Article
Biochemistry & Molecular Biology
Inge L. Werkman, Janine Kovilein, Jenny C. de Jonge, Wia Baron
Summary: Grey matter astrocytes are more supportive of myelination than white matter astrocytes, but specific inhibition of cholesterol biosynthesis in astrocytes is beneficial for white matter astrocyte-mediated modulation of myelination.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Clinical Neurology
Weibing Shen, Yaner Zhang, Chenguang Zhou, Yaoyao Shen
Summary: MOG-EM is an independent inflammatory demyelinating disease, with some patients showing symmetrical deep gray matter involvement on MRI. Symptoms in the case included fever, headache, vomiting, altered consciousness, and neck stiffness, with CSF analysis revealing increased cells and protein, and serum MOG IgG positivity.
Article
Neurosciences
Vilma Alanko, Adhara Gaminde-Blasco, Tania Quintela-Lopez, Raul Loera-Valencia, Alina Solomon, Ingemar Bjorkhem, Angel Cedazo-Minguez, Silvia Maioli, Graziella Tabacaru, Maria Latorre-Leal, Carlos Matute, Miia Kivipelto, Elena Alberdi, Anna Sandebring-Matton
Summary: Oxidized cholesterol metabolite 27-hydroxycholesterol (27-OH) is a potential link between hypercholesterolemia and neurodegenerative diseases as it can cross the blood-brain barrier. This study found that high levels of 27-OH can impact oligodendrocyte function and contribute to the disconnection of neural networks in neurodegenerative diseases.
Article
Neurosciences
Robert A. Mccutcheon, Paul J. Harrison, Oliver D. Howes, Philip K. Mcguire, David M. Taylor, Toby Pillinger
Summary: This study analyzed the receptor affinities of antipsychotic medications and grouped them into four categories based on their predominant receptor affinities. The classification was shown to predict clinical effects of the drugs and has the potential to guide treatment and inform drug development.
BIOLOGICAL PSYCHIATRY
(2023)
Article
Clinical Neurology
Stefan Gingele, Thiemo M. Moellenkamp, Florian Henkel, Lara-Jasmin Schroeder, Martin W. Huemmert, Thomas Skripuletz, Martin Stangel, Viktoria Gudi
Summary: This study focuses on the use of the cuprizone model in aged mice to mimic the impaired regeneration ability seen in multiple sclerosis. The researchers found that there were multiple cellular and molecular changes related to the remyelination process. In aged mice, the gray matter regions showed synaptic and dendritic loss during demyelination, which were not fully recovered in the remyelination phase.
Review
Psychology, Clinical
Bodyl A. Brand, Yudith R. A. Haveman, Franciska de Beer, Janna N. de Boer, Paola Dazzan, Iris E. C. Sommer
Summary: There are significant differences between men and women in the efficacy and tolerability of antipsychotic drugs. Women have slower drug absorption, metabolism, and excretion, leading to higher plasma levels and increased risk for side-effects. Current treatment guidelines are based on studies predominantly conducted in men, which may result in overmedication of women. Women also have higher dopamine receptor occupancy compared to men, necessitating dose adjustments at different hormonal phases.
PSYCHOLOGICAL MEDICINE
(2022)
Review
Neurosciences
Mahsa Motavaf, Xianhua Piao
Summary: Perinatal white matter injury is common in premature infants and can lead to lifelong neurological deficits. The immaturity of oligodendrocytes and failure of myelination are the key factors in the etiology of this condition. Currently, there are no clinical treatment options available, leading to increased interest in cell transplantation and promoting endogenous oligodendrocyte function as potential therapeutic strategies.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Marta Valenza, Roberta Facchinetti, Luca Steardo, Caterina Scuderi
Summary: Palmitoylethanolamide (PEA) is a naturally occurring amide compound with analgesic, neuroprotective, immune-modulating, and anti-inflammatory effects. Recent studies have shown that PEA promotes oligodendrocyte differentiation, which is crucial for myelin formation. PEA has therapeutic potential in restoring white matter defects.
Review
Cell Biology
Yize Sun, Huichun Tong, Tianqi Yang, Li Liu, Xiao-Jiang Li, Shihua Li
Summary: Huntington's disease is a progressive neurodegenerative disorder characterized by mood swings, involuntary movement, and cognitive decline. Previous studies have mainly focused on neuronal degeneration, but clinical imaging studies have shown pathological changes in the white matter area of the brain in HD patients. These changes may be attributed to alterations in myelin and oligodendrocytes.
