Article
Cell Biology
Caio Yogi Yonamine, Marisa Passarelli, Claudia Kimie Suemoto, Carlos Augusto Pasqualucci, Wilson Jacob-Filho, Venancio Avancini Ferreira Alves, Suely Kazue Nagahashi Marie, Maria Lucia Correa-Giannella, Luiz Roberto Britto, Ubiratan Fabres Machado
Summary: Diabetes mellitus is a risk factor for dementia and can induce neuronal dysfunctions through inflammation and other processes. This study found that obese individuals with diabetes had reduced GLUT4 expression and neuronal soma area in the hippocampus. Inflammatory activation decreased GLUT4 expression and negatively affected genes related to neuronal function. Inhibiting HDAC3 could potentially improve GLUT4 expression and counteract the negative effects of inflammation.
Article
Neurosciences
Katrina Aberizk, Meghan A. Collins, Jean Addington, Carrie E. Bearden, Kristin S. Cadenhead, Barbara A. Cornblatt, Daniel H. Mathalon, Thomas H. McGlashan, Diana O. Perkins, Ming T. Tsuang, Scott W. Woods, Tyrone D. Cannon, Elaine F. Walker
Summary: This study investigates the relationship between life event stress (LES) and cortical thickness in individuals at clinical high risk for psychosis (CHR-P). The findings suggest that LES is associated with reduced baseline cortical thickness in both CHR-P and healthy individuals. It is also found that CHR-P status is linked with thinner cortex in select regions even after controlling for LES.
BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING
(2022)
Article
Developmental Biology
A. A. Akishina, R. O. Cherezov, Y. E. Vorontsova, O. B. Simonova
Summary: The study shows for the first time an increase in the expression of aryl hydrocarbon receptor gene and its target genes in human cell cultures after exposure to a histone deacetylase inhibitor (belinostat). Belinostat is currently being considered as a possible therapeutic agent for treating various types of gliomas, including glioblastomas.
RUSSIAN JOURNAL OF DEVELOPMENTAL BIOLOGY
(2022)
Article
Psychiatry
Paola Bucci, Giulia Maria Giordano, Armida Mucci, Paola Rocca, Alessandro Rossi, Alessandro Bertolino, Eugenio Aguglia, Carlo Altamura, Mario Amore, Antonello Bellomo, Massimo Biondi, Bernardo Carpiniello, Giammarco Cascino, Liliana Dell'Osso, Andrea Fagiolini, Luigi Giuliani, Carlo Marchesi, Cristiana Montemagni, Mauro Pettorruso, Maurizio Pompili, Antonio Rampino, Rita Roncone, Rodolfo Rossi, Alberto Siracusano, Elena Tenconi, Antonio Vita, Patrizia Zeppegno, Silvana Galderisi, Mario Maj, Italian Network Res Psychoses
Summary: Gender differences in clinical and psychosocial aspects of schizophrenia have been widely studied, but the findings are inconsistent and further research is needed. This study investigated gender differences in clinical, cognitive, and functional indices in a large sample of schizophrenia patients and healthy controls. Men with schizophrenia had an earlier onset, poorer premorbid adjustment, more severe symptoms, and different coping strategies compared to women. However, these differences did not have a significant impact on overall functioning and outcome.
SCHIZOPHRENIA RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Haran Yogasundaram, Yinggan Zheng, Eric Ly, Justin Ezekowitz, Piotr Ponikowski, Carolyn S. P. Lam, Christopher O'Connor, Robert O. Blaustein, Lothar Roessig, Tracy Temple, Cynthia M. Westerhout, Paul W. Armstrong, Roopinder K. Sandhu
Summary: It is still unclear whether electrocardiographic measurements can predict mortality in patients with chronic heart failure. This study aimed to investigate the association between ECG measurements and mortality in high-risk heart failure patients and found that heart rate, QRS duration, and absence of left ventricular hypertrophy were significantly associated with cardiovascular death.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Meeting Abstract
Psychology, Developmental
David P. Gavin, Gian Paolo Vallerini, Shumila Kazmi, Marina Guizzetti, Maheen Kazmi
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2019)
Article
Neurosciences
Amul J. Sakharkar, Evan J. Kyzar, David P. Gavin, Huaibo Zhang, Ying Chen, Harish R. Krishnan, Dennis R. Grayson, Subhash C. Pandey
Article
Biochemistry & Molecular Biology
Harish R. Krishnan, Huaibo Zhang, Ying Chen, John Peyton Bohnsack, Annie W. Shieh, Handojo Kusumo, Jenny Drnevich, Chunyu Liu, Dennis R. Grayson, Mark Maienschein-Cline, Subhash C. Pandey
Summary: Using an animal model, this study used ATAC-seq and RNA-seq technologies to uncover the epigenomic and transcriptomic changes in the amygdala following acute ethanol exposure. The results suggest that these changes, particularly in the candidate gene Hif3a, are associated with anxiolytic effects and may contribute to the development of alcohol use disorder.
