Article
Psychiatry
Zhen Li, Rong Chen, Dachuan Liu, Xizhe Wang, Wei Yuan
Summary: This study investigated the effects of low-intensity transcranial ultrasound stimulation (TUS) on theta and gamma oscillations in the hippocampus under different behavioral states. The results showed that TUS enhanced the absolute power of theta and gamma oscillations in the anesthesia and awake states, but weakened their phase-amplitude coupling (PAC) under the running state. Additionally, the relative power of theta and gamma oscillations changed with ultrasound intensity, and the PAC index between theta and gamma increased with ultrasound intensity. These findings suggest that TUS can modulate hippocampal oscillations depending on the behavioral state.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Neurosciences
Lindsey M. Crown, Daniel T. Gray, Lesley A. Schimanski, Carol A. Barnes, Stephen L. Cowen
Summary: This study investigates the effects of locomotor activity and age on gamma and theta frequencies in the hippocampus of rats. The results show that age affects the modulation of gamma and theta frequencies, with older rats showing slower increases in gamma frequency and lower theta frequencies. Acceleration is also found to have a lower correlation with gamma frequency in both age groups. Older animals have greater spike phase-locking to gamma and reduced firing rates within place fields, but higher spatial information content per spike. These findings suggest that locomotor behavior and age significantly impact local-field potential activity in the hippocampus.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Mathematics, Applied
Kiyoshi Kotani, Akihiko Akao, Hayato Chiba
Summary: The study investigates the stability and bifurcation of gamma oscillations in the local field potential generated by interactions of inhibitory neurons. It shows that stable gamma oscillations exist within a suitable range of connection probability, and when the tonic current distribution is Lorentzian, the Vlasov equation simplifies to a finite dimensional dynamical system. The numerical computations of neuronal population follow the analyses of the generalized spectral theory and the bifurcation analysis of the reduced equation.
PHYSICA D-NONLINEAR PHENOMENA
(2021)
Article
Neurosciences
Robert G. K. Munn, Amy Wolff, Lucinda J. Speers, David K. Bilkey
Summary: Maternal immune activation (MIA) increases the risk for schizophrenia and other neurodevelopmental disorders. In rat models, MIA mimics the brain and behavioral changes seen in schizophrenia, including memory impairment. This study re-analyzed previous electrophysiological recordings of the hippocampus in MIA and control rats to investigate temporal dysfunction. The findings suggest abnormal gamma power and coherence, altered phase precession of place cells, and an increase in sharp-wave ripple events in the hippocampus of MIA rats, highlighting circuit-level changes that may contribute to information processing deficits in schizophrenia.
Article
Neurosciences
Lucinda J. Speers, Kirsten R. Cheyne, Elena Cavani, Tara Hayward, Robert Schmidt, David K. Bilkey
Summary: The study found that schizophrenia may lead to a greater variability in the starting phase of precession in animals entering new environments, resulting in a disorganization of the ordered representation of experience.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Psychiatry
Daisuke Koshiyama, Makoto Miyakoshi, Kumiko Tanaka-Koshiyama, Yash B. Joshi, Joyce Sprock, David L. Braff, Gregory A. Light
Summary: The study identified abnormal resting-state EEG activity in schizophrenia patients, including elevated power in multiple bands in the temporal and posterior cingulate regions, as well as changes in phase discontinuity rates of alpha and theta waves.
SCHIZOPHRENIA RESEARCH
(2021)
Article
Biology
Eloy Parra-Barrero, Kamran Diba, Sen Cheng
Summary: The study examines the relationships between theta phase, represented position, and true location in navigation through space in mammalian brains. Existing concepts of 'spatial' or 'temporal' theta sweeps are found to be inadequate in explaining how relevant variables change with running speed. A new concept of 'behavior-dependent' sweeps is introduced, where theta sweep length and place field properties vary based on running speed characteristics at different locations in the environment, providing essential structured heterogeneity for understanding the hippocampal code.
