during childhood. Further investigation of pathways other than those examined in this study is needed to identify modifiable targets for reducing the public health burden of cannabis use.
PSYCHOLOGICAL MEDICINE
(2022)
Review
Neurosciences
Ida E. Sonderby, Christopher R. K. Ching, Sophia I. Thomopoulos, Dennis van Der Meer, Daqiang Sun, Julio E. Villalon-Reina, Ingrid Agartz, Katrin Amunts, Celso Arango, Nicola J. Armstrong, Rosa Ayesa-Arriola, Geor Bakker, Anne S. Bassett, Dorret I. Boomsma, Robin Bulow, Nancy J. Butcher, Vince D. Calhoun, Svenja Caspers, Eva W. C. Chow, Sven Cichon, Simone Ciufolini, Michael C. Craig, Benedicto Crespo-Facorro, Adam C. Cunningham, Anders M. Dale, Paola Dazzan, Greig I. de Zubicaray, Srdjann Djurovic, Joanne L. Doherty, Gary Donohoe, Bogdan Draganski, Courtney A. Durdle, Stefan Ehrlich, Beverly S. Emanuel, Thomas Espeseth, Simon E. Fisher, Tian Ge, David C. Glahn, Hans J. Grabe, Raquel E. Gur, Boris A. Gutman, Jan Haavik, Asta K. Haberg, Laura A. Hansen, Ryota Hashimoto, Derrek P. Hibar, Avram J. Holmes, Jouke-Jan Hottenga, Hilleke E. Hulshoff Pol, Maria Jalbrzikowski, Emma E. M. Knowles, Leila Kushan, David E. J. Linden, Jingyu Liu, Astri J. Lundervold, Sandra Martin-Brevet, Kenia Martinez, Karen A. Mather, Samuel R. Mathias, Donna M. McDonald-McGinn, Allan F. McRae, Sarah E. Medland, Torgeir Moberget, Claudia Modenato, Jennifer Monereo Sanchez, Clara A. Moreau, Thomas W. Muhleisen, Tomas Paus, Zdenka Pausova, Carlos Prieto, Anjanibhargavi Ragothaman, Celine S. Reinbold, Tiago Reis Marques, Gabriela M. Repetto, Alexandre Reymond, David R. Roalf, Borja Rodriguez-Herreros, James J. Rucker, Perminder S. Sachdev, James E. Schmitt, Peter R. Schofield, Ana I. Silva, Hreinn Stefansson, Dan J. Stein, Christian K. Tamnes, Diana Tordesillas-Gutierrez, Magnus O. Ulfarsson, Ariana Vajdi, Dennis van 't Ent, Marianne B. M. van den Bree, Evangelos Vassos, Javier Vazquez-Bourgon, Fidel Vila-Rodriguez, G. Bragi Walters, Wei Wen, Lars T. Westlye, Katharina Wittfeld, Elaine H. Zackai, Kari Stefansson, Sebastien Jacquemont, Paul M. Thompson, Carrie E. Bearden, Ole A. Andreassen
Summary: The ENIGMA-CNV and 22q-ENIGMA WGs aim to investigate the effects of CNVs on brain structures, with findings showing differences in cognitive, neurodevelopmental, and neuropsychiatric traits as well as characteristic patterns of brain structural abnormalities. The genotype-first approach provides insights into the etiopathogenesis of brain disorders, and future directions include further understanding the impacts of CNVs on brain structure and behavior.
HUMAN BRAIN MAPPING
(2022)
Article
Psychology, Clinical
Rachael L. Adams, Alister Baird, Jacqueline Smith, Nigel Williams, Marianne B. M. van den Bree, David E. J. Linden, Michael J. Owen, Jeremy Hall, Stefanie C. Linden
Summary: Adult CNV carriers have a significantly increased rate of anxiety and personality disorders. In addition, they have a high rate of psychiatric multimorbidity. These findings support comprehensive psychiatric and medical assessments for CNV carriers and the establishment of multidisciplinary clinical services.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Neurosciences
Clara A. Moreau, Annabelle Harvey, Kuldeep Kumar, Guillaume Huguet, Sebastian G. W. Urchs, Elise A. Douard, Laura M. Schultz, Hanad Sharmarke, Khadije Jizi, Charles-Olivier Martin, Nadine Younis, Petra Tamer, Thomas Rolland, Jean-Louis Martineau, Pierre Orban, Ana Isabel Silva, Jeremy Hall, Marianne B. M. van den Bree, Michael J. Owen, David E. J. Linden, Aurelie Labbe, Sarah Lippe, Carrie E. Bearden, Laura Almasy, David C. Glahn, Paul M. Thompson, Thomas Bourgeron, Pierre Bellec, Sebastien Jacquemont
Summary: Polygenicity and genetic heterogeneity pose challenges in studying psychiatric disorders. This study estimated and compared the effect sizes on brain connectivity of different genetic risk factors and found that psychiatric CNVs had the largest effect sizes, followed by psychiatric conditions, neuroticism and fluid intelligence, and PRSs. The effect sizes of CNVs on connectivity were correlated with their effects on cognition and disease risk.
