Review
Infectious Diseases
Mohammad-Javad Sanaei, Mahboobeh Nahid-Samiei, Milad Shahini Shams Abadi, Mohammad-Hassan Arjmand, Gordon A. Ferns, Davood Bashash, Ghorbanali Rahimian, Nader Bagheri
Summary: B-regs, a subset of B cells with immunosuppressive effects, produce regulatory cytokines like IL-10, TGF-beta, and IL-35, which limit host defense against pathogens and induce suppressive T-regs. High levels of B-regs are associated with viral and bacterial load, leading to poor vaccine responses and increased disease severity. B-regs also protect against hyperinflammatory responses in parasitic infections.
INFECTION GENETICS AND EVOLUTION
(2021)
Article
Biochemistry & Molecular Biology
Alberto Mella, Filippo Mariano, Caterina Dolla, Ester Gallo, Ana Maria Manzione, Maria Cristina Di Vico, Rossana Cavallo, Francesco Giuseppe De Rosa, Cristina Costa, Luigi Biancone
Summary: Kidney transplanted patients have a higher vulnerability to viral and bacterial infections due to continuous immunosuppression, making infectious episodes a major cause of death. Prevention, early diagnosis, and appropriate therapy are crucial in managing these infections.
Review
Immunology
Beata Tokarz-Deptula, Joanna Palma, Lukasz Baraniecki, Michal Stosik, Roman Kolacz, Wieslaw Deptula
Summary: Platelets play a role in inflammation and infections by reacting with the endovascular environment and cells of the immune system. This role is influenced by biologically active substances present in platelet granules and EV structures.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Audrey Labarde, Lina Jakutyte, Cyrille Billaudeau, Beatrix Fauler, Maria Lopez-Sanz, Prishila Ponien, Eric Jacquet, Thorsten Mielke, Silvia Ayora, Rut Carballido-Lopez, Paulo Tavares
Summary: Infection of Bacillus subtilis by bacteriophage SPP1 leads to the hijacking of host replication proteins to assemble hybrid viral-bacterial replisomes, doubling the cell total DNA content within 15 minutes. The replisomes operate at several independent locations within a single viral DNA focus positioned asymmetrically in the cell. These findings demonstrate that bacteriophages restructure the host cytoplasm to confine the essential processes for their multiplication at different cellular locations.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Microbiology
Ang Hu, Zeming Hu, Haohong Zou, Jiankang Zhang, Dongliang Zhang, Hao Wang, Jianing Zhong, Bin Chen
Summary: This article reviews recent clinical and basic studies on the mechanism and function of CARD9, a crucial mediator in fungal, bacterial, viral, and parasitic infections. The article also summarizes the latest treatment and prevention strategies based on CARD9 and discusses the current perspectives and future directions of CARD9.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Chemistry, Multidisciplinary
John Jairo Aguilera-Correa, Jaime Esteban, Maria Vallet-Regi
Summary: Infectious diseases rank third in the top 10 causes of death worldwide, accounting for over 6.7 million deaths in 2016. Nanomedicine, which uses nanotechnology for medical purposes, involves the use of nanoparticles for diagnosing, monitoring, controlling, preventing, and treating diseases, including infectious ones. Nanoparticles, with their highly tunable physical and optical properties, are widely used in nanomedicine for preventing and treating human infectious diseases caused by various viruses and bacteria.
Review
Immunology
Markus Wehrmann, David Vilchez
Summary: Deubiquitinating enzymes (DUBs) play important roles in the infection of human cells by pathogens. This review discusses recent studies on the manipulation of host processes through DUB activity during infection, highlighting the therapeutic potential of inhibiting pathogen-specific DUB activity to prevent infectious diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Environmental Sciences
Sanjeev K. Bhardwaj, Neha Bhardwaj, Vanish Kumar, Deepanshu Bhatt, Abdelmonaim Azzouz, Jayeeta Bhaumik, Ki-Hyun Kim, Akash Deep
Summary: Airborne pathogens, such as the common cold, flu, and tuberculosis, pose a threat to public health, requiring accurate monitoring and identification methods. Traditional detection techniques have limitations, leading to the development of nanomaterial-based biosensors as alternative options for portable, rapid, and direct on-site identification of target microbes. Advancements in nano-biosensors are expected for improved accuracy and portability.