Article
Neurosciences
Jack P. Kennedy, Yuchen Zhou, Y. Qin, Sarah D. Lovett, A. Sheremet, S. N. Burke, A. P. Maurer
Summary: This study explores the relationship between theta rhythm and voluntary movement in hippocampal neurophysiology research, highlighting the impact of running speed on theta frequency and power compared to acceleration. The results suggest that speed plays a more significant role in influencing theta frequency, contradicting previous findings that acceleration is the dominant factor. Caution is advised in interpreting absolute claims about hippocampal physiology from single behavioral repertoires, emphasizing the need to consider multiple sensory inputs in navigation tasks.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Clinical Neurology
C. Basar-Eroglu, K. M. Kuecuek, L. Ruerup, C. Schmiedt-Fehr, B. Mathes
Summary: This study investigated disturbances in oscillatory synchronizations during motion perception in patients with schizophrenia. The results showed decreased inter-trial coherences in delta and theta frequency bands, suggesting abnormalities in motion binding processes in patients.
CLINICAL EEG AND NEUROSCIENCE
(2023)
Article
Neurosciences
B. S. Katerman, Y. Li, J. K. Pazdera, C. Keane, M. J. Kahana
Summary: This study investigated spectral EEG biomarkers of memory retrieval and found that in the moments leading up to recall, there was an increase in theta (4-8 Hz) power, a decrease in alpha (8-20 Hz) power, and an increase in gamma (40-128 Hz) power. This spectral pattern could distinguish between long-term delay and immediate recall conditions.
Article
Neurosciences
Stefano Berto, Miles R. Fontenot, Sarah Seger, Fatma Ayhan, Emre Caglayan, Ashwinikumar Kulkarni, Connor Douglas, Carol A. Tamminga, Bradley C. Lega, Genevieve Konopka
Summary: This study investigated the molecular mechanisms underlying memory formation through analyzing patient-specific brain oscillations and gene expression, revealing correlations between specific genes and oscillatory signatures of memory formation in different frequency bands. The study showed that these genes are associated with neuropsychiatric disorders and ion channel activity, and are enriched in excitatory and inhibitory neurons. The findings provide new insights into the genetic mechanisms that support memory encoding.
NATURE NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Carolina Wilnerzon Thorn, Vasilios Kafetzopoulos, Bernat Kocsis
Summary: The Dopamine D4 receptor (D4R) mechanisms are implicated in psychiatric diseases characterized by cognitive deficits. This study found that D4R activation enhances slow rhythm in the prefrontal cortex (PFC) and suppresses theta rhythm in the hippocampus (HPC), while D4R antagonists have the opposite effect.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Ahmed T. Hussin, Saman Abbaspoor, Kari L. Hoffman
Summary: Research has found that increasing memory age is associated with increased alpha oscillations in the retrosplenial cortex and decreased hippocampocortical synchrony, indicating a potential shift in memory allocation or changes in selection among distributed memory representations in the primate brain.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Pallavi Kaushik, Amir Moye, Marieke Van Vugt, Partha Pratim Roy
Summary: This study investigated the possibility of predicting attention and distraction using EEG data collected in a natural setting, and demonstrated that data extracted in daily life settings can accurately predict attention states, potentially leading to the development of Brain-Computer Interfaces for real-time attention tracking.
