Article
Immunology
Hiroki Shiwaku, Shingo Katayama, Mengxuan Gao, Kanoh Kondo, Yuri Nakano, Yukiko Motokawa, Saori Toyoda, Fuyuko Yoshida, Hiroaki Hori, Tetsuo Kubota, Kinya Ishikawa, Hiroshi Kunugi, Yuji Ikegaya, Hitoshi Okazawa, Hidehiko Takahashi
Summary: This study identified a novel autoantibody against NRXN1 alpha in patients with schizophrenia and demonstrated that these antibodies can cause schizophrenia-related pathology in mice. Removal of these antibodies may be a therapeutic target for some patients carrying these antibodies.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Biochemical Research Methods
Mauricio Guevara Souza, Edgar E. Vallejo, Karol Estrada
Summary: The article presents a new method for detecting rare variant associations through a two-step genetic algorithm, showing sufficient power for detection.
IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS
(2021)
Article
Multidisciplinary Sciences
Dan Zhou, Dongmei Yu, Jeremiah M. Scharf, Carol A. Mathews, Lauren McGrath, Edwin Cook, S. Hong Lee, Lea K. Davis, Eric R. Gamazon
Summary: Research has revealed the significant roles of common small-effect polygenic burden and large-effect variants in the genetic basis of complex traits. Studies have shown that it is possible to quantify the power to detect a lower PB in LEV carriers compared to non-carriers through simulations.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
ChangHui Pak, Tamas Danko, Vincent R. Mirabella, Jinzhao Wang, Yingfei Liu, Madhuri Vangipuram, Sarah Grieder, Xianglong Zhang, Thomas Ward, Yu-Wen Alvin Huang, Kang Jin, Philip Dexheimer, Eric Bardes, Alexis Mitelpunkt, Junyi Ma, Michael McLachlan, Jennifer C. Moore, Pingping Qu, Carolin Purmann, Jeffrey L. Dage, Bradley J. Swanson, Alexander E. Urban, Bruce J. Aronow, Zhiping P. Pang, Douglas F. Levinson, Marius Wernig, Thomas C. Sudhof
Summary: Heterozygous NRXN1 deletions are associated with schizophrenia and other neurodevelopmental disorders, causing impaired neurotransmitter release in human neurons. However, mouse neurons with NRXN1 deletions did not show the same impairment, suggesting a human-specific phenotype. The deletions also led to increased levels of CASK and characteristic gene-expression changes, highlighting the potential for future drug discovery targeting NRXN1 deletions.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Genetics & Heredity
Isak Falk, Millie Zhao, Juba Nait Saada, Qi Guo
Summary: Set-based association analyses for rare variants are powerful tools that can solve the power issue in GWAS for rare variants by learning the combination of kernels.
FRONTIERS IN GENETICS
(2023)
Article
Medicine, Research & Experimental
Elena De Mattia, Marco Silvestri, Jerry Polesel, Fabrizio Ecca, Silvia Mezzalira, Lucia Scarabel, Yitian Zhou, Rossana Roncato, Volker M. Lauschke, Stefano Calza, Michele Spina, Fabio Puglisi, Giuseppe Toffoli, Erika Cecchin
Summary: This study demonstrated that the burden of rare DPYD variants is significantly associated with higher risk of severe fluoropyrimidine-related toxicity. Through the use of next generation sequencing and in silico predictive tools, the functional impact of these rare variants was evaluated, providing insights into their potential role in predicting adverse reactions to chemotherapy drugs.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Psychiatry
Yalan Liu, Lu Shen, Yaowen Zhang, Rongjuan Zhao, Cenying Liu, Sanchuan Luo, Jingjing Chen, Lu Xia, Taoxi Li, Yu Peng, Kun Xia
Summary: This study demonstrated the functional effects of three rare missense mutations of NRXN1 identified in autism patients, showing interference with protein degradation and resulting in abnormal circadian rhythm and sleep behavior. The findings highlight the importance of these mutations in understanding the pathogenesis of abnormal behaviors in organisms.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Multidisciplinary Sciences
Ricky Lali, Michael Chong, Arghavan Omidi, Pedrum Mohammadi-Shemirani, Ann Le, Edward Cui, Guillaume Pare
Summary: Rare variants play a significant role in complex diseases, but identifying their associations is challenging. Researchers have proposed a method called RV-EXCALIBER, which uses large summary-level exome data to robustly calibrate rare variant burden, providing better prediction of the risk of coronary artery disease.