ENVIRONMENT INTERNATIONAL
(2021)
Review
Microbiology
Barbara M. Schultz, Orlando A. Acevedo, Alexis M. Kalergis, Susan M. Bueno
Summary: This review summarizes the role of NETs during bacterial and viral infections, explaining the molecular mechanisms involved in their formation and their relationship with different components of such pathogens.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Virology
Tarani Kanta Barman, Dennis W. Metzger
Summary: This review discusses the role of disease tolerance in viral-bacterial co-infection, focusing on host cytokines and cells that promote tissue protection and damage control.
Article
Urology & Nephrology
J. Curtis Nickel, Garth D. Ehrlich, Jaroslaw E. Krol, Azad Ahmed, Bhaswati Sen, Archana Bhat, Joshua C. Mell, R. Christopher Doiron, Kerri-Lynn Kelly, Joshua P. Earl
Summary: The study examined the urinary microbiota associated with Hunner lesion (HL) interstitial cystitis/bladder pain syndrome (IC/BPS) using molecular diagnostic techniques, finding no significant differences between the bacterial communities of HL and non-HL IC/BPS patients overall. However, male HL patients showed significant differences in specific bacterial species. This suggests that bacteria may not play a significant role in HL IC/BPS patients as a whole.
Article
Immunology
Zhi-Yuan Wei, Zhi-Xin Wang, Jia-Huan Li, Yan-Shuo Wen, Di Gao, Shou-Yue Xia, Yu-Ning Li, Xu-Bin Pan, Yan-Shan Liu, Yun-Yun Jin, Jian-Huan Chen
Summary: This study analyzed A-to-I RNA editing during intracellular bacterial infections using 18 RNA-Seq datasets of 210 mouse samples. A consensus signature of RNA editing for intracellular bacterial infections was identified, mainly involving neutrophil-mediated innate immunity and lipid metabolism. Comparison with single-strand RNA (ssRNA) viruses showed remarkable similarities and differences, providing new insights into the diagnosis and treatment of infectious diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Veterinary Sciences
Erdal Matur, Banu Dokuzeylu, Mukaddes Ozcan, Handan Cetinkaya, Murat Arslan, Erman Or, Songul Erhan, Ulker Cotelioglu
Summary: Serum procalcitonin level can be used as a clinical biomarker in bacterial diseases in dogs, and possibly in some parasitic diseases, although further studies are needed to determine threshold values.
JAPANESE JOURNAL OF VETERINARY RESEARCH
(2021)
Article
Medicine, General & Internal
Yingzhi Liu, Lowell Ling, Sunny H. Wong, Maggie H. T. Wang, J. Ross Fitzgerald, Xuan Zou, Shisong Fang, Xiaodong Liu, Xiansong Wang, Wei Hu, Hung Chan, Yan Wang, Dan Huang, Qing Li, Wai Wong, Gordon Choi, Huachun Zou, David S. C. Hui, Jun Yu, Gary Tse, Tony Gin, William K. K. Wu, Matthew T. Chan, Lin Zhang
Summary: This study investigated the clinical features and outcomes of patients with viral-bacterial respiratory tract co-infections in Hong Kong. The results showed that bacterial co-infection is common in hospitalized patients with viral respiratory tract infection and is associated with higher ICU admission rate and mortality. Active surveillance for bacterial co-infection and early antibiotic treatment may be required to improve outcomes in patients with respiratory viral infection.
Review
Microbiology
Lavoisier Akoolo, Sandra C. Rocha, Nikhat Parveen
Summary: Various protozoan pathogens can cause multiple human diseases, and co-infections may lead to synergistic or antagonistic pathogenic effects that affect host immune responses and disease severity. Understanding the immunological changes caused by protozoan infections can help prevent and treat co-infections.
FRONTIERS IN MICROBIOLOGY
(2022)