BIOLOGICAL PSYCHIATRY
(2023)
Article
Clinical Neurology
Clara A. Moreau, Kuldeep Kumar, Annabelle Harvey, Guillaume Huguet, Sebastian G. W. Urchs, Laura M. Schultz, Hanad Sharmarke, Khadije Jizi, Charles-Olivier Martin, Nadine Younis, Petra Tamer, Jean-Louis Martineau, Pierre Orban, Ana Isabel Silva, Jeremy Hall, Marianne B. M. van den Bree, Michael J. Owen, David E. J. Linden, Sarah Lippe, Carrie E. Bearden, Laura Almasy, David C. Glahn, Paul M. Thompson, Thomas Bourgeron, Pierre Bellec, Sebastien Jacquemont
Summary: This study uses large-scale resting-state functional MRI data to investigate the influence of genetic variants on large-scale brain networks and their correlations with psychiatric disorders and cognitive traits. The findings suggest a substantial genetic component for shared connectivity profiles across conditions and traits, providing new avenues for understanding and treating psychiatric disorders.
Article
Neurosciences
Chaira Serrarens, Sriranga Kashyap, Laura Riveiro-Lago, Maarten Otter, Bea C. M. Campforts, Constance T. R. M. Stumpel, Henk Jansma, David E. J. Linden, Therese A. M. J. van Amelsvoort, Claudia Vingerhoets
Summary: This study investigated the effects of triple X syndrome (47,XXX) on functional connectivity in the brain. The results showed abnormal increase in resting-state functional connectivity in patients. However, these changes were not associated with intelligence quotient (IQ) or social cognition function.
Review
Genetics & Heredity
Yelyzaveta Snihirova, David E. J. Linden, Therese van Amelsvoort, Dennis van der Meer
Summary: 22q11.2 deletion syndrome (22q11DS) is associated with a wide range of neuropsychiatric symptoms, and the clinical presentation is likely influenced by environmental factors. This review explores the role of the environment in 22q11DS and finds that parental factors, stress, and substance use have significant effects on the clinical profile. However, case-control studies have not found significant moderating effects of the environment. The study suggests specific environmental measures that may interact with the 22q11 deletion based on genes and molecular pathways.
Article
Neurosciences
Xi Yang, Xinqi Zhou, Fei Xin, Benjamin Becker, David Linden, Dennis Hernaus
Summary: Age-related changes in brain function have an important role in neurodegenerative diseases. Previous studies have mainly focused on static functional connectivity, but emerging evidence suggests that aging is associated with dynamic changes in brain interactions and transitions. This study replicates the finding of age-associated changes in dynamic functional connectivity using fMRI data from two cultures (Western European and Chinese). Older participants consistently exhibit a lower occurrence and duration of a specific connectivity state (state I) compared to younger participants, as well as more transitions between networks and greater variance in global efficiency.
Article
Clinical Neurology
Ruben L. Andriessen, Mayke Oosterloo, Angelique Hollands, David E. J. Linden, Bianca T. A. de Greef, Albert F. G. Leentjens
Summary: The study found that psychotropic medication is widely prescribed in HD patients, with antidepressant use decreasing proportionally and antipsychotic use increasing with advancing disease stages. This suggests a relative decrease in prevalence of anxiety and depression, and a relative increase in irritability and delusions over disease stages.
PARKINSONISM & RELATED DISORDERS
(2022)
Article
Neurosciences
Duncan James McLauchlan, David E. J. Linden, Anne E. Rosser
Summary: In Huntington's disease, irritability is mainly mediated by excessive response to provocation rather than a failure of motor inhibition, while impulsive behavior is associated with irritability.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Joanne L. Doherty, Adam C. Cunningham, Samuel J. R. A. Chawner, Hayley M. Moss, Diana C. Dima, David E. J. Linden, Michael J. Owen, Marianne B. M. van den Bree, Krish D. Singh
Summary: The study utilized magnetoencephalography to investigate the electrophysiological markers of brain activity in individuals with 22q11.2 deletion syndrome. The findings revealed alterations in local and global network function, which may contribute to the increased vulnerability to neurodevelopmental and psychiatric disorders in this population.
NEUROPSYCHOPHARMACOLOGY
(2023)
Meeting Abstract
Biochemistry & Molecular Biology
Yanq Xiao, Tijs Louwies, Kristen Smith-Edwards, Arthur Beyder, David Linden, Gianrico Farrugia, Purna Kashyap
Article
Clinical Neurology
Duncan James McLauchlan, Thomas Lancaster, David Craufurd, David E. J. Linden, Anne E. Rosser
Summary: Depression is more common in neurodegenerative diseases like Huntington's disease, and the choice of antidepressant treatment for Huntington's disease lacks sufficient evidence. This study used propensity score analyses and cognitive battery assessments to determine the best treatment choices for depression in Huntington's disease and identified the main mechanisms underlying depression.
BRAIN COMMUNICATIONS
(2022)
Meeting Abstract
Clinical Neurology
Ruben L. Andriessen, Mayke Oosterloo, Angelique Hollands, David E. J. Linden, Bianca T. A. De Greef, Albert F. G. Leentjens
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Meeting Abstract
Neurosciences
Dennis van der Meer, Tobias Kaufmann, Alexey Shadrin, Oleksandr Frei, David Linden, Lars Westlye, Anders M. Dale, Ole Andreassen
BIOLOGICAL PSYCHIATRY
(2022)
