Article
Biochemistry & Molecular Biology
Yuan-Hong Jiang, Jia-Fong Jhang, Yuan-Hsiang Hsu, Hann-Chorng Kuo
Summary: This study investigated the usefulness of urinary biomarkers in assessing bladder condition and histopathology in IC/BPS patients. The results show that urinary biomarker levels are associated with symptoms and pathological manifestations, helpful in identifying HIC and NHIC subtypes, but most biomarkers are not strongly correlated with specific bladder histopathological findings.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yuan-Hong Jiang, Jia-Fong Jhang, Lori A. A. Birder, Hann-Chorng Kuo
Summary: The aim of this study was to investigate the expression levels of sensory receptors, inflammatory proteins, and pro-apoptotic proteins in the urothelium of non-Hunner's interstitial cystitis (NHIC) bladders of patients with different clinical and cystoscopic phenotypes. The study concluded that IC/BPS patients with frequency and bladder pain complaints have higher levels of urothelial sensory receptors, and inflammatory and pro-apoptotic proteins. The expression levels of these sensory receptors, inflammatory proteins, and pro-apoptotic proteins are not significantly different among IC/BPS bladders with different conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Urology & Nephrology
Andre Plair, Robert J. Evans, Carl D. Langefeld, Catherine A. Matthews, Gopal Badlani, Stephen J. Walker
Summary: This study examined anesthetic bladder capacity as a biomarker for IC/BPS patient subtypes in a large female cohort. The findings showed a positive correlation between higher BC and non-bladder-centric syndromes, while lower BC was more closely related to bladder-specific pathology, supporting the concept of clinical subgroups in IC/BPS.
Article
Medicine, Research & Experimental
Zhenming Zheng, Jintao Hu, Wenshuang Li, Kaiqun Ma, Caixia Zhang, Kuiqing Li, Yousheng Yao
Summary: This study used 16S rRNA sequencing and untargeted metabolomics techniques to analyze the urinary microbial and metabolite profiles of IC/BPS patients and healthy controls. The results showed differential genera and metabolites associated with the inflammatory response of IC/BPS, including Lactobacillus as a protective bacterium and Sphingomonas as a pathogenic factor. The metabolite theophylline may also play a role in downregulating the inflammatory response of IC/BPS.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Immunology
Masaru Yoshizumi, Naoya Tazawa, Chizuko Watanabe, Hirokazu Mizoguchi
Summary: Activation of TRPV4 can negatively regulate bladder inflammation induced by LPS and alleviate bladder hypersensitivity. This finding may provide new therapeutic targets for refractory bladder pain syndrome.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Hsueh-Yu Mu, Ming-Ping Wu, I-Te Wang, Jeng-Cheng Wu, Hung-Yen Chin
Summary: Overactive bladder (OAB) and interstitial cystitis/painful bladder syndrome (IC/PBS) are two lower urinary tract disorders with overlapping symptoms, making it difficult to accurately differentiate between them. This study identified a subgroup of OAB patients with bladder pain (OAB-BP) that could be distinguished from those with OAB alone through urodynamic study (UDS) findings. The clinical presentations and urodynamic parameters of OAB-BP and IC/PBS were found to be more similar than those of OAB alone.
Article
Medicine, General & Internal
Hung-Yu Lin, Jian-He Lu, Shu-Mien Chuang, Kuang-Shun Chueh, Tai-Jui Juan, Yi-Chang Liu, Yung-Shun Juan
Summary: Interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic bladder disorder characterized by suprapubic pain and discomfort during bladder filling, accompanied by lower urinary tract symptoms. The diagnosis of IC/BPS is still not standardized, but cystoscopy and bladder biopsy can determine the presence of ulcers. The pathophysiology of IC/BPS may involve chronic inflammation, autoimmune disorders, and other factors. Biomarkers in urine and serum specimens could be useful for the diagnosis of IC/BPS.
Article
Pharmacology & Pharmacy
Yuan-Hong Jiang, Jia-Fong Jhang, Teng-Yi Lin, Han-Chen Ho, Yung-Hsiang Hsu, Hann-Chorng Kuo
Summary: The study found that intravesical PRP injection is effective in relieving symptoms of IC/BPS patients, with slightly lower efficacy after a single high-dose PRP injection compared to four low-dose PRP injections. The addition of components and injection site did not significantly affect therapeutic outcomes.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Jin Li, Xianyanling Yi, Jianzhong Ai
Summary: Interstitial cystitis/bladder pain syndrome (IC/BPS) is a debilitating disease with a negative impact on quality of life. Diagnoses and treatments are still unsatisfactory, calling for new approaches. This study aims to provide a comprehensive overview of IC/BPS research, promoting progress in diagnosis, treatment, and prognosis. The complexity of IC/BPS and emerging evidence call for further studies to optimize management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yuan-Hong Jiang, Jia-Fong Jhang, Han-Chen Ho, Dan-Yun Chiou, Hann-Chorng Kuo
Summary: Urine oxidative stress biomarkers and inflammatory cytokines play important roles in diagnosing and differentiating clinical subtypes of interstitial cystitis/bladder pain syndrome (IC/BPS).
Article
Medicine, General & Internal
Pedro Abreu-Mendes, Beatriz Araujo-Silva, Ana Charrua, Francisco Cruz, Rui Pinto
Summary: This study suggests that daily silodosin can be an effective and well-tolerated treatment for refractory BPS/IC female patients. Additionally, stress coping levels may be associated with symptom improvement.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Amy M. Ivare, Aneta Obloza, Jonathan C. Goddard
Summary: Bladder pain syndrome (BPS) is often overlooked in pregnancy, despite being a common symptom. This article reviews the current evidence on the impact of BPS on pregnancy and the available options for diagnosis and management, aiming to improve patient experience and outcomes.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2023)
Article
Food Science & Technology
Wenshuang Li, Zhenming Zheng, Kaiqun Ma, Caixia Zhang, Kuiqing Li, Paierhati Tayier, Yousheng Yao
Summary: This study found that in patients with interstitial cystitis/bladder pain syndrome (IC/BPS), repeated intravesical instillations of Sapylin after botulinum toxin A (BoNT/A) injection can produce significantly better clinical outcomes than BoNT/A alone, with good safety.
Article
Multidisciplinary Sciences
Kun-Lin Hsieh, Hung-Yen Chin, Tsia-Shu Lo, Cheng-Yu Long, Chung-Han Ho, Steven Kuan-Hua Huang, Yao-Chi Chuang, Ming-Ping Wu
Summary: IC/BPS is associated with increased risks of outpatient visits and hospitalizations, with patients having more overall OPD visits and higher IRRs in psychiatry, Chinese medicine, and emergency medicine; IRRs decrease with age, except for gynecology. Similar trends are observed in hospitalizations, with the deductive inference of ulcer type IC/BPS findings to non-ulcer types remaining inconclusive. Adequate recognition of associated factors and proper recommendations for IC/BPS patients can improve healthcare quality.
Article
Biochemistry & Molecular Biology
Yu-Khun Lee, Yuan-Hong Jiang, Jia-Fong Jhang, Han-Chen Ho, Hann-Chorng Kuo
Summary: This study investigated the changes in electron microscopic findings among IC/BPS patients after intravesical PRP injections and found that repeated PRP injections can improve IC/BPS symptoms and promote the recovery of urothelial ultrastructural defects.