NATURE COMMUNICATIONS
(2021)
Article
Cell Biology
Cinzia Cameli, Marta Viggiano, Magali J. Rochat, Alessandra Maresca, Leonardo Caporali, Claudio Fiorini, Flavia Palombo, Pamela Magini, Renee C. Duardo, Fabiola Ceroni, Maria C. Scaduto, Annio Posar, Marco Seri, Valerio Carelli, Paola Visconti, Elena Bacchelli, Elena Maestrini
Summary: Autism spectrum disorder (ASD) is characterized by a complex polygenic background, with a subset of cases presenting a rare large-effect variant. Clinical interpretation in these cases is complicated by incomplete penetrance and variable expressivity. In a trio family with an inherited NRXN1 deletion, whole-exome sequencing revealed an increased burden of exonic rare variants in the ASD child compared to the unaffected mother, suggesting a role of interacting genes in ASD pathogenesis.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Genetics & Heredity
Lorenzo Bomba, Klaudia Walter, Qi Guo, Praveen Surendran, Kousik Kundu, Suraj Nongmaithem, Mohd Anisul Karim, Isobel D. Stewart, Claudia Langenberg, John Danesh, Emanuele Di Angelantonio, David J. Roberts, Willem H. Ouwehand, Ian Dunham, Adam S. Butterworth, Nicole Soranzo
Summary: Metabolite levels measured in the human population were analyzed to identify associations with rare genetic variants. The study identified 40 novel associations, of which 28 were replicated, between rare coding variants and metabolite levels. Algorithms were developed to prioritize driver variants and statistical analyses were used to test the directionality of associations between metabolite and protein levels. The study found that 66% of reported associations involved gene targets of approved drugs or bioactive drug-like compounds, validating efforts in drug target research.
AMERICAN JOURNAL OF HUMAN GENETICS
(2022)
Article
Psychiatry
Ryo Morikawa, Yuichiro Watanabe, Hirofumi Igeta, Reza K. Arta, Masashi Ikeda, Satoshi Okazaki, Satoshi Hoya, Takeo Saito, Ikuo Otsuka, Jun Egawa, Takaki Tanifuji, Nakao Iwata, Toshiyuki Someya
Summary: Novel SETD1A missense variants were exclusively identified in Japanese patients with schizophrenia. However, our study does not provide evidence for the contribution of these variants to the genetic etiology of schizophrenia in the Japanese population.
PSYCHIATRY RESEARCH
(2022)
Article
Plant Sciences
Wanapinun Nawae, Chaiwat Naktang, Salisa Charoensri, Sonicha U-thoomporn, Nattapol Narong, Orwintinee Chusri, Sithichoke Tangphatsornruang, Wirulda Pootakham
Summary: In this study, the genomes of three popular durian cultivars in Thailand were resequenced, revealing genetic diversities and differences from the Malaysian durian. Additionally, certain genes related to stress response showed faster evolution rates in durians. These genome assemblies provide valuable resources for understanding genetic diversity and developing new durian cultivars.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Rheumatology
Hendrick Mambu Mambueni, Christophe Hue, Aude Jobart-Malfait, Roula Said-Nahal, Hanane El Hafci, Herve Petite, Christophe Nich, Maxime Breban, Felicie Costantino, Henri-Jean Garchon
Summary: By re-sequencing a region linked to spondyloarthritis, a rare variant in the FREM2 gene was identified, suggesting its potential implication in the pathogenesis of spondyloarthritis.
Article
Genetics & Heredity
Zebin Yao, Shuisheng Long, Chun Wang, Chengqin Huang, Hairui Zhang, Liao Jian, Jingru Huang, Yusong Guo, Zhongdian Dong, Zhongduo Wang
Summary: In this study, we resequenced the whole genome of four populations of Oryzias curvinotus, including the SY-medaka population. The results showed that the genetic differentiation between SY-medaka and other populations is the highest. The population history analysis suggested that SY-medaka has recently experienced a bottleneck period and is strongly affected by environmental selection. We also identified potential genomic regions and genes that may explain the selection process of SY-medaka.
