Review
Psychiatry
Marcela Almeida, Sun J. Fletcher
Summary: This review explores the gender differences in the expression of serious mental illnesses (SMI) and focuses on the most common SMI affecting women. It discusses treatment options according to specific life stages and emphasizes the importance of recognizing gender biases, cultural considerations, and adaptive responses in order to identify women at risk, promote early symptom recognition, and improve outcomes.
CURRENT OPINION IN PSYCHIATRY
(2022)
Article
Emergency Medicine
Shilpa Kumar, Herbert C. Duber, William Kreuter, Amber K. Sabbatini
Summary: Patients with mental illness experience disparities in cardiovascular outcomes after an ED visit for chest pain, with higher rates of hospitalization and diagnostic testing compared to those without mental illness. Their incidence of major adverse cardiac events is similar to patients without mental illness.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2022)
Article
Psychiatry
Karly A. Murphy, Arlene Dalcin, Emma E. McGinty, Stacy Goldsholl, Ann Heller, Gail L. Daumit
Summary: The paper discusses the challenges of coordinating care for individuals with serious mental illness (SMI) and explores multidisciplinary strategies for overcoming these challenges, using examples from a cardiovascular risk reduction intervention that has shown to be effective in a clinical trial.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Psychiatry
Mary F. Brunette, Minda A. Gowarty, Ashley E. Gaughan-Maher, Sarah Pratt, Kelly A. Aschbrenner, Sheila Considine-Sweeny, Jennifer Elliott, Margaret Almeida, Alicia M. L'Esperance
Summary: The study aims to describe the physical health characteristics and service utilization of young people with serious mental illness (SMI). The results showed that half of the participants smoked cigarettes and had obesity, almost half had hypertension, and about a third had laboratory metabolic abnormalities. Obesity was associated with high blood pressure, prediabetes, sedentary behavior, and low health satisfaction.
EARLY INTERVENTION IN PSYCHIATRY
(2023)
Editorial Material
Health Care Sciences & Services
Victor J. Dzau, Mark B. McClellan, J. Michael McGinnis, Jessica C. Marx, Rebecca D. Sullenger, William ElLaissi
Summary: The National Academy of Medicine initiated a strategic initiative in 2016 to provide expert guidance on pressing health and health care priorities for the forthcoming new administration. The articles published address issues such as health costs, early childhood and maternal health, mental health and addiction, better health for older adults, and infectious disease threats, reflecting the current experience with the COVID-19 pandemic and health inequities.
Article
Oncology
Kimlin Tam Ashing, Gaole Song, Veronica Jones, Charles Brenner, Raynald Samoa
Summary: Cancer inequity affects ethnic minorities and people of lower socioeconomic status, leading to poor access to care and higher prevalence of comorbid conditions like diabetes. This study found that minority cancer patients, especially non-Hispanic Blacks and Hispanic/Latino individuals, were more likely to have diabetes. Older, ethnic minority, overweight/obese, and lower educated cancer patients were also at higher risk for diabetes. Clinicians and health systems should routinely assess cancer patients for diabetes and provide coordinated care.
FRONTIERS IN ONCOLOGY
(2023)
Review
Psychology, Clinical
Xue-Lei Fu, Yan Qian, Xiao-Hong Jin, Hai-Rong Yu, Hua Wu, Lin Du, Hong-Lin Chen, Ya-Qin Shi
Summary: This study quantified the suicide rates among people with serious mental illness (bipolar disorder, major depression, or schizophrenia). The findings showed high suicide rates, especially among individuals with major depression. Male patients were found to have a higher risk of suicide compared to females. Poisoning was the most common method of suicide. The study highlights the need for increased psychological assessment and monitoring, as well as further research on regional and age differences in suicide among this population.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Nutrition & Dietetics
Kyung Won Lee, Dayeon Shin
Summary: This study investigated the association between dietary factors and metabolic abnormalities among single-person households in different regional types in Korea. The findings suggest regional disparities in the relationships of dietary factors and behaviors with obesity, hypertension, and diabetes. Policy interventions targeting unhealthy dietary factors by regional type may help reduce regional health disparities among single-person households in Korea.
