Article
Economics
Michael J. Sweeting, John Marshall, Matthew Glover, Akhtar Nasim, Matthew J. Bown
Summary: The study found that lengthening the surveillance intervals in the UK Abdominal Aortic Aneurysm Screening Programme, especially for small AAAs, can marginally reduce the incremental cost per QALY of the program. However, it is unclear whether the cost savings from refining surveillance strategies justifies a change in clinical practice.
Article
Surgery
Kelli L. Summers, Edmund K. Kerut, Claudie M. Sheahan, Malachi G. Sheahan
Summary: This study analyzed data from a large-scale AAA screening program in the United States and found that male gender, smoking, cardiac disease, family history, and advancing age are high-risk factors for AAA. Current smoking status was the most significant risk factor.
JOURNAL OF VASCULAR SURGERY
(2021)
Article
Surgery
Neil Patel, Varun K. Dalmia, Matthew Carnevale, Evan Lipsitz, Jeffrey Indes
Summary: This study aimed to determine the prevalence of abdominal aortic aneurysm (AAA) in patients outside of the current screening guidelines and analyze the outcomes. Results showed that male ever-smokers aged 45 to 65, male never-smokers aged 65 to 75, male never-smokers aged older than 75, and female ever-smokers aged 65 or older had a prevalence of AAA greater than 1%. In addition, the risk of rupture increased over time in these patients. Patients who underwent AAA repair had significantly lower rates of mortality, stroke, and myocardial infarction.
JOURNAL OF VASCULAR SURGERY
(2023)
Review
Cardiac & Cardiovascular Systems
Jonathan Golledge, Shivshankar Thanigaimani, Janet T. Powell, Phil S. Tsao
Summary: Abdominal aortic aneurysm (AAA) causes a high number of deaths worldwide every year, but no drug therapy has been proven to effectively limit AAA growth in randomized controlled trials. Genome-wide association studies have identified potential drug targets, and treatments to reduce low-density lipoprotein cholesterol and smoking cessation are also being considered. However, previous placebo-controlled randomized trials have not shown convincing evidence of drug efficacy, mainly due to limitations such as small sample sizes and poor participant retention. Further large prospective studies on other targets are needed to address this issue.
EUROPEAN HEART JOURNAL
(2023)
Article
Surgery
Shivshankar Thanigaimani, Vikram Iyer, John Bingley, Daniel Browne, James Phie, Denise Doolan, Jonathan Golledge
Summary: This study examined the association between serum microRNAs (miRNAs) and diagnosis and growth of abdominal aortic aneurysm (AAA), and tested their diagnostic and prognostic value. The expression levels of 800 miRNA tags were assessed in AAA patients, healthy controls, and patients with peripheral artery disease (PAD). The miRNAs let-7b-5p and miR-548n improved the ability to diagnose AAA, but none of the miRNAs had independent prognostic value in predicting AAA growth.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Sara E. Hensley, Gilbert R. Upchurch
Summary: Abdominal aortic aneurysms (AAAs) are defined as aortic dilation greater than 3 cm and affect over 1 million people in the United States. Risk factors for AAA include male sex, family history, smoking, Caucasian ethnicity, and age. Regular ultrasound surveillance is recommended for patients with known AAA. Medical management, including smoking cessation and blood pressure control, is recommended for asymptomatic patients who do not meet the intervention threshold. Repair options include endovascular and open surgical repair with good long-term outcomes. Elective repair is generally recommended for men with AAA greater than 5.5 cm and women with AAA greater than 5.0 cm.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Surgery
Kirsten D. Dansey, Rens R. B. Varkevisser, Nicholas J. Swerdlow, Chun Li, Livia E. V. M. de Guerre, Patric Liang, Christina Marcaccio, Thomas F. X. O'Donnell, Brett J. Carroll, Marc L. Schermerhorn
Summary: This study found that the majority of patients who underwent repair for ruptured AAAs did not meet the screening criteria, especially those aged over 75, under 65, and women. Endovascular repair was the primary treatment for both ruptured and intact AAAs with relatively low in-hospital mortality rates.