SCIENTIFIC REPORTS
(2022)
Article
Neurosciences
Adriano B. L. Tort, Maximilian Hammer, Jiaojiao Zhang, Jurij Brankack, Andreas Draguhn
Summary: The study found a strong correlation between instantaneous breathing frequency and the frequency and amplitude of theta and gamma oscillations in the brain. Changes in theta activity were found to precede and cause changes in breathing frequency, indicating control by the brain's functional state. On the other hand, changes in breathing frequency were found to cause changes in gamma frequency, suggesting influence by a peripheral reafference signal.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Substance Abuse
Julie M. McCarthy, Kelly M. Dumais, Maya Zegel, Diego A. Pizzagalli, David P. Olson, Lauren V. Moran, Amy C. Janes
DRUG AND ALCOHOL DEPENDENCE
(2019)
Article
Medicine, General & Internal
Lauren V. Moran, Dost Ongur, John Hsu, Victor M. Castro, Roy H. Perlis, Sebastian Schneeweiss
NEW ENGLAND JOURNAL OF MEDICINE
(2019)
Meeting Abstract
Psychiatry
Lauren Moran, Dost Ongur, John Hsu, Victor Castro, Roy Perlis, Sebastian Schneeweiss
SCHIZOPHRENIA BULLETIN
(2019)
Editorial Material
Psychiatry
Lauren V. Moran, Perihan Esra Guvenek-Cokol, Roy H. Perlis
Article
Neurosciences
Kainan S. Wang, Maya Zegel, Elena Molokotos, Lauren Moran, David P. Olson, Diego A. Pizzagalli, Amy C. Janes
NEUROPSYCHOPHARMACOLOGY
(2020)
Letter
Neurosciences
Nicola Cascella, Ankur A. Butala, Kelly Mills, Min Jae Kim, Yousef Salimpour, Teresa Wojtasievicz, Brian Hwang, Bernadette Cullen, Martijn Figee, Lauren Moran, Fred Lenz, Akira Sawa, David J. Schretlen, William Anderson
BIOLOGICAL PSYCHIATRY
(2021)
Article
Substance Abuse
Kainan S. Wang, Kaelyn Brown, Blaise B. Frederick, Lauren Moran, David Olson, Diego A. Pizzagalli, Roselinde H. Kaiser, Amy C. Janes
Summary: The study found that nicotine biases resting-state brain function in non-smokers away from the frontoinsular-DMN and toward the SN, reducing internally focused cognition and enhancing salience processing. This suggests that acute nicotine impacts specific networks linked with rumination and depression in non-smokers.
DRUG AND ALCOHOL DEPENDENCE
(2021)
Article
Psychiatry
Heather Burrell Ward, Adam Beermann, Uzma Nawaz, Mark A. Halko, Amy C. Janes, Lauren V. Moran, Roscoe O. O. Brady Jr
Summary: Tobacco use is a major risk factor for early mortality in schizophrenia. A connectome-wide analysis revealed specific circuits related to nicotine addiction in schizophrenia patients that are distinct from those in non-schizophrenia populations.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Health Policy & Services
Nicole M. Benson, Zhiyou Yang, Max Weiss, Vicki Fung, Lauren Moran, Dost Ongur, John Hsu
Summary: This study used a large clinical data set to investigate new diagnoses of schizophrenia spectrum disorder. The findings highlight the significance of examining multiple years of patient history in large data sets to identify new diagnoses.
PSYCHIATRIC SERVICES
(2022)
Meeting Abstract
Neurosciences
Heather Ward, Adam Beermann, Uzma Nawaz, Gulcan Yildiz, Mark Halko, Amy Janes, Lauren Moran, Roscoe Brady
BIOLOGICAL PSYCHIATRY
(2022)
Meeting Abstract
Neurosciences
Heather Ward, Adam Beermann, Uzma Nawaz, Mark Halko, Amy Janes, Lauren Moran, Roscoe Brady
NEUROPSYCHOPHARMACOLOGY
(2021)
Meeting Abstract
Neurosciences
Lauren Moran, Erica Tsang, Dost Ongur, John Hsu, May Choi
NEUROPSYCHOPHARMACOLOGY
(2021)
Meeting Abstract
Neurosciences
Lauren Moran, Joseph Skinner, Ann Shinn, Vinod Rao, S. Trevor Taylor, Kathryn Nielsen, Ian Baptiste, Talia Cohen, Cemre Erkol, Jaisal Merchant, Christin Mujica, Perlis Roy, Dost Ongur
NEUROPSYCHOPHARMACOLOGY
(2021)
Meeting Abstract
Neurosciences
Heather Ward, Adam Beerman, Uzma Nawaz, Mark Halko, Amy Janes, Lauren Moran, Roscoe Brady
NEUROPSYCHOPHARMACOLOGY
(2020)
Meeting Abstract
Public, Environmental & Occupational Health
Lauren V. Moran, Dost Ongur, John Hsu, Victor M. Castro, Roy H. Perlis, Sebastian Schneeweiss
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
(2019)