MOLECULAR PSYCHIATRY
(2022)
Article
Psychiatry
Hooriyah S. S. Rizavi, Omar S. S. Khan, Hui Zhang, Runa Bhaumik, Dennis R. R. Grayson, Ghanshyam N. N. Pandey
Summary: A dysregulated HPA axis is closely related to psychiatric disorders and suicide, but the mechanisms behind this dysregulation are not fully understood. Decreased expression of the glucocorticoid receptor (GR) gene, which can be influenced by epigenetic changes, is a strong indicator of impaired HPA axis control. This study focuses on analyzing the GR gene's 5'UTR in teenage suicide-completers to determine expression levels and epigenetic modifications, as well as examining the expression and epigenetic state of the FK506-binding protein 51 (FKBP5). The findings suggest that epigenetic regulation of the GR gene may contribute to long-lasting modifications in an individual's HPA axis response to stress.
TRANSLATIONAL PSYCHIATRY
(2023)
Meeting Abstract
Substance Abuse
H. R. Krishnan, Y. Chen, H. Zhang, A. W. Lasek, M. S. Brodie, M. Maienschein-Cline, D. R. Grayson, S. C. Pandey
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
Meeting Abstract
Substance Abuse
L. Martins de Carvalho, H. Chen, H. Zhang, H. Krishnan, M. Maienschein-Cline, D. R. Grayson, S. C. Pandey, A. W. Lasek
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
Meeting Abstract
Substance Abuse
E. Gatta, V. Saudagar, J. Auta, Y. Chen, D. R. Grayson, M. Maienschein-Cline, S. C. Pandey, A. Guidotti
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
Meeting Abstract
Substance Abuse
S. C. Pandey, J. P. Bohnsack, H. R. Krishnan, Y. Chen, D. R. Grayson, H. Zhang
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
(2021)
Article
Neurosciences
Gian Paolo Vallerini, You-Hong Cheng, Kayla A. Chase, Rajiv P. Sharma, Handojo Kusumo, Shivani Khakhkhar, Douglas L. Feinstein, Marina Guizzetti, David P. Gavin
Meeting Abstract
Substance Abuse
D. R. Grayson, Y. Chen, H. R. Krishnan, H. Zhang, S. C. Pandey
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
(2020)
Meeting Abstract
Substance Abuse
G. P. Vallerini, K. A. Chase, S. Kazmi, M. Kazmi, D. L. Feinstein, D. P. Gavin
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
(2019)
Meeting Abstract
Substance Abuse
M. Kazmi, S. Kazmi, K. A. Chase, G. P. Vallerini, M. Guizzetti, D. P. Gavin
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
(2019)
Meeting Abstract
Substance Abuse
S. Kazmi, I. El-Khateeb, K. A. Chase, G. P. Vallerini, M. Kazmi, M. Guizzetti, D. P. Gavin
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
(2019)
Meeting Abstract
Substance Abuse
H. R. Krishnan, A. W. Shieh, H. Zhang, Y. Chen, C. Liu, D. R. Grayson, S. C. Pandey
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
(2019)
Meeting Abstract
Substance Abuse
A. W. Lasek, W. Y. Chen, H. Zhang, H. Chen, H. R. Krishnan, D. R. Grayson, S. C. Pandey
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
(2019)