Article
Neurosciences
Sadia Ahmed, Sierrah D. Travis, Francisca V. Diaz-Bahamonde, Demisha D. L. Porter, Sara N. Henry, Julia Mykins, Aditya Ravipati, Aryn Booker, Jing Ju, Hanzhang Ding, Ashwin K. Ramesh, Alicia M. Pickrell, Maosen Wang, Stephen LaConte, Brittany R. Howell, Lijuan Yuan, Paul D. Morton
Summary: Abnormalities in the prefrontal cortex and white matter are key in many neurodevelopmental disorders, with recent focus on the influence of microorganisms on brain development. Research shows that microbiota plays a critical role in promoting white matter myelination during early life, affecting vulnerability to environmental insults leading to disabilities later in life.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Review
Clinical Neurology
Yasmine Kamen, Helena Pivonkova, Kimberley A. Evans, Ragnhildur T. Karadottir
Summary: Studies show that oligodendrocyte precursor cells and myelinating oligodendrocytes exhibit different developmental origins and functional states, which may impact myelination and repair in the adult brain.
Article
Biochemistry & Molecular Biology
Daria A. Kamaeva, Daria V. Kazantseva, Anastasiia S. Boiko, Irina A. Mednova, Liudmila P. Smirnova, Elena G. Kornetova, Svetlana A. Ivanova
Summary: This study investigated the influence of typical and atypical antipsychotics on catalytic antibody activity and serum cytokine levels in patients with schizophrenia. The results showed that treatment with atypical antipsychotics altered the levels of certain pro-inflammatory cytokines and caused a significant decrease in the activity of catalytic antibodies hydrolyzing myelin basic protein. Associations between catalytic activity and interleukins were also observed.
Article
Pharmacology & Pharmacy
Wen Liu, Aaron R. Rohlman, Ryan Vetreno, Fulton T. Crews
Summary: The study found that adolescent binge drinking affects adult OL markers in PFC regions, while also impacting OPC marker expression; furthermore, these effects could lead to lasting changes in PFC function.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Behnaz Azimi Manavi, Amanda L. Stuart, Julie A. Pasco, Jason M. Hodge, D. Kavindi Weerasinghe, Rasika M. Samarasinghe, Lana J. Williams
Summary: Antipsychotic use is associated with an increased risk of fracture, particularly in men and women. Regular monitoring of bone health is suggested for individuals using antipsychotic medications.
SCIENTIFIC REPORTS
(2023)
Review
Neurosciences
Mei Li, Lan Xiao, Xianjun Chen
Summary: Schizophrenia is a complex neuropsychiatric disorder influenced by genetic and epigenetic factors. In addition to neuronal dysfunction, abnormalities in oligodendroglial cells also contribute to the pathogenesis of the disease, characterized by dysregulation of oligodendrocyte and myelin related genes. Histone modifications play important roles in regulating the transcription of genes crucial for oligodendrocyte differentiation and myelination.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Psychology, Clinical
Alexandra Macdonald, Steffany J. Fredman, Daniel J. Taylor, Kristi E. Pruiksma, Tabatha H. Blount, Brittany N. Hall-Clark, Brooke A. Fina, Katherine A. Dondanville, Jim Mintz, Brett T. Litz, Stacey Young-McCaughan, Yunying Le, August I. C. Jenkins, Candice M. Monson, Jeffrey S. Yarvis, Terence M. Keane, Alan L. Peterson
Summary: AIM-CBCT for PTSD is associated with reductions in maladaptive posttraumatic cognitions and psychosocial impairment, but adjunctive interventions may be needed to address insomnia.
JOURNAL OF TRAUMATIC STRESS
(2022)
Article
Psychology, Clinical
Carmen P. McLean, Madeleine L. Miller, Katherine A. Dondanville, Sheila A. M. Rauch, Jeffrey S. Yarvis, Edward C. Wright, Brittany N. Hall-Clark, Brooke A. Fina, Brett T. Litz, Jim Mintz, Stacey Young-McCaughan, Alan L. Peterson, Edna B. Foa
Summary: The study found that participants who received Web-based prolonged exposure therapy (Web-PE) generally found it helpful and appreciated its flexibility. Self-motivation was identified as crucial for engagement in the therapy. While Web-PE therapists were well-regarded, suggestions were made for additional therapist support and technical improvements to the program.