Article
Cardiac & Cardiovascular Systems
Anandita Agarwala, Nathan Bekele, Elena Deych, Michael W. Rich, Aliza Hussain, Laney K. Jones, Amy C. Sturm, Karen Aspry, Elizabeth Nowak, Zahid Ahmad, Christie M. Ballantyne, Anne C. Goldberg
Summary: Black patients with familial hypercholesterolemia have similar prevalence of ASCVD compared to European Ancestry patients, but show greater prevalence of modifiable risk factors such as obesity, hypertension, diabetes, and smoking. They also have lower usage of lipid-lowering agents. The strongest predictors of ASCVD in Black patients were hypertension and cigarette smoking, indicating the importance of managing blood pressure and promoting smoking cessation in this population.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Oncology
Kerri A. Murphy, Amy E. Corveleyn, Elyse R. Park, Kelly E. Irwin
Summary: This study explores the caregiving experience for individuals with cancer and serious mental illness (SMI), focusing on the challenges, rewards, and lessons learned. The impact of mental health symptoms on timely diagnosis, treatment, and care coordination, as well as the lack of specific resources for SMI and cancer caregiving, pose challenges for caregivers. Both family and community caregivers find value and reward in building closer relationships with patients and participating in a person-centered care model. Lessons learned include addressing caregivers' own needs and the importance of advocacy and team approach to reduce mental health stigma and coordinate care.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Psychology, Clinical
Jason Poulos, Sharon-Lise T. Normand, Katya Zelevinsky, John W. Newcomer, Denis Agniel, Haley K. Abing, Marcela Horvitz-Lennon
Summary: Compared to aripiprazole, haloperidol, olanzapine, and risperidone reduced the risk of diabetes, while quetiapine increased the risk of mortality. These findings highlight the need for caution in the use of quetiapine among individuals with serious mental illness.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychology, Multidisciplinary
Karen L. Fortuna, Ashley Williams, George Mois, Kendra Jason, Cynthia L. Bianco
Summary: Individuals with serious mental illness (SMI) have a reduced life expectancy of 10 to 25 years compared to the general population, mainly due to unhealthy behaviors. Despite efforts to promote health behavior change, the mortality gap between SMI individuals and the general population continues to widen, necessitating the exploration of a new paradigm to address early mortality disparities.
PERSPECTIVES ON PSYCHOLOGICAL SCIENCE
(2022)
Article
Psychology, Clinical
Alison R. Hwong, Julie Schmittdiel, Dean Schillinger, John W. Newcomer, Susan Essock, Zheng Zhu, Wendy Dyer, Kelly C. Young-Wolff, Christina Mangurian
Summary: The study found that among smokers with serious mental illness (SMI), the use of smoking cessation pharmacotherapy is significantly higher than those without SMI, showing a potential opportunity to provide more smoking cessation interventions in mental health care settings.
ADDICTIVE BEHAVIORS
(2021)
Article
Public, Environmental & Occupational Health
Mark R. Hawes, Madeline L. Danforth, Nancy Jacquelyn Perez-Flores, Lauren Bochicchio, Daniela Tuda, Ana Stefancic, Leopoldo J. Cabassa
Summary: People with serious mental illness have higher mortality rates and are more likely to have cardiovascular disease. Healthy lifestyle interventions can improve their health, but the reasons for varying effectiveness are not well understood. Our study explored the differences in experiences and application of interventions between those who achieved cardiovascular risk reduction and those who did not. Learning, change, and sticking with it were the key factors distinguishing the two groups.
HEALTH & SOCIAL CARE IN THE COMMUNITY
(2022)
Article
Psychology, Clinical
R. R. Tambling, C. D'Aniello, B. S. Russell
Summary: The study found that a lack of mental health literacy is associated with issues like depression, anxiety, internalized stigma, and caregiver burden, and discussed the implications of poor mental health literacy on treatment as well as the disparities in literacy between different demographic groups.
