期刊
SCHIZOPHRENIA RESEARCH
卷 145, 期 1-3, 页码 33-35出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.schres.2013.01.011
关键词
Schizophrenia; ZDHHC8; 22q11; Cortical volumes; MRI
类别
资金
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (Brazil) [FAPESP 2007/58736-1, 2011/00030-1]
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq, Brazil)
- Coordenadoria de Aperfeicoamento de Pessoal de Ensino Superior (CAPES, Brazil)
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP, Brazil)
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [11/00030-1] Funding Source: FAPESP
ZDHHC8 rs175174 polymorphism is located in 22q11.2 region and its role in brain volume has not been fully addressed. A total of 282 schizophrenia patients and 379 controls were genotyped. A sample of 138 patients underwent brain MRI scan. No association was found between schizophrenia and genotypes. Nevertheless, GG-genotype carriers presented gray matter volume (GMV) reduction in frontal lobe compared to A-allele carriers, and cerebellar hemispheres GMV reductions were found in G-allele carriers compared to AA-genotype. Moreover, A-allele carriers presented posterior brain GMV reductions when compared to GG-genotype. These data suggest that ZDHHC8 may play a role in cortical volumes. (C) 2013 Elsevier B. V. All rights reserved.
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