FRONTIERS IN GENETICS
(2022)
Article
Plant Sciences
Marcin W. Grzybowski, Ravi V. Mural, Gen Xu, Jonathan Turkus, Jinliang Yang, James C. Schnable
Summary: Maize populations show vast diversity in both genetic and phenotypic traits. Resequencing strategies have been used to identify millions of genetic variants within and between maize populations, but inconsistencies in analytical pipelines, reference genome assemblies, and minor allele frequency filtering often limit the reuse and remixing of genetic diversity data for new research questions. This study utilized resequencing data from published and newly sequenced maize samples to create a unified marker set of over 366 million segregating variants, providing increased power to identify known flowering-time genes and track changes in allele frequency across the global distribution of maize.
Article
Neurosciences
Ling Zhao, Thomas W. Muehleisen, Dominique I. Pelzer, Bettina Burger, Eva C. Beins, Andreas J. Forstner, Stefan Herms, Per Hoffmann, Katrin Amunts, Nicola Palomero-Gallagher, Sven Cichon
Summary: Neurotransmitter receptors play a crucial role in signal transmission and their dysfunction is linked to brain disorders. The connection between receptors and their corresponding genes, especially in humans, is not well understood. In this study, both receptor densities and gene expression levels were quantified in the human hippocampus to investigate the relationship. The results showed that differences in receptor densities were mainly observed in metabotropic receptors, while differences in gene expression levels mainly pertained to ionotropic receptors. Furthermore, the correlation between receptor densities and gene expression levels varied widely and was generally weak-to-moderate, indicating that post-translational factors also influence receptor densities.
Article
Biochemistry & Molecular Biology
Azmeraw T. Amare, Anbupalam Thalamuthu, Klaus Oliver Schubert, Janice M. Fullerton, Muktar Ahmed, Simon Hartmann, Sergi Papiol, Urs Heilbronner, Franziska Degenhardt, Fasil Tekola-Ayele, Liping Hou, Yi-Hsiang Hsu, Tatyana Shekhtman, Mazda Adli, Nirmala Akula, Kazufumi Akiyama, Raffaella Ardau, Barbara Arias, Jean-Michel Aubry, Roland Hasler, Helene Richard-Lepouriel, Nader Perroud, Lena Backlund, Abesh Kumar Bhattacharjee, Frank Bellivier, Antonio Benabarre, Susanne Bengesser, Joanna M. Biernacka, Armin Birner, Cynthia Marie-Claire, Pablo Cervantes, Hsi-Chung Chen, Caterina Chillotti, Sven Cichon, Cristiana Cruceanu, Piotr M. Czerski, Nina Dalkner, Maria Del Zompo, J. Raymond DePaulo, Bruno etain, Stephane Jamain, Peter Falkai, Andreas J. Forstner, Louise Frisen, Mark A. Frye, Sebastien Gard, Julie S. Garnham, Fernando S. Goes, Maria Grigoroiu-Serbanescu, Andreas J. Fallgatter, Sophia Stegmaier, Thomas Ethofer, Silvia Biere, Kristiyana Petrova, Ceylan Schuster, Kristina Adorjan, Monika Budde, Maria Heilbronner, Janos L. Kalman, Mojtaba Oraki Kohshour, Daniela Reich-Erkelenz, Sabrina K. Schaupp, Eva C. Schulte, Fanny Senner, Thomas Vogl, Ion-George Anghelescu, Volker Arolt, Udo Dannlowski, Detlef Dietrich, Christian Figge, Markus Jaeger, Fabian U. Lang, Georg Juckel, Carsten Konrad, Jens Reimer, Max Schmauss, Andrea Schmitt, Carsten Spitzer, Martin von Hagen, Jens Wiltfang, Joerg Zimmermann, Till F. M. Andlauer, Andre Fischer, Felix Bermpohl, Philipp Ritter, Silke Matura, Anna Gryaznova, Irina Falkenberg, Cueneyt Yildiz, Tilo Kircher, Julia Schmidt, Marius Koch, Kathrin Gade, Sarah Trost, Ida S. Haussleiter, Martin Lambert, Anja C. Rohenkohl, Vivien Kraft, Paul Grof, Ryota Hashimoto, Joanna Hauser, Stefan Herms, Per Hoffmann, Esther Jimenez, Jean-Pierre Kahn, Layla Kassem, Po-Hsiu Kuo, Tadafumi Kato, John Kelsoe, Sarah Kittel-Schneider, Ewa Ferensztajn-Rochowiak, Barbara Koenig, Ichiro Kusumi, Gonzalo Laje, Mikael Landen, Catharina