INTERNATIONAL JOURNAL OF MENTAL HEALTH AND ADDICTION
(2021)
Review
Health Care Sciences & Services
Riaz Qureshi, Evan Mayo-Wilson, Thanitsara Rittiphairoj, Mara McAdams-DeMarco, Eliseo Guallar, Tianjing Li
Summary: This study examined the methods used for synthesizing harms in systematic reviews and meta-analyses of gabapentin and found that current approaches are inadequate for producing valid summaries of harms to guide decisions. The study calls for a paradigm shift and improvement in methods.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2022)
Review
Health Care Sciences & Services
Riaz Qureshi, Evan Mayo-Wilson, Thanitsara Rittiphairoj, Mara McAdams-DeMarco, Eliseo Guallar, Tianjing Li
Summary: This methodologic study analyzed the overlap in sources of evidence and corresponding results for harms in systematic reviews of gabapentin. The study found differences in harm results across reviews, potentially driven by reviewer preferences rather than standardized approaches. A paradigm shift is needed in the current approach to synthesizing harms.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Weili Zheng, Michael Chilazi, Jihwan Park, Vasanth Sathiyakumar, Leslie J. Donato, Jeffrey W. Meeusen, Mariana Lazo, Eliseo Guallar, Krishnaji R. Kulkarni, Allan S. Jaffe, Raul D. Santos, Peter P. Toth, Steven R. Jones, Seth S. Martin
Summary: This study validates that using fixed conversion factors to estimate Lp(a)-C may result in underestimation of Lp(a)-C and overestimation of Lp(a)-free LDL-C. Applying this method, especially at clinically relevant Lp(a) values, may lead to undertreatment of high-risk patients.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Nutrition & Dietetics
Ria Kwon, Yoosoo Chang, Yejin Kim, Yoosun Cho, Hye Rin Choi, Ga-Young Lim, Jeonggyu Kang, Kye-Hyun Kim, Hoon Kim, Yun Soo Hong, Jihwan Park, Di Zhao, Sanjay Rampal, Juhee Cho, Eliseo Guallar, Hyun-Young Park, Seungho Ryu
Summary: The role of alcohol consumption in the risk of vasomotor symptoms among premenopausal women was examined. Greater alcohol consumption was associated with an increased risk of vasomotor symptoms. Refraining from alcohol consumption may help prevent these symptoms in premenopausal women.
Article
Nutrition & Dietetics
Beiwen Wu, Karen White, May Thu Thu Maw, Jeanne Charleston, Di Zhao, Eliseo Guallar, Lawrence J. Appel, Jeanne M. Clark, Nisa M. Maruthur, Scott J. Pilla
Summary: Adherence to meal timing and food consumption was high in a controlled feeding study, where participants followed a time-restricted intake of meals. Strategies such as careful screening, participant orientation, flexibility in beverages and seasonings, and frequent contact between participants and staff were used to optimize adherence.
Article
Nutrition & Dietetics
Yoosun Cho, Yoosoo Chang, Hye Rin Choi, Jeonggyu Kang, Ria Kwon, Ga-Young Lim, Jiin Ahn, Kye-Hyun Kim, Hoon Kim, Yun Soo Hong, Di Zhao, Sanjay Rampal, Juhee Cho, Hyun-Young Park, Eliseo Guallar, Seungho Ryu
Summary: The study examined the prevalence of vasomotor symptoms (VMS) in premenopausal women with nonalcoholic fatty liver disease (NAFLD) and found that even lean individuals with NAFLD had an increased risk of developing VMS. Further research is needed to understand the longitudinal association between NAFLD and VMS risk.
Article
Environmental Sciences
Maria Grau-Perez, Arce Domingo-Relloso, Tamara Garcia-Barrera, Jose L. Gomez-Ariza, Montserrat Leon-Latre, Belen Moreno-Franco, Martin Laclaustra, Eliseo Guallar, Ana Navas-Acien, Roberto Pastor-Barriuso, Josep Redon, Maria Tellez-Plaza
Summary: This study assessed the association between metal exposures and changes in renal endpoints, finding that zinc, arsenic, chromium, and tungsten may have nephrotoxic effects at low exposure levels, and other metals may also be associated with renal disease.