JOURNAL OF VASCULAR SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Matti Jubouri, Abedalaziz O. Surkhi, Sven Z. C. P. Tan, Damian M. Bailey, Ian M. Williams, Mohamad Bashir
Summary: This study analyzed the international use of the Terumo Aortic Fenestrated Anaconda (TM) device over a 9-year period in 27 countries across 6 continents, with a total of 5,030 devices implanted. The Anaconda (TM) showed superiority in treating complex aortic anatomy and achieving excellent clinical results. The device was primarily used due to competitor rejection or surgeon preference, and most devices were implanted within 6-8 weeks of diagnosis.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Surgery
Lewis Meecham, Jo Jacomelli, Meryl Davis, Arun Pherwani, Tim Lees, Jonothan J. Earnshaw
Summary: The study examined the referral and treatment outcomes of men in the NHS Abdominal Aortic Aneurysm Screening Programme, revealing a low rate of refusal for treatment and significant regional variation in the proportion undergoing endovascular repair. Surgical interventions were consistently carried out with low peri-operative mortality rates.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2021)
Review
Cardiac & Cardiovascular Systems
Kofi B. Quaye, Neena Pack, Timothy Wilson-Byrne, Chandler A. Long
Summary: Advancements in endovascular technologies have allowed us to treat more patients. Further research is warranted on non-operative medical therapies.
CURRENT CARDIOLOGY REPORTS
(2022)
Article
Cardiac & Cardiovascular Systems
Peng Ruan, Lei Gao, Hui Jiang, Tianshu Chu, Jianjun Ge, Xiang Kong
Summary: This study found that the gene encoding protein tyrosine phosphatase non-receptor type 22 (PTPN22) may be a valuable diagnostic biomarker for abdominal aortic aneurysm (AAA). Integrative bioinformatics analysis and cellular validation demonstrated consistently upregulated expression of PTPN22 in aortic tissues and peripheral blood cells of AAA patients.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Surgery
Sungho Lim, Stephen Kwan, Benjamin D. Colvard, Alexandre d'Audiffret, Vikram S. Kashyap, Jae S. Cho
Summary: This study evaluated the effects of interfacility transfer (IT) on mortality after repair of ruptured abdominal aortic aneurysm (rAAA), using a contemporary administrative database. The results showed that IT did not affect the mortality rates after endovascular repair, but it improved the mortality rates for open repair, particularly in high-volume hospitals.
JOURNAL OF VASCULAR SURGERY
(2022)
Article
Surgery
Bibombe P. Mwipatayi, Joseph Faraj, Olufemi Oshin, Robert Fitridge, Jackie Wong, Marc L. Schermerhorn, Jean-Pierre Becquemin, Dittmar Boeckler, Vincente Riambau, Joep A. W. Teijink, Marc R. H. M. van Sambeek, Hence Verhagen
Summary: This study aimed to evaluate the 5-year safety and effectiveness outcomes of patients treated with Endurant stent graft within and outside the approved indications for use (IFU) in the ENGAGE registry. The analysis found no differences in all-cause mortality, aneurysm-related mortality, and secondary procedures between within and outside IFU patients during the 5-year follow-up.
JOURNAL OF VASCULAR SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Dunpeng Cai, Chenming Sun, Takashi Murashita, Xingyi Que, Shi-You Chen
Summary: This study reveals the crucial role of macrophage activation in abdominal aortic aneurysm (AAA) development. It identifies adenosine deaminase acting on RNA (ADAR1) as a novel mechanism underlying macrophage activation and AAA formation.
CIRCULATION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Francesco Lorenzo Serafini, Andrea Delli Pizzi, Pasquale Simeone, Alberto Giammarino, Cristian Mannetta, Michela Villani, Jacopo Izzi, Davide Buca, Giulia Catitti, Piero Chiacchiaretta, Stefano Trebeschi, Sebastiano Miscia, Massimo Caulo, Paola Lanuti
Summary: Abdominal aortic aneurysm (AAA) is a common aortic disease that can be treated with open surgical repair (OSR) or endovascular aortic repair (EVAR). Follow-up monitoring using computed tomography angiography (CTA) for 5 years is necessary to prevent complications. However, CTA involves high radiation exposure. This study explores the potential of peripheral-blood-circulating extracellular vesicles (pbcEVs) as biomarkers for EVAR complications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)