Lavebratt, Marion Leboyer, Susan G. Leckband, Alfonso Tortorella, Mirko Manchia, Lina Martinsson, Michael J. McCarthy, Susan McElroy, Francesc Colom, Vincent Millischer, Marina Mitjans, Francis M. Mondimore, Palmiero Monteleone, Caroline M. Nievergelt, Markus M. Noethen, Tomas Novak, Claire O'Donovan, Norio Ozaki, Andrea Pfennig, Claudia Pisanu, James B. Potash, Andreas Reif, Eva Reininghaus, Guy A. Rouleau, Janusz K. Rybakowski, Martin Schalling, Peter R. Schofield, Barbara W. Schweizer, Giovanni Severino, Paul D. Shilling, Katzutaka Shimoda, Christian Simhandl, Claire M. Slaney, Alessio Squassina, Thomas Stamm, Pavla Stopkova, Mario Maj, Gustavo Turecki, Eduard Vieta, Julia Veeh, Stephanie H. Witt, Adam Wright, Peter P. Zandi, Philip B. Mitchell, Michael Bauer, Martin Alda, Marcella Rietschel, Francis J. McMahon, Thomas G. Schulze, Scott R. Clark, Bernhard T. Baune
Summary: A polygenic score (Li-PGS(+)) for lithium treatment response in bipolar disorder patients was developed in this study. Li-PGS(+) was found to be positively associated with lithium treatment response. Gene-based analysis also identified 36 candidate genes related to lithium's molecular mechanism.
MOLECULAR PSYCHIATRY
(2023)
Article
Multidisciplinary Sciences
Ashley Budu-Aggrey, Anna Kilanowski, Maria K. Sobczyk, Suyash S. Shringarpure, Ruth Mitchell, Kadri Reis, Anu Reigo, Reedik Maegi, Mari Nelis, Nao Tanaka, Ben M. Brumpton, Laurent F. Thomas, Pol Sole-Navais, Christopher Flatley, Antonio Espuela-Ortiz, Esther Herrera-Luis, Jesus V. T. Lominchar, Jette Bork-Jensen, Ingo Marenholz, Aleix Arnau-Soler, Ayoung Jeong, Katherine A. Fawcett, Hansjorg Baurecht, Elke Rodriguez, Alexessander Couto Alves, Ashish Kumar, Patrick M. Sleiman, Xiao Chang, Carolina Medina-Gomez, Chen Hu, Cheng-jian Xu, Cancan Qi, Sarah El-Heis, Philip Titcombe, Elie Antoun, Joao Fadista, Carol A. Wang, Elisabeth Thiering, Baojun Wu, Sara Kress, Dilini M. Kothalawala, Latha Kadalayil, Jiasong Duan, Hongmei Zhang, Sabelo Hadebe, Thomas Hoffmann, Eric Jorgenson, Helene Choquet, Neil Risch, Pal Njolstad, Ole A. Andreassen, Stefan Johansson, Catarina Almqvist, Tong Gong, Vilhelmina Ullemar, Robert Karlsson, Patrik K. E. Magnusson, Agnieszka Szwajda, Esteban G. Burchard, Jacob P. Thyssen, Torben Hansen, Line L. Karhus, Thomas M. Dantoft, Alexander C. S. N. Jeanrenaud, Ahla Ghauri, Andreas Arnold, Georg Homuth, Susanne Lau, Markus M. Noethen, Norbert Huebner, Medea Imboden, Alessia Visconti, Mario Falchi, Veronique Bataille, Pirro Hysi, Natalia Ballardini, Dorret I. Boomsma, Jouke J. Hottenga, Martina Mueller-Nurasyid, Tarunveer S. Ahluwalia, Jakob Stokholm, Bo Chawes, Ann-Marie M. Schoos, Ana Esplugues, Mariona Bustamante, Benjamin Raby, Syed Arshad, Chris German, Tonu Esko, Lili A. Milani, Andres Metspalu, Chikashi Terao, Katrina Abuabara, Mari Loset, Kristian Hveem, Bo Jacobsson, Maria Pino-Yanes, David P. Strachan, Niels Grarup, Allan Linneberg, Young-Ae Lee, Nicole Probst-Hensch, Stephan Weidinger, Marjo-Riitta Jarvelin, Erik Melen, Hakon Hakonarson, Alan D. Irvine, Deborah Jarvis, Tamar Nijsten, Liesbeth Duijts, Judith M. Vonk, Gerard H. Koppelmann, Keith M. Godfrey, Sheila J. Barton, Bjarke Feenstra, Craig E. Pennell, Peter D. Sly, Patrick G. Holt, L. Keoki Williams, Hans Bisgaard, Klaus Bonnelykke, John Curtin, Angela Simpson, Clare Murray, Tamara Schikowski, Supinda Bunyavanich, Scott T. Weiss, John W. Holloway, Josine L. Min, Sara J. Brown, Marie Standl, Lavinia Paternoster
Summary: This study conducted the largest genome-wide association study (GWAS) on atopic dermatitis (AD) to date, identifying 81 replicated AD-associated loci in Europeans and 10 additional loci in a multi-ancestry analysis. The implicated genes are predominantly involved in immune pathways relevant to atopic inflammation and may offer drug repurposing opportunities.