PSYCHOLOGICAL TRAUMA-THEORY RESEARCH PRACTICE AND POLICY
(2022)
Article
Behavioral Sciences
Stacey Young-McCaughan, Alan L. Peterson, Jim Mintz, Willie J. Hale, Katherine A. Dondanville, Elisa Borah, Tabatha H. Blount, Abby E. Blankenship, Brooke A. Fina, Brittany N. Hall-Clark, Ann Marie Hernandez, Vanessa M. Jacoby, Steffany L. Malach, Jacob M. Williams, Katherine E. Compton, Mona O. Bingham, Catherine A. Vriend, Alice W. Inman, Antoinette Brundige, Sonya M. Arzola, M. Danet Lapiz-Bluhm, Douglas E. Williamson, Brett T. Litz, Elizabeth A. Hembree, John D. Roache, Daniel J. Taylor, Kristi E. Pruiksma, Adam M. Borah, Jeffrey S. Yarvis
Summary: This pilot study aimed to explore whether the efficacy of imaginal exposure therapy for posttraumatic stress disorder (PTSD) could be improved by adding aerobic exercise. The results showed that augmenting imaginal exposure with aerobic exercise did not yield better outcomes compared to engaging in either activity alone. Further research is needed to better understand individually administered and combined exercise and exposure therapy interventions for PTSD.
COGNITIVE BEHAVIOUR THERAPY
(2022)
Article
Psychology, Clinical
John C. Moring, Casey L. Straud, Donald B. Penzien, Patricia A. Resick, Alan L. Peterson, Carlos A. Jaramillo, Blessen C. Eapen, Cindy A. McGeary, Jim Mintz, Brett T. Litz, Stacey Young-McCaughan, Terence M. Keane, Donald D. McGeary
Summary: This study examines the relationship between tinnitus and posttraumatic stress disorder (PTSD). The results show that there is considerable overlap between tinnitus-related distress and PTSD symptoms. Participants with severe tinnitus demonstrated higher levels of PTSD symptoms and severity compared to those with mild or moderate tinnitus. This suggests that trauma therapists should assess for the presence of tinnitus to better understand the health problems of patients seeking help.
Article
Physics, Multidisciplinary
Paolo Glorioso, Jinkang Guo, Joaquin F. Rodriguez-Nieva, Andrew Lucas
Summary: Hydrodynamics is a universal effective theory that describes the thermalization of chaotic many-body systems. The article presents the nonlinear fluctuating hydrodynamics of models with simultaneous charge/mass, dipole/centre of mass and momentum conservation. It also discusses the emergence of an unconventional dynamical universality class as thermal fluctuations destroy hydrodynamic behavior below four spatial dimensions.
Article
Physics, Multidisciplinary
Alec Jenkins, Susanne Baumann, Haoxin Zhou, Simon A. Meynell, Yang Daipeng, Kenji Watanabe, Takashi Taniguchi, Andrew Lucas, Andrea F. Young, Ania C. Bleszynski Jayich
Summary: This study uses nitrogen-vacancy center magnetometry to investigate the local breakdown of Ohm's law in a high mobility graphene monolayer. The results show that at room temperature, the current concentration occurs at the edges of the constriction, but as the temperature decreases below 200 K, the current concentrates near the center of the constriction, indicating a crossover from diffusive to viscous electron transport.
PHYSICAL REVIEW LETTERS
(2022)
Article
Psychology, Clinical
Shannon R. Miles, Willie J. Hale, Jim Mintz, Jennifer Schuster Wachen, Brett T. Litz, Katherine A. Dondanville, Jeffrey S. Yarvis, Elizabeth A. Hembree, Stacey Young-McCaughan, Alan L. Peterson, Patricia A. Resick
Summary: Active duty service members respond differently to evidence-based psychotherapies for posttraumatic stress disorder (PTSD) compared to civilians. Hyperarousal symptoms are more likely to persist, even in service members who respond optimally to cognitive processing therapy (CPT). Providers should be aware of the need to treat hyperarousal symptoms before or after CPT.
PSYCHOLOGICAL TRAUMA-THEORY RESEARCH PRACTICE AND POLICY
(2022)
Article
Psychology, Clinical
Stefanie T. LoSavio, Casey L. Straud, Katherine A. Dondanville, Nicole R. Fridling, Jennifer Schuster Wachen, Chelsea J. McMahon, Jim Mintz, Stacey Young-McCaughan, Jeffrey S. Yarvis, Alan L. Peterson, Patricia A. Resick
Summary: The study found that military personnel with hazardous drinking issues were equally likely to achieve good outcomes with cognitive processing therapy as those without, and were not more likely to drop out. Participants with hazardous drinking also showed greater reduction in PTSD symptoms.