ENVIRONMENTAL POLLUTION
(2023)
Article
Cardiac & Cardiovascular Systems
Di Zhao, Eliseo Guallar, Thomas B. B. Woolf, Lindsay Martin, Harold Lehmann, Janelle Coughlin, Katherine Holzhauer, Attia S. A. Goheer, Kathleen M. M. McTigue, Michelle R. R. Lent, Marquis Hawkins, Jeanne M. M. Clark, Wendy L. L. Bennett
Summary: This study found a positive association between the number of daily meals and weight change, while the meal intervals were not associated with weight change. The findings do not support time-restricted eating as a long-term weight loss strategy.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Editorial Material
Medicine, General & Internal
Eliseo Guallar, Steven N. Goodman, A. Russell Localio, Alisa J. Stephens-Shields, Christine Laine
ANNALS OF INTERNAL MEDICINE
(2023)
Letter
Environmental Sciences
Yun Soo Hong, Stephanie L. Battle, Daniela Puiu, Wen Shi, Nathan Pankratz, Di Zhao, Dan E. Arking, Eliseo Guallar
ENVIRONMENTAL HEALTH PERSPECTIVES
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Hyeok-Hee Lee, Hokyou Lee, Deepak L. Bhatt, Ga Bin Lee, Jiyen Han, Dong Wook Shin, Danbee Kang, Jong-Chan Youn, Eliseo Guallar, Juhee Cho, Hyeon Chang Kim
EUROPEAN HEART JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Amir S. Heravi, Di Zhao, Erin D. Michos, Henrique Doria De Vasconcellos, Bharath Ambale-Venkatesh, Donald Lloyd-Jones, Pamela J. Schreiner, Jared P. Reis, James M. Shikany, Cora E. Lewis, Chiadi E. Ndumele, Eliseo Guallar, Pamela Ouyang, Ron C. Hoogeveen, Joao A. C. Lima, Wendy S. Post, Dhananjay Vaidya
Summary: This study investigated the association between oxidative stress and cardiovascular diseases, finding that female individuals had higher levels of oxidative stress. Furthermore, factors such as higher body mass index, lipid levels, smoking, and lack of physical activity were also associated with higher oxidative stress. This suggests that oxidative stress may play an important role in cardiovascular diseases.
Letter
Medicine, General & Internal
Christine Laine, Christina C. Wee, Stephanie Chang, Deborah Cotton, Vineet Chopra, Sankey V. Williams, Yu-Xiao Yang, Eliseo Guallar, Eric A. Ross
ANNALS OF INTERNAL MEDICINE
(2023)
Article
Genetics & Heredity
Vamsee Pillalamarri, Wen Shi, Conrad Say, Stephanie Yang, John Lane, Eliseo Guallar, Nathan Pankratz, Dan E. Arking
Summary: Inter-individual variation in mtDNA copy number, which reflects mitochondrial function and is associated with aging-related diseases, was examined in the exomes of White ancestry individuals. Rare variants in several genes, including known mtDNA depletion syndrome genes and a tyrosine kinase mutation, were found to be associated with mtDNA-CN. Novel genes involved in mitochondrial proteome quality and hematopoiesis were also identified. These findings suggest that strong-effect mutations in the nuclear genome contribute to the genetic architecture of mtDNA-CN.
HUMAN GENETICS AND GENOMICS ADVANCES
(2023)
Article
Oncology
Romualdo Barroso-Sousa, Juliet Forman, Katharine Collier, Zachary T. Weber, Tejas R. Jammihal, Katrina Z. Kao, Edward T. Richardson, Tanya Keenan, Ofir Cohen, Michael P. Manos, Ryan C. Brennick, Patrick A. Ott, F. Stephen Hodi, Deborah A. Dillon, Victoria Attaya, Tess O'Meara, Nancy U. Lin, Eliezer M. Van Allen, Scott Rodig, Eric P. Winer, Elizabeth A. Mittendorf, Catherine J. Wu, Nikhil Wagle, Daniel G. Stover, Sachet A. Shukla, Sara M. Tolaney
Summary: This study identified potential biomarkers of response to immune checkpoint inhibitors (ICIs) in patients with metastatic triple-negative breast cancer (mTNBC), including high tumor mutational burden, presence of CD8+, CD4 memory T cells, follicular helper T cells, and M1 macrophages, and enrichment of inflammatory gene expression pathways. Pre-treatment deficiencies in the homologous recombination DNA damage repair pathway and the absence of or minimal clonal evolution post-treatment may be associated with worse outcomes.
JCO PRECISION ONCOLOGY
(2022)