NATURE COMMUNICATIONS
(2023)
Review
Psychiatry
Gunter Schumann, Ole A. Andreassen, Tobias Banaschewski, Vince D. Calhoun, Nicholas Clinton, Sylvane Desrivieres, Ragnhild Eek Brandlistuen, Jianfeng Feng, Soeren Hese, Esther Hitchen, Per Hoffmann, Tianye Jia, Viktor Jirsa, Andre F. Marquand, Frauke Nees, Markus M. Noethen, Gaia Novarino, Elli Polemiti, Markus Ralser, Michael Rapp, Kerstin Schepanski, Tamara Schikowski, Mel Slater, Peter Sommer, Bernd Carsten Stahl, Paul M. Thompson, Sven Twardziok, Dennis van der Meer, Henrik Walter, Lars Westlye
Summary: This article introduces a research strategy that leverages innovative tools and techniques such as data federation, geospatial observation, and data integration to understand the impact of environmental factors on the brain and mental illness. The presented example demonstrates the potential of this research to identify brain mechanisms underlying mental health symptoms related to environmental adversity and develop targeted interventions. The development of objective biomarkers and evidence-based interventions can greatly improve outcomes of environment-related mental illness.
Article
Neurosciences
Kosma Sakrajda, Karolina Bilska, Piotr M. Czerski, Beata Narozna, Monika Dmitrzak-Weglarz, Stefanie Heilmann-Heimbach, Felix F. Brockschmidt, Stefan Herms, Markus M. Noethen, Sven Cichon, Barbara Wieckowska, Janusz K. Rybakowski, Joanna Pawlak, Aleksandra Szczepankiewicz
Summary: This study suggests the involvement of AHI1 in the mode of action of lithium, as well as the association between mood-stabilizing treatment and innate immunity-related gene expression in BD patients.
PSYCHOPHARMACOLOGY
(2023)
Article
Cell Biology
Eduardo A. Maury, Maxwell A. Sherman, Giulio Genovese, Thomas G. Gilgenast, Tushar Kamath, S. J. Burris, Prashanth Rajarajan, Erin Flaherty, Schahram Akbarian, Andrew Chess, Steven A. McCarroll, Po-Ru Loh, Jennifer E. Phillips-Cremins, Kristen J. Brennand, Evan Z. Macosko, James T. R. Walters, Michael O'Donovan, Patrick Sullivan, Jonathan Sebat, Eunjung A. Lee, Christopher A. Walsh
Summary: This study suggests that somatic copy-number variants (sCNVs) may play a potential role in the risk of schizophrenia (SCZ). Early-developmental sCNVs were more common in SCZ cases, including recurrent somatic deletions in the NRXN1 gene. Additionally, recurrent intragenic deletions of the ABCB11 gene were observed in treatment-resistant SCZ cases.