PSYCHOLOGICAL TRAUMA-THEORY RESEARCH PRACTICE AND POLICY
(2022)
Article
Physics, Multidisciplinary
Jinkang Guo, Paolo Glorioso, Andrew Lucas
Summary: In this paper, an effective field theory for the nonlinear fluctuating hydrodynamics of a single conserved charge is presented. The theory is applicable to systems with or without time-reversal symmetry. By applying the Martin-Siggia-Rose formalism, the authors investigate fluids with charge and multipole conservation, and with broken time-reversal symmetry. They predict the existence of infinitely many new dynamical universality classes.
PHYSICAL REVIEW LETTERS
(2022)
Article
Psychology, Clinical
Jennifer Schuster Wachen, Jim Mintz, Stefanie T. LoSavio, Jan E. Kennedy, Willie J. Hale, Casey L. Straud, Katherine A. Dondanville, John Moring, Abby E. Blankenship, Richard Vandiver, Stacey Young-McCaughan, Jeffrey S. Yarvis, Alan L. Peterson, Patricia A. Resick
Summary: This study investigates the impact of a history of head injury on posttraumatic stress disorder and depression symptoms, finding that individual cognitive processing therapy is more effective for patients with head injury, while group cognitive processing therapy has less significant effects.
JOURNAL OF TRAUMATIC STRESS
(2022)
Article
Psychology, Clinical
Daniel E. Taylor, Kristi Pruiksma, Jim C. Mintz, Danica Slavish, Sophie R. Wardle-Pinkston, Jessica A. Dietch, Katherine Dondanville, Stacey L. Young-McCaughan, Karin T. Nicholson, Brett M. Litz, Terence L. Keane, Alan A. Peterson, Patricia Resick
Summary: Insomnia and nightmares are common in patients with PTSD and are associated with worse health outcomes. Cognitive behavioral therapy for insomnia and nightmares (CBT-I&N) and cognitive processing therapy (CPT) for PTSD are effective treatments. This study found that treating comorbid insomnia, nightmares, and PTSD together resulted in clinically meaningful improvements.
JOURNAL OF TRAUMATIC STRESS
(2023)
Article
Psychology, Clinical
John C. Moring, Alan L. Peterson, Casey L. Straud, Jordan Ortman, Jim Mintz, Stacey Young-McCaughan, Cindy A. McGeary, Donald D. McGeary, Brett T. Litz, Alexandra Macdonald, John D. Roache, Patricia A. Resick, STRONG STAR Consortium
Summary: This study examines the effectiveness of different modalities of cognitive processing therapy for posttraumatic stress disorder (PTSD) and identifies factors such as satisfaction and perceived stigma that can impact treatment outcomes. The results demonstrate the robustness of evidence-based therapies for PTSD and emphasize the importance of addressing stigma before initiating treatment.
JOURNAL OF TRAUMATIC STRESS
(2023)
Article
Psychology, Clinical
Patricia A. L. Resick, Casey L. Straud, Jennifer Schuster T. Wachen, Stefanie T. L. LoSavio, Alan L. D. Peterson, Donald D. McGeary, Stacey J. Young-McCaughan, Daniel J. Taylor, Jim Mintz
Summary: This study examined the discrepancy in scores between self-report and interview measures of posttraumatic stress disorder (PTSD) symptoms, and discussed possible psychometric reasons for the difference. Suggestions for improving the congruence between these measures were discussed.
EUROPEAN JOURNAL OF PSYCHOTRAUMATOLOGY
(2023)
Article
Physics, Multidisciplinary
Chao Yin, Andrew Lucas
Summary: This article proves that quantum information propagates at a finite velocity in models of interacting bosons, and provides an extension of this result in one-dimensional models. The findings are relevant for physically realistic initial conditions in experimentally realized models of interacting bosons.
Article
Psychology, Clinical
Stefanie T. LoSavio, Willie J. Hale, John C. Moring, Abby E. Blankenship, Katherine A. Dondanville, Jennifer Schuster Wachen, Jim Mintz, Alan L. Peterson, Brett T. Litz, Stacey Young-McCaughan, Jeffrey S. Yarvis, Patricia A. Resick
Summary: The study found that there were no significant differences in the efficacy of cognitive processing therapy for active-duty military personnel with or without a history of childhood abuse. History of abuse did not moderate response to individual versus group CPT.
JOURNAL OF CONSULTING AND CLINICAL PSYCHOLOGY
(2021)