Article
Psychology, Clinical
Lara J. Farrell, Allison M. Waters, Evelin Tiralongo, Sharna Mathieu, Matthew McKenzie, Vinay Garbharran, Robert S. Ware, Melanie J. Zimmer-Gembeck, Harry McConnell, Cassie Lavell, Jacinda Cadman, Thomas H. Ollendick, Jennifer L. Hudson, Ronald M. Rapee, Brett McDermott, Daniel Geller, Eric A. Storch
Summary: This study examined the efficacy of weight-adjusted D-cycloserine (DCS) in intensive exposure therapy for youth with obsessive-compulsive disorder (OCD) and found that DCS did not provide additional benefits compared to placebo. However, intensive exposure therapy was effective in reducing symptoms for the overall sample.
DEPRESSION AND ANXIETY
(2022)
Article
Clinical Neurology
Solaphat Hemrungrojn, Sookjaroen Tangwongchai, Thammanard Charernboon, Muthita Phanasathit, Pisit Chaipresertsud, Pacharaporn Maleevach, Yuttachai Likitjaroen, Kammant Phanthumchinda, Ratiya Assawatinna, Arisara Amrapala, Michael Maes
Summary: The purpose of this study was to validate the Thai version of the Neuropsychiatric Inventory Questionnaire (NPI-Q) as a screening tool for behavioral and psychological symptoms of dementia (BPSD) and examine the relationship between cognitive performance and BPSD in elderly individuals with amnestic mild cognitive impairment (aMCI) and dementia of Alzheimer's type (DAT). The results showed that the Thai NPI-Q had good validity and reliability, and cognitive performance was significantly correlated with NPI-Q scores. Some individuals with aMCI may progress to probable dementia.
FRONTIERS IN NEUROLOGY
(2023)
Review
Health Care Sciences & Services
Wan Mohd Azam Wan Mohd Yunus, Hanna-Maria Matinolli, Otto Waris, Subina Upadhyaya, Miika Vuori, Tarja Korpilahti-Leino, Terja Ristkari, Tarja Koffert, Andre Sourander
Summary: Studies have shown high prevalence of depression during pregnancy, and cognitive behavioral therapy (CBT) has been identified as one of the most effective psychosocial interventions. Digitalized CBT interventions for depression during pregnancy showed promising efficacy and positive outcomes, with user feedback being positive.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2022)
Article
Cell Biology
Wei Sun, Hong Cheng, Yang Yang, Dongxin Tang, Xiaolian Li, Lei An
Summary: The study found that the precursor pro-brain-derived neurotrophic factor (proBDNF) plays a crucial role in spatial cognition in adult rodent brains. Blocking proBDNF expression disrupted spatial memory consolidation without affecting learning or memory retrieval. The results underscore the importance of proBDNF in synaptic and cognitive functions in postnatal brains.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Neurosciences
Darryl C. Gidyk, Robert J. McDonald, Robert J. Sutherland
Summary: Results from experiments suggest that rats can maintain normal memory in adversarial learning and discrimination tasks even in the absence of the hippocampus.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Helia Aghamiri, Majid Jafari-Sabet, Mahmood Hoormand
Summary: CBD can ameliorate topiramate-induced memory loss, involving hippocampal and prefrontal cortical NMDA receptors and the CREB/BDNF signaling pathway.
NEUROCHEMICAL RESEARCH
(2023)
Review
Neurosciences
Qiongqiong Wu, Xiaoyi Wang, Ying Wang, Yu-Jun Long, Jing-Ping Zhao, Ren-Rong Wu
Summary: This review focuses on the causal mechanisms and treatment options for the negative symptoms and cognitive dysfunction in schizophrenia, providing insights into potential therapeutic strategies for the future.
NEUROSCIENCE BULLETIN
(2021)
Article
Pediatrics
Steven M. LeVine, Sheila Tsau
Summary: Krabbe disease is a lysosomal storage disease caused by a deficiency in galactosylceramidase. Current treatment methods have limited effectiveness, but preclinical studies have shown progress, especially in gene therapy and substrate reduction therapy. D-cycloserine has shown potential as a therapy in animal experiments, extending the lifespan of twitcher mice.
FRONTIERS IN PEDIATRICS
(2022)
Review
Medicine, General & Internal
Agata Orzechowska, Paulina Maruszewska, Piotr Galecki
Summary: This article explores the relationship between physical and mental health, highlighting the complexities and challenges faced by patients in modern healthcare. It emphasizes the role of cognitive behavioral therapy in addressing multifaceted somatic disorders.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Behavioral Sciences
Michael T. Sapko, Taleen Hanania, Qing Chang, Jonathan C. Javitt
Summary: This study aimed to evaluate the abuse liability of D-cycloserine (DCS) using a self-administration paradigm. The results showed that DCS did not result in self-administration at any of the test doses and had similar behavior to the control group.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2023)
Article
Psychiatry
Zanjbeel Mahmood, Ryan Van Patten, Amber V. Keller, Hannah C. Lykins, Dimitri Perivoliotis, Eric Granholm, Elizabeth W. Twamley
Summary: The study found mixed evidence for the feasibility and acceptability of the integrated CBSST-CCT intervention in people with schizophrenia with high negative symptoms. Some challenges were identified, but recommendations for future investigations were provided. Positive symptoms were significantly associated with attendance rates among CBSST-CCT participants.
PSYCHIATRY RESEARCH
(2021)
Article
Cell Biology
Alexandra Gros, Szu-Han Wang
Summary: Cognitive decline in spatial memory is observed in aging. Understanding the processes affected in aging and the role of prior training is crucial for improving wellbeing. Prior training improves cognition by enhancing short-term and long-term memory, suggesting the potential to mitigate age-related memory decline.
Article
Psychology, Clinical
Kirsten Smith, Anke Ehlers
Summary: This study examined the mediating role of unhelpful coping strategies in the relationship between negative appraisals, memory characteristics, and symptoms of prolonged grief disorder (PGD), posttraumatic stress disorder (PTSD), and depression. The results showed that coping strategies played a significant mediating role in the relationship between appraisals, memory characteristics, and symptoms of these disorders. These findings have important implications for the prediction and treatment of mental health problems following loss.
PSYCHOLOGICAL MEDICINE
(2023)
Review
Obstetrics & Gynecology
M. S. Hunter
Summary: This article discusses cognitive behavioral therapy (CBT) for women experiencing problematic menopausal symptoms, highlighting its effectiveness in reducing VMS impact, improving sleep quality, and enhancing quality of life based on clinical trials. The brief, theory- and evidence-based therapy has been found to be consistently effective in various formats like group sessions, self-help books, and online resources, with or without additional support. Recommendations for using CBT in treating VMS, anxiety, depression, and insomnia in menopausal and postmenopausal women have been made by different organizations.
Article
Psychology, Clinical
Emily E. Bernstein, Katharine A. Phillips, Jennifer L. Greenberg, Joshua Curtiss, Susanne S. Hoeppner, Sabine Wilhelm
Summary: This study re-examined the treatment effects of cognitive-behavioral therapy (CBT) and supportive psychotherapy (SPT) on body dysmorphic disorder (BDD). The findings suggest that CBT primarily targets unhelpful thoughts and BDD rituals, while SPT directly improves BDD-related insight. The time course of differences aligns with the intended targets of CBT, with cognitive effects emerging first and behavioral effects following.
PSYCHOLOGICAL MEDICINE
(2023)