Meeting Abstract
Biochemistry & Molecular Biology
Angelina Vogelsang, Man Long Chung, Lisa Sindermann, Friederike David, Christina Elling, Laura-Effi Seib-Pfeifer, Stefanie Heilmann-Heimbach, Per Hoffmann, Stefan Herms, Boerge Schmidt, Katharina Domschke, Vanessa Nieratschker, Udo Dannlowski, Elisabeth Johanna Leehr, Eric Leibing, Markus M. Noethen, Franziska Geiser, Johannes Schumacher, Carlo Maj, Rupert Conrad, Andreas Forstner
EUROPEAN JOURNAL OF HUMAN GENETICS
(2023)
Meeting Abstract
Biochemistry & Molecular Biology
Friederike David, Fabian Streit, Josef Frank, Lea Sirignano, Lea Zillich, Stefan Herms, Per Hoffmann, Till Andlauer, Tilo Kircher, Udo Dannlowski, Stephanie Witt, Marcella Rietschel, Markus M. Noethen, Andreas Forstner
EUROPEAN JOURNAL OF HUMAN GENETICS
(2023)
Meeting Abstract
Biochemistry & Molecular Biology
Lydia M. Federmann, Lisa Sindermann, Christiane Jockwitz, Friederike David, Alexander Teumer, Dominique I. Hilger, Markus M. Noethen, Katrin Amunts, Udo Dannlowski, Thomas Muehleisen, Svenja Caspers, Sven Cichon, Andreas Forstner
EUROPEAN JOURNAL OF HUMAN GENETICS
(2023)
Meeting Abstract
Biochemistry & Molecular Biology
Sabrina Henne, Sugirthan Sivalingam, Lara Hochfeld, Carlo Maj, Oleg Borisov, Andreas Buness, Markus M. Noethen, Peter Krawitz, Stefanie Heilmann-Heimbach
EUROPEAN JOURNAL OF HUMAN GENETICS
(2023)
Meeting Abstract
Biochemistry & Molecular Biology
Karola Huenten, Friederike David, Sugirthan Sivalingam, Bettina Burger, Eva Beins, Lea Sirignano, Fabian Streit, Frederike Stein, Tamara Krutenko, Petra Ina Pfefferle, Stefan Herms, Per Hoffmann, Marcella Rietschel, Michael Peitz, Sven Cichon, Oliver Bruestle, Markus M. Noethen, Andreas Forstner
EUROPEAN JOURNAL OF HUMAN GENETICS
(2023)
Meeting Abstract
Biochemistry & Molecular Biology
Dominik Jung, Sonali Pechlivanis, Susanne Moebus, Nils Lehmann, Amir A. Mahabdi, Per Hoffmann, Raimund Erbel, Markus M. Noethen, Hagen Sjard Bachmann
EUROPEAN JOURNAL OF HUMAN GENETICS
(2023)
Meeting Abstract
Biochemistry & Molecular Biology
Carlo Maj, Emadeldin Hassanin, Hannah Klinkhammer, Friederike David, Dheeraj Bobbili, Rana Aldisi, Nuria Duenas, Claudia Perne, Markus M. Noethen, Robert Huneburg, Peter Krawitz, Joan Brunet, Gabriel Capella, Patrick May, Andreas Forstner, Andreas Mayr, Isabel Spier, Stefan Aretz
EUROPEAN JOURNAL OF HUMAN GENETICS
(2023)
Meeting Abstract
Biochemistry & Molecular Biology
Eva Beins, Ronja Hollstein, Kerstin Ludwig, Per Hoffmann, Markus M. Noethen, Andreas Forstner
EUROPEAN JOURNAL OF HUMAN GENETICS
(2023)
Review
Psychiatry
Gunter Schumann, Ole A. Andreassen, Tobias Banaschewski, Vince D. Calhoun, Nicholas Clinton, Sylvane Desrivieres, Ragnhild Eek Brandlistuen, Jianfeng Feng, Soeren Hese, Esther Hitchen, Per Hoffmann, Tianye Jia, Viktor Jirsa, Andre F. Marquand, Frauke Nees, Markus M. Noethen, Gaia Novarino, Elli Polemiti, Markus Ralser, Michael Rapp, Kerstin Schepanski, Tamara Schikowski, Mel Slater, Peter Sommer, Bernd Carsten Stahl, Paul M. Thompson, Sven Twardziok, Dennis van der Meer, Henrik Walter, Lars Westlye
Summary: Climate change, pollution, urbanization, socioeconomic inequality, and the COVID-19 pandemic have affected brain health. Research using innovative data integration tools can identify brain mechanisms underlying environment-related mental illness and inform innovative treatments. This research will lead to the development of objective biomarkers and evidence-based interventions to improve outcomes of environment-related mental illness.
